URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Xing Qiu

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentBiostatistics and Computational Biology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester NY 14642
 
 Overview
I am a computational biologist with a strong background in mathematical statistics. My research work focuses on developing statistical and computational methodology of multiple hypothesis testing for analyzing large scale data with complex correlation structures such as *-omics data. In recent years, I have published 30 peer-reviewed papers covering topics such as microarray pre-processing, nonparametric statistical analysis, empirical Bayes methodology, controlling false discovery rate under correlation, and efficient computational method of multiple hypothesis testing based on correlation scores.

 
 Selected Publications
List All   |   Timeline
  1. Zhu T, Hu R, Tian W, Ekholm S, Schifitto G, Qiu X, Zhong J. SPatial REgression Analysis of Diffusion tensor imaging (SPREAD) for longitudinal progression of neurodegenerative disease in individual subjects. Magn Reson Imaging. 2013 Dec; 31(10):1657-67.
    View in: PubMed
  2. Henn AD, Wu S, Qiu X, Ruda M, Stover M, Yang H, Liu Z, Welle SL, Holden-Wiltse J, Wu H, Zand MS. High-resolution temporal response patterns to influenza vaccine reveal a distinct human plasma cell gene signature. Sci Rep. 2013 Jul 31; 3:2327.
    View in: PubMed
  3. Qiu X, Wu H, Hu R. The impact of quantile and rank normalization procedures on the testing power of gene differential expression analysis. BMC Bioinformatics. 2013; 14:124.
    View in: PubMed
  4. Qiu X, Klebanov L. Gene Selection with the d-Sequence Method. Methods Mol Biol. 2013; 972:57-71.
    View in: PubMed
  5. Smolock EM, Korshunov VA, Glazko G, Qiu X, Gerloff J, Berk BC. Ribosomal Protein L17, RpL17, is an Inhibitor of Vascular Smooth Muscle Growth and Carotid Intima Formation. Circulation. 2012 Nov 13; 126(20):2418-27.
    View in: PubMed
  6. Henn AD, Laski M, Yang H, Welle S, Qiu X, Miao H, Barry CT, Wu H, Zand MS. Functionally Distinct Subpopulations of CpG-Activated Memory B Cells. Sci Rep. 2012; 2:345.
    View in: PubMed
  7. Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu X, Sambuughin N, Dirksen RT. Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families. Anesthesiology. 2011 Nov; 115(5):938-45.
    View in: PubMed
  8. Needham M, Hu R, Dwarkadas S, Qiu X. Hierarchical parallelization of gene differential association analysis. BMC Bioinformatics. 2011; 12:374.
    View in: PubMed
  9. Liu X, Tian W, Qiu X, Li J, Thomson S, Li L, Wang HZ. Correlation analysis of quantitative diffusion parameters in ipsilateral cerebral peduncle during Wallerian degeneration with motor function outcome after cerebral ischemic stroke. J Neuroimaging. 2012 Jul; 22(3):255-60.
    View in: PubMed
  10. Sanders JO, Howell J, Qiu X. Comparison of the Paley method using chronological age with use of skeletal maturity for predicting mature limb length in children. J Bone Joint Surg Am. 2011 Jun 1; 93(11):1051-6.
    View in: PubMed
  11. Hu Y, Bandla S, Godfrey TE, Tan D, Luketich JD, Pennathur A, Qiu X, Hicks DG, Peters JH, Zhou Z. HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma. Mod Pathol. 2011 Jul; 24(7):899-907.
    View in: PubMed
  12. Zhu T, Hu R, Qiu X, Taylor M, Tso Y, Yiannoutsos C, Navia B, Mori S, Ekholm S, Schifitto G, Zhong J. Quantification of accuracy and precision of multi-center DTI measurements: a diffusion phantom and human brain study. Neuroimage. 2011 Jun 1; 56(3):1398-411.
    View in: PubMed
