Jacqueline Abranches
| Title | Research Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Microbiology and Immunology in the Center for Oral Biology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester NY 14642
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| 1990 |
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| 1990-1993 Undergraduate Research Fellowship Program, National Council of Research | (CNPq - Brazil) | | 1993 |
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| 1995 | Master's Program Fellowship, Assistance Council for Post-Graduate Studies | (CAPES- Brazil). | | 1995 |
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| 2000 | Doctoral Program fellowship, Assistance Council for Post-Graduate Studies | (CAPES- Brazil). | | 1999 |
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| Teacher of the year | Federal University of Rio de Janeiro, Brazil. |
Dissemination of oral bacteria into the bloodstream has been associated with eating, oral hygiene and dental procedures; including tooth extraction, endodontic treatment, and periodontal surgery. Recently, studies identified Streptococcus mutans, the primary etiological agent of dental caries, as the most prevalent bacterial species found in clinical samples from patients who underwent heart valve and atheromatous plaque surgery. My research focuses on dissecting, at the molecular level, the interactions between S. mutans and Human Coronary Endothelial Cells.
Another field of interest is to understand the stress tolerance mechanisms employed by S. mutans to cope with the constant changes in pH, and nutrient composition and availability in the oral cavity.
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Gaca AO, Abranches J, Kajfasz JK, Lemos JA. Global transcriptional analysis of the stringent response in Enterococcus faecalis. Microbiology. 2012 Aug; 158(Pt 8):1994-2004.
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Kajfasz JK, Mendoza JE, Gaca AO, Miller JH, Koselny KA, Giambiagi-Demarval M, Wellington M, Abranches J, Lemos JA. The Spx Regulator Modulates Stress Responses and Virulence in Enterococcus faecalis. Infect Immun. 2012 Jul; 80(7):2265-75.
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Bitoun JP, Liao S, Yao X, Ahn SJ, Isoda R, Nguyen AH, Brady LJ, Burne RA, Abranches J, Wen ZT. BrpA Is Involved in Regulation of Cell Envelope Stress Responses in Streptococcus mutans. Appl Environ Microbiol. 2012 Apr; 78(8):2914-22.
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Kajfasz JK, Abranches J, Lemos JA. Transcriptome analysis reveals that ClpXP proteolysis controls key virulence properties of Streptococcus mutans. Microbiology. 2011 Oct; 157(Pt 10):2880-90.
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Abranches J, Miller JH, Martinez AR, Simpson-Haidaris PJ, Burne RA, Lemos JA. The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells. Infect Immun. 2011 Jun; 79(6):2277-84.
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de Oliveira NE, Abranches J, Gaca AO, Laport MS, Damaso CR, Bastos Mdo C, Lemos JA, Giambiagi-deMarval M. clpB, a class III heat-shock gene regulated by CtsR, is involved in thermotolerance and virulence of Enterococcus faecalis. Microbiology. 2011 Mar; 157(Pt 3):656-65.
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Wen ZT, Nguyen AH, Bitoun JP, Abranches J, Baker HV, Burne RA. Transcriptome analysis of LuxS-deficient Streptococcus mutans grown in biofilms. Mol Oral Microbiol. 2011 Feb; 26(1):2-18.
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Martinez AR, Abranches J, Kajfasz JK, Lemos JA. Characterization of the Streptococcus sobrinus acid-stress response by interspecies microarrays and proteomics. Mol Oral Microbiol. 2010 Oct; 25(5):331-42.
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Kajfasz JK, Rivera-Ramos I, Abranches J, Martinez AR, Rosalen PL, Derr AM, Quivey RG, Lemos JA. Two Spx proteins modulate stress tolerance, survival, and virulence in Streptococcus mutans. J Bacteriol. 2010 May; 192(10):2546-56.
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Lemos JA, Abranches J, Koo H, Marquis RE, Burne RA. Protocols to study the physiology of oral biofilms. Methods Mol Biol. 2010; 666:87-102.
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Senadheera D, Krastel K, Mair R, Persadmehr A, Abranches J, Burne RA, Cvitkovitch DG. Inactivation of VicK affects acid production and acid survival of Streptococcus mutans. J Bacteriol. 2009 Oct; 191(20):6415-24.
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Burne RA, Ahn SJ, Wen ZT, Zeng L, Lemos JA, Abranches J, Nascimento M. Opportunities for disrupting cariogenic biofilms. Adv Dent Res. 2009; 21(1):17-20.
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Abranches J, Zeng L, Bélanger M, Rodrigues PH, Simpson-Haidaris PJ, Akin D, Dunn WA, Progulske-Fox A, Burne RA. Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175. Oral Microbiol Immunol. 2009 Apr; 24(2):141-5.
