Curriculum Vitae

MARION WALTER ANDERS

Education | Professional Appointments | Honors and Awards
Professional Societies | Professional Activities
Editorial Activities | UR Assignments
Research and Training Support
Training Record | Bibliography

EDUCATION:

1962-1964, University of Minnesota, Minneapolis, Ph.D., Pharmacology.

1960-1962, University of Wisconsin, Madison. Graduate study in the Department of Pharmacology.

1954-1960, Iowa State University, Ames. Degree: D.V.M.

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PROFESSIONAL APPOINTMENTS:

2001-present, University of Rochester, Rochester, NY. Professor and Chair Emeritus, Department of Pharmacology and Physiology.

2001-present, University of Rochester, Rochester, NY. Professor Emeritus, Departments of Environmental Medicine and of Anesthesiology

2000-present, University of Arizona, Tucson. Investigator, Center for Toxicology, School of Pharmacy.

1998-2000, University of Rochester, Rochester, NY. Professor, Department of Anesthesiology.

1996-2000, University of Rochester, Rochester, NY. Chair and Lewis Pratt Ross Professor of Pharmacology and Physiology.

1994-1995, University of Rochester, Rochester, NY. Chair and Paul Stark Professor of Pharmacology.

1982-2000, University of Rochester, Rochester, NY. Professor, Department of Environmental Medicine.

1982-1995, University of Rochester, Rochester, NY. Professor and Chair, Department of Pharmacology.

1975-1982, University of Minnesota, Minneapolis. Professor, Department of Pharmacology.

1969-1975, University of Minnesota, Minneapolis. Associate Professor, Department of Pharmacology.

1968-1969, Cornell University, Ithaca, NY. Associate Professor, Department of Physiology, Biochemistry and Pharmacology.

1965-1968, Cornell University, Ithaca, NY. Assistant Professor, Department of Physiology, Biochemistry and Pharmacology.

1964-1965, University of Minnesota, St. Paul. Instructor, Department of Veterinary Physiology and Pharmacology.

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HONORS AND AWARDS:

MERIT Awardee, National Institute of Environmental Health Sciences, 1986-1996.

Bernard B. Brodie Award in Drug Metabolism, American Society of Pharmacology and Experimental Therapeutics, 1999.

Symposium on "Bioactivation of Foreign Compounds--Challenges for the Future." Held in honor of Professor Drag Anders. Hosted by the Center for Molecular Toxicology, Vanderbilt University, Nashville, TN, 15-16 March 2002.

Merit Award, Society of Toxicology, 2003.

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PROFESSIONAL SOCIETIES:

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PROFESSIONAL ACTIVITIES (Last 10 Years):

1992-1997, Scientific Advisory Panel, Federal Insecticide, Fungicide, and Rodenticide Act (FIFRA), U.S. Environmental Protection Agency.

1994-2000, Science Advisory Board Member, National Center for Toxicological Research of the Food and Drug Administration.

1995-1998, Member, External Advisory Board, University of Florida Superfund Basic Research Program Project.

1996, Invited Speaker, Seventh Annual Graduate Research in Progress (G.R.I.P.) Conference, University of Toronto, Ontario, Canada, 22 February 1996.

1996, Invited Speaker, Workshop on Toxicity of Alternatives to Chlorofluorocarbons (CFCs), National Research Council, Anaheim, CA, 7-8 March 1996.

1996, Lecturer, Mitochondrial Injury in Toxicology, Society of Toxicology Continuing Education Course, Anaheim, CA, 10-14 March 1996.

1996, American Society for Pharmacology and Experimental Therapeutics, 1994 Best Paper Award (H. Heyn, D. J. McCarthy, S. H. Curry, M. S. Eisman, and M. W. Anders: Brain uptake and biotransformation of remacemide hydrochloride, a novel anticonvulsant. Drug Metab. Dispos. 22, 443-446, 1994) Presented at the Experimental Biology '96 Meeting, Washington, DC, 14-17 April 1996.

1996-1998, Chair, Science Advisory Board, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR, 1 July 1996 to 30 June 1998.

1996, Invited Speaker, 14th Annual New England Membrane and Enzymology Group (NUTMEG) Meeting, Sturbridge, MA, 4-5 November 1996.

1996-2001, Member, Scientific Advisory Board, Chemical Industry Institute of Toxicology, Research Triangle Park, NC.

1997, Invited Speaker, Biophysical Society Meeting, New Orleans, LA, 2-6 March 1997.

1997, Seminar, University of Massachusetts Medical School, Worcester, MA, 28 April 1997.

1997, Co-Organizer and Speaker, 1997 Fall Symposium, "Designing Safer Chemicals: Bioactivation and Prediction of Toxicity," Rochester Section Inc. of the American Chemical Society Meeting, Rochester, NY, 1 October 1997.

1997, Burroughs-Wellcome Visiting Scholar in Pharmacology, Marshall University, Huntington, WV, 6-7 October 1997.

1998, Seminar, National Health and Environmental Effects Research Laboratory, Environmental Protection Agency, Research Triangle Park, NC, 17 February 1998.

1998, Search Committee, Deputy Director for Research, National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR.

1998, Invited Speaker, Joint American Chemical Society/International Society for the Study of Xenobiotics Symposium on Mammalian Glutathione S-Transferases, Boston, MA, 24 August 1998.

1998-1999, Member, Subcommittee for Exposure Guidance Levels for Selected Hydrofluorocarbons, Committee on Toxicology, National Research Council.

1999, Member, External Review Committee, Department of Comparative Biosciences, University of Wisconsin at Madison, WI, 15-17 February 1999.

1999, Recipient, Bernard B. Brodie Award in Drug Metabolism, American Society for Pharmacology and Experimental Therapeutics.

1999, Participant, Roundtable on Genetically Modified Crops, National Academy of Sciences and the American Association for the Advancement of Science, July 16, 1999, Washington, DC.

1999, Seminar, Chemical Industry Institute of Toxicology, Research Triangle Park, NC, 12 August 1999.

1999, Invited Speaker, North Jersey ACS Drug Metabolism Discussion Group, Somerset, NJ, 7 October 1999.

1999, Invited Speaker, Harris Lecture, Division of Bioengineering and Environmental Health, MIT, Cambridge, MA, 3-4 November 1999.

1999, Invited Speaker, 13th Annual Meeting of the Japanese Society for Alternatives to Animal Experiments, Juntendo University, Tokyo, Japan, 13-14 November 1999.

1999, Seminar, Department of Pharmacology and Toxicology, Kyorin University, Tokyo, Japan, 15 November 1999.

1999-2000, Search Committee, Director of National Center for Toxicological Research, Food and Drug Administration, Jefferson, AR.

2000-present, Member, External Advisory Group, Center in Molecular Toxicology, Vanderbilt University, Nashville, TN.

2000, Seminar, Department of Physical Therapy, Exercise, and Nutritional Sciences, SUNY, Buffalo, 3 March 2000.

2000, Seminar, Department of Biochemistry, Vanderbilt University, Nashville, TN, 16 March 2000.

2000-2001, Member, Science Board, Food and Drug Administration, Rockville, MD.

2000, Member, External Advisory Committee, Southwest Environmental Health Sciences Center, University of Arizona, Tucson, AZ.

2000, Invited Speaker, GST 2000 International Conference on Glutathione Transferases, Uppsala, Sweden, 19-23 May 2000.

2000, Seminar, Hokkaido University, Sapporo, Japan, 26 June 2000.

2000, Invited Speaker, 27th Annual Meeting of the Japanese Society of Toxicology, Yokohama, Japan, 28-30 June 2000.

2000, Invited Speaker, Drug Metabolism/Toxicology Symposium, Joint Meeting of the British Pharmacological Society and the American Society for Pharmacology and Experimental Therapeutics, Cardiff, UK, 12-14 July 2000.

2000, Invited Speaker and Member, International Scientific Program Advisory Committee, 6th International Symposium on Biological Reactive Intermediates, Paris, France, 16-20 July 2000.

2001, Seminar, Kyorin University, Tokyo, Japan, 10 September 2001.

2001, Nippon Zoki Pharmaceutical Co., Ltd., Osaka, Japan, 13 September 2001.

2002, Symposium on "Bioactivation of Foreign Compounds--Challenges for the Future." Held in honor of Professor Drag Anders. Hosted by the Center for Molecular Toxicology, Vanderbilt University, Nashville, TN 15-16 March 2002.

2003, Recipient, Merit Award, Society of Toxicology.

2003, Seminar, Environmental Biosciences Program, Medical University of South Carolina, Charleston, 4-6 November 2003.

2004, Invited Speaker, Workshop on Drug Development, Arizona Cancer Center, University of Arizona, Tucson, 22 January 2004.

2004, Seminar, Department of Pharmacology, University of Arizona, Tucson, 10 March 2004.

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EDITORIAL ACTIVITIES:

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UNIVERSITY OF ROCHESTER COMMITTEE ASSIGNMENTS:

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RESEARCH AND TRAINING SUPPORT:

Active:

ES03127, National Institute of Environmental Health Sciences, Metabolism and Toxicity of Halogenated Hydrocarbons, $884,081 (1 May 2001 to 30 April 2005), PI: M. W. Anders.

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TRAINING RECORD:

Predoctoral Trainees

W. B. Anderson: Ph.D., 2003. Thesis: Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid. Present position: Senior Research Chemist, Merck Research Laboratories, West Point, PA.

J. C. English: Ph.D., 1985. Thesis: Studies on the inactivation of cytochrome P-450 isozymes by carbon tetrachloride. Present position: Biochemical Toxicologist, Eastman Kodak Company, Rochester, NY.

M. B. Finkelstein: Ph.D., 1995. Thesis: a-Thiolactones and 2,2-difluoro-3-halothiiranes and novel intermediates in the cysteine conjugate b-lyase-catalyzed bioactivation of bromine-containing cysteine S-conjugates. Present position: Senior Research Scientist, Pfizer Inc., Groton, CT.

M. E. Fitzsimmons: Ph.D., 1994. Thesis: Studies on the biotransformation and bioactivation of halogenated thiaalkanoic acids. Present position: Study Director, Covance, Madison, WI.

S. J. Hargus: Ph.D., 1992. Thesis: Nephrotoxic S-conjugates of chlorotrifluoroethylene and tetrafluoroethylene: Stereochemistry of S-(2-chloro-1,1,2-trifluoroethyl)glutathione formation and covalent modification of rat kidney proteins by metabolites of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine and S-(1,1,2,2-tetrafluoroethyl)-L-cysteine. Present position: Food and Drug Administration, Rockville, MD.

J. W. Harris: Ph.D., 1991. Thesis: Studies on the metabolism and bioactivation of haloalkanes and haloalkenes. Present position: Chief Scientific Officer, Bioavailability Systems, LLC, Cocoa Beach, FL.

R. N. Harris: Ph.D., 1980. Thesis: Studies on the mechanism of potentiation of carbon tetrachloride hepatotoxicity by short-chain alcohols. Present position: Pacific Toxicology Labs., Los Angeles, CA.

