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Neil Blumberg

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentPathology and Laboratory Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 608
Rochester NY 14642
 
 Awards And Honors
1966 - 1970National Merit Scholarship Program  | National Merit Scholarship Program
1969     Phi Beta Kappa
1970     BS, Yale, Magna cum laude
1971 - 1974NIH Medical Scientist Training Grant Fellowship
1990     Editorial Board Member  | TRANSFUSION
2005 - 2018Co-Chair REDS III and Chair REDS II Data Monitoring Committee  | NIH-National Heart, Lung and Blood Institute
2008 - 2012Editorial Board Member  | BLOOD
 
 Overview
Blood transfusions are known to be broadly immunomodulatory and are associated with substantially poorer clinical outcomes in surgical and cancer patients, and better outcomes in solid organ allograft recipients. Our laboratory and clinical group has been interested for the last twenty years in the disparate effects of autologous and allogeneic transfusions on immune function, as well as the potential benefits of removing allogeneic white cells and stored supernatant plasma from blood components before transfusions.

Our studies demonstrated that patients receiving leukocyte-reduced allogeneic blood transfusions for leukemia, and those receiving leukocyte-reduced allogeneic or autologous transfusions during surgical procedures, experienced reduced morbidity and mortality compared with patients receiving unmodified allogeneic transfusions. We were the first to document that one likely mechanism for these benefits is that allogeneic transfusions promote type 2 (Th2) cellular immunity and down regulate type 1 (Th1) immunity. Leukoreduction or use of autologous transfusions reduces these immunologic effects. We also have pioneered clinical outcomes and cost-effectiveness analyses in the study of transfusion immunomodulation.

Transfusions, however, can also promote inflammatory processes. Platelet transfusions are associated with a dose dependent increase in multi-organ failure syndrome in surgical patients. Work done in collaboration with Dr. Rick Phipps's laboratory has shown that stored platelet transfusion supernatant promotes cellular secretion of PGE2 , IL6 and IL8 in vitro through a soluble CD40L dependent mechanism. Current investigations include clinical and laboratory studies of the effects of stored platelet supernatant CD40L on clinical outcomes and in vitro immunologic function. We are also exploring the possible use of autologous stored platelet supernatant for immunotherapeutic use.

 
 Selected Publications
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  1. Blumberg N. ABO mismatched platelet transfusions in trauma patients. CMAJ. 2014 Jan 7; 186(1):63.
    View in: PubMed
  2. Glance LG, Blumberg N, Eaton MP, Lustik SJ, Osler TM, Wissler R, Zollo R, Karcz M, Feng C, Dick AW. Preoperative thrombocytopenia and postoperative outcomes after noncardiac surgery. Anesthesiology. 2014 Jan; 120(1):62-75.
    View in: PubMed
  3. Refaai MA, Blumberg N. Transfusion immunomodulation from a clinical perspective: an update. Expert Rev Hematol. 2013 Dec; 6(6):653-63.
    View in: PubMed
  4. Refaai MA, Blumberg N. The transfusion dilemma - Weighing the known and newly proposed risks of blood transfusions against the uncertain benefits. Best Pract Res Clin Anaesthesiol. 2013 Mar; 27(1):17-35.
    View in: PubMed
  5. Cholette JM, Powers KS, Alfieris GM, Angona R, Henrichs KF, Masel D, Swartz MF, Daugherty LE, Belmont K, Blumberg N. Transfusion of Cell Saver Salvaged Blood in Neonates and Infants Undergoing Open Heart Surgery Significantly Reduces RBC and Coagulant Product Transfusions and Donor Exposures: Results of a Prospective, Randomized, Clinical Trial*. Pediatr Crit Care Med. 2013 Feb; 14(2):137-47.
    View in: PubMed
  6. Sahler J, Woeller C, Spinelli S, Blumberg N, Phipps R. A novel method for overexpression of peroxisome proliferator-activated receptor-? in megakaryocyte and platelet microparticles achieves transcellular signaling. J Thromb Haemost. 2012 Dec; 10(12):2563-72.
    View in: PubMed
  7. Lannan KL, Sahler J, Spinelli SL, Phipps RP, Blumberg N. Transfusion immunomodulation - the case for leukoreduced and (perhaps) washed transfusions. Blood Cells Mol Dis. 2013 Jan; 50(1):61-8.
    View in: PubMed
  8. Blumberg N, Heal JM, Phillips GL, Phipps RP. Platelets--to transfuse or not to transfuse. Lancet. 2012 Oct 13; 380(9850):1287-9.
    View in: PubMed
  9. Sahler J, Spinelli S, Phipps R, Blumberg N. CD40 ligand (CD154) involvement in platelet transfusion reactions. Transfus Clin Biol. 2012 Jun; 19(3):98-103.
    View in: PubMed
  10. Refaai MA, Carter J, Henrichs KF, Davidson DC, Pollock SJ, Casey AE, Spinelli SL, Phipps RP, Francis CW, Blumberg N. Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B. Transfusion. 2013 Feb; 53(2):382-93.
    View in: PubMed
  11. Cholette JM, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spinelli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Lerner NB, Blumberg N. Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: results of a prospective, randomized, controlled clinical trial. Pediatr Crit Care Med. 2012 May; 13(3):290-9.
