URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Guenter Oberdoerster

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentEnvironmental Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester NY 14642
 
 Awards And Honors
1982     Joseph von Fraunhofer Prize, 1982 (Munich, F.R.Germany)(for demonstrating pulmonary carcinogenicity of inhaled Cd in rats)
1996     Career Achievement Award, Inhalation Specialty Section of the Society of Toxicology, 1996 (for meritorious contributions to the field of Inhalation Toxicology)
1997     Paper of the Year Award, Inhalation Specialty Section of SOT, 1997 (Pulmonary inflammatory chemokine and mutagenic response in rats after subchronic inhalation of carbon black. Tox. & Appl. Pharma.136: 372-380, 1996).
2003     Thomas T. Mercer Joint Prize, 2003 (awarded by AAAR and ISAM for outstanding contributions in the field of aerosols in medicine).
 
 Overview
Toxicology of Airborne Environmental and Occupational Particles and Nanoparticles

Numerous epidemiological studies have shown that acute adverse health effects are associated with exposures to ambient airborne particles. These effects occur mostly in sensitive parts of the population such as the elderly with a compromised cardiorespiratory system. We hypothesize that ultrafine particles (particle size below 0.1 µm) are one potential source causing these effects. Such particles occur in fumes generated by heating and combustion processes and are also normal constituents of the ambient aerosol, specifically in urban areas generated from numerous sources (e.g., internal combustion engines, power plants, incinerators). In addition, a new source of exposure to particles below 100 nm in size - engineered nanoparticles - has become a cause for concern, giving rise to the emerging field of nanotoxicology (see below).

Our studies with laboratory-generated ultrafine particles have shown that these particles have a significantly greater potency to induce inflammatory lung injury than larger-sized particles with the same chemical composition. Our studies are aimed at investigating cellular and molecular mechanisms of ultrafine particle-induced lung injury as well as secondary effects on the cardiovascular and the central nervous systems. An important component of this research is to develop rodent models with a compromised target organ system to evaluate cellular mechanisms of effects following inhalation exposure. Evaluating translocation pathways of inhaled nano-sized particles after deposition in the respiratory tract to other organ systems is an important part of our studies.

A more recent area of activity involves nanotoxicology, investigating the unique biokinetics and the toxicological potential of engineered nanoparticles. We investigate the propensity of these particles of different shapes (e.g., spheres, tubes, rods), different chemistries (e.g., metals, semiconductors, carbon) and different surface characteristics (coating, charge, porosity) to translocate from the site of deposition in the respiratory tract to extrapulmonary organs such as heart, liver, bone marrow and brain is being studied. Examination of the influence of physicochemical properties of nanoparticles on their effects and biokinetics is the ultimate objective of these studies. We engage in multidisciplinary team efforts to determine effects and underlying mechanisms of translocated nanoparticles (e.g., cellular oxidative stress).

 
 Selected Publications
List All   |   Timeline
  1. Allen JL, Liu X, Weston D, Conrad K, Oberdörster G, Cory-Slechta DA. Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice. Neurotoxicology. 2014 Mar; 41:80-8.
    View in: PubMed
  2. Allen JL, Conrad K, Oberdörster G, Johnston CJ, Sleezer B, Cory-Slechta DA. Developmental exposure to concentrated ambient particles and preference for immediate reward in mice. Environ Health Perspect. 2013 Jan; 121(1):32-8.
    View in: PubMed
  3. Oberdörster G. Nanotoxicology: in vitro-in vivo dosimetry. Environ Health Perspect. 2012 Jan; 120(1):A13; author reply A13.
    View in: PubMed
  4. Han X, Gelein R, Corson N, Wade-Mercer P, Jiang J, Biswas P, Finkelstein JN, Elder A, Oberdörster G. Validation of an LDH assay for assessing nanoparticle toxicity. Toxicology. 2011 Sep 5; 287(1-3):99-104.
    View in: PubMed
  5. Oberdörster G. Safety assessment for nanotechnology and nanomedicine: concepts of nanotoxicology. J Intern Med. 2010 Jan; 267(1):89-105.
    View in: PubMed
  6. Rushton EK, Jiang J, Leonard SS, Eberly S, Castranova V, Biswas P, Elder A, Han X, Gelein R, Finkelstein J, Oberdörster G. Concept of assessing nanoparticle hazards considering nanoparticle dosemetric and chemical/biological response metrics. J Toxicol Environ Health A. 2010; 73(5):445-61.
