URMC Research Network - Michael Pichichero

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Michael Pichichero

Title	Clinical Professor
Institution	School of Medicine and Dentistry
Department	Pediatrics
Address	Legacy Pediatrics 1815 South Clinton Avenue Rochester NY 14618

Awards And Honors

1972			Phi Beta Kappa
1976			Alpha Omega Alpha, 1976
2002	-	2007	Best Doctors in America, 2002, 2003, 2004, 2005, 2006, 2007
2002	-	2007	Best Pediatricians in America, 2002, 2003, 2004, 2005, 2006, 2007
2004	-	2007	Top Physicians in America-2004, 2005, 2006, 2007
2005			Pediatric Infectious Disease Society of US, Breese Award for Outstanding Contribution to Clinical Research, Teaching and Practice, 2005

Overview

Dr. Pichichero and his colleagues' vaccine studies helped define the key variables that determine immunogenicity of the Haemophilus influenzae b (Hib) conjugate vaccines in the young infant. Encouraging findings have been made with Streptococcus pneumoniae capsular polysaccharide vaccines of several serotypes employing the conjugate vaccine technology. Continuation of these studies should further define structural factors governing immunogenicity of conjugate vaccines, analyze the role of epitopes of the carrier component, and pursue structure-immunogenicity relationships in conjugates of specific pneumococcal serotypes.
Combination vaccines are a necessity for the future of human vaccine development. The immunogenicity of acellular pertussis (DTaP) vaccines combined with various Hib conjugate vaccines, Hepatitis B vaccine, and inactivated poliovirus vaccine results in reduced immunogenicity for some of the included antigens. The mechanism(s) and biological relevance of this immunologic interference phenomena is an area of active research in Dr. Pichichero's lab.
Bacteria resistant to standard antibiotic therapy are causing acute otitis media with increasing frequency. New antibiotics are needed to cure these infections and to prevent long-term middle ear disease and associated hearing loss. Dr. Pichichero's group studies the epidemiology, etiology, and optimal treatment of otitis media. Sore throat caused by Group A beta hemolytic streptococci occur with concomitant colonization by organisms that may protect the streptococci through beta lactamase inactivation of penicillin at the site of infection. Dr. Pichichero's group evaluates alternative treatments to decrease the relapse rate of streptococcal infections.
Recent Publications
Pichichero ME "The Importance of Bacteriologic Eradication in the Treatment of Group A Streptococcal Tonsillopharyngitis." Clin Pediatr (Phila). 2007 May;46(4_suppl):3S-16S
Casey JR, Pichichero ME. "Symptomatic Relapse of Group A {beta}-Hemolytic Streptococcal Tonsillopharyngitis in Children." Clin Pediatr (Phila). 2007 May;46(4):307-10
Pichichero ME "Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift." Diagn Microbiol Infect Dis. 2007 Mar;57(3 Suppl):S13-8
Pichichero ME. "Who should get the HPV vaccine?" J Fam Pract. 2007 Mar;56(3):197-202
Casey JR, Pichichero ME. "Safe use of selected cephalosporins in penicillin-allergic patients: A meta-analysis." Otolaryngol Head Neck Surg. 2007 Mar;136(3):340-7.
Casey JR, Pichichero ME. "The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis." Diagn Microbiol Infect Dis. 2007 Feb 8;
Zeng M, Xu Q, Pichichero ME. "Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine." Vaccine. 2007 Jan 26;

Publication list, as provided by PubMed.
PubMed is maintained by the National Library of Medicine and provides complete abstracts of all publications,
as well as links to the full text of many articles (at journal homepages).

Selected Publications

Friedel V, Chang A, Wills J, Vargas R, Xu Q, Pichichero ME. Impact of Respiratory Viral Infections on a-Hemolytic Streptococci and Otopathogens in the Nasopharynx of Young Children. Pediatr Infect Dis J. 2013 Jan; 32(1):27-31.

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Xu Q, Almudervar A, Casey JR, Pichichero ME. Nasopharyngeal bacterial interactions in children. Emerg Infect Dis. 2012 Nov; 18(11):1738-45.

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Casey JR, Block SL, Hedrick J, Almudevar A, Pichichero ME. Comparison of amoxicillin/clavulanic Acid high dose with cefdinir in the treatment of acute otitis media. Drugs. 2012 Oct 22; 72(15):1991-7.