    View in: PubMed
  12. Reesink HW, Lee J, Keller A, Dennington P, Pink J, Holdsworth R, Schennach H, Goldman M, Petraszko T, Sun J, Meng Y, Qian K, Rehacek V, Turek P, Krusius T, Juvonen E, Tiberghien P, Legrand D, Semana G, Muller JY, Bux J, Reil A, Lin CK, Daly H, McSweeney E, Porretti L, Greppi N, Rebulla P, Okazaki H, Sánchez-Guerrero SA, Baptista-González HA, Martínez-Murillo C, Guerra-Márquez A, Rodriguez-Moyado H, Middelburg RA, Wiersum-Osselton JC, Brand A, van Tilburg C, Dinesh D, Dagger J, Dunn P, Brojer E, Letowska M, Maslanka K, Lachert E, Uhrynowska M, Zhiburt E, Palfi M, Berlin G, Frey BM, Puig Rovira L, Muñiz-Diaz E, Castro E, Chapman C, Green A, Massey E, Win N, Williamson L, Silliman CC, Chaffin DJ, Ambruso DR, Blumberg N, Tomasulo P, Land KJ, Norris PJ, Illoh OC, Davey RJ, Benjamin RJ, Eder AF, McLaughlin L, Kleinman S, Panzer S. Measures to prevent transfusion-related acute lung injury (TRALI). Vox Sang. 2012 Oct; 103(3):231-59.
    View in: PubMed
  13. Rogers MA, Levine DA, Blumberg N, Flanders SA, Chopra V, Langa KM. Triggers of hospitalization for venous thromboembolism. Circulation. 2012 May 1; 125(17):2092-9.
    View in: PubMed
  14. Blumberg N, Sime PJ, Phipps RP. The mystery of transfusion-related acute lung injury. Transfusion. 2011 Oct; 51(10):2054-7.
    View in: PubMed
  15. Rogers MA, Blumberg N, Heal JM, Kuhn L, Greene MT, Shuman E, Chenoweth CE, Chang R, Saint S. Role of transfusion in the development of urinary tract-related bloodstream infection. Arch Intern Med. 2011 Sep 26; 171(17):1587-9.
    View in: PubMed
  16. Henrichs KF, Howk N, Masel DS, Thayer M, Refaai MA, Kirkley SA, Heal JM, Blumberg N. Providing ABO-identical platelets and cryoprecipitate to (almost) all patients: approach, logistics, and associated decreases in transfusion reaction and red blood cell alloimmunization incidence. Transfusion. 2012 Mar; 52(3):635-40.
    View in: PubMed
  17. Rogers MA, Levine DA, Blumberg N, Fisher GG, Kabeto M, Langa KM. Antigenic challenge in the etiology of autoimmune disease in women. J Autoimmun. 2012 May; 38(2-3):J97-J102.
    View in: PubMed
  18. Spinella PC, Doctor A, Blumberg N, Holcomb JB. Does the storage duration of blood products affect outcomes in critically ill patients? Transfusion. 2011 Aug; 51(8):1644-50.
    View in: PubMed
  19. Yazer MH, Raval JS, Triulzi DJ, Blumberg N. ABO-mismatched transfusions are not over-represented in febrile non-haemolytic transfusion reactions to platelets. Vox Sang. 2012 Feb; 102(2):175-7.
    View in: PubMed
  20. Grimshaw K, Sahler J, Spinelli SL, Phipps RP, Blumberg N. New frontiers in transfusion biology: identification and significance of mediators of morbidity and mortality in stored red blood cells. Transfusion. 2011 Apr; 51(4):874-80.
    View in: PubMed
  21. Refaai MA, Fialkow LB, Heal JM, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Corsetti JP, Francis CW, Bankey PE, Blumberg N. An association of ABO non-identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients. Vox Sang. 2011 Jul; 101(1):55-60.
    View in: PubMed
  22. Sahler J, Bernard JJ, Spinelli SL, Blumberg N, Phipps RP. The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-?B inhibition. Thromb Res. 2011 May; 127(5):426-34.
    View in: PubMed
  23. Blumberg N, Heal JM, Gettings KF, Phipps RP, Masel D, Refaai MA, Kirkley SA, Fialkow LB. An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions. Transfusion. 2010 Dec; 50(12):2738-44.
    View in: PubMed
  24. Refaai MA, Phipps RP, Spinelli SL, Blumberg N. Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes. Thromb Res. 2011 Apr; 127(4):287-91.
    View in: PubMed
  25. Rogers MA, Blumberg N, Heal JM, Langa KM. Utilization of blood transfusion among older adults in the United States. Transfusion. 2011 Apr; 51(4):710-8.
    View in: PubMed
  26. Spinelli SL, Maggirwar SB, Blumberg N, Phipps RP. Nuclear emancipation: a platelet tour de force. Sci Signal. 2010; 3(144):pe37.
    View in: PubMed
  27. Cholette JM, Mamikonian L, Alfieris GM, Blumberg N, Lerner NB. Aspirin resistance following pediatric cardiac surgery. Thromb Res. 2010 Sep; 126(3):200-6.
    View in: PubMed
  28. Refaai MA, Chuang C, Menegus M, Blumberg N, Francis CW. Outcomes after platelet transfusion in patients with heparin-induced thrombocytopenia. J Thromb Haemost. 2010 Jun; 8(6):1419-21.
    View in: PubMed
  29. Blumberg N, Sime PJ, Phipps RP. Leukoreduction of blood transfusions--there is such a thing as a free lunch. Crit Care Med. 2010 Feb; 38(2):720-1.
