URMC Research Network - W. Richard Burack

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W. Richard Burack

Title	Associate Professor
Institution	School of Medicine and Dentistry
Department	Pathology and Laboratory Medicine
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 626 Rochester NY 14642

Other Positions


Title	Director, Hematopathology Unit
Institution	School of Medicine and Dentistry
Department	Pathology and Laboratory Medicine
Title	Associate Professor
Institution	University of Rochester Medical Center
Department	Cancer Center

Awards And Honors

2004			Class of 2006 Distinguished Teacher Award \| Washington Univ School of Medicine
2005			Class of 2008 Lecturer of the Year \| Washington Univ School of Medicine
2006			Class of 2009 Professor of the Year \| Washington Univ School of Medicine
2007			Class of 2010 Professor of the Year \| Washington Univ School of Medicine
2010			Excellence in 2nd Year Teaching \| University of Rochester School of Medicine

Overview

Dr. Burack's research interests are membrane phospholipase biology and the T cell immunologic synapse. He is currently studying molecular mechanisms of lymphoma progression in patients

Selected Publications

Burack WR. Symposium on Myeloid Neoplasms on June 9, 2012 in honor of Dr. John M. Bennett. Leuk Res. 2012 Dec; 36(12):1440.

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Rauh MJ, Rahman F, Good D, Silverman J, Brennan MK, Dimov N, Liesveld J, Ryan DH, Richard Burack W, Bennett JM. Blastic plasmacytoid dendritic cell neoplasm with leukemic presentation, lacking cutaneous involvement: Case series and literature review. Leuk Res. 2012 Jan; 36(1):81-6.

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Hilchey SP, Rosenberg AF, Hyrien O, Secor-Socha S, Cochran MR, Brady MT, Wang JC, Sanz I, Burack WR, Quataert SA, Bernstein SH. Follicular lymphoma tumor-infiltrating T-helper (T(H)) cells have the same polyfunctional potential as normal nodal T(H) cells despite skewed differentiation. Blood. 2011 Sep 29; 118(13):3591-602.

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Spence JM, Rothberg PG, Wang N, Burack WR. Demonstration of array-based analysis for highly multiplexed PCR assays application to detection of IGH@-BCL2 translocations in FFPE follicular lymphoma specimens. J Mol Diagn. 2011 May; 13(3):252-62.

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Ferrantino M, Eichelberger J, Burack HR, Li F, Lee FE. A 48-year-old woman with a large mediastinal mass. Chest. 2010 Nov; 138(5):1260-4.

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Cooper AR, Burack WR, Allerton JP. A case of Kaposi sarcoma-associated herpesvirus/human herpesvirus 8-unrelated but Epstein-Barr virus-positive primary effusion lymphoma-like lymphoma in the setting of human immunodeficiency virus and hepatitis C virus infection. Leuk Lymphoma. 2010 Dec; 51(12):2303-5.

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Bennett JM, Pryor J, Laughlin TS, Rothberg PG, Burack WR. Is the association of "cup-like" nuclei with mutation of the NPM1 gene in acute myeloid leukemia clinically useful? Am J Clin Pathol. 2010 Oct; 134(4):648-52.

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Burack WR, Laughlin TS, Friedberg JW, Spence JM, Rothberg PG. PCR assays detect B-lymphocyte clonality in formalin-fixed, paraffin-embedded specimens of classical hodgkin lymphoma without microdissection. Am J Clin Pathol. 2010 Jul; 134(1):104-11.

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Hilchey SP, Kobie JJ, Cochran MR, Secor-Socha S, Wang JC, Hyrien O, Burack WR, Mosmann TR, Quataert SA, Bernstein SH. Human follicular lymphoma CD39+-infiltrating T cells contribute to adenosine-mediated T cell hyporesponsiveness. J Immunol. 2009 Nov 15; 183(10):6157-66.

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Bernstein SH, Burack WR. The incidence, natural history, biology, and treatment of transformed lymphomas. Hematology Am Soc Hematol Educ Program. 2009; 532-41.

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Vomastek T, Iwanicki MP, Burack WR, Tiwari D, Kumar D, Parsons JT, Weber MJ, Nandicoori VK. Extracellular signal-regulated kinase 2 (ERK2) phosphorylation sites and docking domain on the nuclear pore complex protein Tpr cooperatively regulate ERK2-Tpr interaction. Mol Cell Biol. 2008 Nov; 28(22):6954-66.

