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Yi Zhang

TitleResearch Associate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPathology and Laboratory Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
 
 Awards And Honors
2003     Life Science Research Foundation Finalist  | Princeton University
2003     Helen Hay Whitney Foundation finalist
2006     Advanced Training in Science Teaching  | Yale Graduate Teaching Center
2008     James P. Wilmot Cancer Center Symposium 1st place award  | University of Rochester Medical Center
2011     Empire State Stem Cell Board IDEA Award  | New York State
2014     New York State Stem Cell Sciences funding  | New York State Department of Health
 
 Overview
Dr. Zhang's graduate work revealed a role for the Wnt regulator Axin in the regulation of Jun N-terminal kinase. As a postdoc, he discovered a connection between the anti-angiogenesis drug fumagillin and the Wnt signaling pathway, which both provided strong evidence for the role of the Wnt pathway in angiogenesis, as well as explained the role of the fumagillin target, MetAP2, in cellular growth control.

 
 Selected Publications
List All   |   Timeline
  1. Bard-Chapeau EA, Szumska D, Jacob B, Chua BQ, Chatterjee GC, Zhang Y, Ward JM, Urun F, Kinameri E, Vincent SD, Ahmed S, Bhattacharya S, Osato M, Perkins AS, Moore AW, Jenkins NA, Copeland NG. Mice carrying a hypomorphic evi1 allele are embryonic viable but exhibit severe congenital heart defects. PLoS One. 2014; 9(2):e89397.
    View in: PubMed
  2. Juneja SC, Vonica A, Zeiss C, Lezon-Geyda K, Yatsula B, Sell DR, Monnier VM, Lin S, Ardito T, Eyre D, Reynolds D, Yao Z, Awad HA, Yu H, Wilson M, Honnons S, Boyce BF, Xing L, Zhang Y, Perkins AS. Deletion of Mecom in mouse results in early-onset spinal deformity and osteopenia. Bone. 2014 Mar; 60:148-61.
    View in: PubMed
  3. Zhang Y, Owens K, Hatem L, Glass CH, Karuppaiah K, Camargo F, Perkins AS. Essential role of PR-domain protein MDS1-EVI1 in MLL-AF9 leukemia. Blood. 2013 Oct 17; 122(16):2888-92.
    View in: PubMed
  4. Arshad M, Ye Z, Gu X, Wong CK, Liu Y, Li D, Zhou L, Zhang Y, Bay WP, Yu VC, Li P. RNF13, a RING finger protein, mediates endoplasmic reticulum stress-induced apoptosis through the inositol-requiring enzyme (IRE1a)/c-Jun NH2-terminal kinase pathway. J Biol Chem. 2013 Mar 22; 288(12):8726-36.
    View in: PubMed
  5. Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda K, Wheeler J, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. Targeting a DNA binding motif of the EVI1 protein by a pyrrole-imidazole polyamide. Biochemistry. 2011 Dec 6; 50(48):10431-41.
    View in: PubMed
  6. Zhang Y, Stehling-Sun S, Lezon-Geyda K, Juneja SC, Coillard L, Chatterjee G, Wuertzer CA, Camargo F, Perkins AS. PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood. 2011 Oct 6; 118(14):3853-61.
    View in: PubMed
  7. Cirone P, Lin S, Griesbach HL, Zhang Y, Slusarski DC, Crews CM. A role for planar cell polarity signaling in angiogenesis. Angiogenesis. 2008; 11(4):347-60.
    View in: PubMed
  8. Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM. A chemical and genetic approach to the mode of action of fumagillin. Chem Biol. 2006 Sep; 13(9):1001-9.
    View in: PubMed
  9. Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM. Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27):10379-84.
    View in: PubMed
  10. Cheung PY, Zhang Y, Long J, Lin S, Zhang M, Jiang Y, Wu Z. p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs. J Biol Chem. 2004 Oct 29; 279(44):45308-11.
    View in: PubMed
  11. Rui HL, Fan E, Zhou HM, Xu Z, Zhang Y, Lin SC. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. J Biol Chem. 2002 Nov 8; 277(45):42981-6.
    View in: PubMed
  12. Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC. Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways. J Biol Chem. 2002 May 17; 277(20):17706-12.
    View in: PubMed
  13. Zhang Y, Qiu WJ, Liu DX, Neo SY, He X, Lin SC. Differential molecular assemblies underlie the dual function of Axin in modulating the WNT and JNK pathways. J Biol Chem. 2001 Aug 24; 276(34):32152-9.
    View in: PubMed
  14. Fong CW, Zhang Y, Neo SY, Lin SC. Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor alpha in a calcium-sensitive manner. Biochem J. 2000 Dec 15; 352 Pt 3:747-53.
    View in: PubMed
  15. Zhang Y, Neo SY, Han J, Lin SC. Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem. 2000 Aug 11; 275(32):25008-14.
    View in: PubMed
  16. Neo SY, Zhang Y, Yaw LP, Li P, Lin SC. Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels. Biochem Biophys Res Commun. 2000 May 27; 272(1):144-50.
    View in: PubMed
  17. Zhang Y, Neo SY, Wang X, Han J, Lin SC. Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. J Biol Chem. 1999 Dec 3; 274(49):35247-54.
    View in: PubMed
  18. Zhang Y, Neo SY, Han J, Yaw LP, Lin SC. RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. J Biol Chem. 1999 Jan 29; 274(5):2851-7.
    View in: PubMed
  19. Zhang Y, Lin SC. Molecular characterization of the cyclin-dependent kinase inhibitor p27 promoter. Biochim Biophys Acta. 1997 Sep 12; 1353(3):307-17.
    View in: PubMed
  20. Liu SY, Zhang WY, Li HY, Dai XJ, Zhang Y, Xu JC, Chen LL, Wang SQ, Qian CH. [Studies on the isolation of endogenous sleep factors from Tupaia Belangeri Chinensis (TBC) after sleep deprivation]. Sheng Li Xue Bao. 1994 Feb; 46(1):83-9.
    View in: PubMed

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