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Sharma SK, Pichichero ME. Functional deficits of pertussis-specific CD4(+) T cells in infants compared to adults following DTaP vaccination. Clin Exp Immunol. 2012 Sep; 169(3):281-91.

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Kaur R, Kim T, Casey JR, Pichichero ME. Antibody in middle ear fluid of children originates predominantly from sera and nasopharyngeal secretions. Clin Vaccine Immunol. 2012 Oct; 19(10):1593-6.

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Khan MN, Sharma SK, Filkins LM, Pichichero ME. PcpA of Streptococcus pneumoniae mediates adherence to nasopharyngeal and lung epithelial cells and elicits functional antibodies in humans. Microbes Infect. 2012 Oct; 14(12):1102-10.

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Xu Q, Casey JR, Chang A, Pichichero ME. When Co-colonizing the Nasopharynx Haemophilus influenzae Predominates Over Streptococcus pneumoniae Except Serotype 19A Strains to Cause Acute Otitis Media. Pediatr Infect Dis J. 2012 Jun; 31(6):638-40.

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Khan MN, Kaur R, Pichichero ME. Bactericidal antibody response against P6, protein D, and OMP26 of nontypeable Haemophilus influenzae after acute otitis media in otitis-prone children. FEMS Immunol Med Microbiol. 2012 Aug; 65(3):439-47.

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Pichichero ME, Kaur R, Casey JR, Xu Q, Almudevar A, Ochs M. Antibody response to Streptococcus pneumoniae proteins PhtD, LytB, PcpA, PhtE and Ply after nasopharyngeal colonization and acute otitis media in children. Hum Vaccin Immunother. 2012 Jun; 8(6):799-805.

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Liu K, Pichichero ME. Clinical significance of serum S100A12 in acute otitis media in young children. Pediatr Infect Dis J. 2012 Mar; 31(3):e56-8.

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Sharma SK, Casey JR, Pichichero ME. Reduced serum IgG responses to pneumococcal antigens in otitis-prone children may be due to poor memory B-cell generation. J Infect Dis. 2012 Apr; 205(8):1225-9.

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Khan MN, Pichichero ME. Vaccine candidates PhtD and PhtE of Streptococcus pneumoniae are adhesins that elicit functional antibodies in humans. Vaccine. 2012 Apr 16; 30(18):2900-7.

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Liu K, Chen L, Kaur R, Pichichero M. Transcriptome signature in young children with acute otitis media due to Streptococcus pneumoniae. Microbes Infect. 2012 Jul; 14(7-8):600-9.

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Wheeler CM, Harvey BM, Pichichero ME, Simon MW, Combs SP, Blatter MM, Marshall GS, Catteau G, Dobbelaere K, Descamps D, Dubin G, Schuind A. Immunogenicity and Safety of Human Papillomavirus-16/18 AS04-adjuvanted Vaccine Coadministered With Tetanus Toxoid, Reduced Diphtheria Toxoid, and Acellular Pertussis Vaccine and/or Meningococcal Conjugate Vaccine to Healthy Girls 11 to 18 Years of Age: Results From a Randomized Open Trial. Pediatr Infect Dis J. 2011 Dec; 30(12):e225-34.

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Shaikh N, Hoberman A, Kaleida PH, Rockette HE, Kurs-Lasky M, Hoover H, Pichichero ME, Roddey OF, Harrison C, Hadley JA, Schwartz RH. Otoscopic signs of otitis media. Pediatr Infect Dis J. 2011 Oct; 30(10):822-6.

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Sharma SK, Casey JR, Pichichero ME. Reduced memory CD4+ T-cell generation in the circulation of young children may contribute to the otitis-prone condition. J Infect Dis. 2011 Aug 15; 204(4):645-53.

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Kaur R, Casey JR, Pichichero ME. Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children. Pediatr Infect Dis J. 2011 Aug; 30(8):645-50.

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Kaur R, Chang A, Xu Q, Casey JR, Pichichero ME. Phylogenetic relatedness and diversity of non-typable Haemophilus influenzae in the nasopharynx and middle ear fluid of children with acute otitis media. J Med Microbiol. 2011 Dec; 60(Pt 12):1841-8.

