URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Dosage Compensation, Genetic

"Dosage Compensation, Genetic" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information
Genetic mechanisms that allow GENES to be expressed at a similar level irrespective of their GENE DOSAGE. This term is usually used in discussing genes that lie on the SEX CHROMOSOMES. Because the sex chromosomes are only partially homologous, there is a different copy number, i.e., dosage, of these genes in males vs. females. In DROSOPHILA, dosage compensation is accomplished by hypertranscription of genes located on the X CHROMOSOME. In mammals, dosage compensation of X chromosome genes is accomplished by random X CHROMOSOME INACTIVATION of one of the two X chromosomes in the female.


publications
This graph shows the total number of publications written about "Dosage Compensation, Genetic" by people in the URMC Research Network by year, and whether "Dosage Compensation, Genetic" was a major or minor topic of these publication.