L. J. Jolivette: Ph.D., 2001. Thesis: Computational modeling of the microsomal glutathione transferase-catalyzed reaction of glutathione with halogenated alkenes. Present position: GlaxoSmithKline, King of Prussia, PA.

V. L. Kubic: Ph.D., 1976. Thesis: The metabolism of dihalomethanes. Present position: Assistant Professor, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.

H. M. B. Lantum, M.D., 2003. Thesis: Perturbation of the tyrosine degradation pathway by dichloroacetic acid (DCA) - A mechanism for DCA-induced multiorgan toxicity and hepatocarcinogenesis. Present Position: Biochemical and Analytical Toxicology, Eastman Kodak Company, Rochester, NY.

T. D. Lindstrom: Ph.D., 1977. Thesis: Studies on the biochemical hepatotoxicity of carbon tetrachloride. Present position: Senior Pharmacologist, Lilly Research Laboratories, Indianapolis, IN.

J. C. Livesey: Ph.D., 1982. Thesis: Studies on the metabolism and toxicity of 1,2-dihaloethanes. Present position: Assistant Professor of Physiology and Pharmacology, University of the Pacific School of Pharmacy and Health Sciences, Stockton, CA.

G. A. Maylin, D.V.M.: M.S., 1969. Thesis: The kinetics and stereochemistry of metabolism of ethylbenzene. Present position: Associate Professor of Toxicology and Director, Division of Toxicology, Diagnostic Laboratory, New York State College of Veterinary Medicine, Cornell University, and Director, New York State Racing and Wagering Board Drug Testing and Research Program, Cornell University, Ithaca, NY.

M. A. Otieno: Ph.D., 1997. Thesis: Nephrotoxic haloalkenes and their cysteine S-conjugates: Molecular events associated with their toxicity. Present position: AstraZeneca Pharmaceuticals, Wilmington, DE.

E. S. Shen: M.S., 1981. Thesis: The effect of hypoxia on carbon tetrachloride hepatotoxicity. Present position: Merck-DuPont, Wilmington, DE.

J. L. Stevens: Ph.D., 1980. Thesis: Metabolism and toxicity of the haloforms. Present position: Lilly Research Labs, Greenfield, IN.

V. P. Uttamsingh, Ph.D., 1999. Thesis: Multiple acylases catalyze the deacetylation of S-substituted N-acetyl-L-cysteines. Present position: Millennium Pharmaceuticals, Inc., Cambridge, MA.

W. W. Webb: Ph.D., 1985. Thesis: Studies on the rat endoplasmic reticulum Ca²⁺-ATPase and its relationship to toxic cell death. Present position: Medical practitioner, Ypsilanti, MI.

H. Yin: Ph.D., 1995. Thesis: Biotransformation and bioactivation of halogenated alkanes. Present position: Senior Scientist II, Drug Metabolism and Pharmacokinetics, Novartis Pharmaceuticals Corp., East Hanover, NJ.

Postdoctoral trainees and visiting scientists

Dr. A. E. Ahmed, 1975-1977, Postdoctoral. (Ph.D., 1975, University of Minnesota, Medicinal Chemistry) Present position: Professor, Department of Pathology, University of Texas Medical Branch, Galveston.

Dr. Y. Aniya, 1983-1984, 1986, Visiting Professor. (Ph.D., 1980, University of the Ryukyus, Okinawa, Japan, Medical Sciences) Present position: Professor of Pharmacology and Toxicology, School of Health Science, University of the Ryukyus, Okinawa, Japan.

Dr. K. Banki, 1985-1988, Postdoctoral. (M.D., 1979, Semmelweis University, Budapest, Hungary) Present position: Research Assistant Professor, Department of Pathology, State University of New York Health Sciences Center, Syracuse, NY.

Dr. A. Brundin, 1979-1980, Postdoctoral. (Ph.D., 1978, University of Umeå, Umeå, Sweden, Chemistry) Present position: Chemist, Nordtend A/S, Stavanger, Norway.

Dr. W. Dekant, 1986-1987, Postdoctoral. (Ph.D., 1984, University of Würzburg, Organic Chemistry) Present position: Associate Professor, Institute for Toxicology, University of Würzburg, Federal Republic of Germany.

Dr. D. R. Dohn, 1980-1983, Postdoctoral. (Ph.D., 1980, University of California-Davis, Biochemistry) Present position: Research Biochemist, Pesticide Metabolism Section, ICI Americas Inc., Richmond, CA.

Dr. A. A. Elfarra, 1982-1985, Postdoctoral. (Ph.D., 1982, University of Minnesota, Medicinal Chemistry) Present position: Associate Professor, Department of Comparative Biosciences, School of Veterinary Medicine, University of Wisconsin, Madison.

Dr. Y. Gietl, 1988-1990, Postdoctoral. (Ph.D., 1988, University of Frankfurt, Pharmacology) Present Position: Knoll AG, Department of Biochemie, Ludwigshafen, Federal Republic of Germany.

Dr. M. Hashmi, 1988-1994, Postdoctoral. (Ph.D., 1984, Aligarh Muslim University, Aligarh, India, Medicinal Chemistry) Present position: Scientist, Visus Pharmaceuticals, Halifax, MA, and Adjunct Assistant Professor, University of Rochester, NY.

Dr. H. Heyn, 1992-1994, Postdoctoral. (Ph.D., 1992, Medical University of South Carolina, Pharmacology) Present position: CellTech, Rochester, NY.

Dr. Ramaswamy Iyer, 1994-1997, Postdoctoral. (Ph.D., 1994, University of Minnesota, Medicinal Chemistry) Present position: Research Investigator, Bristol-Myers Squibb Company, Princeton, NJ.

Dr. I. Jakobson, 1984, Visiting Scientist. (Ph.D., 1982, University of Stockholm, Biochemistry) Present position: Research Department, National Institute of Occupational Health, Solna, Sweden.

Dr. M. Kitada, 1981-1982, Postdoctoral. (Ph.D., 1978, University of Tokyo, Biochemistry) Present position: Hospital Pharmacy, Chiba University School of Medicine, Chiba, Japan.

Dr. V. L. Kubic, 1979, Postdoctoral. (Ph.D., 1976, University of Minnesota, Pharmacology) Present position: Assistant Professor, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.

Dr. L. H. Lash, 1985-1987, Postdoctoral. (Ph.D., 1985, Emory University, Biochemistry) Present position: Professor, Department of Pharmacology, Wayne State University, Detroit, MI.

Dr. G. D. Loizou, 1990-1993, Postdoctoral. (Ph.D., 1990, University of Bath, United Kingdom) Present position: Biological Modelling, Biomedical Sciences Group, HSL, Sheffield, United Kingdom.

Dr. M. D. Maines, 1971-1973, Postdoctoral. (Ph.D., 1970, University of Missouri, Pharmacology) Present position: Professor, Department of Biochemistry and Biophysics, University of Rochester, Rochester, NY.

Dr. Elaine M. Mokrzan, 1994-1995, Assistant. (Ph.D., 1990, University of North Carolina, Chapel Hill, Pharmacology) Not professionally active.

Dr. N. J. Patel, 1990-1993, Postdoctoral. (Ph.D., 1990, University of California at Los Angeles, Pharmacology) Present position: Senior Biochemical Pharmacologist in Drug Metabolism, Lilly Corporate Center, Indianapolis, IN.

Dr. G. H. R. Rao, 1971, Postdoctoral. (Ph.D., 1968, Kansas State University, Entomology) Present position: Professor, Department of Laboratory Medicine and Pathology, University of Minnesota, Minneapolis.

Dr. H. Remmer, 1986, Visiting Professor. (M.D., 1945, University of Berlin) Present position: Professor Emeritus, Institut für Toxikologie, Universität Tübingen, Tübingen, Federal Republic of Germany.

Dr. M. Shimoji, 1995-1998, Postdoctoral. (Ph.D., 1993, Hokkaido University, Japan) Present position: Postdoctoral Fellow, Uppsala University, Uppsala, Sweden.

Dr. E. Tanaka, 1992-1994, Postdoctoral. (D.V.M., 1981, Hokkaido University, Japan; Ph.D., 1992, Nippon Veterinary and Zootechnical College, Japan) Present position: Mitsubishi Kasei Corporation Research Center, Yokohama, Japan.

Dr. Z. Tong, 1995-1998, Postdoctoral (Ph.D., 1996, University of Florida) Present position: Wyeth-Ayerst Research, Princeton, NJ.

Dr. Z. Tu, 1995-1999, Postdoctoral. (M.D., 1989, Tianjin Medical College, P.R. China; Ph.D., 1994, University of Nebraska Medical Center). Present position: Division of Immunology and Allergy, University Hospitals, Case Western Reserve University, Cleveland, OH.

Dr. H.-F. Tzeng, 1998-1999, Postdoctoral. (Ph.D., 1998, Vanderbilt University). Present position: Department of Zoology, National Chi Nan University, Nantou, Taiwan, ROC.

Dr. S. Vamvakas, 1988-1990, Postdoctoral. (M.D., 1985, University of Würzburg) Present position: Principal Scientific Administrator, European Medicines Evaluation Agency-Human Unit, European Agency for the Evaluation of Medicinal Products, London, England

Dr. J. C. Veltman, 1985-1988, Postdoctoral. (Ph.D., 1986, University of Illinois, Pharmacology) Present position: Research Toxicologist, Alcon Laboratories, Inc., Ft. Worth, TX.

Dr. K. D. Webster, 1985-1988, Postdoctoral. (Ph.D., 1986, University of Minnesota, Medicinal Chemistry) Present position: Associate Professor, Campbell University, School of Pharmacy, Buies Creek, NC.

Dr. M. F. Wempe, 1998-2001, Postdoctoral. (Ph.D., 1996, Miami University) Present position: Novartis Pharmaceuticals Corp., East Hanover, NJ.

Dr. Lin Xu, 2002-2004, Postdoctoral. (Ph.D., 2000, University of British Columbia, Natural Products Chemistry) Present position: Merck and Co., Inc., Boston, MA.

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BIBLIOGRAPHY

Peer-reviewed Publications

Anders, M. W., and Mannering, G. J. (1962) New peak-shift technique for gas-liquid chromatography. Anal. Chem. 34, 730-733.

Anders, M. W. (1966) Rapid micromethod for the gas chromatographic determination of blood barbituates. Anal. Chem. 38, 1945-1947.

Anders, M. W., Alvares, A. P., and Mannering, G. J. (1966) Inhibition of drug metabolism. II. Metabolism of 2-diethylaminoethyl 2,2-diphenylvalerate HCl (SKF 525-A). Mol. Pharmacol. 2, 328-334.

Stitzel, R. E., Anders, M. W., and Mannering, G. J. (1966) Inhibition of drug metabolism. III. Inhibition of hexobarbital metabolism in the intact rat and in the isolated perfused liver by 2-diethylaminoethyl 2,2-diphenylvalerate HCl (SKF 525-A) and its N-deethylated derivatives. Mol. Pharmacol. 2, 335-340.