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Thomas JC, Figueira M, Fennie KP, Laufer AS, Kong Y, Pichichero ME, Pelton SI, Pettigrew MM. Streptococcus pneumoniae clonal complex 199: genetic diversity and tissue-specific virulence. PLoS One. 2011; 6(4):e18649.

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Casey JR, Block S, Puthoor P, Hedrick J, Almudevar A, Pichichero ME. A simple scoring system to improve clinical assessment of acute otitis media. Clin Pediatr (Phila). 2011 Jul; 50(7):623-9.

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Xu Q, Kaur R, Casey JR, Sabharwal V, Pelton S, Pichichero ME. Nontypeable Streptococcus pneumoniae as an otopathogen. Diagn Microbiol Infect Dis. 2011 Feb; 69(2):200-4.

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Gall SA, Myers J, Pichichero M. Maternal immunization with tetanus-diphtheria-pertussis vaccine: effect on maternal and neonatal serum antibody levels. Am J Obstet Gynecol. 2011 Apr; 204(4):334.e1-5.

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Michel LV, Kalmeta B, McCreary M, Snyder J, Craig P, Pichichero ME. Vaccine candidate P6 of nontypable Haemophilus influenzae is not a transmembrane protein based on protein structural analysis. Vaccine. 2011 Feb 11; 29(8):1624-7.

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Chang A, Kaur R, Michel LV, Casey JR, Pichichero M. Haemophilus influenzae vaccine candidate outer membrane protein P6 is not conserved in all strains. Hum Vaccin. 2011 Jan 1; 7(1):102-5.

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Xu Q, Kaur R, Casey JR, Adlowitz DG, Pichichero ME, Zeng M. Identification of Streptococcus pneumoniae and Haemophilus influenzae in culture-negative middle ear fluids from children with acute otitis media by combination of multiplex PCR and multi-locus sequencing typing. Int J Pediatr Otorhinolaryngol. 2011 Feb; 75(2):239-44.

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Kaur R, Casey JR, Pichichero ME. Serum antibody response to three non-typeable Haemophilus influenzae outer membrane proteins during acute otitis media and nasopharyngeal colonization in otitis prone and non-otitis prone children. Vaccine. 2011 Jan 29; 29(5):1023-8.

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Liu K, Casey J, Pichichero M. Serum intercellular adhesion molecule 1 variations in young children with acute otitis media. Clin Vaccine Immunol. 2010 Dec; 17(12):1909-16.

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Baxter R, Jeanfreau R, Block SL, Blatter M, Pichichero M, Jain VK, Dewé W, Innis BL. A Phase III evaluation of immunogenicity and safety of two trivalent inactivated seasonal influenza vaccines in US children. Pediatr Infect Dis J. 2010 Oct; 29(10):924-30.

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Pichichero ME, Kaur R, Casey JR, Sabirov A, Khan MN, Almudevar A. Antibody response to Haemophilus influenzae outer membrane protein D, P6, and OMP26 after nasopharyngeal colonization and acute otitis media in children. Vaccine. 2010 Oct 18; 28(44):7184-92.

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Pichichero ME. Bacterial conjunctivitis in children: antibacterial treatment options in an era of increasing drug resistance. Clin Pediatr (Phila). 2011 Jan; 50(1):7-13.

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Chang A, Adlowitz DG, Yellamatty E, Pichichero M. Haemophilus influenzae outer membrane protein P6 molecular characterization may not differentiate all strains of H. Influenzae from H. haemolyticus. J Clin Microbiol. 2010 Oct; 48(10):3756-7.

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Kaur R, Adlowitz DG, Casey JR, Zeng M, Pichichero ME. Simultaneous assay for four bacterial species including Alloiococcus otitidis using multiplex-PCR in children with culture negative acute otitis media. Pediatr Infect Dis J. 2010 Aug; 29(8):741-5.

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Casey JR, Adlowitz DG, Pichichero ME. New patterns in the otopathogens causing acute otitis media six to eight years after introduction of pneumococcal conjugate vaccine. Pediatr Infect Dis J. 2010 Apr; 29(4):304-9.

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Comstock TL, Paterno MR, Usner DW, Pichichero ME. Efficacy and safety of besifloxacin ophthalmic suspension 0.6% in children and adolescents with bacterial conjunctivitis: a post hoc, subgroup analysis of three randomized, double-masked, parallel-group, multicenter clinical trials. Paediatr Drugs. 2010 Apr 1; 12(2):105-12.