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Kajfasz JK, Martinez AR, Rivera-Ramos I, Abranches J, Koo H, Quivey RG, Lemos JA. Role of Clp proteins in expression of virulence properties of Streptococcus mutans. J Bacteriol. 2009 Apr; 191(7):2060-8.
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Abranches J, Martinez AR, Kajfasz JK, Chávez V, Garsin DA, Lemos JA. The molecular alarmone (p)ppGpp mediates stress responses, vancomycin tolerance, and virulence in Enterococcus faecalis. J Bacteriol. 2009 Apr; 191(7):2248-56.
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Lemos JA, Nascimento MM, Lin VK, Abranches J, Burne RA. Global regulation by (p)ppGpp and CodY in Streptococcus mutans. J Bacteriol. 2008 Aug; 190(15):5291-9.
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Abranches J, Nascimento MM, Zeng L, Browngardt CM, Wen ZT, Rivera MF, Burne RA. CcpA regulates central metabolism and virulence gene expression in Streptococcus mutans. J Bacteriol. 2008 Apr; 190(7):2340-9.
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Nascimento MM, Lemos JA, Abranches J, Lin VK, Burne RA. Role of RelA of Streptococcus mutans in global control of gene expression. J Bacteriol. 2008 Jan; 190(1):28-36.
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Lemos JA, Lin VK, Nascimento MM, Abranches J, Burne RA. Three gene products govern (p)ppGpp production by Streptococcus mutans. Mol Microbiol. 2007 Sep; 65(6):1568-81.
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Hasona A, Zuobi-Hasona K, Crowley PJ, Abranches J, Ruelf MA, Bleiweis AS, Brady LJ. Membrane composition changes and physiological adaptation by Streptococcus mutans signal recognition particle pathway mutants. J Bacteriol. 2007 Feb; 189(4):1219-30.
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Abranches J, Candella MM, Wen ZT, Baker HV, Burne RA. Different roles of EIIABMan and EIIGlc in regulation of energy metabolism, biofilm development, and competence in Streptococcus mutans. J Bacteriol. 2006 Jun; 188(11):3748-56.
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Koo H, Seils J, Abranches J, Burne RA, Bowen WH, Quivey RG. Influence of apigenin on gtf gene expression in Streptococcus mutans UA159. Antimicrob Agents Chemother. 2006 Feb; 50(2):542-6.
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Abranches J, Lemos JA, Burne RA. Osmotic stress responses of Streptococcus mutans UA159. FEMS Microbiol Lett. 2006 Feb; 255(2):240-6.
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Lemos JA, Brown TA, Abranches J, Burne RA. Characteristics of Streptococcus mutans strains lacking the MazEF and RelBE toxin-antitoxin modules. FEMS Microbiol Lett. 2005 Dec 15; 253(2):251-7.
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Lemos JA, Abranches J, Burne RA. Responses of cariogenic streptococci to environmental stresses. Curr Issues Mol Biol. 2005 Jan; 7(1):95-107.
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Abranches J, Chen YY, Burne RA. Galactose metabolism by Streptococcus mutans. Appl Environ Microbiol. 2004 Oct; 70(10):6047-52.
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Nascimento MM, Lemos JA, Abranches J, Gonçalves RB, Burne RA. Adaptive acid tolerance response of Streptococcus sobrinus. J Bacteriol. 2004 Oct; 186(19):6383-90.
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Abranches J, Chen YY, Burne RA. Characterization of Streptococcus mutans strains deficient in EIIAB Man of the sugar phosphotransferase system. Appl Environ Microbiol. 2003 Aug; 69(8):4760-9.
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Koo H, Pearson SK, Scott-Anne K, Abranches J, Cury JA, Rosalen PL, Park YK, Marquis RE, Bowen WH. Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. Oral Microbiol Immunol. 2002 Dec; 17(6):337-43.
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Phan TN, Nguyen PT, Abranches J, Marquis RE. Fluoride and organic weak acids as respiration inhibitors for oral streptococci in acidified environments. Oral Microbiol Immunol. 2002 Apr; 17(2):119-24.
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Nguyen PT, Abranches J, Phan TN, Marquis RE. Repressed respiration of oral streptococci grown in biofilms. Curr Microbiol. 2002 Apr; 44(4):262-6.
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Abranches J, Morais PB, Rosa CA, Mendonça-Hagler LC, Hagler AN. The incidence of killer activity and extracellular proteases in tropical yeast communities. Can J Microbiol. 1997 Apr; 43(4):328-36.
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