    View in: PubMed
  30. Blumberg N, Heal JM, Phillips GL. Platelet transfusions: trigger, dose, benefits, and risks. F1000 Med Rep. 2010; 2:5.
    View in: PubMed
  31. Spinelli SL, Casey AE, Pollock SJ, Gertz JM, McMillan DH, Narasipura SD, Mody NA, King MR, Maggirwar SB, Francis CW, Taubman MB, Blumberg N, Phipps RP. Platelets and megakaryocytes contain functional nuclear factor-kappaB. Arterioscler Thromb Vasc Biol. 2010 Mar; 30(3):591-8.
    View in: PubMed
  32. Bernard JJ, Seweryniak KE, Koniski AD, Spinelli SL, Blumberg N, Francis CW, Taubman MB, Palis J, Phipps RP. Foxp3 regulates megakaryopoiesis and platelet function. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1874-82.
    View in: PubMed
  33. Rogers MA, Blumberg N, Saint S, Langa KM, Nallamothu BK. Hospital variation in transfusion and infection after cardiac surgery: a cohort study. BMC Med. 2009; 7:37.
    View in: PubMed
  34. Heal JM, Phipps RP, Blumberg N. One big unhappy family: transfusion alloimmunization, thrombosis, and immune modulation/inflammation. Transfusion. 2009 Jun; 49(6):1032-6.
    View in: PubMed
  35. Springer DL, Miller JH, Spinelli SL, Pasa-Tolic L, Purvine SO, Daly DS, Zangar RC, Jin S, Blumberg N, Francis CW, Taubman MB, Casey AE, Wittlin SD, Phipps RP. Platelet proteome changes associated with diabetes and during platelet storage for transfusion. J Proteome Res. 2009 May; 8(5):2261-72.
    View in: PubMed
  36. Phipps RP, Blumberg N. Statin islands and PPAR ligands in platelets. Arterioscler Thromb Vasc Biol. 2009 May; 29(5):620-1.
    View in: PubMed
  37. Coppage M, Baker M, Fialkow L, Meehan D, Gettings K, Chen L, Massey HT, Blumberg N. Lack of significant de novo HLA allosensitization in ventricular assist device recipients transfused with leukoreduced, ABO identical blood products. Hum Immunol. 2009 Jun; 70(6):413-6.
    View in: PubMed
  38. Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP. The platelet as an immune cell-CD40 ligand and transfusion immunomodulation. Immunol Res. 2009 Dec; 45(2-3):251-60.
    View in: PubMed
  39. Kanda J, Ichinohe T, Matsuo K, Benjamin RJ, Klumpp TR, Rozman P, Blumberg N, Mehta J, Sohn SK, Uchiyama T. Impact of ABO mismatching on the outcomes of allogeneic related and unrelated blood and marrow stem cell transplantations for hematologic malignancies: IPD-based meta-analysis of cohort studies. Transfusion. 2009 Apr; 49(4):624-35.
    View in: PubMed
  40. Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, Lyman GH. Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer. Arch Intern Med. 2008 Nov 24; 168(21):2377-81.
    View in: PubMed
  41. O'Brien JJ, Baglole CJ, Garcia-Bates TM, Blumberg N, Francis CW, Phipps RP. 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. J Thromb Haemost. 2009 Jan; 7(1):182-9.
    View in: PubMed
  42. O'Brien JJ, Spinelli SL, Tober J, Blumberg N, Francis CW, Taubman MB, Palis J, Seweryniak KE, Gertz JM, Phipps RP. 15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes. Blood. 2008 Nov 15; 112(10):4051-60.
    View in: PubMed
  43. Hillyer CD, Blumberg N, Glynn SA, Ness PM. Transfusion recipient epidemiology and outcomes research: possibilities for the future. Transfusion. 2008 Aug; 48(8):1530-7.
    View in: PubMed
  44. Ray DM, Spinelli SL, Pollock SJ, Murant TI, O'Brien JJ, Blumberg N, Francis CW, Taubman MB, Phipps RP. Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb Haemost. 2008 Jan; 99(1):86-95.
    View in: PubMed
  45. Spinelli SL, O'Brien JJ, Bancos S, Lehmann GM, Springer DL, Blumberg N, Francis CW, Taubman MB, Phipps RP. The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. PPAR Res. 2008; 2008:328172.
    View in: PubMed
  46. Rogers MA, Blumberg N, Heal JM, Hicks GL. Increased risk of infection and mortality in women after cardiac surgery related to allogeneic blood transfusion. J Womens Health (Larchmt). 2007 Dec; 16(10):1412-20.
    View in: PubMed
  47. Cholette JM, Blumberg N, Phipps RP, McDermott MP, Gettings KF, Lerner NB. Developmental changes in soluble CD40 ligand. J Pediatr. 2008 Jan; 152(1):50-4, 54.e1.
    View in: PubMed
  48. Blumberg N, Heal JM, Liesveld JL, Phillips GL, Rowe JM. Platelet transfusion and survival in adults with acute leukemia. Leukemia. 2008 Mar; 22(3):631-5.
    View in: PubMed
  49. Blumberg N, Heal JM. Universal leukocyte reduction of blood transfusions. Clin Infect Dis. 2007 Oct 15; 45(8):1014-5.
