Yi Zhang
| Title | Research Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pathology and Laboratory Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
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| 2002 |
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| National Science Scholarship | A*STAR Singapore International Fellowship | | 2003 |
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| Life Science Research Foundation Finalist | Princeton University | | 2003 |
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| Helen Hay Whitney Foundation finalist | | 2006 |
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| Advanced Training in Science Teaching | Yale Graduate Teaching Center | | 2008 |
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| James P. Wilmot Cancer Center Symposium 1st place award | University of Rochester Medical Center | | 2011 |
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| Empire State Stem Cell Board IDEA Award | New York State |
Dr. Zhang's graduate work revealed a role for the Wnt regulator Axin in the regulation of Jun N-terminal kinase. As a postdoc, he discovered a connection between the anti-angiogenesis drug fumagillin and the Wnt signaling pathway, which both provided strong evidence for the role of the Wnt pathway in angiogenesis, as well as explained the role of the fumagillin target, MetAP2, in cellular growth control.
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Zhang Y, Sicot G, Cui X, Vogel M, Wuertzer CA, Lezon-Geyda K, Wheeler J, Harki DA, Muzikar KA, Stolper DA, Dervan PB, Perkins AS. Targeting a DNA Binding Motif of the EVI1 Protein by a Pyrrole-Imidazole Polyamide. Biochemistry. 2011 Dec 6; 50(48):10431-41.
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Zhang Y, Stehling-Sun S, Lezon-Geyda K, Juneja SC, Coillard L, Chatterjee G, Wuertzer CA, Camargo F, Perkins AS. PR-domain-containing Mds1-Evi1 is critical for long-term hematopoietic stem cell function. Blood. 2011 Oct 6; 118(14):3853-61.
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Cirone P, Lin S, Griesbach HL, Zhang Y, Slusarski DC, Crews CM. A role for planar cell polarity signaling in angiogenesis. Angiogenesis. 2008; 11(4):347-60.
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Zhang Y, Yeh JR, Mara A, Ju R, Hines JF, Cirone P, Griesbach HL, Schneider I, Slusarski DC, Holley SA, Crews CM. A chemical and genetic approach to the mode of action of fumagillin. Chem Biol. 2006 Sep; 13(9):1001-9.
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Yeh JR, Ju R, Brdlik CM, Zhang W, Zhang Y, Matyskiela ME, Shotwell JD, Crews CM. Targeted gene disruption of methionine aminopeptidase 2 results in an embryonic gastrulation defect and endothelial cell growth arrest. Proc Natl Acad Sci U S A. 2006 Jul 5; 103(27):10379-84.
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Cheung PY, Zhang Y, Long J, Lin S, Zhang M, Jiang Y, Wu Z. p150(Glued), Dynein, and microtubules are specifically required for activation of MKK3/6 and p38 MAPKs. J Biol Chem. 2004 Oct 29; 279(44):45308-11.
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Rui HL, Fan E, Zhou HM, Xu Z, Zhang Y, Lin SC. SUMO-1 modification of the C-terminal KVEKVD of Axin is required for JNK activation but has no effect on Wnt signaling. J Biol Chem. 2002 Nov 8; 277(45):42981-6.
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Zhang Y, Qiu WJ, Chan SC, Han J, He X, Lin SC. Casein kinase I and casein kinase II differentially regulate axin function in Wnt and JNK pathways. J Biol Chem. 2002 May 17; 277(20):17706-12.
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Zhang Y, Qiu WJ, Liu DX, Neo SY, He X, Lin SC. Differential molecular assemblies underlie the dual function of Axin in modulating the WNT and JNK pathways. J Biol Chem. 2001 Aug 24; 276(34):32152-9.
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Fong CW, Zhang Y, Neo SY, Lin SC. Specific induction of RGS16 (regulator of G-protein signalling 16) mRNA by protein kinase C in CEM leukaemia cells is mediated via tumour necrosis factor alpha in a calcium-sensitive manner. Biochem J. 2000 Dec 15; 352 Pt 3:747-53.
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Zhang Y, Neo SY, Han J, Lin SC. Dimerization choices control the ability of axin and dishevelled to activate c-Jun N-terminal kinase/stress-activated protein kinase. J Biol Chem. 2000 Aug 11; 275(32):25008-14.
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Neo SY, Zhang Y, Yaw LP, Li P, Lin SC. Axin-induced apoptosis depends on the extent of its JNK activation and its ability to down-regulate beta-catenin levels. Biochem Biophys Res Commun. 2000 May 27; 272(1):144-50.
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Zhang Y, Neo SY, Wang X, Han J, Lin SC. Axin forms a complex with MEKK1 and activates c-Jun NH(2)-terminal kinase/stress-activated protein kinase through domains distinct from Wnt signaling. J Biol Chem. 1999 Dec 3; 274(49):35247-54.
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Zhang Y, Neo SY, Han J, Yaw LP, Lin SC. RGS16 attenuates galphaq-dependent p38 mitogen-activated protein kinase activation by platelet-activating factor. J Biol Chem. 1999 Jan 29; 274(5):2851-7.
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Zhang Y, Lin SC. Molecular characterization of the cyclin-dependent kinase inhibitor p27 promoter. Biochim Biophys Acta. 1997 Sep 12; 1353(3):307-17.
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Liu SY, Zhang WY, Li HY, Dai XJ, Zhang Y, Xu JC, Chen LL, Wang SQ, Qian CH. [Studies on the isolation of endogenous sleep factors from Tupaia Belangeri Chinensis (TBC) after sleep deprivation]. Sheng Li Xue Bao. 1994 Feb; 46(1):83-9.
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