  13. Liu X, Tian W, Kolar B, Yeaney GA, Qiu X, Johnson MD, Ekholm S. MR diffusion tensor and perfusion-weighted imaging in preoperative grading of supratentorial nonenhancing gliomas. Neuro Oncol. 2011 Apr; 13(4):447-55.
    View in: PubMed
  14. Liu X, Tian W, Li L, Kolar B, Qiu X, Chen F, Dogra VS. Hyperintensity on diffusion weighted image along ipsilateral cortical spinal tract after cerebral ischemic stroke: a diffusion tensor analysis. Eur J Radiol. 2012 Feb; 81(2):292-7.
    View in: PubMed
  15. Sepesi B, Watson TJ, Zhou D, Polomsky M, Litle VR, Jones CE, Raymond DP, Hu R, Qiu X, Peters JH. Are endoscopic therapies appropriate for superficial submucosal esophageal adenocarcinoma? An analysis of esophagectomy specimens. J Am Coll Surg. 2010 Apr; 210(4):418-27.
    View in: PubMed
  16. Hu R, Qiu X, Glazko G. A new gene selection procedure based on the covariance distance. Bioinformatics. 2010 Feb 1; 26(3):348-54.
    View in: PubMed
  17. Will RE, Stokes IA, Qiu X, Walker MR, Sanders JO. Cobb angle progression in adolescent scoliosis begins at the intervertebral disc. Spine (Phila Pa 1976). 2009 Dec 1; 34(25):2782-6.
    View in: PubMed
  18. Sepesi B, Raymond DP, Polomsky M, Watson TJ, Litle VR, Jones CE, Hu R, Qiu X, Peters JH. Does the value of PET-CT extend beyond pretreatment staging? An analysis of survival in surgical patients with esophageal cancer. J Gastrointest Surg. 2009 Dec; 13(12):2121-7.
    View in: PubMed
  19. Nott SL, Huang Y, Li X, Fluharty BR, Qiu X, Welshons WV, Yeh S, Muyan M. Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations. J Biol Chem. 2009 May 29; 284(22):15277-88.
    View in: PubMed
  20. Hu R, Qiu X, Glazko G, Klebanov L, Yakovlev A. Detecting intergene correlation changes in microarray analysis: a new approach to gene selection. BMC Bioinformatics. 2009; 10:20.
    View in: PubMed
  21. Li X, Nott SL, Huang Y, Hilf R, Bambara RA, Qiu X, Yakovlev A, Welle S, Muyan M. Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell models. J Mol Endocrinol. 2008 May; 40(5):211-29.
    View in: PubMed
  22. Klebanov L, Qiu X, Yakovlev A. Testing differential expression in nonoverlapping gene pairs: a new perspective for the empirical Bayes method. J Bioinform Comput Biol. 2008 Apr; 6(2):301-16.
    View in: PubMed
  23. Wuertzer CA, Sullivan MA, Qiu X, Federoff HJ. CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. Mol Ther. 2008 Mar; 16(3):481-6.
    View in: PubMed
  24. Qiu X, Yakovlev A. Comments on probabilistic models behind the concept of false discovery rate. J Bioinform Comput Biol. 2007 Aug; 5(4):963-75.
    View in: PubMed
  25. Klebanov L, Qiu X, Welle S, Yakovlev A. Statistical methods and microarray data. Nat Biotechnol. 2007 Jan; 25(1):25-6; author reply 26-7.
    View in: PubMed
  26. Qiu X, Yakovlev A. Some comments on instability of false discovery rate estimation. J Bioinform Comput Biol. 2006 Oct; 4(5):1057-68.
    View in: PubMed
  27. Almudevar A, Klebanov LB, Qiu X, Salzman P, Yakovlev AY. Utility of correlation measures in analysis of gene expression. NeuroRx. 2006 Jul; 3(3):384-95.
    View in: PubMed
  28. Qiu X, Xiao Y, Gordon A, Yakovlev A. Assessing stability of gene selection in microarray data analysis. BMC Bioinformatics. 2006; 7:50.
    View in: PubMed
  29. Qiu X, Klebanov L, Yakovlev A. Correlation between gene expression levels and limitations of the empirical bayes methodology for finding differentially expressed genes. Stat Appl Genet Mol Biol. 2005; 4:Article34.
    View in: PubMed
  30. Qiu X, Brooks AI, Klebanov L, Yakovlev N. The effects of normalization on the correlation structure of microarray data. BMC Bioinformatics. 2005; 6:120.
    View in: PubMed

Visualizations


Qiu's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department