    View in: PubMed
  50. Blumberg N, Zhao H, Wang H, Messing S, Heal JM, Lyman GH. The intention-to-treat principle in clinical trials and meta-analyses of leukoreduced blood transfusions in surgical patients. Transfusion. 2007 Apr; 47(4):573-81.
    View in: PubMed
  51. Kaufman J, Spinelli SL, Schultz E, Blumberg N, Phipps RP. Release of biologically active CD154 during collection and storage of platelet concentrates prepared for transfusion. J Thromb Haemost. 2007 Apr; 5(4):788-96.
    View in: PubMed
  52. Rogers MA, Blumberg N, Saint SK, Kim C, Nallamothu BK, Langa KM. Allogeneic blood transfusions explain increased mortality in women after coronary artery bypass graft surgery. Am Heart J. 2006 Dec; 152(6):1028-34.
    View in: PubMed
  53. Blumberg N, Gettings KF, Turner C, Heal JM, Phipps RP. An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions. Transfusion. 2006 Oct; 46(10):1813-21.
    View in: PubMed
  54. O'Brien JJ, Ray DM, Spinelli SL, Blumberg N, Taubman MB, Francis CW, Wittlin SD, Phipps RP. The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands. Prostaglandins Other Lipid Mediat. 2007 Jan; 82(1-4):68-76.
    View in: PubMed
  55. Khan SY, Kelher MR, Heal JM, Blumberg N, Boshkov LK, Phipps R, Gettings KF, McLaughlin NJ, Silliman CC. Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood. 2006 Oct 1; 108(7):2455-62.
    View in: PubMed
  56. Ray DM, Spinelli SL, O'Brien JJ, Blumberg N, Phipps RP. Platelets as a novel target for PPARgamma ligands : implications for inflammation, diabetes, and cardiovascular disease. BioDrugs. 2006; 20(4):231-41.
    View in: PubMed
  57. Heal JM, Liesveld JL, Phillips GL, Blumberg N. What would Karl Landsteiner do? The ABO blood group and stem cell transplantation. Bone Marrow Transplant. 2005 Nov; 36(9):747-55.
    View in: PubMed
  58. Blumberg N, Fine L, Gettings KF, Heal JM. Decreased sepsis related to indwelling venous access devices coincident with implementation of universal leukoreduction of blood transfusions. Transfusion. 2005 Oct; 45(10):1632-9.
    View in: PubMed
  59. Blumberg N. Deleterious clinical effects of transfusion immunomodulation: proven beyond a reasonable doubt. Transfusion. 2005 Aug; 45(2 Suppl):33S-39S; discussion 39S-40S.
    View in: PubMed
  60. Horan JT, Liesveld JL, Fenton P, Blumberg N, Walters MC. Hematopoietic stem cell transplantation for multiply transfused patients with sickle cell disease and thalassemia after low-dose total body irradiation, fludarabine, and rabbit anti-thymocyte globulin. Bone Marrow Transplant. 2005 Jan; 35(2):171-7.
    View in: PubMed
  61. Heal JM, Blumberg N. Optimizing platelet transfusion therapy. Blood Rev. 2004 Sep; 18(3):149-65.
    View in: PubMed
  62. Akbiyik F, Ray DM, Gettings KF, Blumberg N, Francis CW, Phipps RP. Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. Blood. 2004 Sep 1; 104(5):1361-8.
    View in: PubMed
  63. Blumberg N, Heal JM. Erythropoietin to treat anaemia in patients with head and neck cancer. Lancet. 2004 Jan 3; 363(9402):80-1; author reply 81-2.
    View in: PubMed
  64. Koumas L, Smith TJ, Feldon S, Blumberg N, Phipps RP. Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes. Am J Pathol. 2003 Oct; 163(4):1291-300.
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  65. Blumberg N, Heal JM, Gettings KF. WBC reduction of RBC transfusions is associated with a decreased incidence of RBC alloimmunization. Transfusion. 2003 Jul; 43(7):945-52.
    View in: PubMed
  66. Goldman J, Liesveld J, Nichols D, Heal J, Blumberg N. ABO incompatibility between donor and recipient and clinical outcomes in allogeneic stem cell transplantation. Leuk Res. 2003 Jun; 27(6):489-91.
    View in: PubMed
  67. Blumberg N, Heal JM. Regarding 'Meta-analysis of randomized trials comparing the risk of postoperative infection between recipients of allogeneic and autologous blood transfusion' by Vamvakas et al. Vox Sang. 2003 May; 84(4):331-2; author reply 332-3.
    View in: PubMed
  68. Blumberg N, Phipps RP, Kaufman J, Heal JM. The causes and treatment of reactions to platelet transfusions. Transfusion. 2003 Feb; 43(2):291-2; author reply 292.
    View in: PubMed
  69. Blumberg N, Heal JM. ABO-mismatched platelet transfusions and clinical outcomes after cardiac surgery. Transfusion. 2002 Nov; 42(11):1527-8; author reply 1528-9.
    View in: PubMed
  70. Blumberg N, Heal JM, Cowles JW, Hicks GL, Risher WH, Samuel PK, Kirkley SA. Leukocyte-reduced transfusions in cardiac surgery results of an implementation trial. Am J Clin Pathol. 2002 Sep; 118(3):376-81.
    View in: PubMed
  71. Vanderlinde ES, Heal JM, Blumberg N. Autologous transfusion. BMJ. 2002 Mar 30; 324(7340):772-5.
    View in: PubMed
  72. Rios JA, Korones DN, Heal JM, Blumberg N. WBC-reduced blood transfusions and clinical outcome in children with acute lymphoid leukemia. Transfusion. 2001 Jul; 41(7):873-7.