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Pichichero M. Widening differences in acute otitis media study populations. Clin Infect Dis. 2009 Dec 1; 49(11):1648-9.

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Pichichero ME. Booster vaccinations: can immunologic memory outpace disease pathogenesis? Pediatrics. 2009 Dec; 124(6):1633-41.

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Sabirov A, Casey JR, Murphy TF, Pichichero ME. Breast-feeding is associated with a reduced frequency of acute otitis media and high serum antibody levels against NTHi and outer membrane protein vaccine antigen candidate P6. Pediatr Res. 2009 Nov; 66(5):565-70.

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Shaikh N, Martin JM, Casey JR, Pichichero ME, Wald ER, Colborn DK, Gerber MA, Kearney DH, Balentine TL, Haralam MA, Hoberman A. Development of a patient-reported outcome measure for children with streptococcal pharyngitis. Pediatrics. 2009 Oct; 124(4):e557-63.

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Pichichero ME, Gentile A, Giglio N, Alonso MM, Fernandez Mentaberri MV, Zareba G, Clarkson T, Gotelli C, Gotelli M, Yan L, Treanor J. Mercury levels in premature and low birth weight newborn infants after receipt of thimerosal-containing vaccines. J Pediatr. 2009 Oct; 155(4):495-9.

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Arévalo MT, Xu Q, Paton JC, Hollingshead SK, Pichichero ME, Briles DE, Girgis N, Zeng M. Mucosal vaccination with a multicomponent adenovirus-vectored vaccine protects against Streptococcus pneumoniae infection in the lung. FEMS Immunol Med Microbiol. 2009 Apr; 55(3):346-51.

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Xu Q, Pichichero ME, Casey JR, Zeng M. Novel type of Streptococcus pneumoniae causing multidrug-resistant acute otitis media in children. Emerg Infect Dis. 2009 Apr; 15(4):547-51.

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De Wals P, Erickson L, Poirier B, Pépin J, Pichichero ME. How to compare the efficacy of conjugate vaccines to prevent acute otitis media? Vaccine. 2009 May 11; 27(21):2877-83.

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Xu Q, Pichichero ME, Simpson LL, Elias M, Smith LA, Zeng M. An adenoviral vector-based mucosal vaccine is effective in protection against botulism. Gene Ther. 2009 Mar; 16(3):367-75.

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Guerra FA, Blatter MM, Greenberg DP, Pichichero M, Noriega FR. Safety and immunogenicity of a pentavalent vaccine compared with separate administration of licensed equivalent vaccines in US infants and toddlers and persistence of antibodies before a preschool booster dose: a randomized, clinical trial. Pediatrics. 2009 Jan; 123(1):301-12.

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Pichichero ME, Reed MD. Variations in amoxicillin pharmacokinetic/pharmacodynamic parameters may explain treatment failures in acute otitis media. Paediatr Drugs. 2009; 11(4):243-9.

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Xu Q, Pichichero ME, Zeng M. Adherence of Streptococcus pyogenes to human epithelial cells is modulated by Haemophilus influenzae. Scand J Infect Dis. 2009; 41(4):244-51.

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Pichichero ME. The PANDAS syndrome. Adv Exp Med Biol. 2009; 634:205-16.

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Casey JR, Pichichero ME. A comparison of 2 white blood cell count devices to aid judicious antibiotic prescribing. Clin Pediatr (Phila). 2009 Apr; 48(3):291-4.

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Pichichero ME, Casey JR. Diagnostic inaccuracy and subject exclusions render placebo and observational studies of acute otitis media inconclusive. Pediatr Infect Dis J. 2008 Nov; 27(11):958-62.

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Pichichero ME. Vaccine-induced immunologic memory and pace of pathogenesis: predicting the need for boosters. Expert Rev Vaccines. 2008 Nov; 7(9):1299-303.

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DePestel DD, Benninger MS, Danziger L, LaPlante KL, May C, Luskin A, Pichichero M, Hadley JA. Cephalosporin use in treatment of patients with penicillin allergies. J Am Pharm Assoc (2003). 2008 Jul-Aug; 48(4):530-40.

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Pichichero ME, Casey JR, Hoberman A, Schwartz R. Pathogens causing recurrent and difficult-to-treat acute otitis media, 2003-2006. Clin Pediatr (Phila). 2008 Nov; 47(9):901-6.