Anders, M. W., and Mannering, G. J. (1966) Inhibition of drug metabolism. IV. Induction of drug metabolism by 2-diethylaminoethyl 2,2-diphenylvalerate HCl (SKF 525-A) and 2,4-dichloro-6-phenylphenoxyethyldiethylamine HBr (Lilly 18947) and the effect of induction on the inhibitory properties of SKF 525-A type compounds. Mol. Pharmacol. 2, 341-346.

Anders, M. W. (1968) Acetone enhancement of microsomal aniline para-hydroxylase activity. Arch. Biochem. Biophys. 126, 269-275.

Anders, M. W. (1968) Inhibition of microsomal drug metabolism by methylenedioxybenzenes. Biochem. Pharmacol. 17, 2367-2370.

Anders, M. W. (1969) In vitro stimulation of microsomal aniline hydroxylation by 2,2'-bipyridine. Biochem. Pharmacol. 18, 2561-2565.

Furner, R. L., McCarthy, J. S., Stitzel, R. E., and Anders, M. W. (1969) Stereoselective metabolism of the enantiomers of hexobarbital. J. Pharmacol. Exp. Ther. 169, 153-158.

Anders, M. W., and Latorre, J. P. (1970) High-speed ion exchange chromatography of barbiturates, diphenylhydantoin and their hydroxylated metabolites. Anal. Chem. 42, 1430-1432.

Anders, M. W., and Cooper, M. J. (1971) Gas chromatographic resolution of optically active alcohols as 3b-acetoxy-D⁵-etienates. Anal. Chem. 43, 1093-1094.

Anders, M. W., and Latorre, J. P. (1971) High-speed liquid chromatography of glucuronide and sulfate conjugates. J. Chromatog. 55, 409-413.

Anders, M. W. (1972) Effect of phenobarbital and 3-methylcholanthrene administration on the in vitro enhancement of microsomal aromatic hydroxylation. Arch. Biochem. Biophys. 153, 502-507.

Anders, M. W., Cooper, M. J., and Takemori, A. E. (1973) Kinetics of microsomal metabolism and binding of enantiomerically related substrates. Drug Metab. Dispos. 1, 642-644.

Cooper, M. J., Anders, M. W., and Mirkin, B. L. (1973) Ion-pair extraction and high speed liquid chromatography of cephalothin and deacetylcephalothin in human serum and urine. Drug Metab. Dispos. 1, 659-662.

Dunham, E. W., and Anders, M. W. (1973) High-speed liquid chromatographic analysis of prostaglandins in rat kidney. Prostaglandins 4, 85-92.

Maines, M. D., and Anders, M. W. (1973) The possible implication of heme transfer from cytochrome P-420 to albumin in the metabolism of cytochrome P-450. Drug Metab. Dispos. 1, 293-296.

Maines, M. D., and Anders, M. W. (1973) Reconstitution of carbon monoxide-binding particles after removal of heme by serum albumin. Mol. Pharmacol. 9, 219-228.

Maines, M. D., and Anders, M. W. (1973) Characterization of the heme of cytochrome P-450 using gas chromatography/mass spectrometry. Arch. Biochem. Biophys. 159, 201-205.

Maylin, G. A., Cooper, M. J., and Anders, M. W. (1973) Effect of phenobarbital treatment on the stereochemistry of the in vitro metabolism of ethylbenzene. J. Med. Chem. 16, 606-610.

Quebbemann, A. J., and Anders, M. W. (1973) Renal conjugation and excretion of phenol and p-nitrophenol in the chicken: support for a concept of differing mechanisms of renal transfer. J. Pharmacol. Exp. Ther. 184, 695-708.

Rao, G. H. R., and Anders, M. W. (1973) Inhibition of microsomal drug metabolism by anticholinesterase insecticides. Bull. Environ. Contam. Toxicol. 9, 4-9.

Rao, G. H. R., and Anders, M. W. (1973) Alfatoxin detection by high-speed liquid chromatography and mass spectrometry. J. Chromatog. 84, 402-406.

Cooper, M. J., and Anders, M. W. (1974) Analysis of long chain fatty acids as 2-naphthacyl esters by high-pressure liquid chromatography and mass spectrometry. Anal. Chem. 46, 1849-1852.

Cooper, M. J., and Anders, M. W. (1974) Metabolic and pharmacodynamic interactions of enantiomers of propoxyphene and methorphan. Life Sci. 15, 1665-1672.

Hanna, P. E., Grund, V. R., and Anders, M. W. (1974) Conformationally restricted analogs of histamine H1 receptor antagonists. 2-Phenyl- and 2-benzyl-1,2,3,4-tetrahydro-4-dimethylaminoisoquinoline. J. Med. Chem. 17, 1020-1023.

Kubic, V. L., Anders, M. W., Engel, R. R., Barlow, C. H., and Caughey, W. S. (1974) Metabolism of dihalomethanes to carbon monoxide. I. In vivo studies. Drug Metab. Dispos. 2, 53-57.

Maines, M. D., Anders, M. W., and Muller-Eberhard, U. (1974) Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins. Mol. Pharmacol. 10, 204-213.

Cooper, M. J., and Anders, M. W. (1975) Gas chromatographic microdetermination of acetanilide in blood. J. Chromatog. 104, 215-216.

Kubic, V. L., and Anders, M. W. (1975) Metabolism of dihalomethanes to carbon monoxide. II. In vitro studies. Drug Metab. Dispos. 3, 104-112.

Ahmed, A. E., and Anders, M. W. (1976) Metabolism of dihalomethanes to formaldehyde and inorganic halide. I. In vitro studies. Drug Metab. Dispos. 4, 357-361.

Cooper, M. J., Sinaiko, A. R., Anders, M. W., and Mirkin, B. L. (1976) High pressure liquid chromatographic analysis of hydrochlorothiazide in human serum and urine. Anal. Chem. 48, 1110-1111.

Ahmed, A. E., Kubic, V. L., and Anders, M. W. (1977) Metabolism of haloforms to carbon monoxide. I. In vitro studies. Drug Metab. Dispos. 5, 198-204.

Cooper, M. J., Mirkin, B. L., and Anders, M. W. (1977) A rapid micromethod for the high pressure liquid chromatographic determination of theophylline in human serum. J. Chromatog. 143, 324-326.

Gammans, R. E., Sehon, R. D., Anders, M. W., and Hanna, P. E. (1977) Microsomal N-hydroxylation of trans-4'-halo-4-acetamidostilbenes. Drug Metab. Dispos. 5, 310-316.

Lindstrom, T. D., and Anders, M. W. (1977) Studies on the mechanism of carbon tetrachloride autoprotection: effect of a protective dose of carbon tetrachloride on lipid peroxidation and glutathione peroxidase-glutathione reductase. Toxicol. Lett. 1, 109-114.

Lindstrom, T. D., and Anders, M. W. (1977) Effect of cycloheximide and actinomycin D on carbon tetrachloride hepatoxicity. Toxicol. Appl. Pharmacol. 42, 167-173.

Montgomery, M. R., Wier, G. T., Zieve, F. J., and Anders, M. W. (1977) Human intoxication following inhalation exposure to synthetic jet lubricating oil. Clin. Toxicol. 11, 423-426.

Rolewicz, T. F., Mirkin, B. L., Cooper, M. J., and Anders, M. W. (1977) Metabolic disposition of cephalothin and deacetylcephalothin in children: comparison of high-performance liquid chromatographic and microbial assay procedures. Clin. Pharmacol. Ther. 22, 928-935.

Ahmed, A. E., and Anders, M. W. (1978) Metabolism of dihalomethanes to formaldehyde and inorganic halide. II. Studies on the mechanism of the reaction. Biochem. Pharmacol. 27, 2021-2025.

Anders, M. W. (1978) Inhibition and enhancement of microsomal drug metabolism by diethyl maleate. Biochem. Pharmacol. 27, 1098-1101.

Anders, M. W., Stevens, J. L., Sprague, R. W., Shaath, Z., and Ahmed, A. E. (1978) Metabolism of haloforms to carbon monoxide. II. In vivo studies. Drug Metab. Dispos. 6, 556-560.

Gammans, R. E., Sehon, R. D., Anders, M. W., and Hanna, P. E. (1978) Microsomal N-hydroxylation of trans-4'-acetamidostilbenes. Drug Metab. Dispos. 6, 226-231.

Hanson, S. K., and Anders, M. W. (1978) Effect of diethyl maleate treatment, fasting and time of administration on allyl alcohol hepatotoxicity. Toxicol. Lett. 1, 301-305.

Hanson, S. K., Anders, M. W., and Montgomery, M. R. (1978) Oxygen metabolism in rabbit bone marrow and liver. Biochem. Biophys. Res. Commun. 85, 783-787.

Kubic, V. L., and Anders, M. W. (1978) Metabolism of dihalomethanes to carbon monoxide–III. Studies on the mechanisms of the reaction. Biochem. Pharmacol. 27, 2349-2355.

Lindstrom, T. D., and Anders, M. W. (1978) The effect of agents known to alter carbon tetrachloride hepatotoxicity and cytochrome P-450 levels on carbon tetrachloride stimulated lipid peroxidation and ethane evolution in the intact rat. Biochem. Pharmacol. 27, 563-567.

Lindstrom, T. D., and Anders, M. W. (1978) The effect of phenobarbital and 3-methylcholanthrene treatment on carbon tetrachloride-stimulated heme degradation and carbon monoxide expiration in vivo. Toxicol. Lett 1, 307-314.

Lindstrom, T. D., Anders, M. W., and Remmer, H. (1978) Effect of phenobarbital and diethyl maleate on carbon tetrachloride toxicity in isolated hepatocytes. Exp. Mol. Pathol. 28, 48-57.

Merriman, R. L., Swanson, A., Anders, M. W., and Sladek, N. E. (1978) Microdetermination of caffeine in blood by gas chromatography/mass spectrometry. J. Chromatog. 146, 85-90.

Anders, M. W., and Gander, J. E. (1979) Acetone enhancement of cumene hydroperoxide supported microsomal aniline hydroxylation. Life Sci. 25, 1085-1090.

Geisler, C., Swanson, A., Zieve, L., and Anders, M. W. (1979) Phthalate interference in plasma long-chain fatty acid determination by gas chromatography. Clin. Chem. 25, 308-310.

Livesey, J. C., and Anders, M. W. (1979) In vitro metabolism of 1,2-dihaloethanes to ethylene. Drug Metab. Dispos. 7, 199-203.

Repine, J. E., Eaton, J. W., Anders, M. W., Hoidal, J. R., and Fox, R. B. (1979) Generation of hydroxyl radical by chemicals, enzymes and human phagocytes in vitro: detection with the anti-flammatory agent, dimethyl sulfoxide. J. Clin. Invest. 64, 1642-1651.

Stevens, J. L., and Anders, M. W. (1979) Metabolism of haloforms to carbon monoxide. III. Studies on the mechanism of the reaction. Biochem. Pharmacol. 28, 3189-3194.

