Majed Refaai
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pathology and Laboratory Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 608
Rochester NY 14642
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Dr. Refaai's recent studies have included: The in-vitro effect of ABO anti-bodies on platelet function; The correlation between cancer and tissue factor (TF) plasma concentrations and its role in developing DVT; The relationship between the circulating TF and the cancer tissue concentrations of TF in different types of mouse models; Beriplex phase IIIb drug study for bleeding patients with Warfarin overdose; Beriplex phase IIIb drug study for surgical patients who require a quick reversal of Warfarin; The effect of ABO non-identical blood products transfusion on platelet function (in-vivo); Platelet transfusion in patients with positive heparin-induced thrombocytopenia; Comparison of tissue factor pathway inhibitor (TFPI) concentration and activity in mononuclear cells from normal individuals versus patients with Paroxysmal Nocturnal Hemoglobinuria; Comparison of TFPI concentrations in normal mouse plasma and endothelial cells versus a diabetic mouse model; Analysis of fatty acid ethyl ester (FAEE) concentrations in binge drinking, chronic alcoholics, and postmortem biopsies.
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Zantek ND, Hsu P, Refaai MA, Ledford-Kraemer M, Meijer P, Van Cott EM. Factor VII assay performance: an analysis of the North American Specialized Coagulation Laboratory Association proficiency testing results. Int J Lab Hematol. 2013 Jun; 35(3):314-21.
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Refaai MA, Blumberg N. The transfusion dilemma - Weighing the known and newly proposed risks of blood transfusions against the uncertain benefits. Best Pract Res Clin Anaesthesiol. 2013 Mar; 27(1):17-35.
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Refaai MA, Carter J, Henrichs KF, Davidson DC, Pollock SJ, Casey AE, Spinelli SL, Phipps RP, Francis CW, Blumberg N. Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B. Transfusion. 2013 Feb; 53(2):382-93.
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Henrichs KF, Howk N, Masel DS, Thayer M, Refaai MA, Kirkley SA, Heal JM, Blumberg N. Providing ABO-identical platelets and cryoprecipitate to (almost) all patients: approach, logistics, and associated decreases in transfusion reaction and red blood cell alloimmunization incidence. Transfusion. 2012 Mar; 52(3):635-40.
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Refaai MA, Fialkow LB, Heal JM, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Corsetti JP, Francis CW, Bankey PE, Blumberg N. An association of ABO non-identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients. Vox Sang. 2011 Jul; 101(1):55-60.
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Blumberg N, Heal JM, Gettings KF, Phipps RP, Masel D, Refaai MA, Kirkley SA, Fialkow LB. An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions. Transfusion. 2010 Dec; 50(12):2738-44.
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Refaai MA, Phipps RP, Spinelli SL, Blumberg N. Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes. Thromb Res. 2011 Apr; 127(4):287-91.
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Refaai MA, Chuang C, Menegus M, Blumberg N, Francis CW. Outcomes after platelet transfusion in patients with heparin-induced thrombocytopenia. J Thromb Haemost. 2010 Jun; 8(6):1419-21.
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Refaai MA, Frenkel E, Sarode R. Platelet aggregation responses vary over a period of time in healthy controls. Platelets. 2010; 21(6):460-3.
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Sarode R, Refaai MA, Matevosyan K, Burner JD, Hampton S, Rutherford C. Prospective monitoring of plasma and platelet transfusions in a large teaching hospital results in significant cost reduction. Transfusion. 2010 Feb; 50(2):487-92.
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Holland L, Warkentin TE, Refaai M, Crowther MA, Johnston MA, Sarode R. Suboptimal effect of a three-factor prothrombin complex concentrate (Profilnine-SD) in correcting supratherapeutic international normalized ratio due to warfarin overdose. Transfusion. 2009 Jun; 49(6):1171-7.
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Refaai MA, Cusick RM, Paranjape G, Sutor LJ. Low CD34 collection from a healthy blood progenitor cell donor: a case report. J Clin Apher. 2009; 24(6):262-4.
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Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, Lyman GH. Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer. Arch Intern Med. 2008 Nov 24; 168(21):2377-81.
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O'Keeffe T, Refaai M, Tchorz K, Forestner JE, Sarode R. A massive transfusion protocol to decrease blood component use and costs. Arch Surg. 2008 Jul; 143(7):686-90; discussion 690-1.
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Refaai MA, Warkentin TE, Axelson M, Matevosyan K, Sarode R. Delayed-onset heparin-induced thrombocytopenia, venous thromboembolism, and cerebral venous thrombosis: a consequence of heparin "flushes". Thromb Haemost. 2007 Nov; 98(5):1139-40.
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Refaai MA, Ahn C, Lu L, Wu K, Broze GJ. Protein Z and ZPI levels and cardiovascular events. J Thromb Haemost. 2006 Jul; 4(7):1628-9.
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Refaai MA, Van Cott EM, Lukoszyk M, Hughes J, Eby CS. Loss of factor VIII and von Willebrand factor activities during cold storage of whole blood is reversed by rewarming. Lab Hematol. 2006; 12(2):99-102.
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Refaai MA, Wright RW, Parvin CA, Gronowski AM, Scott MG, Eby CS. Ischemia-modified albumin increases after skeletal muscle ischemia during arthroscopic knee surgery. Clin Chim Acta. 2006 Apr; 366(1-2):264-8.
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Refaai MA, Lukoszyk M, Hughes J, Eby CS, Van Cott EM. Cold-dependent loss of factor VIII von Willebrand factor activities in citrated whole blood is reversed by rewarming. Am J Clin Pathol. 2005 Dec; 124(6):972; author reply 973.
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Refaai MA, Van Cott EM, Laposata M. The timing of a positive test result for heparin-induced thrombocytopenia relative to the platelet count and anticoagulant therapy in 43 consecutive cases. Am J Clin Pathol. 2003 Apr; 119(4):497-504.
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Refaai MA, Nguyen PN, Cluette-Brown JE, Laposata M. Ethyl arachidonate is the predominant fatty acid ethyl ester in the brains of alcohol-intoxicated subjects at autopsy. Lipids. 2003 Mar; 38(3):269-73.
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Refaai MA, Laposata M, Van Cott EM. Clinical significance of a borderline titer in a negative ELISA test for heparin-induced thrombocytopenia. Am J Clin Pathol. 2003 Jan; 119(1):61-5.
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Laposata M, Hasaba A, Best CA, Yoerger DM, McQuillan BM, Salem RO, Refaai MA, Soderberg BL. Fatty acid ethyl esters: recent observations. Prostaglandins Leukot Essent Fatty Acids. 2002 Aug-Sep; 67(2-3):193-6.
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Refaai MA, Nguyen PN, Steffensen TS, Evans RJ, Cluette-Brown JE, Laposata M. Liver and adipose tissue fatty acid ethyl esters obtained at autopsy are postmortem markers for premortem ethanol intake. Clin Chem. 2002 Jan; 48(1):77-83.
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Salem RO, Refaai MA, Cluette-Brown JE, Russo JW, Laposata M. Fatty acid ethyl esters in liver and adipose tissues as postmortem markers for ethanol intake. Clin Chem. 2001 Apr; 47(4):722-5.
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Laposata M, Kabakibi A, Walden MP, Cluette-Brown JE, Nanji AA, Refaai MA, Werner J, Nanji AA. Differences in the fatty acid composition of fatty acid ethyl esters in organs and their secretions. Alcohol Clin Exp Res. 2000 Oct; 24(10):1488-91.
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