    View in: PubMed
  7. Oberdörster G, Elder A, Rinderknecht A. Nanoparticles and the brain: cause for concern?. J Nanosci Nanotechnol. 2009 Aug; 9(8):4996-5007.
    View in: PubMed
  8. Zareba W, Couderc JP, Oberdörster G, Chalupa D, Cox C, Huang LS, Peters A, Utell MJ, Frampton MW. ECG parameters and exposure to carbon ultrafine particles in young healthy subjects. Inhal Toxicol. 2009 Feb; 21(3):223-33.
    View in: PubMed
  9. Ehrenberg MS, Friedman AE, Finkelstein JN, Oberdörster G, McGrath JL. The influence of protein adsorption on nanoparticle association with cultured endothelial cells. Biomaterials. 2009 Feb; 30(4):603-10.
    View in: PubMed
  10. Mortensen LJ, Oberdörster G, Pentland AP, Delouise LA. In vivo skin penetration of quantum dot nanoparticles in the murine model: the effect of UVR. Nano Lett. 2008 Sep; 8(9):2779-87.
    View in: PubMed
  11. Donaldson K, Borm PJ, Oberdorster G, Pinkerton KE, Stone V, Tran CL. Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: the key role of the proximal alveolar region. Inhal Toxicol. 2008 Jan; 20(1):53-62.
    View in: PubMed
  12. Elder A, Couderc JP, Gelein R, Eberly S, Cox C, Xia X, Zareba W, Hopke P, Watts W, Kittelson D, Frampton M, Utell M, Oberdörster G. Effects of on-road highway aerosol exposures on autonomic responses in aged, spontaneously hypertensive rats. Inhal Toxicol. 2007 Jan; 19(1):1-12.
    View in: PubMed
  13. Elder A, Gelein R, Silva V, Feikert T, Opanashuk L, Carter J, Potter R, Maynard A, Ito Y, Finkelstein J, Oberdörster G. Translocation of inhaled ultrafine manganese oxide particles to the central nervous system. Environ Health Perspect. 2006 Aug; 114(8):1172-8.
    View in: PubMed
  14. Elder A, Oberdörster G. Translocation and effects of ultrafine particles outside of the lung. Clin Occup Environ Med. 2006; 5(4):785-96.
    View in: PubMed
  15. Frampton MW, Stewart JC, Oberdörster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang LS, Utell MJ. Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environ Health Perspect. 2006 Jan; 114(1):51-8.
    View in: PubMed
  16. Oberdörster G, Maynard A, Donaldson K, Castranova V, Fitzpatrick J, Ausman K, Carter J, Karn B, Kreyling W, Lai D, Olin S, Monteiro-Riviere N, Warheit D, Yang H. Principles for characterizing the potential human health effects from exposure to nanomaterials: elements of a screening strategy. Part Fibre Toxicol. 2005 Oct 6; 2:8.
    View in: PubMed
  17. Elder A, Gelein R, Finkelstein JN, Driscoll KE, Harkema J, Oberdörster G. Effects of subchronically inhaled carbon black in three species. I. Retention kinetics, lung inflammation, and histopathology. Toxicol Sci. 2005 Dec; 88(2):614-29.
    View in: PubMed
  18. Oberdörster G, Oberdörster E, Oberdörster J. Nanotoxicology: an emerging discipline evolving from studies of ultrafine particles. Environ Health Perspect. 2005 Jul; 113(7):823-39.
    View in: PubMed
  19. Elder A, Johnston C, Gelein R, Finkelstein J, Wang Z, Notter R, Oberdörster G. Lung inflammation induced by endotoxin is enhanced in rats depleted of alveolar macrophages with aerosolized clodronate. Exp Lung Res. 2005 Jul-Aug; 31(6):527-46.
    View in: PubMed
  20. Silva VM, Corson N, Elder A, Oberdörster G. The rat ear vein model for investigating in vivo thrombogenicity of ultrafine particles (UFP). Toxicol Sci. 2005 Jun; 85(2):983-9.
    View in: PubMed
  21. Beckett WS, Chalupa DF, Pauly-Brown A, Speers DM, Stewart JC, Frampton MW, Utell MJ, Huang LS, Cox C, Zareba W, Oberdörster G. Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: a human inhalation study. Am J Respir Crit Care Med. 2005 May 15; 171(10):1129-35.