Anders, M. W., Ratnayake, J. H., Hanna, P. E., and Fuchs, J. A. (1980) Involvement of thioredoxin in sulfoxide reduction by mammalian tissues. Biochem. Biophys. Res. Commun. 97, 846-851.

Harris, R. N., and Anders, M. W. (1980) Effect of fasting, diethyl maleate and alcohols on carbon tetrachloride-induced hepatotoxicity. Toxicol. Appl. Pharmacol. 56, 191-198.

Kubic, V. L., and Anders, M. W. (1980) Metabolism of carbon tetrachloride to phosgene. Life Sci. 26, 2151-2155.

Stevens, J. L., Ratnayake, J. H., and Anders, M. W. (1980) Metabolism of dihalomethanes to carbon monoxide. V. Studies in isolated rat hepatocytes. Toxicol. Appl. Pharmacol. 55, 484-489.

Yu, L., Wilkinson, C. F., and Anders, M. W. (1980) Generation of carbon monoxide during the microsomal metabolism of methylenedioxyphenyl compounds. Biochem. Pharmacol. 29, 1113-1122.

Anders, M. W., Ratnayake, J. H., Hanna, P. E., and Fuchs, J. A. (1981) Thioredoxin-dependent renal sulfoxide reduction. Drug Metab. Dispos. 9, 307-310.

Harris, R. N., and Anders, M. W. (1981) Phosgene: a possible role in the potentiation of carbon tetrachloride hepatoxicity by 2-propanol. Life Sci. 29, 503-507.

Harris, R. N., and Anders, M. W. (1981) 2-Propanol treatment induces selectively the metabolism of carbon tetrachloride to phosgene: implications for carbon tetrachloride hepatotoxicity. Drug Metab. Dispos. 9, 551-556.

Kubic, V. L., and Anders, M. W. (1981) Mechanism of the microsomal reduction of carbon tetrachloride and halothane. Chem.-Biol. Interact. 34, 201-207.

Ratnayake, J. H., Hanna, P. E., Anders, M. W., and Duggan, D. E. (1981) Sulfoxide reduction: in vitro reduction of sulindac by rat hepatic cytosolic enzymes. Drug Metab. Dispos. 9, 85-87.

Stevens, J. L., and Anders, M. W. (1981) Metabolism of haloforms to carbon monoxide. IV. Studies on the reaction mechanism in vivo. Chem.-Biol. Interact. 37, 365-374.

Stevens, J. L., and Anders, M. W. (1981) Effect of cysteine diethyl maleate, and phenobarbital treatments on the hepatotoxicity of [¹H]- and [² H]chloroform. Chem.-Biol. Interact. 37, 207-217.

Swanson, A. R., and Anders, M. W. (1981) Analysis of ¹³C-carbon monoxide by gas chromatography/mass spectrometry. J. Chromatog. 207, 365-372.

Anders, M. W., and Sunram, J. M. (1982) Transplacental passage of dichloromethane and carbon monoxide. Toxicol. Lett. 12, 231-234.

Brundin, A., Ratnayake, J. H., Sunram, J. M., and Anders, M. W. (1982) Glutathione-dependent reductive dehalogenation of 2,2',4'-trichloroacetophenone to 2',4'-dichloroacetophenone. Biochem. Pharmacol. 31, 3885-3890.

Diamond, G. L., Anders, M. W., Tremaine, L. M., and Quebbemann, A. J. (1982) Salicylate enhancement of renal glucuronide conjugation and tubular excretory transfer of phenols. Drug Metab. Dispos. 10, 573-578.

Dohn, D. R., and Anders, M. W. (1982) Assay of cysteine conjugate b-lyase activity with S-(2-benzothiazolyl)cysteine as the substrate. Anal. Biochem. 120, 379-386.

Dohn, D. R., and Anders, M. W. (1982) The enzymatic reaction of chlorotrifluoroethylene with glutathione. Biochem. Biophys. Res. Commun. 109, 1339-1345.

Harris, R. N., Ratnayake, J. H., Garry, V. F., and Anders, M. W. (1982) Interactive hepatotoxicity of chloroform and carbon tetrachloride. Toxicol. Appl. Pharmacol. 63, 281-291.

Livesey, J. C., Anders, M. W., Langvardt, P. W., Putzig, C. L., and Reitz, R. H. (1982) Stereochemistry of the glutathione-dependent biotransformation of vicinal-dihaloalkanes to alkenes. Drug Metab. Dispos. 10, 201-204.

Shen, E. S., Garry, V. F., and Anders, M. W. (1982) Effect of hypoxia on carbon tetrachloride hepatotoxicity. Biochem. Pharmacol. 31, 3787-3793.

Anders, M. W., Sunram, J. M., and Wilkinson, C. F. (1984) Mechanism of the metabolism of 1,3-benzodioxoles to carbon monoxide. Biochem. Pharmacol. 33, 577-580.

Aniya, Y., and Anders, M. W. (1985) Chloroform-induced alteration of glutathione S-transferase activity. Biochem. Pharmacol. 34, 249-255.

Aniya, Y., and Anders, M. W. (1985) Alteration of hepatic glutathione S-transferases and release into serum after treatment with bromobenzene, carbon tetrachloride, or N-nitrosodimethylamine. Biochem. Pharmacol. 34, 4239-4244.

Dohn, D. R., Leininger, J. R., Lash, L. H., Quebbemann, A. J., and Anders, M. W. (1985) Nephrotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)glutathione and S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine, the glutathione and cysteine conjugates of chlorotrifluoroethene. J. Pharmacol. Exp. Ther. 235, 851-857.

Dohn, D. R., Quebbemann, A. J., Borch, R. F., and Anders, M. W. (1985) Enzymatic reaction of chlorotrifluoroethene with glutathione: ¹⁹F NMR evidence for stereochemical control of the reaction. Biochemistry 24, 5137-5143.

Elfarra, A. A., Baggs, R. B., and Anders, M. W. (1985) Structure-nephrotoxicity relationships of S-(2-chloroethyl)-DL-cysteine and analogs: role for an episulfonium ion. J. Pharmacol. Exp. Ther. 233, 512-516.

English, J. C., and Anders, M. W. (1985) Metabolism of N-nitrosodimethylamine and carbon tetrachloride by a common isozyme of cytochrome P-450. Drug Metab. Dispos. 13, 449-452.

Kitada, M., McLenithan, J. C., and Anders, M. W. (1985) Purification and characterization of S-phenacylglutathione reductase from rat liver. J. Biol. Chem. 260, 11749-11754.

Webb, W. W., and Anders, M. W. (1985) Coupling of ATP synthesis to the reversal of the rat liver microsomal Ca²⁺-ATPase. Biochemistry 24, 7741-7745.

Banki, K., Elfarra, A. A., Lash, L. H., and Anders, M. W. (1986) Metabolism of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine to hydrogen sulfide and the role of hydrogen sulfide in S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine-induced mitochondrial toxicity. Biochem. Biophys. Res. Commun. 138, 707-713.

Elfarra, A. A., Lash, L. H., and Anders, M. W. (1986) Metabolic activation and detoxication of nephrotoxic cysteine and homocysteine S-conjugates. Proc. Natl. Acad. Sci. USA 83, 2667-2671.

Kelner, M. J., McLenithan, J. C., and Anders, M. W. (1986) Thiol stimulation of the cytochrome P-450-dependent reduction of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT) to 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD). Biochem. Pharmacol. 35, 1805-1807.

Lash, L. H., and Anders, M. W. (1986) Cytotoxicity of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine in isolated rat kidney cells. J. Biol. Chem. 261, 13076-13081.

Lash, L. H., Elfarra, A. A., and Anders, M. W. (1986) Renal cysteine conjugate b-lyase: bioactivation of nephrotoxic cysteine S-conjugates in mitochondrial outer membrane. J. Biol. Chem. 261, 5930-5935.

Lash, L. H., Elfarra, A. A., and Anders, M. W. (1986) S-(1,2-Dichlorovinyl)-L-homocysteine-induced cytotoxicity in isolated rat kidney cells. Arch. Biochem. Biophys. 251, 432-439.

Dekant, W., Lash, L. H., and Anders, M. W. (1987) Bioactivation mechanism of the cytotoxic and nephrotoxic S-conjugate S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine. Proc. Natl. Acad. Sci. USA 84, 7443-7447.

Elfarra, A. A., Lash, L. H., and Anders, M. W. (1987) a-Ketoacids stimulate renal cysteine conjugate b-lyase activity and potentiate the cytotoxicity of S-(1,2-dichlorovinyl)-L-cysteine. Mol. Pharmacol. 31, 208-212.

Lash, L. H., and Anders, M. W. (1987) Mechanism of S-(1,2-dichlorovinyl)-L-cysteine- and S-(1,2-dichlorovinyl)-L-homocysteine-induced renal mitochondrial toxicity. Mol. Pharmacol. 32, 549-556.

Veltman, J. C., and Anders, M. W. (1987) Cytotoxicity of N,N-bis(2-chloroethyl)-N-nitrosourea in hypoxic rat hepatocytes. Cancer Res. 47, 5087-5091.

Webb, W. W., Elfarra, A. A., Webster, K. D., Thom, R. E., and Anders, M. W. (1987) Role for an episulfonium ion in S-(2-chloroethyl)-DL-cysteine-induced cytotoxicity and its reaction with glutathione. Biochemistry 26, 3017-3023.

Aniya, Y., McLenithan, J. C., and Anders, M. W. (1988) Isozyme selective arylation of cytosolic glutathione S-transferase by [¹⁴C]bromobenzene metabolites. Biochem. Pharmacol. 37, 251-257.

Dekant, W., Berthold, K., Vamvakas, S., Henschler, D., and Anders, M. W. (1988) Thioacylating intermediates as metabolites of S-(1,2-dichlorovinyl)-L-cysteine and S-(1,2,2-trichlorovinyl)-L-cysteine formed by cysteine conjugate ß-lyase. Chem. Res. Toxicol. 1, 175-178.

Dekant, W., Vamvakas, S., Henschler, D., and Anders, M. W. (1988) Enzymatic conjugation of hexachloro-1,3-butadiene with glutathione: formation of 1-(glutathion-S-yl)-1,2,3,4,4-pentachlorobuta-1,3-diene and 1,4-bis(glutathion-S-yl)-1,2,3,4-tetrachlorobuta-1,3-diene. Drug Metab. Dispos. 16, 701-706.

Vamvakas, S., Elfarra, A. A., Dekant, W., Henschler, D., and Anders, M. W. (1988) Mutagenicity of amino acid and glutathione S-conjugates in the Ames test. Mutat. Res. 206, 83-90.

Veltman, J. C., Dekant, W., Guengerich, F. P., and Anders, M. W. (1988) Cytotoxicity and bioactivation mechanism of benzyl 2-chloro-1,1,2-trifluoroethyl sulfide and benzyl 1,2,3,4,4-pentachlorobuta-1,3-dienyl sulfide. Chem. Res. Toxicol. 1, 35-40.

