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W. Richard Burack

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPathology and Laboratory Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
Other Positions
TitleDirector, Hematopathology Unit
InstitutionSchool of Medicine and Dentistry
DepartmentPathology and Laboratory Medicine

TitleAssociate Professor
InstitutionUniversity of Rochester Medical Center
DepartmentCancer Center

 
 Awards And Honors
2004     Class of 2006 Distinguished Teacher Award  | Washington Univ School of Medicine
2005     Class of 2008 Lecturer of the Year  | Washington Univ School of Medicine
2006     Class of 2009 Professor of the Year  | Washington Univ School of Medicine
2007     Class of 2010 Professor of the Year  | Washington Univ School of Medicine
2010     Excellence in 2nd Year Teaching  | University of Rochester School of Medicine
 
 Overview
Dr. Burack's research interests are membrane phospholipase biology and the T cell immunologic synapse. He is currently studying molecular mechanisms of lymphoma progression in patients

 
 Selected Publications
List All   |   Timeline
  1. Friedberg JW, Mahadevan D, Cebula E, Persky D, Lossos I, Agarwal AB, Jung J, Burack R, Zhou X, Leonard EJ, Fingert H, Danaee H, Bernstein SH. Phase II Study of Alisertib, a Selective Aurora A Kinase Inhibitor, in Relapsed and Refractory Aggressive B- and T-Cell Non-Hodgkin Lymphomas. J Clin Oncol. 2014 Jan 1; 32(1):44-50.
    View in: PubMed
  2. Bernstein SH, Epner E, Unger JM, Leblanc M, Cebula E, Burack R, Rimsza L, Miller TP, Fisher RI. A phase II multicenter trial of hyperCVAD MTX/Ara-C and rituximab in patients with previously untreated mantle cell lymphoma; SWOG 0213. Ann Oncol. 2013 Jun; 24(6):1587-93.
    View in: PubMed
  3. Burack WR. Symposium on Myeloid Neoplasms on June 9, 2012 in honor of Dr. John M. Bennett. Leuk Res. 2012 Dec; 36(12):1440.
    View in: PubMed
  4. Rauh MJ, Rahman F, Good D, Silverman J, Brennan MK, Dimov N, Liesveld J, Ryan DH, Burack WR, Bennett JM. Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation, lacking cutaneous involvement: Case series and literature review. Leuk Res. 2012 Jan; 36(1):81-6.
    View in: PubMed
  5. Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, Brady MT, Wang JC, Sanz I, Burack WR, Quataert SA, Bernstein SH. Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation. Blood. 2011 Sep 29; 118(13):3591-602.
    View in: PubMed
  6. Spence JM, Rothberg PG, Wang N, Burack WR. Demonstration of array-based analysis for highly multiplexed PCR assays application to detection of IGH@-BCL2 translocations in FFPE follicular lymphoma specimens. J Mol Diagn. 2011 May; 13(3):252-62.
    View in: PubMed
  7. Yeung CC, Powers ML, Nguyen TD, Kreisel F, Frater JL, Zehnbauer BA, Burack R, Hassan A. Relevance of IgVH gene somatic hypermutation and interphase cytogenetics in lymphomatous presentation of chronic lymphocytic leukemia/small lymphocytic lymphoma. Int J Surg Pathol. 2011 Oct; 19(5):563-9.
    View in: PubMed
  8. Amador-Ortiz C, Chen L, Hassan A, Frater JL, Burack R, Nguyen TT, Kreisel F. Combined core needle biopsy and fine-needle aspiration with ancillary studies correlate highly with traditional techniques in the diagnosis of nodal-based lymphoma. Am J Clin Pathol. 2011 Apr; 135(4):516-24.
    View in: PubMed
  9. Ferrantino M, Eichelberger J, Burack HR, Li F, Lee FE. A 48-year-old woman with a large mediastinal mass. Chest. 2010 Nov; 138(5):1260-4.
    View in: PubMed
  10. Cooper AR, Burack WR, Allerton JP. A case of Kaposi sarcoma-associated herpesvirus/human herpesvirus 8-unrelated but Epstein-Barr virus-positive primary effusion lymphoma-like lymphoma in the setting of human immunodeficiency virus and hepatitis C virus infection. Leuk Lymphoma. 2010 Dec; 51(12):2303-5.
    View in: PubMed
  11. Bennett JM, Pryor J, Laughlin TS, Rothberg PG, Burack WR. Is the association of "cup-like" nuclei with mutation of the NPM1 gene in acute myeloid leukemia clinically useful? Am J Clin Pathol. 2010 Oct; 134(4):648-52.
    View in: PubMed
  12. Burack WR, Laughlin TS, Friedberg JW, Spence JM, Rothberg PG. PCR assays detect B-lymphocyte clonality in formalin-fixed, paraffin-embedded specimens of classical hodgkin lymphoma without microdissection. Am J Clin Pathol. 2010 Jul; 134(1):104-11.
    View in: PubMed
  13. Hilchey SP, Kobie JJ, Cochran MR, Secor-Socha S, Wang JC, Hyrien O, Burack WR, Mosmann TR, Quataert SA, Bernstein SH. Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. J Immunol. 2009 Nov 15; 183(10):6157-66.
