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Buthionine Sulfoximine

"Buthionine Sulfoximine" is a descriptor in the National Library of Medicine's controlled vocabulary thesaurus, MeSH (Medical Subject Headings). Descriptors are arranged in a hierarchical structure, which enables searching at various levels of specificity.

MeSH information
A synthetic amino acid that depletes glutathione by irreversibly inhibiting gamma-glutamylcysteine synthetase. Inhibition of this enzyme is a critical step in glutathione biosynthesis. It has been shown to inhibit the proliferative response in human T-lymphocytes and inhibit macrophage activation. (J Biol Chem 1995;270(33):1945-7)


publications
This graph shows the total number of publications written about "Buthionine Sulfoximine" by people in the URMC Research Network by year, and whether "Buthionine Sulfoximine" was a major or minor topic of these publication.