Bidlack, J.M. and Abraham, M.K. (2001) Mitogen-induced activation of mouse T cells increases kappa opioid receptor expression. In Neuroimmune Circuits, Drugs of Abuse and Infectious Disease, H. Friedman, T. Klein and J.M. Madden (eds.), Plenum Press, NY, Adv. Exp. Med. Biol. 493:103-110.

Martin-Kleiner, I. and Bidlack, J.M. (2001) Chronic opioid treatment of the mouse thymoma cell lines, R1.G1 and R1EGO, leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity. Int. Immunopharmacol. 1:13-20.

Neumeyer, J.L., Gu, X.-H., van Vliet, L.A., DeNunzio, N.J., Rusovici, D.E., Cohen, D.J., Negus, S.S., Mello, N.K. and Bidlack, J.M. (2001) Mixed k and m agonists/antagonists as potential pharmacotherapeutics for cocaine abuse. Synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan. Bioorg. Med. Chem. Lett. 11:2735-2740.

Peterson, P.K., Gekker, G., Lokensgard, J.R., Bidlack, J.M., Chang, A.-C., Fang, X., and Portoghese, P.S. (2001) k-Opioid receptor agonist suppression of HIV-1 expression in CD4⁺ lymphocytes. Biochem. Pharmacol. 61:1145-1151.

Suzuki, S., Chuang, L.F., Doi, R.H., Bidlack, J.M. and Chuang, R.Y. (2001) Kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: Morphine-induced up-regulation as evidenced by RT-PCR and indirect immunofluorescence. Int. Immunopharmacol. 1:1733-1742.

Wentland, M.P., Lou, R., Dehnhardt, C.M., Duan, W., Cohen, D.J. and Bidlack, J.M. (2001) 3-Carboxamido analogues of morphine and naltrexone: Synthesis and opioid receptor binding properties. Bioorg. Med. Chem. Lett. 11:1717-1721.

Wentland, M.P., Lou, R., Ye, Y., Cohen, D.J., Richardson, G.P. and Bidlack, J.M. (2001) 8-Carboxamidocyclazocine analogues: Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Bioorg. Med. Chem. Lett. 11:623-626.

Bidlack, J.M., Cohen, D.J., McLaughlin, J.P., Lou, R., Ye, Y. and Wentland, M.P. (2002) 8-Carboxamidocyclazocine: A long-acting, novel benzomorphan. J. Pharmacol. Exp. Ther. 302:374-380.

Negus, S.S., Bidlack, J.M., Mello, N.K., Furness, M.S., Rice, K.C., and Brandt, M.R. (2002) Delta opioid antagonist effects of buprenorphine in rhesus monkeys. Behav. Pharmacol. 13:557-570.

Parkhill, A.L. and Bidlack, J.M. (2002) Several delta-opioid receptor ligands display no subtype selectivity to the human delta-opioid receptor. Eur. J. Pharmacol. 451:257-264.

Bowen, C.A., Stevens Negus, S., Zong, R., Neumeyer, J.L., Bidlack, J.M., and Mello, N.K. (2003) Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys. Neuropsychopharmacology 28:1125-1139.

Kuehne, M.E., He, L., Jokiel, P.A., Pace, C.J., Fleck, M.W., Maisonneuve, I.M., Glick, S.D., and Bidlack J.M. (2003) Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents. J. Med. Chem. 46:2716-2730.

Neumeyer, J.L., Zhang, A., Xiong, W., Gu, X.H., Hilbert, J.E., Knapp, B.I., Negus, S.S., Mello, N.K., and Bidlack, J.M. (2003) Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors. J. Med. Chem. 46:5162-5170.

Wentland, M.P., Sun, X., Ye, Y., Lou, R., and Bidlack, J.M. (2003) Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues. Bioorg. Med. Chem. Lett. 13:1911-1914.

Wentland, M.P., Ye, Y., Cioffi, C.L., Lou, R., Zhou, Q., Xu, G., Duan, W., Dehnhardt, C.M., Sun, X., Cohen, D.J., and Bidlack, J.M. (2003) Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines. J. Med. Chem. 46:838-849.

Bidlack, J.M. and Parkhill, A.L. (2004) Assay of G protein-coupled receptor activation of G proteins in native cell membranes using [35S]GTP gamma S binding. Methods Mol. Biol. 237:135-143.

Csutoras, C., Zhang, A., Bidlack, J.M., and Neumeyer, J.L. (2004) An investigation of the N-demethylation fo 3-deoxymorphine and the affinity of the alkylation products to mu, delta, and kappa receptors. Bioorg. Med. Chem. 12:2687-2690.

Gekker, G., Hu, S., Wentland, M.P., Bidlack, J.M., Lokensgard, J.R., and Peterson, P.K. (2004) Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells. J. Pharmacol. Exp. Ther. 309:600-606.

Rusovici, D.E., Negus, S.S., Mello, N.K., and Bidlack, J.M. (2004) Kappa-opioid receptors are differentially labeled by arylacetamides and benzomorphans. Eur. J. Pharmacol. 485:119-125.

Zhang, A., Xiong, W., Bidlack, J.M., Hilbert, J.E., Knapp, B.I., Wentland, M.P., and Neumeyer, J.L. (2004) 10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors. J. Med. Chem. 47:165-174.

Zhang, A., Xiong, W., Hilbert, J.E., DeVita, E.K., Bidlack, J.M., and Neumeyer, J.L. (2004) 2-Aminotiazole-derived opioids. Bioisosteric replacement of phenols. J. Med. Chem. 47:1886-1888.

Zhen, Z., Bradel-Tretheway, B.G., Dewhurst, S., and Bidlack, J.M. (2004) Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectors. J. Neurosci. Methods 136:133-139.

Bart, G., Schluger, J.H., Borg, L., Ho, A., Bidlack, J.M. and Kreek, M.J.  (2005)  Nalmefene  induced elevation in serum prolactin in normal human volunteers:  Partial kappa opioid agonist activity?  Neuropsychopharmacology 30:2254-2262.

Mathews, J.L., Neumeyer, J.L., Negus, S.S. and Bidlack, J.M. (2005) Characterization of a novel bivalent morphinan possessing kappa agonist and mu agonist/antagonist properties.  J. Pharmacol. Exp. Ther.  315:821-827.

Peng, X., Knapp, B.I., Bidlack, J.M. and Neumeyer, J.L. (2006) Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and hetero-pharmacophores at mu, delta, and kappa opioid receptors.  J. Med. Chem. 49:256-262.

Wentland, M.P., Lu, Q., Lou, R., Bu, Y., Knapp, B.I. and Bidlack, J.M. (2005) Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone.  Bioorg. Med. Chem. Lett 15:2107-2110.

Wentland, M.P., Sun, X., Bu, Y., Lou, R., Cohen, D.J. and Bidlack, J.M. (2005) Redefining the structure-activity relationships of 2,6-methano-3-benzazocines.  Part 3. 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine.  Bioorg. Med. Chem. Lett 15:2547-2551.

Zhen, Z., Bradel-Trethewey, B., Sumagin, S., Bidlack, J.M. and Dewhurst, S. (2005)  The human herpes virus 6 protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro.  J. Virol. 79:11914-11924.

Sun, B. and Bidlack, J.M. (in press) The expression of prodynorphin gene is down-regulated by activation with lipopolysaccharide in U-937 macrophage cells.  J. Neuroimmunol.

Parkhill, A.L. and Bidlack, J.M. (in press) Reduction of lipopolysaccharide-induced interleukin 6 production by the kappa opioid U50, 488 in a mouse monocyte-like cell line.  Int. Immunopharmacol.

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