    View in: PubMed
  73. Phipps RP, Kaufman J, Blumberg N. Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. Lancet. 2001 Jun 23; 357(9273):2023-4.
    View in: PubMed
  74. Blumberg N, Heal JM, Hicks GL, Risher WH. Association of ABO-mismatched platelet transfusions with morbidity and mortality in cardiac surgery. Transfusion. 2001 Jun; 41(6):790-3.
    View in: PubMed
  75. Anolik JH, Blumberg N, Snider J, Francis CW. Posttransfusion purpura secondary to an alloantibody reactive with HPA-5a (Br(b)). Transfusion. 2001 May; 41(5):633-6.
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  76. Vo TD, Cowles J, Heal JM, Blumberg N. Platelet washing to prevent recurrent febrile reactions to leucocyte-reduced transfusions. Transfus Med. 2001 Feb; 11(1):45-7.
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  77. Goldfinger D, Klapper E, Pepkowitz SH, Millar SI, Heal JM, Blumberg N, Wuest D, Reich L, Mayer K. Universal WBC reduction and patient advocacy. Transfusion. 2000 Dec; 40(12):1545-6.
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  78. Blumberg N, Heal JM. Mortality risks, costs, and decision making in transfusion medicine. Am J Clin Pathol. 2000 Dec; 114(6):934-7.
    View in: PubMed
  79. Heal JM, Blumberg N. The second century of ABO: and now for something completely different. Transfusion. 1999 Nov-Dec; 39(11-12):1155-9.
    View in: PubMed
  80. Blumberg N. The costs and consequences of management fads and politically driven regulatory oversight. Arch Pathol Lab Med. 1999 Jul; 123(7):580-4.
    View in: PubMed
  81. Griggs JJ, Blumberg N. Recombinant erythropoietin and blood transfusions in cancer chemotherapy-induced anemia. Anticancer Drugs. 1998 Nov; 9(10):925-32.
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  82. Kirkley SA, Cowles J, Pellegrini VD, Harris CM, Boyd AD, Blumberg N. Blood transfusion and total joint replacement surgery: T helper 2 (TH2) cytokine secretion and clinical outcome. Transfus Med. 1998 Sep; 8(3):195-204.
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  83. Blumberg N. Perioperative allogeneic blood transfusion does not cause adverse sequelae in patients with cancer: a meta-analysis of unconfounded studies. Br J Surg. 1998 Aug; 85(8):1163-4.
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  84. Blumberg N. Anesthesiology. N Engl J Med. 1998 Mar 5; 338(10):686; author reply 686-7.
    View in: PubMed
  85. Blumberg N, Heal JM. Blood transfusion immunomodulation: the silent epidemic. Arch Pathol Lab Med. 1998 Feb; 122(2):117-9.
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  86. Blumberg N. Allogeneic transfusion and infection: economic and clinical implications. Semin Hematol. 1997 Jul; 34(3 Suppl 2):34-40.
    View in: PubMed
  87. Blumberg N, Heal JM. The transfusion immunomodulation theory: the Th1/Th2 paradigm and an analogy with pregnancy as a unifying mechanism. Semin Hematol. 1996 Oct; 33(4):329-40.
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  88. Blumberg N, Heal JM. Immunomodulation by blood transfusion: an evolving scientific and clinical challenge. Am J Med. 1996 Sep; 101(3):299-308.
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  89. Blumberg N, Heal JM. Immunological tolerance. Science. 1996 Jun 7; 272(5267):1408.
    View in: PubMed
  90. Blumberg N, Heal JM. Immunological tolerance. Science. 1996 Jun 7; 272(5267):1408b.
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  91. Blumberg N, Kirkley SA, Heal JM. A cost analysis of autologous and allogeneic transfusions in hip-replacement surgery. Am J Surg. 1996 Mar; 171(3):324-30.
    View in: PubMed
  92. Heal JM, Masel D, Blumberg N. Interaction of platelet fc and complement receptors with circulating immune complexes involving the AB0 system. Vox Sang. 1996; 71(4):205-11.
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  93. Dzik S, Blajchman MA, Blumberg N, Kirkley SA, Heal JM, Wood K. Current research on the immunomodulatory effect of allogeneic blood transfusion. Vox Sang. 1996; 70(4):187-94.
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  94. Blumberg N, Heal JM. Noncausal relationship between cancer recurrence and perioperative blood transfusions. Ann Surg. 1995 Dec; 222(6):757-8.
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  95. Blumberg N, Heal JM. Transfusion and the immune system: a paradigm shift in progress? Transfusion. 1995 Oct; 35(10):879-83.
    View in: PubMed
  96. Kirkley SA, Cowles J, Pellegrini VD, Harris CM, Boyd AD, Blumberg N. Cytokine secretion after allogeneic or autologous blood transfusion. Lancet. 1995 Feb 25; 345(8948):527.
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  97. Blumberg N, Heal JM, Kirkley SA, DiPersio JF, Rapoport AP, Rowe JM. Leukodepleted-ABO-identical blood components in the treatment of hematologic malignancies: a cost analysis. Am J Hematol. 1995 Feb; 48(2):108-15.