Aniya, Y., and Anders, M. W. (1989) Regulation of rat liver microsomal glutathione S-transferase activity by thiol/disulfide exchange. Arch. Biochem. Biophys. 270, 330-334.

Aniya, Y., and Anders, M. W. (1989) Activation of rat liver microsomal glutathione S-transferase by reduced oxygen species. J. Biol. Chem. 264, 1998-2002.

Banki, K., and Anders, M. W. (1989) Inhibition of rat kidney mitochondrial DNA, RNA, and protein synthesis by halogenated cysteine S-conjugates. Carcinogenesis 10, 767-772.

Lash, L. H., and Anders, M. W. (1989) Uptake of nephrotoxic S-conjugates by isolated rat renal proximal tubular cells. J. Pharmacol. Exp. Ther. 248, 531-537.

Vamvakas, S., Dekant, W., and Anders, M. W. (1989) Mutagenicity of benzyl S-haloalkyl and S-haloalkenyl sulfides in the Ames-test. Biochem. Pharmacol. 38, 935-939.

Webster, K. D., and Anders, M. W. (1989) Bioactivation mechanism of L-thiomorpholine-3-carboxylic acid. Arch. Biochem. Biophys. 273, 562-571.

Lash, L. H., Elfarra, A. A., Nemeth, D. R., and Anders, M. W. (1990) Bioactivation mechanism of cytotoxic homocysteine S-conjugates. Arch. Biochem. Biophys. 276, 322-330.

Lash, L. H., Nelson, R. M., Van Dyke, R. A., and Anders, M. W. (1990) Purification and characterization of human kidney cytosolic conjugate b-lyase activity. Drug Metab. Dispos. 18, 50-54.

Vamvakas, S., and Anders, M. W. (1990) Perturbation of calcium homeostasis as a link between acute cell injury and carcinogenesis in the kidney. Toxicol. Lett. 53, 115-120.

Vamvakas, S., Sharma, V. K., Sheu, S.-S., and Anders, M. W. (1990) Perturbations of intracellular calcium distribution in kidney cells by nephrotoxic haloalkenyl cysteine S-conjugates. Mol. Pharmacol. 38, 455-461.

Dekant, W., Urban, G., Görsmann, C., and Anders, M. W. (1991) Thioketene formation from a-haloalkenyl 2-nitrophenyl disulfides: models for biological reactive intermediates of cytotoxic S-conjugates. J. Am. Chem. Soc. 113, 5120-5122.

Gietl, Y., and Anders, M. W. (1991) Biosynthesis and biliary excretion of S-conjugates of hexachlorobuta-1,3-diene in the perfused rat liver. Drug Metab. Dispos. 19, 274-277.

Gietl, Y., Vamvakas, S., and Anders, M. W. (1991) Intestinal absorption of S-(pentachlorobutadienyl)glutathione and S-(pentachlorobutadienyl)-L-cysteine, the glutathione and cysteine S-conjugates of hexachlorobuta-1,3-diene. Drug Metab. Dispos. 19, 703-707.

Hargus, S. J., and Anders, M. W. (1991) Immunochemical detection of covalently modified kidney proteins in S-(1,1,2,2-tetrafluoroethyl)-L-cysteine-treated rats. Biochem. Pharmacol. 42, R17-R20.

Hargus, S. J., Fitzsimmons, M. E., Aniya, Y., and Anders, M. W. (1991) Stereochemistry of the microsomal glutathione S-transferase-catalyzed addition of glutathione to chlorotrifluoroethene. Biochemistry 30, 717-721.

Harris, J. W., and Anders, M. W. (1991) Metabolism of the hydrochlorofluorocarbon 1,2-dichloro-1,1-difluoroethane. Chem. Res. Toxicol. 4, 180-186.

Harris, J. W., and Anders, M. W. (1991) In vivo metabolism of the hydrochlorofluorocarbon 1,1-dichloro-1-fluoroethane (HCFC-141b). Biochem. Pharmacol. 41, R13-R16.

Harris, J. W., Pohl, L. R., Martin, J. L., and Anders, M. W. (1991) Tissue acylation by the chlorofluorocarbon substitute 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123). Proc. Natl. Acad. Sci. USA 88, 1407-1410.

Hashmi, M., and Anders, M. W. (1991) Enzymatic reaction of b-N-methylaminoalanine with L-amino acid oxidase. Biochim. Biophys. Acta 1074, 36-39.

Aniya, Y., and Anders, M. W. (1992) Activation of rat liver microsomal glutathione S-transferase by hydrogen peroxide: role for protein-dimer formation. Arch. Biochem. Biophys. 296, 611-616.

Finkelstein, M. B., Baggs, R. B., and Anders, M. W. (1992) Nephrotoxicity of the glutathione and cysteine conjugates of 2-bromo-2-chloro-1,1-difluoroethene. J. Pharmacol. Exp. Ther. 261, 1248-1252.

Harris, J. W., Dekant, W., and Anders, M. W. (1992) In vivo detection and characterization of protein adducts resulting from bioactivation of haloethene cysteine S-conjugates by ¹⁹F NMR: chlorotrifluoroethene and tetrafluoroethene. Chem. Res. Toxicol. 5, 34-41.

Harris, J. W., Fitzsimmons, M. E., and Anders, M. W. (1992) Synthesis of [2-³H-ethyl]S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine and its use in covalent-binding studies. Anal. Biochem. 204, 300-304.

Harris, J. W., Jones, J. P., Martin, J. L., LaRosa, A. C., Olson, M. J., Pohl, L. R., and Anders, M. W. (1992) Pentahaloethane-based chlorofluorocarbon substitutes and halothane: correlation of in vivo hepatic protein-trifluoroacetylation and urinary trifluoroacetic acid excretion with calculated enthalpies of activation. Chem. Res. Toxicol. 5, 720-725.

Hashmi, M., Vamvakas, S., and Anders, M. W. (1992) Bioactivation mechanism of S-(3-oxopropyl)-N-acetyl-L-cysteine, the mercapturic acid of acrolein. Chem. Res. Toxicol. 5, 360-365.

Park, S. B., Osterloh, J. D., Vamvakas, S., Hashmi, M., Anders, M. W., and Cashman, J. R. (1992) Flavin-containing monooxygenase-dependent stereoselective S-oxygenation and cytotoxicity of cysteine S-conjugates and mercapturates. Chem. Res. Toxicol. 5, 193-201.

Simmons, T. W., Anders, M. W., and Ballatori, N. (1992) L-Cysteine and S-(1,2-dichlorovinyl)-L-cysteine transport in rat liver canalicular membrane vesicles: potential reabsorption mechanisms for biliary metabolites of glutathione and its S-conjugates. J. Pharmacol. Exp. Ther. 262, 1182-1188.

Vamvakas, S., Bittner, D., Dekant, W., and Anders, M. W. (1992) Events that precede and that follow S-(1,2-dichlorovinyl)-L-cysteine-induced release of mitochondrial Ca²⁺ and their association with cytotoxicity to renal cells. Biochem. Pharmacol. 44, 1131-1138.

Fitzsimmons, M. E., and Anders, M. W. (1993) Fatty acid b-oxidation-dependent bioactivation of halogenated thiaalkanoic acids in isolated rat hepatocytes. Chem. Res. Toxicol. 6, 662-668.

Loizou, G. D., and Anders, M. W. (1993) Gas-uptake pharmacokinetics and biotransformation of 1,1-dichloro-1-fluoroethane (HCFC-141b). Drug Metab. Dispos. 21, 634-639.

Patel, N. J., Fullone, J. S., and Anders, M. W. (1993) Brain uptake of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of the neurotoxin dichloroacetylene. Mol. Brain Res. 17, 53-58.

Shan, X., Jones, D. P., Hashmi, M., and Anders, M. W. (1993) Selective depletion of mitochondrial glutathione concentrations by (R,S)-3-hydroxy-4-pentenoate potentiates oxidative cell death. Chem. Res. Toxicol. 6, 75-81.

Yin, H., Jones, J. P., and Anders, M. W. (1993) Slow-binding inhibition of carboxylesterase and other serine hydrolases by chlorodifluoroacetaldehyde. Chem. Res. Toxicol. 6, 630-634.

Birner, G., Richling, C., Henschler, D., Anders, M. W., and Dekant, W. (1994) Metabolism of tetrachloroethene in rats: identification of Ne-(dichloroacetyl)-L-lysine and Ne-(trichloroacetyl)-L-lysine as protein adducts. Chem. Res. Toxicol. 7, 724-732.

Finkelstein, M. B., Vamvakas, S., Bittner, D., and Anders, M. W. (1994) Structure-mutagenicity and structure-cytotoxicity studies on bromine-containing cysteine S-conjugates and related compounds. Chem. Res. Toxicol. 7, 157-163.

Fitzsimmons, M. E., Baggs, R. B., and Anders, M. W. (1994) Nephrotoxicity and hepatotoxicity of 5,6-dichloro-4-thia-5-hexenoic acid: evidence for fatty acid b-oxidation-dependent bioactivation. J. Pharmacol. Exp. Ther. 271, 515-523.

Hashmi, M., Dechert, S., Dekant, W., and Anders, M. W. (1994) Bioactivation of [¹³C]dichloromethane in mouse, rat, and human liver cytosol: ¹³C nuclear magnetic resonance spectroscopic studies. Chem. Res. Toxicol. 7, 291-296.

Heyn, H., Bankmann, Y. G., and Anders, M. W. (1994) Tissue distribution and stereoselectivity of remacemide-glycine hydrolase. Drug Metab. Dispos. 22, 973-974.

Heyn, H., McCarthy, D. J., Curry, S. H., Eisman, M. S., and Anders, M. W. (1994) Brain uptake and biotransformation of remacemide hydrochloride, a novel anticonvulsant. Drug Metab. Dispos. 22, 443-446.

Loizou, G. D., Urban, G., Dekant, W., and Anders, M. W. (1994) Gas-uptake pharmacokinetics of 2,2-dichloro-1,1,1-trifluoroethane (HCFC-123). Drug Metab. Dispos. 22, 511-517.

Patel, N., Birner, G., Dekant, W., and Anders, M. W. (1994) Glutathione-dependent biosynthesis and bioactivation of S-(1,2-dichlorovinyl)glutathione and S-(1,2-dichlorovinyl)-L-cysteine, the glutathione and cysteine S-conjugates of dichloroacetylene, in rat tissues and subcellular fractions. Drug Metab. Dispos. 22, 143-147.

Finkelstein, M. B., Dekant, W., Kende, A. S., and Anders, M. W. (1995) a-Thiolactones as novel intermediates in the cysteine conjugate b-lyase-catalyzed bioactivation of bromine-containing cysteine S-conjugates. J. Am. Chem. Soc. 117, 9590-9591.

Finkelstein, M. B., Patel, N. J., and Anders, M. W. (1995) Metabolism of [¹⁴C]- and [³⁵S]S-(1,2-dichlorovinyl)-L-cysteine in the male Fischer 344 rat. Drug Metab. Dispos. 23, 124-128.

