Archibald Perkins
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pathology and Laboratory Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
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| 1979 |
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| Phi Beta Kappa | | 1979 |
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| Sigma Xi |
Dr. Perkins' current research focus is on Evi1, a complex locus that plays a critical role in both normal hematopoesis and myeloid leukemogenesis. Evidence indicates that Evi1 is an important player in maintenance of the leukemic stem cell compartment by increasing proliferation and prolonging survivial, in part through regulation of the transcription factor Gata2 and the anti-apoptotic molecue Bc12a1. His current work encompasses embryogenesis in gentically modified mice, identification of chromosomal Evi1 binding targets, Evi1 protein-protein interactions, clinical implications of chromosomal rearrangements involving Evi1, and exploration of potential therapeutic approaches to block the function of Evi1 in leukemia.
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Bresnick EH, Katsumura KR, Lee HY, Johnson KD, Perkins AS. Master regulatory GATA transcription factors: mechanistic principles and emerging links to hematologic malignancies. Nucleic Acids Res. 2012 Jul 1; 40(13):5819-31.
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Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda K, Wheeler J, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. Targeting a DNA Binding Motif of the EVI1 Protein by a Pyrrole-Imidazole Polyamide. Biochemistry. 2011 Dec 6; 50(48):10431-41.
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Zhang Y, Stehling-Sun S, Lezon-Geyda K, Juneja SC, Coillard L, Chatterjee G, Wuertzer CA, Camargo F, Perkins AS. PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood. 2011 Oct 6; 118(14):3853-61.
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Halene S, Gaines P, Sun H, Zibello T, Lin S, Khanna-Gupta A, Williams SC, Perkins A, Krause D, Berliner N. C/EBPepsilon directs granulocytic-vs-monocytic lineage determination and confers chemotactic function via Hlx. Exp Hematol. 2010 Feb; 38(2):90-103.
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Qiu Y, Lynch J, Guo L, Yatsula B, Perkins AS, Michalak M. Regulation of the calreticulin gene by GATA6 and Evi-1 transcription factors. Biochemistry. 2008 Mar 25; 47(12):3697-704.
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Perkins AS, Friedberg JW. Burkitt lymphoma in adults. Hematology Am Soc Hematol Educ Program. 2008; 341-8.
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Jackson-Fisher AJ, Bellinger G, Shum E, Duong JK, Perkins AS, Gassmann M, Muller W, Kent Lloyd KC, Stern DF. Formation of Neu/ErbB2-induced mammary tumors is unaffected by loss of ErbB4. Oncogene. 2006 Sep 14; 25(41):5664-72.
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Yatsula B, Galvao C, McCrann M, Perkins AS. Assessment of F-MuLV-induced tumorigenesis reveals new candidate tumor genes including Pecam1, St7, and Prim2. Leukemia. 2006 Jan; 20(1):162-5.
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Boyd KE, Xiao YY, Fan K, Poholek A, Copeland NG, Jenkins NA, Perkins AS. Sox4 cooperates with Evi1 in AKXD-23 myeloid tumors via transactivation of proviral LTR. Blood. 2006 Jan 15; 107(2):733-41.
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Yatsula B, Lin S, Read AJ, Poholek A, Yates K, Yue D, Hui P, Perkins AS. Identification of binding sites of EVI1 in mammalian cells. J Biol Chem. 2005 Sep 2; 280(35):30712-22.
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Yuasa H, Oike Y, Iwama A, Nishikata I, Sugiyama D, Perkins A, Mucenski ML, Suda T, Morishita K. Oncogenic transcription factor Evi1 regulates hematopoietic stem cell proliferation through GATA-2 expression. EMBO J. 2005 Jun 1; 24(11):1976-87.
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Kluger HM, Kluger Y, Gilmore-Hebert M, DiVito K, Chang JT, Rodov S, Mironenko O, Kacinski BM, Perkins AS, Sapi E. cDNA microarray analysis of invasive and tumorigenic phenotypes in a breast cancer model. Lab Invest. 2004 Mar; 84(3):320-31.