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  98. Heal JM, Blumberg N, Kirkley SA, DiPersio JF, Rapoport AP, Rowe JM. Leukocyte-reduced transfusions of ABO-identical platelets and clinical outcome in autologous bone marrow transplantation for lymphoma. Bone Marrow Transplant. 1994 Dec; 14(6):943-8.
    View in: PubMed
  99. Kirkley SA, Blumberg N. Use of single donor platelets. Blood Rev. 1994 Sep; 8(3):142-7.
    View in: PubMed
  100. Blumberg N, Heal JM. Perioperative blood transfusion and colorectal cancer recurrence. Transfusion. 1994 May; 34(5):450-2.
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  101. Blumberg N, Heal JM. Effects of transfusion on immune function. Cancer recurrence and infection. Arch Pathol Lab Med. 1994 Apr; 118(4):371-9.
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  102. Heal JM, Kenmotsu N, Rowe JM, Blumberg N. A possible survival advantage in adults with acute leukemia receiving ABO-identical platelet transfusions. Am J Hematol. 1994 Feb; 45(2):189-90.
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  103. Heal JM, Masel D, Rowe JM, Blumberg N. Circulating immune complexes involving the ABO system after platelet transfusion. Br J Haematol. 1993 Nov; 85(3):566-72.
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  104. Blumberg N, Heal JM. Blood transfusions and prognosis in colorectal cancer. N Engl J Med. 1993 Oct 28; 329(18):1355; author reply 1355-6.
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  105. Heal JM, Rowe JM, Blumberg N. ABO and platelet transfusion revisited. Ann Hematol. 1993 Jun; 66(6):309-14.
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  106. Blumberg N, Albert M, Krabill K. Pathologists are doctors. Ann Intern Med. 1993 Apr 1; 118(7):575.
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  107. Heal JM, Rowe JM, McMican A, Masel D, Finke C, Blumberg N. The role of ABO matching in platelet transfusion. Eur J Haematol. 1993 Feb; 50(2):110-7.
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  108. Cox MT, Roberts M, LaJoie J, Enfonde M, Kress D, Blumberg N. An apparent primary immune response involving anti-Jka and anti-P1 detected 10 days after transfusion. Transfusion. 1992 Nov-Dec; 32(9):874.
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  109. Murphy PJ, Connery C, Hicks GL, Blumberg N. Homologous blood transfusion as a risk factor for postoperative infection after coronary artery bypass graft operations. J Thorac Cardiovasc Surg. 1992 Oct; 104(4):1092-9.
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  110. Blumberg N, Heal JM. White cell reduction, ultraviolet irradiation, and platelet refractoriness in acute myeloid leukemia. Transfusion. 1992 Sep; 32(7):688-9.
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  111. Triulzi DJ, Vanek K, Ryan DH, Blumberg N. A clinical and immunologic study of blood transfusion and postoperative bacterial infection in spinal surgery. Transfusion. 1992 Jul-Aug; 32(6):517-24.
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  112. Basile M, Moskowitz B, Harris J, Blumberg N, Bennett JM. Malignant melanoma: primary presentation in bone marrow and lymph node. Med Pediatr Oncol. 1992; 20(1):75-7.
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  113. Heal JM, Cowles J, Masel D, Rowe JM, Blumberg N. Antibodies to plasma proteins: an association with platelet transfusion refractoriness. Br J Haematol. 1992 Jan; 80(1):83-90.
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  114. Sherer DM, Abramowicz JS, Ryan RM, Sheils LA, Blumberg N, Woods JR. Severe fetal hydrops resulting from ABO incompatibility. Obstet Gynecol. 1991 Nov; 78(5 Pt 2):897-9.
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  115. Murphy P, Heal JM, Blumberg N. Infection or suspected infection after hip replacement surgery with autologous or homologous blood transfusions. Transfusion. 1991 Mar-Apr; 31(3):212-7.
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  116. Blumberg N, Triulzi DJ, Heal JM. Transfusion-induced immunomodulation and its clinical consequences. Transfus Med Rev. 1990 Oct; 4(4 Suppl 1):24-35.
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  117. Blumberg N, Heal JM. Transfusion-induced immunomodulation and its possible role in cancer recurrence and perioperative bacterial infection. Yale J Biol Med. 1990 Sep-Oct; 63(5):429-33.
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  118. Blumberg N. Beyond ABO and D antigen matching: how far and for whom? Transfusion. 1990 Jul-Aug; 30(6):482-4.
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  119. Blumberg N, Chuang-Stein C, Heal JM. The relationship of blood transfusion, tumor staging, and cancer recurrence. Transfusion. 1990 May; 30(4):291-4.
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  120. Triulzi DJ, Blumberg N. Variability in response to cryoprecipitate treatment for hemostatic defects in uremia. Yale J Biol Med. 1990 Jan-Feb; 63(1):1-7.
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  121. Triulzi DJ, Blumberg N, Heal JM. Association of transfusion with postoperative bacterial infection. Crit Rev Clin Lab Sci. 1990; 28(2):95-107.
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  122. Heal JM, Mullin A, Blumberg N. The importance of ABH antigens in platelet crossmatching. Transfusion. 1989 Jul-Aug; 29(6):514-20.
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  123. Blumberg N, Heal JM. Transfusion and recipient immune function. Arch Pathol Lab Med. 1989 Mar; 113(3):246-53.
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  124. Blumberg N, Heal JM. Transfusion and host defenses against cancer recurrence and infection. Transfusion. 1989 Mar-Apr; 29(3):236-45.
