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Chloramphenicol O-Acetyltransferase

"Chloramphenicol O-Acetyltransferase" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information
An enzyme that catalyzes the acetylation of chloramphenicol to yield chloramphenicol 3-acetate. Since chloramphenicol 3-acetate does not bind to bacterial ribosomes and is not an inhibitor of peptidyltransferase, the enzyme is responsible for the naturally occurring chloramphenicol resistance in bacteria. The enzyme, for which variants are known, is found in both gram-negative and gram-positive bacteria. EC 2.3.1.28.


publications
This graph shows the total number of publications written about "Chloramphenicol O-Acetyltransferase" by people in the URMC Research Network by year, and whether "Chloramphenicol O-Acetyltransferase" was a major or minor topic of these publication.