    View in: PubMed
  22. Frampton MW, Utell MJ, Zareba W, Oberdörster G, Cox C, Huang LS, Morrow PE, Lee FE, Chalupa D, Frasier LM, Speers DM, Stewart J. Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma. Res Rep Health Eff Inst. 2004 Dec; (126):1-47; discussion 49-63.
    View in: PubMed
  23. Chalupa DC, Morrow PE, Oberdörster G, Utell MJ, Frampton MW. Ultrafine particle deposition in subjects with asthma. Environ Health Perspect. 2004 Jun; 112(8):879-82.
    View in: PubMed
  24. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Kreyling W, Cox C. Translocation of inhaled ultrafine particles to the brain. Inhal Toxicol. 2004 Jun; 16(6-7):437-45.
    View in: PubMed
  25. Semmler M, Seitz J, Erbe F, Mayer P, Heyder J, Oberdörster G, Kreyling WG. Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs. Inhal Toxicol. 2004 Jun; 16(6-7):453-9.
    View in: PubMed
  26. Elder AC, Gelein R, Azadniv M, Frampton M, Finkelstein J, Oberdörster G. Systemic effects of inhaled ultrafine particles in two compromised, aged rat strains. Inhal Toxicol. 2004 Jun; 16(6-7):461-71.
    View in: PubMed
  27. Elder AC, Gelein R, Oberdörster G, Finkelstein J, Notter R, Wang Z. Efficient depletion of alveolar macrophages using intratracheally inhaled aerosols of liposome-encapsulated clodronate. Exp Lung Res. 2004 Mar; 30(2):105-20.
    View in: PubMed
  28. Kittelson DB, Watts WF, Johnson JP, Remerowki ML, Ische EE, Oberdörster G, Gelein RM, Elder A, Hopke PK, Kim E, Zhao W, Zhou L, Jeong CH. On-road exposure to highway aerosols. 1. Aerosol and gas measurements. Inhal Toxicol. 2004; 16 Suppl 1:31-9.
    View in: PubMed
  29. Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhal Toxicol. 2004; 16 Suppl 1:41-53.
    View in: PubMed
  30. Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdörster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang LS, Utell MJ. Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhal Toxicol. 2004; 16 Suppl 1:59-72.
    View in: PubMed
  31. Daniel Maxim L, Yu CP, Oberdörster G, Utell MJ. Quantitative risk analyses for RCF: survey and synthesis. Regul Toxicol Pharmacol. 2003 Dec; 38(3):400-16.
    View in: PubMed
  32. Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdörster G, Utell MJ, Frampton MW. Ultrafine particle deposition in humans during rest and exercise. Inhal Toxicol. 2003 May; 15(6):539-52.
    View in: PubMed
  33. Pryhuber GS, Huyck HL, Baggs R, Oberdörster G, Finkelstein JN. Induction of chemokines by low-dose intratracheal silica is reduced in TNFR I (p55) null mice. Toxicol Sci. 2003 Mar; 72(1):150-7.
    View in: PubMed
  34. Avakian MD, Dellinger B, Fiedler H, Gullet B, Koshland C, Marklund S, Oberdörster G, Safe S, Sarofim A, Smith KR, Schwartz D, Suk WA. The origin, fate, and health effects of combustion by-products: a research framework. Environ Health Perspect. 2002 Nov; 110(11):1155-62.
    View in: PubMed
  35. Oberdörster G, Sharp Z, Atudorei V, Elder A, Gelein R, Lunts A, Kreyling W, Cox C. Extrapulmonary translocation of ultrafine carbon particles following whole-body inhalation exposure of rats. J Toxicol Environ Health A. 2002 Oct 25; 65(20):1531-43.
    View in: PubMed
  36. Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. Endotoxin potentiates ozone-induced pulmonary chemokine and inflammatory responses. Exp Lung Res. 2002 Sep; 28(6):419-33.
    View in: PubMed
  37. Oberdörster G, Utell MJ. Ultrafine particles in the urban air: to the respiratory tract--and beyond? Environ Health Perspect. 2002 Aug; 110(8):A440-1.
    View in: PubMed
  38. Oberdörster G. Toxicokinetics and effects of fibrous and nonfibrous particles. Inhal Toxicol. 2002 Jan; 14(1):29-56.
    View in: PubMed
  39. Greim H, Borm P, Schins R, Donaldson K, Driscoll K, Hartwig A, Kuempel E, Oberdörster G, Speit G. Toxicity of fibers and particles. Report of the workshop held in Munich, Germany, 26-27 October 2000. Inhal Toxicol. 2001 Sep; 13(9):737-54.
