Recent Publications

R.S. Freeman, S. Estus and E.M. Johnson, Jr. (1994) Analysis of cell cycle-related gene expression in postmitotic neurons: selective induction of cyclin D1 during programmed cell death. Neuron 12:343-355. 

R.J. Crowder and R.S. Freeman. (1998) Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the survival of nerve growth factor-dependent sympathetic neurons. J. Neurosci. 18:2933-2943. 

S.B. Maggirwar, P.D. Sarmiere, S. Dewhurst and R.S. Freeman. (1998) Nerve growth factor-dependent activation of NF-kB contributes to survival of sympathetic neurons. J. Neurosci. 18:10356-10365. 

E.A. Lipscomb, P.D. Sarmiere, R.J. Crowder, and R.S. Freeman.(1999) Expression of the SM-20 gene promotes death in nerve growth factor-dependent sympathetic neurons. J. Neurochem. 73:429-432.

R.J. Crowder and R. S. Freeman. (1999) The survival of sympathetic neurons promoted by potassium depolarization, but not by cyclic AMP, requires phosphatidylinositol 3-kinase and Akt. J. Neurochem. 73:466-475.

R.J. Crowder and R.S. Freeman. (2000) Glycogen synthase kinase-3b activity is critical for neuronal death caused by inhibiting phosphatidylinositol 3-kinase or akt but not for death caused by nerve growth factor withdrawal. J. Biol. Chem.  275:34266-34271.

Lipscomb, E.A., Sarmiere, P.D., and Freeman, R.S. (2001) SM-20: A novel mitochondrial protein that causes caspase-dependent cell death in nerve growth factor-dependent sympathetic neurons. J. Biol. Chem. 276:5085-5092.

Freeman, R.S. and Barone, M.C. (2005) Targeting hypoxia-inducible factor (HIF) as a therapeutic strategy for CNS disorders. Curr. Drug Targets 4:85-92.

Xie, L., Johnson, R.S., and Freeman, R.S. (2005) Inhibition of NGF deprivation-induced death by low oxygen involved suppression of BIMEL and activation of HIF-1. J. Cell Biol. 168:911-920.