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Halldórsdóttir AM, Zehnbauer BA, Burack WR. Application of BIOMED-2 clonality assays to formalin-fixed paraffin embedded follicular lymphoma specimens: superior performance of the IGK assays compared to IGH for suboptimal specimens. Leuk Lymphoma. 2007 Jul; 48(7):1338-43.

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Seo J, Chung YS, Sharma GG, Moon E, Burack WR, Pandita TK, Choi K. Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53. Oncogene. 2005 Dec 8; 24(55):8176-86.

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Markiewicz MA, Carayannopoulos LN, Naidenko OV, Matsui K, Burack WR, Wise EL, Fremont DH, Allen PM, Yokoyama WM, Colonna M, Shaw AS. Costimulation through NKG2D enhances murine CD8+ CTL function: similarities and differences between NKG2D and CD28 costimulation. J Immunol. 2005 Sep 1; 175(5):2825-33.

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Burack WR, Shaw AS. Live Cell Imaging of ERK and MEK: simple binding equilibrium explains the regulated nucleocytoplasmic distribution of ERK. J Biol Chem. 2005 Feb 4; 280(5):3832-7.

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Lee KH, Dinner AR, Tu C, Campi G, Raychaudhuri S, Varma R, Sims TN, Burack WR, Wu H, Wang J, Kanagawa O, Markiewicz M, Allen PM, Dustin ML, Chakraborty AK, Shaw AS. The immunological synapse balances T cell receptor signaling and degradation. Science. 2003 Nov 14; 302(5648):1218-22.

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Burack WR, Lee KH, Holdorf AD, Dustin ML, Shaw AS. Cutting edge: quantitative imaging of raft accumulation in the immunological synapse. J Immunol. 2002 Sep 15; 169(6):2837-41.

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Burack WR, Cheng AM, Shaw AS. Scaffolds, adaptors and linkers of TCR signaling: theory and practice. Curr Opin Immunol. 2002 Jun; 14(3):312-6.

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Hailman E, Burack WR, Shaw AS, Dustin ML, Allen PM. Immature CD4(+)CD8(+) thymocytes form a multifocal immunological synapse with sustained tyrosine phosphorylation. Immunity. 2002 Jun; 16(6):839-48.

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Nguyen A, Burack WR, Stock JL, Kortum R, Chaika OV, Afkarian M, Muller WJ, Murphy KM, Morrison DK, Lewis RE, McNeish J, Shaw AS. Kinase suppressor of Ras (KSR) is a scaffold which facilitates mitogen-activated protein kinase activation in vivo. Mol Cell Biol. 2002 May; 22(9):3035-45.

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Holdorf AD, Lee KH, Burack WR, Allen PM, Shaw AS. Regulation of Lck activity by CD4 and CD28 in the immunological synapse. Nat Immunol. 2002 Mar; 3(3):259-64.

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Burack WR, Dibble AR, Biltonen RL. The relationship between compositional phase separation and vesicle morphology: implications for the regulation of phospholipase A2 by membrane structure. Chem Phys Lipids. 1997 Nov 19; 90(1-2):87-95.

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Burack WR, Dibble AR, Allietta MM, Biltonen RL. Changes in vesicle morphology induced by lateral phase separation modulate phospholipase A2 activity. Biochemistry. 1997 Aug 26; 36(34):10551-7.

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Burack WR, Sturgill TW. The activating dual phosphorylation of MAPK by MEK is nonprocessive. Biochemistry. 1997 May 20; 36(20):5929-33.

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Burack WR, Gadd ME, Biltonen RL. Modulation of phospholipase A2: identification of an inactive membrane-bound state. Biochemistry. 1995 Nov 14; 34(45):14819-28.

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Burack WR, Biltonen RL. Lipid bilayer heterogeneities and modulation of phospholipase A2 activity. Chem Phys Lipids. 1994 Sep 6; 73(1-2):209-22.

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Burack WR, Yuan Q, Biltonen RL. Role of lateral phase separation in the modulation of phospholipase A2 activity. Biochemistry. 1993 Jan 19; 32(2):583-9.

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Lathrop BK, Burack WR, Biltonen RL, Rule GS. Expression of a group II phospholipase A2 from the venom of Agkistrodon piscivorus piscivorus in Escherichia coli: recovery and renaturation from bacterial inclusion bodies. Protein Expr Purif. 1992 Dec; 3(6):512-7.

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