"Cholera Toxin" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus,
MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure,
which enables searching at various levels of specificity.
An ENTEROTOXIN from VIBRIO CHOLERAE. It consists of two major protomers, the heavy (H) or A subunit and the B protomer which consists of 5 light (L) or B subunits. The catalytic A subunit is proteolytically cleaved into fragments A1 and A2. The A1 fragment is a MONO(ADP-RIBOSE) TRANSFERASE. The B protomer binds cholera toxin to intestinal epithelial cells, and facilitates the uptake of the A1 fragment. The A1 catalyzed transfer of ADP-RIBOSE to the alpha subunits of heterotrimeric G PROTEINS activates the production of CYCLIC AMP. Increased levels of cyclic AMP are thought to modulate release of fluid and electrolytes from intestinal crypt cells.
- Cholera Toxin
- Toxin, Cholera
- Cholera Exotoxin
- Exotoxin, Cholera
- Cholera Enterotoxin CT
- CT, Cholera Enterotoxin
- Enterotoxin CT, Cholera
- Cholera Toxin Protomer B
- Cholera Toxin B Subunit
Below are MeSH descriptors whose meaning is more general than "Cholera Toxin".
Below are MeSH descriptors whose meaning is more specific than "Cholera Toxin".
This graph shows the total number of publications written about "Cholera Toxin" by people in the URMC Research Network by year, and whether "Cholera Toxin" was a major or minor topic of these publication.