    View in: PubMed
  40. Johnston CJ, Oberdörster G, Finkelstein JN. Recovery from oxidant-mediated lung injury: response of metallothionein, MIP-2, and MCP-1 to nitrogen dioxide, oxygen, and ozone exposures. Inhal Toxicol. 2001 Aug; 13(8):689-702.
    View in: PubMed
  41. Oberdörster G. Pulmonary effects of inhaled ultrafine particles. Int Arch Occup Environ Health. 2001 Jan; 74(1):1-8.
    View in: PubMed
  42. Mast RW, Yu CP, Oberdörster G, McConnell EE, Utell MJ. A retrospective review of the carcinogenicity of refractory ceramic fiber in two chronic fischer 344 rat inhalation studies: an assessment of the MTD and implications for risk assessment. Inhal Toxicol. 2000 Dec; 12(12):1141-72.
    View in: PubMed
  43. Johnston CJ, Finkelstein JN, Mercer P, Corson N, Gelein R, Oberdörster G. Pulmonary effects induced by ultrafine PTFE particles. Toxicol Appl Pharmacol. 2000 Nov 1; 168(3):208-15.
    View in: PubMed
  44. Johnston CJ, Driscoll KE, Finkelstein JN, Baggs R, O'Reilly MA, Carter J, Gelein R, Oberdörster G. Pulmonary chemokine and mutagenic responses in rats after subchronic inhalation of amorphous and crystalline silica. Toxicol Sci. 2000 Aug; 56(2):405-13.
    View in: PubMed
  45. Oberdörster G, Finkelstein JN, Johnston C, Gelein R, Cox C, Baggs R, Elder AC. Acute pulmonary effects of ultrafine particles in rats and mice. Res Rep Health Eff Inst. 2000 Aug; (96):5-74; disc. 75-86.
    View in: PubMed
  46. Oberdörster G. Determinants of the pathogenicity of man-made vitreous fibers (MMVF). Int Arch Occup Environ Health. 2000 Jun; 73 Suppl:S60-8.
    View in: PubMed
  47. Driscoll KE, Costa DL, Hatch G, Henderson R, Oberdorster G, Salem H, Schlesinger RB. Intratracheal instillation as an exposure technique for the evaluation of respiratory tract toxicity: uses and limitations. Toxicol Sci. 2000 May; 55(1):24-35.
    View in: PubMed
  48. Johnston CJ, Oberdörster G, Gelein R, Finkelstein JN. Newborn mice differ from adult mice in chemokine and cytokine expression to ozone, but not to endotoxin. Inhal Toxicol. 2000 Mar; 12(3):205-24.
    View in: PubMed
  49. Elder AC, Finkelstein J, Johnston C, Gelein R, Oberdörster G. Induction of adaptation to inhaled lipopolysaccharide in young and old rats and mice. Inhal Toxicol. 2000 Mar; 12(3):225-43.
    View in: PubMed
  50. Elder AC, Gelein R, Finkelstein JN, Cox C, Oberdörster G. Pulmonary inflammatory response to inhaled ultrafine particles is modified by age, ozone exposure, and bacterial toxin. Inhal Toxicol. 2000; 12 Suppl 4:227-46.
    View in: PubMed
  51. Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. Silica binds serum proteins resulting in a shift of the dose-response for silica-induced chemokine expression in an alveolar type II cell line. Toxicol Appl Pharmacol. 1999 Dec 1; 161(2):111-22.
    View in: PubMed
  52. Hesterberg TW, Axten C, McConnell EE, Hart GA, Miiller W, Chevalier J, Everitt J, Thevenaz P, Oberdörster G. Studies on the inhalation toxicology of two fiberglasses and amosite asbestos in the syrian golden hamster. Part I. Results of a subchronic study and dose selection for a chronic study. Inhal Toxicol. 1999 Sep; 11(9):747-84.
    View in: PubMed
  53. McConnell EE, Axten C, Hesterberg TW, Chevalier J, Miiller WC, Everitt J, Oberdörster G, Chase GR, Thevenaz P, Kotin P. Studies on the inhalation toxicology of two fiberglasses and amosite asbestos in the Syrian golden hamster. Part II. Results of chronic exposure. Inhal Toxicol. 1999 Sep; 11(9):785-835.