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Amin DN, Perkins AS, Stern DF. Gene expression profiling of ErbB receptor and ligand-dependent transcription. Oncogene. 2004 Feb 19; 23(7):1428-38.
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Chatterjee G, Rosner A, Han Y, Zelazny ET, Li B, Cardiff RD, Perkins AS. Acceleration of mouse mammary tumor virus-induced murine mammary tumorigenesis by a p53 172H transgene: influence of FVB background on tumor latency and identification of novel sites of proviral insertion. Am J Pathol. 2002 Dec; 161(6):2241-53.
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Kone J, Arroyo J, Savinelli T, Lin S, Boyd K, Wu Y, Nimmakayalu M, Copeland NG, Jenkins NA, Qumsiyeh M, Hu P, Prescott A, Wu H, Yang L, Roe B, Perkins AS. F-MuLV acceleration of myelomonocytic tumorigenesis in SV40 large T antigen transgenic mice is accompanied by retroviral insertion at Fli1 and a novel locus, Fim4. Leukemia. 2002 Sep; 16(9):1827-34.
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Hui P, Glusac EJ, Sinard JH, Perkins AS. Clonal analysis of cutaneous fibrous histiocytoma (dermatofibroma). J Cutan Pathol. 2002 Aug; 29(7):385-9.
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Ma X, Husain T, Peng H, Lin S, Mironenko O, Maun N, Johnson S, Tuck D, Berliner N, Krause DS, Perkins AS. Development of a murine hematopoietic progenitor complementary DNA microarray using a subtracted complementary DNA library. Blood. 2002 Aug 1; 100(3):833-44.
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Kogan SC, Ward JM, Anver MR, Berman JJ, Brayton C, Cardiff RD, Carter JS, de Coronado S, Downing JR, Fredrickson TN, Haines DC, Harris AW, Harris NL, Hiai H, Jaffe ES, MacLennan IC, Pandolfi PP, Pattengale PK, Perkins AS, Simpson RM, Tuttle MS, Wong JF, Morse HC. Bethesda proposals for classification of nonlymphoid hematopoietic neoplasms in mice. Blood. 2002 Jul 1; 100(1):238-45.
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Wysolmerski JJ, Dann PR, Zelazny E, Dunbar ME, Insogna KL, Guise TA, Perkins AS. Overexpression of parathyroid hormone-related protein causes hypercalcemia but not bone metastases in a murine model of mammary tumorigenesis. J Bone Miner Res. 2002 Jul; 17(7):1164-70.
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Perkins AS. Functional genomics in the mouse. Funct Integr Genomics. 2002 Aug; 2(3):81-91.
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Zelazny E, Li B, Anagnostopoulos AM, Coleman A, Perkins AS. Cooperating oncogenic events in murine mammary tumorigenesis: assessment of ErbB2, mutant p53, and mouse mammary tumor virus. Exp Mol Pathol. 2001 Jun; 70(3):183-93.
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Hui P, Parkash V, Perkins AS, Carcangiu ML. Pathogenesis of placental site trophoblastic tumor may require the presence of a paternally derived X chromosome. Lab Invest. 2000 Jun; 80(6):965-72.
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Kim JH, Hui P, Yue D, Aycock J, Leclerc C, Bjoring AR, Perkins AS. Identification of candidate target genes for EVI-1, a zinc finger oncoprotein, using a novel selection strategy. Oncogene. 1998 Sep 24; 17(12):1527-38.
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Roberts A, Kretzschmar E, Perkins AS, Forman J, Price R, Buonocore L, Kawaoka Y, Rose JK. Vaccination with a recombinant vesicular stomatitis virus expressing an influenza virus hemagglutinin provides complete protection from influenza virus challenge. J Virol. 1998 Jun; 72(6):4704-11.
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Krause DS, Perkins AS. Gotta find GATA a friend. Nat Med. 1997 Sep; 3(9):960-1.
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Li B, Rosen JM, McMenamin-Balano J, Muller WJ, Perkins AS. neu/ERBB2 cooperates with p53-172H during mammary tumorigenesis in transgenic mice. Mol Cell Biol. 1997 Jun; 17(6):3155-63.