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Noel GJ, Blumer JL, Pichichero ME, Hedrick JA, Schwartz RH, Balis DA, Melkote R, Bagchi P, Arguedas A. A randomized comparative study of levofloxacin versus amoxicillin/clavulanate for treatment of infants and young children with recurrent or persistent acute otitis media. Pediatr Infect Dis J. 2008 Jun; 27(6):483-9.

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Casey JR, Kahn R, Gmoser D, Atlas E, Urbani K, Luber S, Pellman H, Pichichero ME. Frequency of symptomatic relapses of group A beta-hemolytic streptococcal tonsillopharyngitis in children from 4 pediatric practices following penicillin, amoxicillin, and cephalosporin antibiotic treatment. Clin Pediatr (Phila). 2008 Jul; 47(6):549-54.

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Pichichero ME, Casey JR. Comparison of study designs for acute otitis media trials. Int J Pediatr Otorhinolaryngol. 2008 Jun; 72(6):737-50.

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Pichichero ME, Casey JR, Block SL, Guttendorf R, Flanner H, Markowitz D, Clausen S. Pharmacodynamic analysis and clinical trial of amoxicillin sprinkle administered once daily for 7 days compared to penicillin V potassium administered four times daily for 10 days in the treatment of tonsillopharyngitis due to Streptococcus pyogenes in children. Antimicrob Agents Chemother. 2008 Jul; 52(7):2512-20.

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Pichichero ME. Improving vaccine delivery using novel adjuvant systems. Hum Vaccin. 2008 Jul-Aug; 4(4):262-70.

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Pichichero ME, Gentile A, Giglio N, Umido V, Clarkson T, Cernichiari E, Zareba G, Gotelli C, Gotelli M, Yan L, Treanor J. Mercury levels in newborns and infants after receipt of thimerosal-containing vaccines. Pediatrics. 2008 Feb; 121(2):e208-14.

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Pichichero ME, Doern GV, Kuti JL, Nicolau DP. Probability of achieving requisite pharmacodynamic exposure for oral beta-lactam regimens against Haemophilus influenzae in children. Paediatr Drugs. 2008; 10(6):391-7.

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Pichichero ME, Casey JR. Systematic review of factors contributing to penicillin treatment failure in Streptococcus pyogenes pharyngitis. Otolaryngol Head Neck Surg. 2007 Dec; 137(6):851-857.

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Pichichero ME, Casey JR. Emergence of a multiresistant serotype 19A pneumococcal strain not included in the 7-valent conjugate vaccine as an otopathogen in children. JAMA. 2007 Oct 17; 298(15):1772-8.

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Pichichero ME, Casey JR. Evolving microbiology and molecular epidemiology of acute otitis media in the pneumococcal conjugate vaccine era. Pediatr Infect Dis J. 2007 Oct; 26(10 Suppl):S12-6.

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Pichichero ME, Casey JR. Bacterial eradication rates with shortened courses of 2nd- and 3rd-generation cephalosporins versus 10 days of penicillin for treatment of group A streptococcal tonsillopharyngitis in adults. Diagn Microbiol Infect Dis. 2007 Oct; 59(2):127-30.

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Zeng M, Xu Q, Elias M, Pichichero ME, Simpson LL, Smith LA. Protective immunity against botulism provided by a single dose vaccination with an adenovirus-vectored vaccine. Vaccine. 2007 Oct 23; 25(43):7540-8.

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Denoël PA, Goldblatt D, de Vleeschauwer I, Jacquet JM, Pichichero ME, Poolman JT. Quality of the Haemophilus influenzae type b (Hib) antibody response induced by diphtheria-tetanus-acellular pertussis/Hib combination vaccines. Clin Vaccine Immunol. 2007 Oct; 14(10):1362-9.

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Pichichero ME, Bernstein H, Blatter MM, Schuerman L, Cheuvart B, Holmes SJ. Immunogenicity and safety of a combination diphtheria, tetanus toxoid, acellular pertussis, hepatitis B, and inactivated poliovirus vaccine coadministered with a 7-valent pneumococcal conjugate vaccine and a Haemophilus influenzae type b conjugate vaccine. J Pediatr. 2007 Jul; 151(1):43-9, 49.e1-2.