Fitzsimmons, M. E., Thorpe, C., and Anders, M. W. (1995) Medium-chain acyl-CoA dehydrogenase-dependent bioactivation of 5,6-dichloro-4-thia-5-hexenoyl-CoA. Biochemistry 34, 4276-4286.

Loizou, G. D., and Anders, M. W. (1995) Gas-uptake pharmacokinetics and metabolism of 2-chloro-1,1,1,2-tetrafluoroethane (HCFC-124) in the rat, mouse, and hamster. Drug Metab. Dispos. 23, 875-880.

Tanaka, E., and Anders, M. W. (1995) Biosynthesis of S-(2-chloro-1,1,2-trifluoroethyl)glutathione in rat and human hepatocytes and in HepG2 cells. Drug Metab. Dispos. 23, 48-54.

Yin, H., Anders, M. W., Korzekwa, K. R., Higgins, L. A., Thummel, K. E., Kharasch, E. D., and Jones, J. P. (1995) Designing safer chemicals: predicting the rates of halogenated alkane metabolism. Proc. Natl. Acad. Sci. USA 92, 11076-11080.

Yin, H., Jones, J. P., and Anders, M. W. (1995) Metabolism of 1-fluoro-1,1,2-trichloroethane, 1,2-dichloro-1,1-difluoroethane, and 2-chloro-1,1,1-trifluoroethane. Chem. Res. Toxicol. 8, 262-268.

Zhang, T.-L., Wang, L., Hashmi, M., Anders, M. W., Thorpe, C., and Ridge, D. P. (1995) Fourier-transform ion cyclotron resonance mass spectrometric evidence for the formation of a-chloroethenethiolates and thioketenes from chloroalkene-derived, cytotoxic 4-thiaalkanoates. Chem. Res. Toxicol. 8, 907-910.

Finkelstein, M. B., Dekant, W., and Anders, M. W. (1996) Cysteine conjugate b-lyase-catalyzed bioactivation of bromine-containing cysteine S-conjugates: stoichiometry and formation of 2,2-difluoro-3-halothiiranes. Chem. Res. Toxicol. 9, 227-231.

Hashmi, M., Gräf, S., Braun, M., and Anders, M. W. (1996) Enantioselective depletion of mitochondrial glutathione concentrations by (S)- and (R)-3-hydroxy-4-pentenoate. Chem. Res. Toxicol. 9, 361-364.

Iyer, R. A., and Anders, M. W. (1996) Cysteine conjugate b-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product Compound A in human, nonhuman primate, and rat renal cytosol and mitochondria. Anesthesiology 85, 1454-1461.

Lock, E. A., Sani, Y., Moore, R. B., Finkelstein, M. B., Anders, M. W., and Seawright, A. A. (1996) Bone marrow and renal injury associated with haloalkene cysteine conjugates in calves. Arch. Toxicol. 70, 607-619.

Shimoji, M., Aniya, Y., and Anders, M. W. (1996) Preferential proteolysis and activation of oxidatively modified liver microsomal glutathione S-transferase of rat. Biol. Pharm. Bull. 19, 209-213.

Yin, H., Anders, M. W., and Jones, J. P. (1996) Metabolism of 1,2-dichloro-1-fluoroethane and 1-fluoro-1,2,2-trichloroethane: electronic factors govern the regioselectivity of cytochrome P450-dependent oxidation. Chem. Res. Toxicol. 9, 50-57.

Yin, H., Crowder, R. J., Jones, J. P., and Anders, M. W. (1996) Reaction of trifluoroacetaldehyde with amino acids, nucleotides, lipid nucleophiles, and their analogs. Chem. Res. Toxicol. 9, 140-146.

Iyer, R. A., and Anders, M. W. (1997) Cysteine conjugate bb-lyase-dependent biotransformation of the cysteine S-conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A). Chem. Res. Toxicol. 10, 811-819.

Iyer, R. A., Baggs, R. B., and Anders, M. W. (1997) Nephrotoxicity of the glutathione and cysteine conjugates of the sevoflurane degradation product 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A) in male, Fischer 344 rats. J. Pharmacol. Exp. Ther. 283, 1544-1551.

Loizou, G. D., Tran, C. L., and Anders, M. W. (1997) Physiologically based pharmacokinetic analysis of the concentration-dependent metabolism of halothane. Xenobiotica 27, 87-100.

Otieno, M. A., and Anders, M. W. (1997) Cysteine S-conjugates activate transcription factor NF-kB in cultured renal epithelial cells. Am. J. Physiol. 273, F136-F143.

Otieno, M. A., and Anders, M. W. (1997) Stable transfection of LLC-PK1 cells with human microsomal glutathione S-transferase gene increases haloalkene glutathione S-conjugate formation and cytotoxicity. Biochem. Biophys. Res. Commun. 234, 481-484.

Otieno, M. A., Baggs, R. B., Hayes, J. D., and Anders, M. W. (1997) Immunolocalization of microsomal glutathione S-transferase in rat tissues. Drug Metab. Dispos. 25, 12-20.

Tu, Z., and Anders, M. W. (1997) Enhancement of gene expression by transcription factor AP-1 is dependent on orientation of AP-1 element. Biochem. Biophys. Res. Commun. 238, 285-288.

Baker-Malcolm, J. F., Haeffner-Gormley, L., Wang, L., Anders, M. W., and Thorpe, C. (1998) Elimination reactions in the medium-chain acyl-CoA dehydrogenase: bioactivation of cytotoxic 4-thiaalkanoic acids. Biochemistry 37, 1383-1393.

Iyer, R. A., Frink, E. J., Jr., Ebert, T. J., and Anders, M. W. (1998) Cysteine conjugate b-lyase-dependent metabolism of Compound A (2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene) in human subjects anesthetized with sevoflurane and in rats given Compound A. Anesthesiology 88, 611-618.

Jolivette, L. J., Kende, A. S., and Anders, M. W. (1998) Thietanium ion formation from 2-chloro-4-methylthiobutanoic acid. Chem. Res. Toxicol. 11, 794-799.

Tong, Z., Board, P. G., and Anders, M. W. (1998) Glutathione transferase zeta catalyzes the oxygenation of the carcinogen dichloroacetic acid to glyoxylic acid. Biochem. J. 331, 371-374.

Tong, Z., Board, P. G., and Anders, M. W. (1998) Glutathione transferase zeta-catalyzed biotransformation of dichloroacetic acid and other a-haloacids. Chem. Res. Toxicol. 11, 1332-1338.

Tong, Z., Utell, M. J., Morrow, P. E., Rusch, G. M., and Anders, M. W. (1998) Metabolism of 1,1-dichloro-1-fluoroethane (HCFC-141b) in human volunteers. Drug Metab. Dispos. 26, 711-713.

Tu, Z., and Anders, M. W. (1998) Expression and characterization of human g-glutamylcysteine synthetase. Arch. Biochem. Biophys. 354, 247-254.

Tu, Z., and Anders, M. W. (1998) Up-regulation of glutamate-cysteine ligase gene expression by butylated hydroxytoluene is mediated by transcription factor AP-1. Biochem. Biophys. Res. Commun. 244, 801-805.

Tu, Z., and Anders, M. W. (1998) Identification of an important cysteine residue in human glutamate-cysteine ligase catalytic subunit by site-directed mutagenesis. Biochem. J. 336, 675-680.

Uttamsingh, V., Iyer, R. A., Baggs, R. B., and Anders, M. W. (1998) Fate and toxicity of 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A)-derived mercapturates in male, Fischer 344 rats. Anesthesiology 89, 1174-1183.

Uttamsingh, V., Keller, D. A., and Anders, M. W. (1998) Acylase I-catalyzed deacetylation of N-acetyl-L-cysteine and S-alkyl-N-acetyl-L-cysteines. Chem. Res. Toxicol. 11, 800-809.

Anderson, W. B., Board, P. G., Gargano, B., and Anders, M. W. (1999) Inactivation of glutathione transferase zeta by dichloroacetic acid and other fluorine-lacking a-haloalkanoic acids. Chem. Res. Toxicol. 12, 1144-1149.

Uttamsingh, V., and Anders, M. W. (1999) Acylase-catalyzed deacetylation of haloalkene-derived mercapturates. Chem. Res. Toxicol. 12, 937-942.

Wempe, M. F., Anderson, W. B., Tzeng, H.-F., Board, P. G., and Anders, M. W. (1999) Glutathione transferase zeta-catalyzed biotransformation of deuterated dihaloacetic acids. Biochem. Biophys. Res. Commun. 261, 779-783.

Blackburn, A. C., Tzeng, H.-F., Anders, M. W., and Board, P. G. (2000) Discovery of a functional polymorphism in human glutathione transferase zeta by expressed sequence tag database analysis. Pharmacogenetics 10, 49-57.

Kraus, T., Uttamsingh, V., Anders, M. W., and Wolf, S. (2000) Porcine kidney microsomal cysteine S-conjugate N-acetyltransferase-catalyzed N-acetylation of haloalkene-derived cysteine S-conjugates. Drug Metab. Dispos. 28, 440-445.

Luu, N., Iyer, R. A., Anders, M. W., and Ridge, D. P. (2000) Fourier-transform ion cyclotron resonance mass spectrometric studies of elimination reactions of anionic bases with metabolites of a fluorinated anesthetic agent: modeling bioactivation in the gas phase. Int. J. Mass Spectrom. 195/196, 203-213.

Tzeng, H.-F., Blackburn, A. C., Board, P. G., and Anders, M. W. (2000) Polymorphism- and species-dependent inactivation of glutathione transferase zeta by dichloroacetate. Chem. Res. Toxicol. 13, 231-236.

Uttamsingh, V., Baggs, R. B., Krenitsky, D. M., and Anders, M. W. (2000) Immunohistochemical localization of the acylases that catalyze the deacetylation of N-acetyl-L-cysteine and haloalkene-derived mercapturates. Drug Metab. Dispos. 28, 625-632.

Blackburn, A. C., Coggan, M., Tzeng, H. F., Lantum, H., Polekhina, G., Parker, M. W., Anders, M. W., and Board, P. G. (2001) GSTZ1d: a new allele of glutathione transferase zeta and maleylacetoacetate isomerase. Pharmacogenetics 11, 671-678.

Board, P. G., Chelvanayagam, G., Jermiin, L. S., Tetlow, N., Tzeng, H. F., Anders, M. W., and Blackburn, A. C. (2001) Identification of novel glutathione transferases and polymorphic variants by expressed sequence tag database analysis. Drug Metab. Dispos. 29, 544-547.

Chen, Y., Cai, J., Anders, M. W., Stevens, J. L., and Jones, D. P. (2001) Role of mitochondrial dysfunction in S-(1,2-dichlorovinyl)-l-cysteine-induced apoptosis. Toxicol. Appl. Pharmacol. 170, 172-180.

DeCory, H. H., Piech-Dumas, K. M., Sheu, S. S., Federoff, H. J., and Anders, M. W. (2001) Efflux of glutathione conjugate of monochlorobimane from striatal and cortical neurons. Drug Metab. Dispos. 29, 1256-1262.