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Khanna-Gupta A, Lopingco MC, Savinelli T, Zibello T, Berliner N, Perkins AS. Retroviral insertional activation of the EVI1 oncogene does not prevent G-CSF-induced maturation of the murine pluripotent myeloid cell line 32Dcl3. Oncogene. 1996 Feb 1; 12(3):563-9.
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Perkins AS, Kim JH. Zinc fingers 1-7 of EVI1 fail to bind to the GATA motif by itself but require the core site GACAAGATA for binding. J Biol Chem. 1996 Jan 12; 271(2):1104-10.
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Lopingco MC, Perkins AS. Molecular analysis of Evi1, a zinc finger oncogene involved in myeloid leukemia. Curr Top Microbiol Immunol. 1996; 211:211-22.
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Wolff L, Perkins AS. Molecular regulation of myelopoiesis. Trends Cell Biol. 1995 Sep; 5(9):369-71.
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Brannan CI, Perkins AS, Vogel KS, Ratner N, Nordlund ML, Reid SW, Buchberg AM, Jenkins NA, Parada LF, Copeland NG. Targeted disruption of the neurofibromatosis type-1 gene leads to developmental abnormalities in heart and various neural crest-derived tissues. Genes Dev. 1994 May 1; 8(9):1019-29.
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Liu JP, Baker J, Perkins AS, Robertson EJ, Efstratiadis A. Mice carrying null mutations of the genes encoding insulin-like growth factor I (Igf-1) and type 1 IGF receptor (Igf1r). Cell. 1993 Oct 8; 75(1):59-72.
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Stanton BR, Perkins AS, Tessarollo L, Sassoon DA, Parada LF. Loss of N-myc function results in embryonic lethality and failure of the epithelial component of the embryo to develop. Genes Dev. 1992 Dec; 6(12A):2235-47.
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Skalnik DG, Dorfman DM, Perkins AS, Jenkins NA, Copeland NG, Orkin SH. Targeting of transgene expression to monocyte/macrophages by the gp91-phox promoter and consequent histiocytic malignancies. Proc Natl Acad Sci U S A. 1991 Oct 1; 88(19):8505-9.
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Perkins AS, Fishel R, Jenkins NA, Copeland NG. Evi-1, a murine zinc finger proto-oncogene, encodes a sequence-specific DNA-binding protein. Mol Cell Biol. 1991 May; 11(5):2665-74.
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Perkins AS, Mercer JA, Jenkins NA, Copeland NG. Patterns of Evi-1 expression in embryonic and adult tissues suggest that Evi-1 plays an important regulatory role in mouse development. Development. 1991 Feb; 111(2):479-87.
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Skalnik DG, Dorfman DM, Perkins AS, Jenkins NA, Copeland NG, Orkin SH. Targeting of transgene expression to monocytes by cytochrome b heavy chain gene 5'-flanking sequences induces histiocytic malignancies. Trans Assoc Am Physicians. 1990; 103:129-36.
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Perkins AS, Kirschmeier PT, Weinstein IB. Transduction of the human insulin gene via retroviral vectors fails to yield spliced transcripts. DNA. 1989 Jan-Feb; 8(1):59-68.
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Perkins AS. The pathology of murine myelogenous leukemias. Curr Top Microbiol Immunol. 1989; 149:3-21.
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Kirschmeier PT, Housey GM, Johnson MD, Perkins AS, Weinstein IB. Construction and characterization of a retroviral vector demonstrating efficient expression of cloned cDNA sequences. DNA. 1988 Apr; 7(3):219-25.
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Perkins AS, Kirschmeier PT, Gattoni-Celli S, Weinstein IB. Design of a retrovirus-derived vector for expression and transduction of exogenous genes in mammalian cells. Mol Cell Biol. 1983 Jun; 3(6):1123-32.
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Segre GV, Perkins AS, Witters LA, Potts J. Metabolism of parathyroid hormone by isolated rat Kupffer cells and hepatocytes. J Clin Invest. 1981 Feb; 67(2):449-57.
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