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  125. Cowles JW, Spitalnik SL, Blumberg N. The fine specificity of Lewis blood group antibodies. Evidence for maturation of the immune response. Vox Sang. 1989; 56(2):107-11.
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  126. Blumberg N, Heal JM. Evidence for plasma-mediated immunomodulation--transfusions of plasma-rich blood components are associated with a greater risk of acquired immunodeficiency syndrome than transfusions of red blood cells alone. Transplant Proc. 1988 Dec; 20(6):1138-42.
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  127. Heal JM, Chuang C, Blumberg N. Perioperative blood transfusions and prostate cancer recurrence and survival. Am J Surg. 1988 Nov; 156(5):374-80.
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  128. Blumberg N, Agarwal MM, Chuang C. A possible association between survival time and transfusion in cervical cancer. Yale J Biol Med. 1988 Nov-Dec; 61(6):493-500.
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  129. Blumberg N, Heal J. Renal allograft survival in transfused and non-transfused patients. Lancet. 1988 Apr 23; 1(8591):946.
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  130. Blumberg N, Heal J, Chuang C, Murphy P, Agarwal M. Further evidence supporting a cause and effect relationship between blood transfusion and earlier cancer recurrence. Ann Surg. 1988 Apr; 207(4):410-5.
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  131. Masel DS, Blumberg N, Heal JM. A chloroquine elution technique for platelet serology. Transfusion. 1988 Mar-Apr; 28(2):132-6.
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  132. Corsetti JP, Cowles JW, Cox MT, Blumberg N. A rapid and accurate single-drop modification of the acid-elution technique for detecting fetomaternal hemorrhage. Vox Sang. 1988; 54(1):39-42.
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  133. Szal M, Blumberg N. Clinical correlates in patients with elevated platelet-associated immunoglobulins. Ann Clin Lab Sci. 1988 Jan-Feb; 18(1):24-33.
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  134. Blumberg N, Heal JM. Perioperative blood transfusion and solid tumour recurrence. Blood Rev. 1987 Dec; 1(4):219-29.
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  135. Heal JM, Blumberg N, Masel D. An evaluation of crossmatching, HLA, and ABO matching for platelet transfusions to refractory patients. Blood. 1987 Jul; 70(1):23-30.
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  136. Corsetti JP, Cox C, Leary JF, Cox MT, Blumberg N, Doherty RA. Comparison of quantitative acid-elution technique and flow cytometry for detecting fetomaternal hemorrhage. Ann Clin Lab Sci. 1987 May-Jun; 17(3):197-206.
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  137. Cowles JW, Blumberg N. Neutralization of P blood group antibodies by synthetic solid-phase antigens. Transfusion. 1987 May-Jun; 27(3):272-5.
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  138. Britton RM. Confidentiality in family practice. Med Aspects Hum Sex. 1987 May; 21(5):59-60, 63, 67.
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  139. Cass RM, Blumberg N. Single-unit blood transfusion: doubtful dogma defeated. JAMA. 1987 Feb 6; 257(5):628-9.
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  140. Blumberg N, Heal JM. Perioperative blood transfusion and solid tumor recurrence--a review. Cancer Invest. 1987; 5(6):615-25.
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  141. Cowles JW, Cox MT, McMican A, Blumberg N. Comparison of monoclonal antisera with conventional antisera for Lewis blood group antigen determination. Vox Sang. 1987; 52(1-2):83-4.
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  142. Blumberg N, Laczin J, McMican A, Heal J, Arvan D. A critical survey of fresh-frozen plasma use. Transfusion. 1986 Nov-Dec; 26(6):511-3.
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  143. Blumberg N, Heal JM, Murphy P, Agarwal MM, Chuang C. Association between transfusion of whole blood and recurrence of cancer. Br Med J (Clin Res Ed). 1986 Aug 30; 293(6546):530-3.
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  144. Blumberg N, Masel D, Stoler M. Disparities in estimates of IgG bound to normal platelets. Blood. 1986 Jan; 67(1):200-2.
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  145. Cowles JW, Spitalnik SL, Blumberg N. Detection of anti-Lea in Le(a-b+) individuals by kinetic ELISA. Vox Sang. 1986; 50(3):164-8.
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  146. Blumberg N, Agarwal MM, Chuang C. Relation between recurrence of cancer of the colon and blood transfusion. Br Med J (Clin Res Ed). 1985 Apr 6; 290(6474):1037-9.
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  147. Spitalnik S, Cowles J, Cox MT, Blumberg N. Detection of IgG anti-Lewis (a) antibodies in cord sera by kinetic Elisa. Vox Sang. 1985; 48(4):235-8.
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  148. Spitalnik S, Pfaff W, Cowles J, Ireland JE, Scornik JC, Blumberg N. Correlation of humoral immunity to Lewis blood group antigens with renal transplant rejection. Transplantation. 1984 Mar; 37(3):265-8.
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  149. Blumberg N, Masel D, Mayer T, Horan P, Heal J. Removal of HLA-A,B antigens from platelets. Blood. 1984 Feb; 63(2):448-50.
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  150. Blumberg N, Ross K, Avila E, Peck K. Should chronic transfusions be matched for antigens other than ABO and Rho(D)? Vox Sang. 1984; 47(3):205-8.
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  151. Ramsey G, Stoler M, Blumberg N. Red-cell alloantibody response in AIDS. Lancet. 1983 Sep 3; 2(8349):575.