Pombrio, J. M., Giangreco, A., Li, L., Wempe, M. F., Anders, M. W., Sweet, D. H., Pritchard, J. B., and Ballatori, N. (2001) Mercapturic acids (N-acetylcysteine S-conjugates) as endogenous substrates for the renal organic anion transporter-1. Mol. Pharmacol. 60, 1091-1099.

Jolivette, L. J., and Anders, M. W. (2002) Structure-activity relationships for the biotransformation of haloalkenes by rat liver microsomal glutathione transferase 1. Chem. Res. Toxicol. 15, 1036-1041.

Lantum, H. B. M., Baggs, R. B., Krenitsky, D. M., and Anders, M. W. (2002) Immunohistochemical localization and activity of glutathione transferase zeta (GSTZ1-1) in rat tissues. Drug Metab. Dispos. 30, 616-625.

Lantum, H. B., Baggs, R. B., Krenitsky, D.M., and Anders, M. W. (2002) Nephrotoxicity of chlorofluoroacetic acid in rats. Toxicol. Sci. 70, 261-268.

Enomoto, A., Wempe, M. F., Tsuchida, H., Shin, H. J., Cha, S.H., Anzai, N., Goto, A., Sakamoto, A., Niwa, T., Kanai, Y., Anders, M. W., and Endou, H. (2002) Molecular identification of a novel carnitine transporter specific to human testis: insights into the mechanism of carnitine recognition. J. Biol. Chem. 277, 36262-36271.

Uchino, H., Kanai, Y., Kim do, K., Wempe, M. F., Chairoungdua, A., Morimoto, E., Anders, M. W., and Endou, H. (2002) Transport of amino acid-related compounds mediated by L-type amino acid transporter 1 (LAT1): insights into the mechanisms of substrate recognition. Mol. Pharmacol. 61, 729-737.

Tong, Z., and Anders, M. W. (2002) Reactive intermediate formation from the 2-(fluoromethoxy)-1,1,3,3,3-pentafluoro-1-propene (Compound A)-derived cysteine S-conjugate S-[2-(fluoromethoxy)-1,1,3,3,3-pentafluoropropyl]-L-cysteine in pyridoxal model systems. Chem. Res. Toxicol. 15, 623-628.

Lantum, H. M. B., Liebler, D. C., Board, P. G., and Anders, M. W. (2002) Alkylation and inactivation of human glutathione transferase zeta (hGSTZ1-1) by maleylacetone and fumarylacetone. Chem. Res. Toxicol. 15, 707-716.

Bayer, T., Amberg, A., Bertermann, R., Rusch, G. M., Anders, M. W., and Dekant, W. (2002) Biotransformation of 1,1,1,3,3-pentafluoropropane (HFC-245fa). Chem. Res. Toxicol. 15, 723-733.

Lantum, H. B. M., Board, P. G., and Anders, M. W. (2002) Kinetics of the biotransformation of maleylacetone and chlorofluoroacetic acid by polymorphic variants of human glutathione transferase zeta (hGSTZ1-1). Chem. Res. Toxicol. 15, 957-963.

Anderson, W. B., Liebler, D. C., Board, P. G., and Anders, M. W. (2002) Mass spectral characterization of dichloroacetic acid-modified human glutathione transferase zeta. Chem. Res. Toxicol. 15, 1387-97.

Jolivette, L. J., and Anders, M. W. (2003) Computational and experimental studies on the distribution of addition and substitution products of the microsomal glutathione transferase 1-catalyzed conjugation of glutathione with fluoroalkenes. Chem. Res. Toxicol. 16, 137-144.

Lantum, H. M. B., Pierce, R. H., and Cornejo, J. (2002) Perturbation of maleylacetoacetic acid metabolism in rats with dichloroacetic acid-induced glutathione transferase zeta deficiency. Tox. Sci. 70, 261-268.

Board PG, Taylor MC, Coggan M, Parker MW, Lantum HB and Anders MW (2003) Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique. Biochem. J. 374:731-737.

Board, P. G., Taylor, M. C., Coggan, M., Parker, M. W., Lantum, H. B., and Anders, M. W. (2003) Clarification of the role of key active site residues of glutathione transferase zeta/maleylacetoacetate isomerase by a new spectrophotometric technique. Biochem. J. 374, 731-737.

Lantum, H. B. M., Iyer, R. A., and Anders, M. W. (2004) Acivicin-induced alterations in renal and hepatic glutathione concentrations and in g-glutamyltransferase activities. Biochem. Pharmacol. 67, 1421-1426.

Anderson, W. B., Board, P. G., and Anders, M. W. (2004) Glutathione transferase zeta-catalyzed bioactivation of dichloroacetic acid: reaction of glyoxylate with amino acid nucleophiles. Chem. Res. Toxicol. 17, 650-662.

Xu, L., Krenitsky, D. M., Seacat, A. M., Butenhoff, J. L., and Anders, M. W. (2004) Biotransformation of N-ethyl-N-(2-hydroxyethyl)perfluorosulfonamide by rat liver microsomes, cytosol, and slices and by expressed rat and human cytochromes P450. Chem. Res. Toxicol. 17, 767-775.

Lim, C., Matthaei, K. I., Blackburn, A. C., Davis, R., Dahlstrom, J. E., Koina, M., Anders, M. W., and Board, P. G. (2004) Mice deficient in glutathione transferase zeta/maleylacetoacetate isomerase exhibit a range of pathological changes and elevated expression of mu and pi class glutathione transferases. Am. J. Pathol. 165, 679-693.

Xu, L., Krenitsky, D. M., Seacat, A. M., Butenhoff, J. L., Tephly, T. R., and Anders, M. W. (2004) N-Glucuronidation of perfluorooctanesulfonamide by rat liver microsomes and by expressed rat and human UDP-glucuronosyltransferases. Submitted for publication.

Review Articles, Symposium Proceedings, Book Chapters, and Reports

Anders, M. W., and Mannering, G. J. (1967) Application of gas chromatography to toxicology. Prog. Chem. Toxicol. 3, 121-128.

Anders, M. W. (1969) Stimulatory effect of acetone on the activity of microsomal para-hydroxylase. In Microsomes and Drug Oxidations (Gillette, J. R., Conney, A. H., Cosmides, G. J., Estabrook, R. W., Fouts, J. R., and Mannering, G. J., Eds.) pp. 533-540, Academic Press, New York.

Anders, M. W. (1971) Gas chromatography. In Concepts in Biochemical Pharmacology (Brodie, B. B., and Gillette, J., Eds.) Vol. 28, No. 2, pp. 63-93, Springer-Verlag, Berlin.

Anders, M. W. (1971) Enhancement and inhibition of drug metabolism. Annu. Rev. Pharmacol. 11, 37-56.

Anders, M. W. (1973) Enhancement and inhibition of microsomal drug metabolism. Prog. Drug Res. 17, 11-32.

Anders, M. W., Cooper, M. J., Rolewicz, T. F., Mirkin, B. L., Garattini, S., and Sereni, F. (1975) Application of high pressure liquid chromatography in pediatric pharmacology. Pharmacokinetics of cephalothin in man. In Basic and Therapeutic Aspects of Perinatal Pharmacology (Morselli, P. M., Ed.) pp. 405-509, Raven Press, New York.

Cooper, M. J., and Anders, M. W. (1975) High pressure liquid chromatography of fatty acids and lipids. J. Chromatogr. Sci. 13, 407-411.

Cooper, M. J., Anders, M. W., Sinaiko, A. R., Mirkin, B. L., Gray, C. H., Lim, C. K., and Stoll, M. W. (1976) Application of HPLC to the study of the disposition of hydrochlorothiazide in adults and children. In High Pressure Liquid Chromatography in Clinical Chemistry (Dixon, P. F., Ed.) pp. 175-182, Acadcemic Press, New York.

Anders, M. W., Kubic, V. L., and Ahmed, A. E. (1977) Metabolism of halogenated methanes and macromolecular binding. J. Environ. Pathol. Toxicol. 1, 117-124.

Anders, M. W., Kubic, V. L., and Ahmed, A. E. (1978) Bioorganic mechanisms of the metabolism of dihalomethanes to carbon monoxide, formaldehyde, formic acid and inorganic halide. In Industrial and Environmental Xenobiotics. In Vitro Versus In Vivo Biotransformation and Toxicity (Fouts, J. R., and Gut, I., Eds.) pp. 22-24, Excerpta Medica, Amsterdam.

Ahmed, A. E., Kubic, V. L., Stevens, J. L., and Anders, M. W. (1980) Halogenated methanes: metabolism and toxicity. Fed. Proc. 39, 3150-3155.

Anders, M. W. (1980) Metabolism of drugs by the kidney. Kidney Int. 18, 636-647.

Anders, M. W., and Livesey, J. C. (1980) Metabolism of 1,2-dihaloethanes. In Banbury Report 5: Ethylene Dichloride: A Potential Health Risk? (Ames, B., Infante, P., and Reitz, R., Eds.) pp. 331-341, Cold Spring Harbor Laboratory, Cold Spring Harbor, NY.

Anders, M. W. (1982) Aliphatic halogenated hydrocarbons. In Metabolic Basis of Detoxification: Metabolism of Functional Groups (Jakoby, W. B., Bend, J. R., and Caldwell, J., Eds.) pp. 29-49, Academic Press, New York.

Anders, M. W. (1982) Mechanism of haloalkane and haloalkene biotransformation. Trends Pharmacol. Sci. 3, 356-357.

Anders, M. W., and Harris, R. N. (1982) Effect of 2-propanol treatment on carbon tetrachloride metabolism and toxicity. Adv. Exp. Med. Biol. 136A, 591-602.

Anders, M. W. (1982-83) Bioactivation of halogenated hydrocarbons. J. Toxicol. Clin. Toxicol. 19, 699-709.

Anders, M. W. (1984) Biotransformation of halogenated hydrocarbons. In Drug Metabolism and Drug Toxicity (Mitchell, J. R., and Horning, M. G., Eds.) pp. 55-70, Raven Press, New York.

Anders, M. W. (1984). Metabolic pathways and macromolecular binding. Food Solvents Workshop I: Methylene Chloride. Bethesda, MD, 8-9 March 1984, Bethesda, MD.

Elfarra, A. A., and Anders, M. W. (1984) Renal processing of glutathione conjugates: role in nephrotoxicity. Biochem. Pharmacol. 33, 3729-3732.

Anders, M. W. (1985). Metabolism and toxicity of halogenated solvents. Seminar on Environmental Toxicology, Taipei, Taiwan, 26 March-2 April 1985.

Anders, M. W., English, J. C., de Matteis, F., and Elcombe, C. R. (1985) Reduction of halogenated compounds by cytochrome P-450. In Microsomes and Drug Oxidations (Caldwell, J., Ed.) pp. 274-283, Taylor and Francis, London and Philadelphia.

Anders, M. W., and Jakobson, I. (1985) Biotransformation of halogenated solvents. Scand. J. Work Environ. Health 11, 23-32.