    View in: PubMed
  54. Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. Antioxidant treatment attenuates cytokine and chemokine levels in murine macrophages following silica exposure. Toxicol Appl Pharmacol. 1999 Aug 1; 158(3):211-20.
    View in: PubMed
  55. Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha-induced oxidant stress. Am J Physiol. 1999 Jun; 276(6 Pt 1):L979-88.
    View in: PubMed
  56. Hsieh TH, Yu CP, Oberdörster G. A dosimetry model of nickel compounds in the rat lung. Inhal Toxicol. 1999 Mar; 11(3):229-48.
    View in: PubMed
  57. Johnston CJ, Finkelstein JN, Oberdörster G, Reynolds SD, Stripp BR. Clara cell secretory protein-deficient mice differ from wild-type mice in inflammatory chemokine expression to oxygen and ozone, but not to endotoxin. Exp Lung Res. 1999 Jan-Feb; 25(1):7-21.
    View in: PubMed
  58. Oberdörster G, Yu CP. Lung dosimetry--considerations for noninhalation studies. Exp Lung Res. 1999 Jan-Feb; 25(1):1-6.
    View in: PubMed
  59. Barrett EG, Johnston C, Oberdörster G, Finkelstein JN. Silica-induced chemokine expression in alveolar type II cells is mediated by TNF-alpha. Am J Physiol. 1998 Dec; 275(6 Pt 1):L1110-9.
    View in: PubMed
  60. Johnston CJ, Finkelstein JN, Gelein R, Oberdörster G. Pulmonary cytokine and chemokine mRNA levels after inhalation of lipopolysaccharide in C57BL/6 mice. Toxicol Sci. 1998 Dec; 46(2):300-7.
    View in: PubMed
  61. Osier M, Oberdörster G. Intratracheal inhalation vs intratracheal instillation: differences in particle effects. Fundam Appl Toxicol. 1997 Dec; 40(2):220-7.
    View in: PubMed
  62. Baggs RB, Ferin J, Oberdörster G. Regression of pulmonary lesions produced by inhaled titanium dioxide in rats. Vet Pathol. 1997 Nov; 34(6):592-7.
    View in: PubMed
  63. Finkelstein JN, Johnston C, Barrett T, Oberdörster G. Particulate-cell interactions and pulmonary cytokine expression. Environ Health Perspect. 1997 Sep; 105 Suppl 5:1179-82.
    View in: PubMed
  64. Osier M, Baggs RB, Oberdörster G. Intratracheal instillation versus intratracheal inhalation: influence of cytokines on inflammatory response. Environ Health Perspect. 1997 Sep; 105 Suppl 5:1265-71.
    View in: PubMed
  65. Oberdörster G. Pulmonary carcinogenicity of inhaled particles and the maximum tolerated dose. Environ Health Perspect. 1997 Sep; 105 Suppl 5:1347-55.
    View in: PubMed
  66. Yu CP, Ding YJ, Zhang L, Oberdörster G, Mast RW, Maxim LD, Utell MJ. Retention modeling of refractory ceramic fibers (RCF) in humans. Regul Toxicol Pharmacol. 1997 Feb; 25(1):18-25.
    View in: PubMed
  67. Oberdörster G, Cox C, Gelein R. Intratracheal instillation versus intratracheal-inhalation of tracer particles for measuring lung clearance function. Exp Lung Res. 1997 Jan-Feb; 23(1):17-34.
    View in: PubMed
  68. Johnston CJ, Finkelstein JN, Gelein R, Baggs R, Oberdörster G. Characterization of the early pulmonary inflammatory response associated with PTFE fume exposure. Toxicol Appl Pharmacol. 1996 Sep; 140(1):154-63.
    View in: PubMed
  69. Hesterberg TW, McConnel EE, Miiller WC, Chevalier J, Everitt J, Thevenaz P, Fleissner H, Oberdörster G. Use of lung toxicity and lung particle clearance to estimate the maximum tolerated dose (MTD) for a fiber glass chronic inhalation study in the rat. Fundam Appl Toxicol. 1996 Jul; 32(1):31-44.
    View in: PubMed
  70. Kenaga C, Cherian MG, Cox C, Oberdörster G. Metallothionein induction and pulmonary responses to inhaled cadmium chloride in rats and mice. Fundam Appl Toxicol. 1996 Apr; 30(2):204-12.