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Casey JR, Pichichero ME. Symptomatic relapse of group A beta-hemolytic streptococcal tonsillopharyngitis in children. Clin Pediatr (Phila). 2007 May; 46(4):307-10.

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Pichichero ME. Use of selected cephalosporins in penicillin-allergic patients: a paradigm shift. Diagn Microbiol Infect Dis. 2007 Mar; 57(3 Suppl):13S-18S.

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Pichichero ME, Casey JR. Safe use of selected cephalosporins in penicillin-allergic patients: a meta-analysis. Otolaryngol Head Neck Surg. 2007 Mar; 136(3):340-7.

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Pichichero ME. Who should get the HPV vaccine? J Fam Pract. 2007 Mar; 56(3):197-202.

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Casey JR, Pichichero ME. The evidence base for cephalosporin superiority over penicillin in streptococcal pharyngitis. Diagn Microbiol Infect Dis. 2007 Mar; 57(3 Suppl):39S-45S.

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Farrell DJ, Klugman KP, Pichichero M. Increased antimicrobial resistance among nonvaccine serotypes of Streptococcus pneumoniae in the pediatric population after the introduction of 7-valent pneumococcal vaccine in the United States. Pediatr Infect Dis J. 2007 Feb; 26(2):123-8.

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Zeng M, Xu Q, Pichichero ME. Protection against anthrax by needle-free mucosal immunization with human anthrax vaccine. Vaccine. 2007 May 4; 25(18):3588-94.

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Arguedas A, Dagan R, Pichichero M, Leibovitz E, Blumer J, McNeeley DF, Melkote R, Noel GJ. An open-label, double tympanocentesis study of levofloxacin therapy in children with, or at high risk for, recurrent or persistent acute otitis media. Pediatr Infect Dis J. 2006 Dec; 25(12):1102-9.

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Xu Q, Arevalo MT, Pichichero ME, Zeng M. A new complementing cell line for replication-incompetent E1-deleted adenovirus propagation. Cytotechnology. 2006 Jul; 51(3):133-40.

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Pichichero M, Papa T, Blatter M, Mitchell D, Kratz R, Sneed J, Bassily E, Casey J, Gilmet G. Immune memory in children previously vaccinated with an experimental quadrivalent meningococcal polysaccharide diphtheria toxoid conjugate vaccine. Pediatr Infect Dis J. 2006 Nov; 25(11):995-1000.

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Pichichero ME, Casey JR, Francis AB, Marsocci SM, Murphy M, Hoeger W, Cleary C. Acellular pertussis vaccine boosters combined with diphtheria and tetanus toxoid boosters for adolescents: safety and immunogenicity assessment when preceded by different 5-dose DTaP/DTwP schedules. Clin Pediatr (Phila). 2006 Sep; 45(7):613-20.

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Nolan T, Bernstein H, Blatter MM, Bromberg K, Guerra F, Kennedy W, Pichichero M, Senders SD, Trofa A, Collard A, Sullivan DC, Descamps D. Immunogenicity and safety of an inactivated hepatitis A vaccine administered concomitantly with diphtheria-tetanus-acellular pertussis and haemophilus influenzae type B vaccines to children less than 2 years of age. Pediatrics. 2006 Sep; 118(3):e602-9.

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Pichichero ME, Brixner DI. Rethinking the total cost of care in AOM and ABS: The impact of improved diagnostic accuracy and antibiotic treatment where high efficacy and adherence are achievable. Am J Manag Care. 2006 Aug; 12(10 Suppl):S283-91.

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Pichichero ME, Brixner DI. A review of recommended antibiotic therapies with impact on outcomes in acute otitis media and acute bacterial sinusitis. Am J Manag Care. 2006 Aug; 12(10 Suppl):S292-302.

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Pichichero ME. Pathogen shifts and changing cure rates for otitis media and tonsillopharyngitis. Clin Pediatr (Phila). 2006 Jul; 45(6):493-502.

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Brunton S, Pichichero M. Considerations in the use of antibiotics for streptococcal pharyngitis. J Fam Pract. 2006 Jul; Suppl:S9-16.

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Pichichero ME. The new meningococcal conjugate vaccine. A profile of its safety, efficacy, and indications for use. Postgrad Med. 2006 Jun-Jul; 119(1):47-54, 64.