    View in: PubMed
  14. Bernstein SH, Burack WR. The incidence, natural history, biology, and treatment of transformed lymphomas. Hematology Am Soc Hematol Educ Program. 2009; 532-41.
    View in: PubMed
  15. Vomastek T, Iwanicki MP, Burack WR, Tiwari D, Kumar D, Parsons JT, Weber MJ, Nandicoori VK. Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol. 2008 Nov; 28(22):6954-66.
    View in: PubMed
  16. Halldórsdóttir AM, Frühwirth M, Deutsch A, Aigelsreiter A, Beham-Schmid C, Agnarsson BA, Neumeister P, Richard Burack W. Quantifying the role of aberrant somatic hypermutation in transformation of follicular lymphoma. Leuk Res. 2008 Jul; 32(7):1015-21.
    View in: PubMed
  17. Halldórsdóttir AM, Zehnbauer BA, Burack WR. Application of BIOMED-2 clonality assays to formalin-fixed paraffin embedded follicular lymphoma specimens: superior performance of the IGK assays compared to IGH for suboptimal specimens. Leuk Lymphoma. 2007 Jul; 48(7):1338-43.
    View in: PubMed
  18. Seo J, Chung YS, Sharma GG, Moon E, Burack WR, Pandita TK, Choi K. Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53. Oncogene. 2005 Dec 8; 24(55):8176-86.
    View in: PubMed
  19. Markiewicz MA, Carayannopoulos LN, Naidenko OV, Matsui K, Burack WR, Wise EL, Fremont DH, Allen PM, Yokoyama WM, Colonna M, Shaw AS. Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation. J Immunol. 2005 Sep 1; 175(5):2825-33.
    View in: PubMed
  20. Tu PH, Giannini C, Judkins AR, Schwalb JM, Burack R, O'Neill BP, Yachnis AT, Burger PC, Scheithauer BW, Perry A. Clinicopathologic and genetic profile of intracranial marginal zone lymphoma: a primary low-grade CNS lymphoma that mimics meningioma. J Clin Oncol. 2005 Aug 20; 23(24):5718-27.
    View in: PubMed
  21. Burack WR, Shaw AS. Live Cell Imaging of ERK and MEK: simple binding equilibrium explains the regulated nucleocytoplasmic distribution of ERK. J Biol Chem. 2005 Feb 4; 280(5):3832-7.
    View in: PubMed
  22. Lee KH, Dinner AR, Tu C, Campi G, Raychaudhuri S, Varma R, Sims TN, Burack WR, Wu H, Wang J, Kanagawa O, Markiewicz M, Allen PM, Dustin ML, Chakraborty AK, Shaw AS. The immunological synapse balances T cell receptor signaling and degradation. Science. 2003 Nov 14; 302(5648):1218-22.
    View in: PubMed
  23. Burack WR, Lee KH, Holdorf AD, Dustin ML, Shaw AS. Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J Immunol. 2002 Sep 15; 169(6):2837-41.
    View in: PubMed
  24. Burack WR, Cheng AM, Shaw AS. Scaffolds, adaptors and linkers of TCR signaling: theory and practice. Curr Opin Immunol. 2002 Jun; 14(3):312-6.
    View in: PubMed
  25. Hailman E, Burack WR, Shaw AS, Dustin ML, Allen PM. Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity. 2002 Jun; 16(6):839-48.
    View in: PubMed
  26. Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol. 2002 May; 22(9):3035-45.
    View in: PubMed
  27. Holdorf AD, Lee KH, Burack WR, Allen PM, Shaw AS. Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nat Immunol. 2002 Mar; 3(3):259-64.
    View in: PubMed
  28. Burack WR, Dibble AR, Biltonen RL. The relationship between compositional phase separation and vesicle morphology: implications for the regulation of phospholipase A2 by membrane structure. Chem Phys Lipids. 1997 Nov 19; 90(1-2):87-95.
    View in: PubMed
  29. Burack WR, Dibble AR, Allietta MM, Biltonen RL. Changes in vesicle morphology induced by lateral phase separation modulate phospholipase A2 activity. Biochemistry. 1997 Aug 26; 36(34):10551-7.
    View in: PubMed
  30. Burack WR, Sturgill TW. The activating dual phosphorylation of MAPK by MEK is nonprocessive. Biochemistry. 1997 May 20; 36(20):5929-33.
    View in: PubMed
  31. Burack WR, Gadd ME, Biltonen RL. Modulation of phospholipase A2: identification of an inactive membrane-bound state. Biochemistry. 1995 Nov 14; 34(45):14819-28.
    View in: PubMed
  32. Burack WR, Biltonen RL. Lipid bilayer heterogeneities and modulation of phospholipase A2 activity. Chem Phys Lipids. 1994 Sep 6; 73(1-2):209-22.
    View in: PubMed
  33. Burack WR, Yuan Q, Biltonen RL. Role of lateral phase separation in the modulation of phospholipase A2 activity. Biochemistry. 1993 Jan 19; 32(2):583-9.
    View in: PubMed
  34. Lathrop BK, Burack WR, Biltonen RL, Rule GS. Expression of a group II phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus in Escherichia coli: recovery and renaturation from bacterial inclusion bodies. Protein Expr Purif. 1992 Dec; 3(6):512-7.
    View in: PubMed

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