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Selected Publications

He X, Liu Y, Sharma VK, Dirksen RT, Waugh R, Sheu S-S, and Min W. (2003) ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes. Am. J. Pathol. 163:243-251.

Sheu S-S, Anders MW, Xu L, and Sharma VK. (2003) Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof. US Provisional Patent Application. No. 60/524,833.

Brookes PS, Yoon Y, Robotham JL, Anders MW, and Sheu S-S. (2004) Calcium, ATP & ROS: a mitochondrial love-hate triangle. Am. J. Physiol. (Cell Physiol.) 287:817-833.

Anders MW, Robotham JL, and Sheu S-S.  Mitochondria-targeted antioxidant prodrugs and methods of use.  US Provisional Patent Application, 2005.

Beutner G, Sharma VK, Lin L, Ryu SY, Dirksen RT, and Sheu S-S.  (2005)  Type 1 ryanodine receptor in cardiac mitochondria: Transducer of excitation-metabolism coupling.  Biochim. Biophys. Acta 1717:1-10.

Brookes PS, Sheu S-S, Anders MW.  Method for attenuating mitochondria-mediated cell injury.  US Provisional Patent Application, 2005.

Itoh S, Lemay S, Osawa M, Che W, Duan Y, Tompkins A, Brookes PS, Sheu S-S, and Abe J-I.  (2005)  Mitochondrial Dok-4 recruits SRC kinase and regulates NF-κB activation in endothelial cells.  J. Biol. Chem. 280:26383-96.

Watanabe T, Suzuki J, Yamawaki H, Sharma VK, Sheu S-S, and Berk BC.  (2005)  Losartan metabolite EXP3179 activates Akt and eNOS via VEGF receptor-2 in endothelial cells: AT1 receptor-independent effects of EXP3179.  Circulation 112:1798-805.

Anders MW, Robotham JL, Sheu S-S.  (2006)  Mitochondria: New drug targets for oxidative stress-induced diseases.  Expert Opin. Drug Metab. Toxicol., 2:71-79.

Brdiczka DG, Zorov DB, and Sheu S-S.  (2006)  Mitochondrial contact sites: Their role in energy metabolism and apoptosis.  Biochim. Biophys. Acta 1762:148-163.

Sheu S-S and Lemasters JJ.  (2006)  Special Issue: “Mitochondria in Diseases and Therapeutics”.  Biochim. Biophys. Acta 1762:139.

Sheu S-S, Nauduri D, and Anders, M.W.  (2006)  Targeting antioxidants to mitochondria: A new therapeutic direction.  Biochim. Biophys. Acta 1762:256-265.

Maekawa N, Abe J-I, Itoh S, Ding B, Sharma VK, Sheu S-S, Blaxall BC, Berk BC. (2006) Inhibiting p90 ribosomal S6 kinase prevents Na-H exchanger-mediated cardiac ischemia-reperfusion injury.  Circulation 113:2516-2523.

Altschafl BA, Beutner G, Sharma VK, Sheu SS, Valdivia HH. (2007) The mitochondrial ryanodine receptor in rat heart: a pharmaco-kinetic profile. Biochim Biophys Acta. 1768:1784-1795.

Duan Y, Gross RA, Sheu SS. (2007) Ca2+-dependent generation of mitochondrial reactive oxygen species serves as a signal for poly(ADP-ribose) polymerase-1 activation during glutamate excitotoxicity. J Physiol. 585(Pt 3):741-758.

Hom JR, Gewandter JS, Michael L, Sheu SS, Yoon Y. (2007) Thapsigargin induces biphasic fragmentation of mitochondria through calcium-mediated mitochondrial fission and apoptosis. J Cell Physiol. 212:498-508.

Lin L, Sharma VK, Sheu SS. (2007) Mechanisms of reduced mitochondrial Ca2+ accumulation in failing hamster heart. Pflugers Arch. 454:395-402.

Mao W, Fukuoka S, Iwai C, Liu J, Sharma VK, Sheu SS, Fu M, Liang CS. (2007) Cardiomyocyte apoptosis in autoimmune cardiomyopathy: mediated via endoplasmic reticulum stress and exaggerated by norepinephrine. Am J Physiol Heart Circ Physiol. 293:H1636-H1645.

Venkatesh K, Chivatakarn O, Sheu SS, Giger RJ. (2007) Molecular dissection of the myelin-associated glycoprotein receptor complex reveals cell type-specific mechanisms for neurite outgrowth inhibition. J Cell Biol. 177:393-399.

Daubert JP, Sheu SS. (2008) Mystery of biphasic defibrillation waveform efficacy is it calcium? J. Am. Coll. Cardiol. 52:836-838.

Liu J, Mao W, Iwai C, Fukuoka S, Vulapalli R, Huang H, Wang T, Sharma VK, Sheu SS, Fu M, Liang CS. (2008) Adoptive passive transfer of rabbit beta1-adrenoceptor peptide immune cardiomyopathy into the Rag2-/- mouse: participation of the ER stress. J Mol Cell Cardiol. 44:304-314.

Mao W, Iwai C, Liu J, Sheu SS, Fu M, Liang CS. (2008) Darbepoetin alfa exerts a cardioprotective effect in autoimmune cardiomyopathy via reduction of ER stress and activation of the PI3K/Akt and STAT3 pathways. J Mol Cell Cardiol. 45:250-260.

Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, Sheu SS, Ouyang K, Chen J, Dirksen RT, Cheng H. (2008) Superoxide flashes in single mitochondria. Cell. 134:279-290.

Yu T, Sheu SS, Robotham JL, Yoon Y. (2008) Mitochondrial fission mediates high glucose-induced cell death through elevated production of reactive oxygen species. Cardiovasc Res. 79:341-351.