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Pichichero M, Casey J. Comparison of European and U.S. results for cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis. Eur J Clin Microbiol Infect Dis. 2006 Jun; 25(6):354-64.

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Pichichero ME. Prevention of cervical cancer through vaccination of adolescents. Clin Pediatr (Phila). 2006 Jun; 45(5):393-8.

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Pichichero ME, Wright T. The use of tympanocentesis in the diagnosis and management of acute otitis media. Curr Infect Dis Rep. 2006 May; 8(3):189-95.

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Pichichero ME, DeTora LM, Johnson DR. An adolescent and adult formulation combined tetanus, diphtheria and five-component pertussis vaccine. Expert Rev Vaccines. 2006 Apr; 5(2):175-87.

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Pichichero ME, Blatter MM, Kennedy WA, Hedrick J, Descamps D, Friedland LR. Acellular pertussis vaccine booster combined with diphtheria and tetanus toxoids for adolescents. Pediatrics. 2006 Apr; 117(4):1084-93.

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Arguedas A, Dagan R, Leibovitz E, Hoberman A, Pichichero M, Paris M. A multicenter, open label, double tympanocentesis study of high dose cefdinir in children with acute otitis media at high risk of persistent or recurrent infection. Pediatr Infect Dis J. 2006 Mar; 25(3):211-8.

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Pichichero ME. Cephalosporins can be prescribed safely for penicillin-allergic patients. J Fam Pract. 2006 Feb; 55(2):106-12.

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Echols R, Hamed K, Arguedas A, Dagan R, Sher L, Sáez-Llorens X, Pichichero ME. Gatifloxacin therapy for children: turn on the light. Clin Infect Dis. 2005 Dec 15; 41(12):1824-5.

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Brunton S, Pichichero ME. Acute otitis media: influence of the PCV-7 vaccine on changes in the disease and its management. J Fam Pract. 2005 Nov; 54(11):961-8.

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Pichichero ME. Meningococcal conjugate vaccines. Expert Opin Biol Ther. 2005 Nov; 5(11):1475-89.

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Casey JR, Pichichero ME. Metaanalysis of short course antibiotic treatment for group a streptococcal tonsillopharyngitis. Pediatr Infect Dis J. 2005 Oct; 24(10):909-17.

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Pichichero ME. Preferred antibiotics for treatment of acute otitis media: comparison of practicing pediatricians, general practitioners, and otolaryngologists. Clin Pediatr (Phila). 2005 Sep; 44(7):575-8.

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Zeng M, Xu Q, Hesek ED, Pichichero ME. N-fragment of edema factor as a candidate antigen for immunization against anthrax. Vaccine. 2006 Jan 30; 24(5):662-70.

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Pichichero ME. Evolving shifts in otitis media pathogens: relevance to a managed care organization. Am J Manag Care. 2005 Aug; 11(6 Suppl):S192-201.

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Pichichero ME, Arguedas A, Dagan R, Sher L, Saez-Llorens X, Hamed K, Echols R. Safety and efficacy of gatifloxacin therapy for children with recurrent acute otitis media (AOM) and/or AOM treatment failure. Clin Infect Dis. 2005 Aug 15; 41(4):470-8.

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Pichichero ME. Meningococcal conjugate vaccine in adolescents and children. Clin Pediatr (Phila). 2005 Jul-Aug; 44(6):479-89.

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Pichichero ME, Rennels MB, Edwards KM, Blatter MM, Marshall GS, Bologa M, Wang E, Mills E. Combined tetanus, diphtheria, and 5-component pertussis vaccine for use in adolescents and adults. JAMA. 2005 Jun 22; 293(24):3003-11.

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Pichichero ME, Casey JR. Acellular pertussis vaccines for adolescents. Pediatr Infect Dis J. 2005 Jun; 24(6 Suppl):S117-26.

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Casey JR, Pichichero ME. Higher dosages of azithromycin are more effective in treatment of group A streptococcal tonsillopharyngitis. Clin Infect Dis. 2005 Jun 15; 40(12):1748-55.

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Sher L, Arguedas A, Husseman M, Pichichero M, Hamed KA, Biswas D, Pierce P, Echols R. Randomized, investigator-blinded, multicenter, comparative study of gatifloxacin versus amoxicillin/clavulanate in recurrent otitis media and acute otitis media treatment failure in children. Pediatr Infect Dis J. 2005 Apr; 24(4):301-8.

