Xing Qiu
| Title | Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biostatistics and Computational Biology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester NY 14642
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I am a computational biologist with a strong background in mathematical statistics. My research work focuses on developing statistical and computational methodology of multiple hypothesis testing for analyzing large scale data with complex correlation structures such as *-omics data. In recent years, I have published 30 peer-reviewed papers covering topics such as microarray pre-processing, nonparametric statistical analysis, empirical Bayes methodology, controlling false discovery rate under correlation, and efficient computational method of multiple hypothesis testing based on correlation scores.
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Smolock EM, Korshunov VA, Glazko G, Qiu X, Gerloff J, Berk BC. Ribosomal Protein L17, RpL17, is an Inhibitor of Vascular Smooth Muscle Growth and Carotid Intima Formation. Circulation. 2012 Nov 13; 126(20):2418-27.
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Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu X, Sambuughin N, Dirksen RT. Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families. Anesthesiology. 2011 Nov; 115(5):938-45.
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Needham M, Hu R, Dwarkadas S, Qiu X. Hierarchical parallelization of gene differential association analysis. BMC Bioinformatics. 2011; 12:374.
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Liu X, Tian W, Qiu X, Li J, Thomson S, Li L, Wang HZ. Correlation Analysis of Quantitative Diffusion Parameters in Ipsilateral Cerebral Peduncle during Wallerian Degeneration with Motor Function Outcome after Cerebral Ischemic Stroke. J Neuroimaging. 2012 Jul; 22(3):255-60.
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Sanders JO, Howell J, Qiu X. Comparison of the Paley method using chronological age with use of skeletal maturity for predicting mature limb length in children. J Bone Joint Surg Am. 2011 Jun 1; 93(11):1051-6.
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Hu Y, Bandla S, Godfrey TE, Tan D, Luketich JD, Pennathur A, Qiu X, Hicks DG, Peters JH, Zhou Z. HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma. Mod Pathol. 2011 Jul; 24(7):899-907.
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Zhu T, Hu R, Qiu X, Taylor M, Tso Y, Yiannoutsos C, Navia B, Mori S, Ekholm S, Schifitto G, Zhong J. Quantification of accuracy and precision of multi-center DTI measurements: a diffusion phantom and human brain study. Neuroimage. 2011 Jun 1; 56(3):1398-411.
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Liu X, Tian W, Kolar B, Yeaney GA, Qiu X, Johnson MD, Ekholm S. MR diffusion tensor and perfusion-weighted imaging in preoperative grading of supratentorial nonenhancing gliomas. Neuro Oncol. 2011 Apr; 13(4):447-55.
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Liu X, Tian W, Li L, Kolar B, Qiu X, Chen F, Dogra VS. Hyperintensity on diffusion weighted image along ipsilateral cortical spinal tract after cerebral ischemic stroke: A diffusion tensor analysis. Eur J Radiol. 2012 Feb; 81(2):292-7.
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Sepesi B, Watson TJ, Zhou D, Polomsky M, Litle VR, Jones CE, Raymond DP, Hu R, Qiu X, Peters JH. Are endoscopic therapies appropriate for superficial submucosal esophageal adenocarcinoma? An analysis of esophagectomy specimens. J Am Coll Surg. 2010 Apr; 210(4):418-27.
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Hu R, Qiu X, Glazko G. A new gene selection procedure based on the covariance distance. Bioinformatics. 2010 Feb 1; 26(3):348-54.
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Sepesi B, Raymond DP, Polomsky M, Watson TJ, Litle VR, Jones CE, Hu R, Qiu X, Peters JH. Does the value of PET-CT extend beyond pretreatment staging? An analysis of survival in surgical patients with esophageal cancer. J Gastrointest Surg. 2009 Dec; 13(12):2121-7.
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Nott SL, Huang Y, Li X, Fluharty BR, Qiu X, Welshons WV, Yeh S, Muyan M. Genomic responses from the estrogen-responsive element-dependent signaling pathway mediated by estrogen receptor alpha are required to elicit cellular alterations. J Biol Chem. 2009 May 29; 284(22):15277-88.
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Hu R, Qiu X, Glazko G, Klebanov L, Yakovlev A. Detecting intergene correlation changes in microarray analysis: a new approach to gene selection. BMC Bioinformatics. 2009; 10:20.
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Li X, Nott SL, Huang Y, Hilf R, Bambara RA, Qiu X, Yakovlev A, Welle S, Muyan M. Gene expression profiling reveals that the regulation of estrogen-responsive element-independent genes by 17 beta-estradiol-estrogen receptor beta is uncoupled from the induction of phenotypic changes in cell models. J Mol Endocrinol. 2008 May; 40(5):211-29.
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Wuertzer CA, Sullivan MA, Qiu X, Federoff HJ. CNS delivery of vectored prion-specific single-chain antibodies delays disease onset. Mol Ther. 2008 Mar; 16(3):481-6.
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Qiu X, Yakovlev A. Comments on probabilistic models behind the concept of false discovery rate. J Bioinform Comput Biol. 2007 Aug; 5(4):963-75.
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Qiu X, Yakovlev A. Some comments on instability of false discovery rate estimation. J Bioinform Comput Biol. 2006 Oct; 4(5):1057-68.
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Almudevar A, Klebanov LB, Qiu X, Salzman P, Yakovlev AY. Utility of correlation measures in analysis of gene expression. NeuroRx. 2006 Jul; 3(3):384-95.
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Qiu X, Xiao Y, Gordon A, Yakovlev A. Assessing stability of gene selection in microarray data analysis. BMC Bioinformatics. 2006; 7:50.
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Qiu X, Klebanov L, Yakovlev A. Correlation between gene expression levels and limitations of the empirical bayes methodology for finding differentially expressed genes. Stat Appl Genet Mol Biol. 2005; 4:Article34.
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Qiu X, Brooks AI, Klebanov L, Yakovlev N. The effects of normalization on the correlation structure of microarray data. BMC Bioinformatics. 2005; 6:120.
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