"Dactinomycin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
A compound composed of a two CYCLIC PEPTIDES attached to a phenoxazine that is derived from STREPTOMYCES parvullus. It binds to DNA and inhibits RNA synthesis (transcription), with chain elongation more sensitive than initiation, termination, or release. As a result of impaired mRNA production, protein synthesis also declines after dactinomycin therapy. (From AMA Drug Evaluations Annual, 1993, p2015)
- Cosmegen Lyovac
- Lyovac, Cosmegen
- MSD Brand of Dactinomycin
- Merck Brand of Dactinomycin
- Merck Frosst Brand of Dactinomycin
- Merck Sharp & Dohme Brand of Dactinomycin
- Lemery Brand of Dactinomycin
Below are MeSH descriptors whose meaning is more general than "Dactinomycin".
Below are MeSH descriptors whose meaning is more specific than "Dactinomycin".
This graph shows the total number of publications written about "Dactinomycin" by people in the URMC Research Network by year, and whether "Dactinomycin" was a major or minor topic of these publication.