    View in: PubMed
  71. Oberdörster G, Finkelstein J, Ferin J, Godleski J, Chang LY, Gelein R, Johnston C, Crapo JD. Ultrafine particles as a potential environmental health hazard. Studies with model particles. Chest. 1996 Mar; 109(3 Suppl):68S-69S.
    View in: PubMed
  72. Morrow PE, Haseman JK, Hobbs CH, Driscoll KE, Vu V, Oberdörster G. The maximum tolerated dose for inhalation bioassays: toxicity vs overload. Fundam Appl Toxicol. 1996 Feb; 29(2):155-67.
    View in: PubMed
  73. Driscoll KE, Carter JM, Howard BW, Hassenbein DG, Pepelko W, Baggs RB, Oberdörster G. Pulmonary inflammatory, chemokine, and mutagenic responses in rats after subchronic inhalation of carbon black. Toxicol Appl Pharmacol. 1996 Feb; 136(2):372-80.
    View in: PubMed
  74. Oberdörster G. Evaluation and use of animal models to assess mechanisms of fibre carcinogenicity. IARC Sci Publ. 1996; (140):107-25.
    View in: PubMed
  75. Oberdorster G. Significance of particle parameters in the evaluation of exposure-dose-response relationships of inhaled particles. Inhal Toxicol. 1996; 8 Suppl:73-89.
    View in: PubMed
  76. Warheit DB, Driscoll KE, Oberdoerster G, Walker C, Kuschner M, Hesterberg TW. Contemporary issues in fiber toxicology. Fundam Appl Toxicol. 1995 May; 25(2):171-83.
    View in: PubMed
  77. Oberdörster G. The NTP talc inhalation study: a critical appraisal focused on lung particle overload. Regul Toxicol Pharmacol. 1995 Apr; 21(2):233-41.
    View in: PubMed
  78. Oberdörster G. Lung particle overload: implications for occupational exposures to particles. Regul Toxicol Pharmacol. 1995 Feb; 21(1):123-35.
    View in: PubMed
  79. Oberdorster G, Gelein RM, Ferin J, Weiss B. Association of particulate air pollution and acute mortality: involvement of ultrafine particles? Inhal Toxicol. 1995 Jan-Feb; 7(1):111-24.
    View in: PubMed
  80. Gavett SH, Oberdörster G. Cadmium chloride and cadmium metallothionein-induced pulmonary injury and recruitment of polymorphonuclear leukocytes. Exp Lung Res. 1994 Nov-Dec; 20(6):517-37.
    View in: PubMed
  81. Oberdörster G, Ferin J, Lehnert BE. Correlation between particle size, in vivo particle persistence, and lung injury. Environ Health Perspect. 1994 Oct; 102 Suppl 5:173-9.
    View in: PubMed
  82. Oberdörster G, Cherian MG, Baggs RB. Correlation between cadmium-induced pulmonary carcinogenicity, metallothionein expression, and inflammatory processes: a species comparison. Environ Health Perspect. 1994 Sep; 102 Suppl 3:257-63.
    View in: PubMed
  83. Todd P, Sklar V, Ramirez WF, Smith GJ, Morgenthaler GW, McKinnon JT, Oberdorster G, Schulz J. Inhalation risk in low-gravity spacecraft. Acta Astronaut. 1994 Jul; 33:305-15.
    View in: PubMed
  84. Oberdörster G, Cherian MG, Baggs RB. Importance of species differences in experimental pulmonary carcinogenicity of inhaled cadmium for extrapolation to humans. Toxicol Lett. 1994 Jun; 72(1-3):339-43.
    View in: PubMed
  85. Yu CP, Zhang L, Oberdörster G, Mast RW, Glass LR, Utell MJ. Clearance of refractory ceramic fibers (RCF) from the rat lung: development of a model. Environ Res. 1994 May; 65(2):243-53.
    View in: PubMed
  86. Janssen YM, Marsh JP, Driscoll KE, Borm PJ, Oberdörster G, Mossman BT. Increased expression of manganese-containing superoxide dismutase in rat lungs after inhalation of inflammatory and fibrogenic minerals. Free Radic Biol Med. 1994 Mar; 16(3):315-22.
    View in: PubMed
  87. Oberdörster G, White R, Rabin R, Clarkson T, Irons R, Gardner D, Taylor GR, Sonnenfeld G, Thomas R. Space exploration and toxicology: a new frontier. Fundam Appl Toxicol. 1994 Feb; 22(2):161-71.