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  152. Blumberg N, Hicks G, Woll J, Nusbacher J, Cox MT, Wilbur D, Schwedfeger D, McMican A. Successful cardiac bypass surgery in the presence of a potent cold agglutinin without plasma exchange. Transfusion. 1983 Jul-Aug; 23(4):363.
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  153. Cox MT, McMican A, Blumberg N. Case report of an anti-Jk b persisting for sixteen years. Transfusion. 1983 Jul-Aug; 23(4):362.
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  154. Spitalnik SL, Cowles JW, Cox MT, Blumberg N. Neutralization of Lewis blood group antibodies by synthetic immunoadsorbents. Am J Clin Pathol. 1983 Jul; 80(1):63-5.
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  155. Blumberg N, McMican A, Heal J. Rh sensitization. Obstet Gynecol. 1983 Jul; 62(1):135-6.
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  156. Ramsey G, Arvan DA, Stewart S, Blumberg N. Do preoperative laboratory tests predict blood transfusion needs in cardiac operations? J Thorac Cardiovasc Surg. 1983 Apr; 85(4):564-9.
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  157. Holt JT, Spitalnik SL, McMican AE, Wilson G, Blumberg N. A technetium-99m red cell survival technique for in vivo compatibility testing. Transfusion. 1983 Mar-Apr; 23(2):148-51.
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  158. Blumberg N, Peck K, Ross K, Avila E. Immune response to chronic red blood cell transfusion. Vox Sang. 1983; 44(4):212-7.
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  159. Pisciotto P, Rosen D, Silver H, Genco P, Blumberg N, Katz AJ, Morse EE. Treatment of thrombotic thrombocytopenic purpura. Evaluation of plasma exchange and review of the literature. Vox Sang. 1983; 45(3):185-96.
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  160. Spitalnik S, Cowles J, Cox MT, Baker D, Holt J, Blumberg N. A new technique in quantitative immunohematology: solid-phase kinetic enzyme-linked immunosorbent assay. Vox Sang. 1983; 45(6):440-8.
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  161. Ramsey G, Desley C, Ross K, Peck K, Spennachio J, Blumberg N. The type and screen: are patient charges a valid measure of cost reduction? Ann Clin Lab Sci. 1983 Jan-Feb; 13(1):55-8.
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  162. Pisciotto P, Sataro P, Blumberg N. Incidence of adverse reactions in blood donors taking antihypertensive medications. Transfusion. 1982 Nov-Dec; 22(6):530-1.
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  163. Blumberg N, Masel D, Mayer T, Horan P, Heal J. Passive acquisition of new HLA phenotypes by human platelets incubated in plasma. Blood. 1982 Jul; 60(1):276.
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  164. Morse EE, Synder E, Blumberg N, Katz AJ. Analysis of two types of granulocyte transfusions in patients with acute leukemia and septicemia. Ann Clin Lab Sci. 1982 Mar-Apr; 12(2):106-10.
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  165. Blumberg N, Shah I, Katz AJ, Morse EE. Granulocyte yields using the Haemonetics 30. Effects of variations in corticosteroid regimen and donor selection. Vox Sang. 1982; 42(5):225-32.
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  166. Kurtz SR, Valeri DA, Gray A, Lindberg JR, McMican A, Blumberg N, Valeri CR. A new approach to washing red blood cells frozen with a high concentration of glycerol in a special freezing container. Vox Sang. 1982; 43(3):132-7.
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  167. Spitalnik S, Cox MT, Spennacchio J, Guenther R, Blumberg N. The serology of Sda effects of transfusion and pregnancy. Vox Sang. 1982; 42(6):308-12.
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  168. Blumberg N, Shah I, Hoagland J, Shirer L, Katz AJ. Evaluation of individuals deferred from blood donation for medical reasons. Vox Sang. 1982 Jan; 42(1):1-7.
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  169. Katz AJ, Genco PV, Blumberg N, Snyder EL, Camp B, Morse EE. Platelet collection and transfusion using the fenwal CS-3000 cell separator. Transfusion. 1981 Sep-Oct; 21(5):560-3.
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  170. Blumberg N, Katz AJ. Therapeutic plasmapheresis and cytapheresis. A review. Conn Med. 1981 Feb; 45(2):85-90.
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  171. Blumberg NA. Abdominal parasitic twin: an unusual cause of duodenal obstruction. Br J Surg. 1980 Sep; 67(9):675-6.
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  172. Buchholz DH, Blumberg N, Bove JR. Long-term granulocyte transfusion in patients with malignant neoplasms. Arch Intern Med. 1979 Mar; 139(3):317-20.
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  173. Blumberg N, Bove JR. Un-cross-matched blood for emergency transfusion. One year's experience in a civilian setting. JAMA. 1978 Nov 3; 240(19):2057-9.
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  174. Blumberg N, Genco P, Katz A, Bove J. Collection of granulocytes for transfusion. The effect of collection methods on cell enzyme release. Vox Sang. 1978; 35(4):207-14.
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  175. Blumberg N. Tumor angiogenesis factor. Speculations on an approach to cancer chemotherapy. Yale J Biol Med. 1974; 47(2):71-81.
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  176. BLUMBERG NA. Wounds of the heart. Br J Surg. 1960 May; 47:667-77.
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  177. BLUMBERG NA. Volvulus of the splenic flexure; report of a case with a review of the literature. Br J Surg. 1958 Nov; 46(197):292-4.
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