Selected Publications

Kelley GG, Reks SE, Ondrako JM, and Smrcka AV  (2001)  Phospholipase C(epsilon): a novel Ras effector.  EMBO J. 20:743-754.

Scott JK, Huang SF, Gangadhar BP, Samoriski GM, Clapp P, Gross RA, Taussig R, and Smrcka AV  (2001)  Evidence that a protein-protein interaction 'hot spot' on heterotrimeric G protein betagamma subunits is used for recognition of a subclass of effectors.  EMBO J. 20:767-776.

Yoshikawa DM, Bresciano K, Hatwar M, and Smrcka AV  (2001)  Characterization of a phospholipase C beta 2-binding site near the amino-terminal coiled-coil of G protein beta gamma subunits.  J. Biol. Chem. 276:11246-11251.

Smrcka AV and Scott JK  (2002)  Discovery of ligands for beta gamma subunits from phage-displayed peptide libraries.  Meth. Enzymol. 344:557-576.

Ghosh M, Peterson YK, Lanier SM, and Smrcka AV.  (2003)  Receptor- and nucleotide exchange-independent mechanisms for promoting G protein subunit dissociation.  J. Biol. Chem. 278:34747-34750.

Goubaeva F, Ghosh M, Malik S, Yang J, Hinkle PM, Griendling KK, Neubig RR, and Smrcka AV  (2003)  Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides.  J. Biol. Chem. 278:19634-19641.

Li Z, Hannigan M, Mo Z, Liu B, Lu W, Wu Y, Smrcka AV, Wu G, Li L, Liu M, Huang CK, and Wu D  (2003)  Directional sensing requires G beta gamma-mediated PAK1 and PIX alpha-dependent activation of Cdc42.  Cell 114:215-227.

Ghosh M and Smrcka AV  (2004)  Assay for G protein-dependent activation of phospholipase C beta using purified protein components.  Methods Mol. Biol. 237:67-75.

Ghosh M, Wang H, Kelley GG, and Smrcka AV  (2004)  Purification of phospholipase C beta and phospholipase C epsilon from Sf9 cells.  Methods Mol. Biol. 237:55-64.

Kelley GG, Reks SE, and Smrcka AV  (2004)  Hormonal regulation of phospholipase Cepsilon through distinct and overlapping pathways involving G12 and Ras family G-proteins.  Biochem. J. 378:129-139.

Shajahan AN, Tiruppathi C, Smrcka AV, Malik AB, and Minshall RD  (2004)  Gbetagamma activation of Src induces caveolae-mediated endocytosis in endothelial cells.  J. Biol. Chem. 279:48055-48062.

Bonacci TM, Ghosh M, Malik S, and Smrcka AV  (2005)  Regulatory interactions between the amino terminus of G-protein betagamma subunits and the catalytic domain of phospholipase Cbeta2.  J. Biol. Chem. 280:10174-10181.

Davis TL, Bonacci TM, Sprang SR, and Smrcka AV  (2005)  Structural and molecular characterization of a preferred protein interaction surface on G protein beta gamma subunits.  Biochemistry 44:10593-10604.

Malik S, Ghosh M, Bonacci TM, Tall GG, and Smrcka AV  (2005)  Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells.  Mol. Pharmacol. 68:129-136.

Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC and Smrcka AV.  (2005)  Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy.  Circ. Res. 97:1305-1313.

Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, and Smrcka AV  (2006)  Differential targeting of Gbetagamma-subunit signaling with small molecules.  Science 312:443-446.

Kelley GG, Kaproth-Joslin KA, Reks SE, Smrcka AV, and Wojcikiewicz RJ  (2006)  G-protein-coupled receptor agonists activate endogenous phospholipase Cepsilon and phospholipase Cbeta3 in a temporally distinct manner.  J. Biol. Chem. 281:2639-2648.

Mahon MJ, Bonacci TM, Divieti P, and Smrcka AV  (2006)  A docking site for G protein betagamma subunits on the parathyroid hormone 1 receptor supports signaling through multiple pathways.  Mol. Endocrinol. 20:136-146.

Sato M, Cismowski MJ, Toyota E, Smrcka AV, Lucchesi PA, Chilian WM, and Lanier SM  (2006)  Identification of a receptor-independent activator of G protein signaling (AGS8) in ischemic heart and its interaction with Gbetagamma.  Proc. Natl. Acad. Sci. USA 103:797-802.