    View in: PubMed
  88. Kreyling WG, Cox C, Ferron GA, Oberdörster G. Lung clearance in Long-Evans rats after inhalation of porous, monodisperse cobalt oxide particles. Exp Lung Res. 1993 Jul-Aug; 19(4):445-67.
    View in: PubMed
  89. Oberdörster G, Ferin J, Gelein R, Soderholm SC, Finkelstein J. Role of the alveolar macrophage in lung injury: studies with ultrafine particles. Environ Health Perspect. 1992 Jul; 97:193-9.
    View in: PubMed
  90. Ferin J, Oberdörster G, Penney DP. Pulmonary retention of ultrafine and fine particles in rats. Am J Respir Cell Mol Biol. 1992 May; 6(5):535-42.
    View in: PubMed
  91. Oberdörster G, Ferin J, Morrow PE. Volumetric loading of alveolar macrophages (AM): a possible basis for diminished AM-mediated particle clearance. Exp Lung Res. 1992 Jan-Mar; 18(1):87-104.
    View in: PubMed
  92. Ferin J, Oberdörster G. Polymer degradation and ultrafine particles: potential inhalation hazards for astronauts. Acta Astronaut. 1992; 27:257-9.
    View in: PubMed
  93. Oberdörster G. Pulmonary deposition, clearance and effects of inhaled soluble and insoluble cadmium compounds. IARC Sci Publ. 1992; (118):189-204.
    View in: PubMed
  94. Oberdörster G, Ferin J, Finkelstein J, Soderholm S. Thermal degradation events as health hazards: particle vs gas phase effects, mechanistic studies with particles. Acta Astronaut. 1992; 27:251-6.
    View in: PubMed
  95. McBride RK, Oberdoerster G, Marin MG. Effects of ozone on the cholinergic secretory responsiveness of ferret tracheal glands. Environ Res. 1991 Jun; 55(1):79-90.
    View in: PubMed
  96. Bräunlich A, Enderlein G, Heuchert G, Oberdoerster G, Stark H, Wulke P. [Documentation based on main intervention measures for prevention of chronic diseases in women employed in agriculture]. Z Arztl Fortbild (Jena). 1990; 84(23):1223-5.
    View in: PubMed
  97. Heuchert G, Bräunlich A, Enderlein G, Kreibich H, Oberdoerster G, Stark H, Wulke P. [The search for interventional priorities for the prevention of chronic diseases in females employed in the health service]. Z Gesamte Hyg. 1989 Dec; 35(12):693-6.
    View in: PubMed
  98. Wieczorek H, Oberdörster G. Kinetics of inhaled 54MnCl2 aerosols: influence of inhaled concentration. Pol J Occup Med. 1989; 2(3):248-60.
    View in: PubMed
  99. Oberdörster G. Dosimetric principles for extrapolating results of rat inhalation studies to humans, using an inhaled Ni compound as an example. Health Phys. 1989; 57 Suppl 1:213-20.
    View in: PubMed
  100. Wieczorek H, Oberdörster G. Effects of selected chelating agents on organ distribution and excretion of manganese after inhalation exposure to 54MnCl2. I. Injection of chelating agents. Pol J Occup Med. 1989; 2(3):261-7.
    View in: PubMed
  101. Heuchert G, Schneider D, Oberdoerster G, Bräunlich A, Wulke P. [Utilization of health status indicators in relation to occupational health qualifications and surveillance studies]. Z Arztl Fortbild (Jena). 1988; 82(19):956-7.
    View in: PubMed
  102. Oberdoerster G. [Prevalence of selected chronic diseases in employees--results of preventive occupational medicine screening]. Z Gesamte Hyg. 1987 Nov; 33(11):567-9.
    View in: PubMed
  103. Newland MC, Cox C, Hamada R, Oberdörster G, Weiss B. The clearance of manganese chloride in the primate. Fundam Appl Toxicol. 1987 Aug; 9(2):314-28.
    View in: PubMed
  104. Cugier B, Stach H, Oberdoerster G. [Effectiveness of early presentation to the Medical Consultation Commission in the city of Dresden]. Z Gesamte Hyg. 1987 Aug; 33(8):381-7.
    View in: PubMed
  105. Enderlein G, Heuchert G, Kreibich H, Oberdoerster G, Ruppe K, Wulke P. [Occupational medicine fitness and control studies 1983-1985--review and results of computer-aided assessment]. Z Gesamte Hyg. 1987 May; 33(5):230-6.