Anders, M. W., and Pohl, L. R. (1985) Halogenated alkanes. In Bioactivation of Foreign Compounds (Anders, M. W., Ed.) pp. 283-315, Academic Press, New York.

Anders, M. W., Lash, L. H., and Elfarra, A. A. (1986) Nephrotoxic amino acid and glutathione S-conjugates: formation and renal activation. Adv. Exp. Med. Biol. 197, 443-455.

Elfarra, A. A., Jakobson, I., and Anders, M. W. (1986) Mechanism of S-(1,2-dichlorovinyl)glutathione-induced nephrotoxicity. Biochem. Pharmacol. 35, 283-288.

Lash, L. H., and Anders, M. W. (1986) Bioactivation and cytotoxicity of nephrotoxic amino acid and glutathione S-conjugates. Comments Toxicol. 1, 87-107.

Anders, M. W., Banki, K., Dohn, D. R., and Lash, L. H. (1987) Biosynthesis and bioactivation of toxic glutathione S-conjugates. Fed. Proc. 46, 2434-2436.

Anders, M. W., Elfarra, A. A., and Lash, L. H. (1987) Cellular effects of reactive intermediates: nephrotoxicity of S-conjugates of amino acids. Arch. Toxicol. 60, 103-108.

Anders, M. W. (1988) Bioactivation mechanisms and hepatocellular damage. In The Liver: Biology and Pathobiology (Arias, I. M., Jakoby, W. B., Popper, H., Schachter, D., and Shafritz, D. A., Eds.) pp. 389-400, Raven Press, New York.

Anders, M. W. (1988) Glutathione-dependent toxicity: biosynthesis and bioactivation of cytotoxic S-conjugates. ISI Atlas of Science: Pharmacology 2, 99-104.

Anders, M. W., Lash, L., Dekant, W., Elfarra, A. A., and Dohn, D. R. (1988) Biosynthesis and biotransformation of glutathione S-conjugates to toxic metabolites. CRC Crit. Rev. Toxicol. 18, 311-341.

Dekant, W., Lash, L. H., and Anders, M. W. (1988) Fate of glutathione conjugates and bioactivation of cysteine S-conjugates by cysteine conjugate b-lyase. In Glutathione Conjugation: Its Mechanism and Biological Significance (Sies, H., and Ketterer, B., Eds.) pp. 415-447, Academic Press, Orlando.

Lash, L. H., Anders, M. W., and Jones, D. P. (1988) Glutathione homeostasis and glutathione S-conjugate toxicity in the kidney. Rev. Biochem. Toxicol. 9, 29-67.

Veltman, J. C., and Anders, M. W. (1988) Drug metabolism and toxicity in hypoxic states. In Microsomes and Drug Oxidations (Miners, J. O., Ed.) pp. 338-345, Taylor & Francis, England.

Anders, M. W. (1989) Biotransformation and bioactivation of xenobiotics by the kidney. In Intermediary Xenobiotic Metabolism in Animals: Methodology, Mechanisms and Significance (Hutson, D. H., Caldwell, J., and Paulson, G. D., Eds.) pp. 81-97, Taylor & Francis, London.

Dekant, W., Vamvakas, S., and Anders, M. W. (1989) Bioactivation of nephrotoxic haloalkenes by glutathione conjugation: formation of toxic and mutagenic intermediates by cysteine conjugate b-lyase. Drug Metab. Rev. 20, 43-83.

Lash, L. H., Dekant, W., and Anders, M. W. (1989) Bioactivation mechanism and cytotoxicity of S-(2-chloro-1,1,2-trifluoroethyl)-L-cysteine. In Nephrotoxicity. In Vitro to In Vivo, Animals to Man (Bach, P. H., and Lock, E. A., Eds.) pp. 595-600, Plenum Press, London.

Anders, M. W., Vamvakas, S., and Dekant, W. (1990) Bioactivation of haloalkenes through glutathione conjugation. In Glutathione S-Transferases and Drug Resistance (Hayes, J. D., Pickett, C. B., and Mantle, T. J., Eds.) pp. 121-130, Taylor & Francis, London.

Cooper, A. J. L., and Anders, M. W. (1990) Glutamine transaminase K and cysteine conjugate b-lyase. Ann. N.Y. Acad. Sci. 585, 118-127.

Dekant, W., Vamvakas, S., and Anders, M. W. (1990) Bioactivation of hexachlorobutadiene by glutathione conjugation. Food Chem. Toxicol. 28, 285-293.

Monks, T. J., Anders, M. W., Dekant, W., Stevens, J. L., Lau, S. S., and van Bladeren, P. J. (1990) Glutathione conjugate mediated toxicities. Toxicol. Appl. Pharmacol. 106, 1-19.

Vamvakas, S., and Anders, M. W. (1990) Formation of reactive intermediates by Phase II enzymes: glutathione-dependent bioactivation reactions. Adv. Exp. Med. Biol. 283, 13-24.

Anders, M. W. (1991) Metabolism and toxicity of hydrochlorofluorocarbons: current knowledge and needs for the future. Environ. Health Perspect. 96, 185-191.

Anders, M. W. (1991) Glutathione-dependent bioactivation of xenobiotics: implications for mutagenicity and carcinogenicity. In Xenobiotics and Cancer. Implications for Chemical Carcinogenesis and Cancer Chemotherapy (Ernster, L., Esumi, H., Fujii, Y., Gelboin, H. V., Kato, R., and Sugimura, T., Eds.) pp. 89-99, Japan Sci. Soc. Press, Tokyo.

Anders, M. W., Dekant, W., and Vamvakas, S. (1992) Glutathione-dependent toxicity. Xenobiotica 22, 1135-1145.

Dekant, W., Vamvakas, S., and Anders, M. W. (1992) The kidney as a target organ for xenobiotics bioactivated by glutathione conjugation. In Tissue-Specific Toxicity. Biochemical Mechanisms (Dekant, W., and Neumann, H. G., Eds.) pp. 163-194, Academic Press, London.

Anders, M. W., and Dekant, W. (1993) Renal xenobiotic metabolism: role in bioactivation of nephrotoxic xenobiotics. In Renal Disposition and Nephrotoxicity of Xenobiotics (Anders, M. W., Dekant, W., Henschler, D., Oberleithner, H., and Silbernagl, S., Eds.) pp. 155-183, Academic Press, San Diego.

Dekant, W., Anders, M. W., and Monks, T. J. (1993) Bioactivation of halogenated xenobiotics by S-conjugate formation. In Renal Disposition and Nephrotoxicity of Xenobiotics (Anders, M. W., Dekant, W., Henschler, D., Oberleithner, H., and Silbernagl, S., Eds.) pp. 187-215, Academic Press, San Diego.

Shan, X., Finkelstein, M., Jones, D. P., and Anders, M. W. (1993) Experimental manipulation of mitochondrial glutathione concentrations. In Methods in Toxicology (Lash, L. H., and Jones, D. P., Eds.) pp. 227-245, Academic Press, San Diego.

Vamvakas, S., Bittner, D., Dekant, W., and Anders, M. W. (1993) Covalent binding of reactive intermediates of xenobiotics to mitochondrial DNA. In Mitochondrial Dysfunction (Lash, L. H., and Jones, D. P., Eds.) Vol. 2, pp. 453-460, Academic Press, San Diego.

Anders, M. W., and Dekant, W. (1994) Aminoacylases. Adv. Pharmacol. 27, 433-450.

Dekant, W., Vamvakas, S., and Anders, M. W. (1994) Formation and fate of nephrotoxic and cytotoxic glutathione S-conjugates: cysteine conjugate b-lyase pathway. Adv. Pharmacol. 27, 115-162.

Vamvakas, S., and Anders, M. W. (1994) Bioconversion of prodrugs by conjugate-processing enzymes. Adv. Pharmacol. 27, 481-501.

Anders, M. W. (1995) Mitochondrial bioactivation of cysteine S-conjugates and 4-thiaalkanoates: implications for mitochondrial dysfunction and mitochondrial diseases. Biochim. Biophys. Acta 1271, 51-57.

Anders, M. W., Dekant, W., and Vamvakas, S. (1995) Glutathione-dependent bioactivation of xenobiotics. In Biothiols (Packer, L., and Cadenas, E., Eds.) pp. 135-163, Marcel Dekker, New York.

Anders, M. W., Yin, H., and Jones, J. P. (1996) Application of computational chemistry in the study of biologically reactive intermediates. Adv. Exp. Med. Biol. 387, 347-353.

Anders, M. W., and Dekant, W. (1998) Glutathione-dependent bioactivation of haloalkenes. Ann. Rev. Pharmacol. Toxicol. 38, 501-537.

Anders, M. W. (2000) S-Conjugate-dependent toxicity: alternatives to animal studies. Altern. Animal Test. Experiment. 7, 37-46.

Morrow, P. E., Witschi, H., Vore, M., Hakkinen, P. J., MacGregor, J., Anders, M. W., and Willhite, C. (2000) Profiles in toxicology. Harold Carpenter Hodge (1904-1990). Toxicol. Sci. 53, 157-158.

Anders, M. W. (2001) Formation and fate of reactive intermediates of haloalkanes, haloalkenes, and a-haloacids. Adv. Exp. Med. Biol. 500, 113-120.

Cooper, A. J. L., Bruschi, S. A., and Anders, M. W. (2002) Toxic, halogenated cysteine S-conjugates and targeting of mitochondrial enzymes of energy metabolism. Biochem. Pharmacol. 64, 553-564.

Anders, M. W. (2004) Formation and toxicity of anesthetic degradation products. Ann. Rev. Pharmacol. Toxicol., in press.

Anders, M. W. (2004) Glutathione-dependent toxicity. Drug Metab. Rev. 36, 581-592. (In honor of Prof. Dr. Herbert Remmer.)

Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., and Sheu, S.-S. (2004) Calcium, ATP & ROS: a mitochondrial love-hate triangle. Am. J. Physiol., in press.

Brookes, P. S., Yoon, Y., Robotham, J. L., Anders, M. W., and Sheu, S.-S. (2004) Calcium, ATP & ROS: a mitochondrial love-hate triangle. Am. J. Physiol. 287, C817-C833.

Anders, M. W. (2005) Formation and toxicity of anesthetic degradation products. Ann. Rev. Pharmacol. Toxicol. 45, 147-176.

Edited Treatises

Anders, M. W., and Carlson, R. G., Eds. (1984) Toxicology: Determinants of Susceptibility and Predictability (Pharmacological Reviews 36, No. 2, 1984), Williams and Wilkins, Baltimore.

Anders, M. W., Ed. (1985) Bioactivation of Foreign Compounds, Academic Press, Orlando.

Anders, M. W., Dekant, W., Henschler, D., Oberleithner, H., and Silbernagl, S., Eds. (1993) Renal Disposition and Nephrotoxicity of Xenobiotics, Academic Press, San Diego.

Anders, M. W., and Dekant, W., Eds. (1994) Conjugation-Dependent Carcinogenicity and Toxicity of Foreign Compounds, Advances in Pharmacology, Vol. 27, pp. xvi + 512, Academic Press, San Diego.

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