    View in: PubMed
  106. Waldman DL, Weber DA, Oberdörster G, Drago SR, Utell MJ, Hyde RW, Morrow PE. Chemical breakdown of technetium-99m DTPA during nebulization. J Nucl Med. 1987 Mar; 28(3):378-82.
    View in: PubMed
  107. Peters JM, Thomas D, Falk H, Oberdörster G, Smith TJ. Contribution of metals to respiratory cancer. Environ Health Perspect. 1986 Dec; 70:71-83.
    View in: PubMed
  108. Oberdörster G, Utell MJ, Morrow PE, Hyde RW, Weber DA. Bronchial and alveolar absorption of inhaled 99mTc-DTPA. Am Rev Respir Dis. 1986 Nov; 134(5):944-50.
    View in: PubMed
  109. Oberdörster G, Utell MJ, Weber DA, Ivanovich M, Hyde RW, Morrow PE. Lung clearance of inhaled 99mTc-DTPA in the dog. J Appl Physiol. 1984 Aug; 57(2):589-95.
    View in: PubMed
  110. Oberdoerster F, Giersdorf P, Thom A. [Traditional care in specialty societies of the Society for Total Public Health of East Germany]. Z Gesamte Hyg. 1984 Jun; 30(6):362-3.
    View in: PubMed
  111. Oberdoerster G, Ferin J, Marcello NL, Meinhold SH. Effect of intrabronchially instilled amosite on lavagable lung and pleural cells. Environ Health Perspect. 1983 Sep; 51:41-7.
    View in: PubMed
  112. Marks LB, Notter RH, Oberdorster G, McBride JT. Ultrasonic and jet aerosolization of phospholipids and the effects on surface activity. Pediatr Res. 1983 Sep; 17(9):742-7.
    View in: PubMed
  113. Takenaka S, Oldiges H, König H, Hochrainer D, Oberdörster G. Carcinogenicity of cadmium chloride aerosols in W rats. J Natl Cancer Inst. 1983 Feb; 70(2):367-73.
    View in: PubMed
  114. Lehnert BE, Oberdörster G, Slutsky AS. Constant-flow ventilation of apneic dogs. J Appl Physiol. 1982 Aug; 53(2):483-9.
    View in: PubMed
  115. Oberdoerster G, Baumert HP, Hochrainer D, Stoeber W. The clearance of cadmium aerosols after inhalation exposure. Am Ind Hyg Assoc J. 1979 Jun; 40(6):443-50.
    View in: PubMed
  116. Oberdörster G, Gibb FR, Beiter H, Lu ST, Morrow PE. Studies of the lymphatic drainage of dog lungs. J Toxicol Environ Health. 1978 Jul; 4(4):571-86.
    View in: PubMed
  117. Oberdörster G, Prigge E, Hochrainer D. [Sensitivity to acetylcholine of the broncho-alveolar system of the rat after chronic exposure to a sulfate aerosol in association with SO2]. Bronchopneumologie. 1977 Jul-Aug; 27(4):276-81.
    View in: PubMed
  118. Hirsch H, Oberdörster G, Zimmer R, Benner KU, Lang R. The recovery of the electrocorticogram of normothermic canine brains after complete cerebral ischemia. Arch Psychiatr Nervenkr. 1975 Dec 31; 221(2):171-9.
    View in: PubMed
  119. Oberdörster G, Lang R, Zimmer R. Influence of adenosine and lowered cerebral blood flow on the cerebrovascular effects of theophylline. Eur J Pharmacol. 1975 Feb; 30(2):197-204.
    View in: PubMed
  120. Zimmer R, Lang R, Oberdörster G. Effects of catecholamine infusions on cerebral blood flow and oxygen consumption of the isolated perfused dog brain. Stroke. 1974 May-Jun; 5(3):397-405.
    View in: PubMed
  121. Lang R, Zimmer R, Oberdörster G. Impairment of cerebrovascular autoregulation by theophylline. Exp Neurol. 1973 Sep; 40(3):661-74.
    View in: PubMed
  122. Becker KH, Boltze KH, Lorenz D, Oberdörster G. [Phenylbutylamino derivatives with a stimulating effect on the adrenergic beta-receptors and their action on the coronary circulation of dogs]. Arzneimittelforschung. 1966 Jul; 16(7):833-5.
    View in: PubMed

Visualizations


Oberdoerster's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department