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Pichichero ME, Casey JR. Acute otitis media: making sense of recent guidelines on antimicrobial treatment. J Fam Pract. 2005 Apr; 54(4):313-22.

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Pichichero ME. A review of evidence supporting the American Academy of Pediatrics recommendation for prescribing cephalosporin antibiotics for penicillin-allergic patients. Pediatrics. 2005 Apr; 115(4):1048-57.

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Pichichero ME, Decker MD. Verification of components of acellular pertussis vaccines that have been distributed solely, been in routine use for the last two decades and contributed greatly to control of pertussis in Japan. Biologicals. 2005 Mar; 33(1):59.

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Pichichero M, Casey J, Blatter M, Rothstein E, Ryall R, Bybel M, Gilmet G, Papa T. Comparative trial of the safety and immunogenicity of quadrivalent (A, C, Y, W-135) meningococcal polysaccharide-diphtheria conjugate vaccine versus quadrivalent polysaccharide vaccine in two- to ten-year-old children. Pediatr Infect Dis J. 2005 Jan; 24(1):57-62.

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Casey JR, Pichichero ME. Acellular pertussis vaccine safety and efficacy in children, adolescents and adults. Drugs. 2005; 65(10):1367-89.

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Pichichero ME, Poole MD. Comparison of performance by otolaryngologists, pediatricians, and general practioners on an otoendoscopic diagnostic video examination. Int J Pediatr Otorhinolaryngol. 2005 Mar; 69(3):361-6.

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Perrin EM, Murphy ML, Casey JR, Pichichero ME, Runyan DK, Miller WC, Snider LA, Swedo SE. Does group A beta-hemolytic streptococcal infection increase risk for behavioral and neuropsychiatric symptoms in children? Arch Pediatr Adolesc Med. 2004 Sep; 158(9):848-56.

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Casey JR, Pichichero ME. Changes in frequency and pathogens causing acute otitis media in 1995-2003. Pediatr Infect Dis J. 2004 Sep; 23(9):824-8.

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Pichichero ME. Group A streptococcal vaccines. JAMA. 2004 Aug 11; 292(6):738-9.

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Casey JR, Pichichero ME. Meta-analysis of cephalosporins versus penicillin for treatment of group A streptococcal tonsillopharyngitis in adults. Clin Infect Dis. 2004 Jun 1; 38(11):1526-34.

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Casey JR, Pichichero ME. Meta-analysis of cephalosporin versus penicillin treatment of group A streptococcal tonsillopharyngitis in children. Pediatrics. 2004 Apr; 113(4):866-82.

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Low DE, Pichichero ME, Schaad UB. Optimizing antibacterial therapy for community-acquired respiratory tract infections in children in an era of bacterial resistance. Clin Pediatr (Phila). 2004 Mar; 43(2):135-51.

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Clark HF, Bernstein DI, Dennehy PH, Offit P, Pichichero M, Treanor J, Ward RL, Krah DL, Shaw A, Dallas MJ, Laura D, Eiden JJ, Ivanoff N, Kaplan KM, Heaton P. Safety, efficacy, and immunogenicity of a live, quadrivalent human-bovine reassortant rotavirus vaccine in healthy infants. J Pediatr. 2004 Feb; 144(2):184-90.

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Pichichero ME, Casey JR. Acute otitis media disease management. Minerva Pediatr. 2003 Oct; 55(5):415-38.

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Pichichero ME. Osteopathic manipulation to prevent otitis media--does it work? Arch Pediatr Adolesc Med. 2003 Sep; 157(9):852-3.

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Pichichero ME, Hoeger WJ, Casey JR. Azithromycin for the treatment of pertussis. Pediatr Infect Dis J. 2003 Sep; 22(9):847-9.

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Pichichero ME. Diagnostic accuracy of otitis media and tympanocentesis skills assessment among pediatricians. Eur J Clin Microbiol Infect Dis. 2003 Sep; 22(9):519-24.

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Curtin CD, Casey JR, Murray PC, Cleary CT, Hoeger WJ, Marsocci SM, Murphy ML, Francis AB, Pichichero ME. Efficacy of cephalexin two vs. three times daily vs. cefadroxil once daily for streptococcal tonsillopharyngitis. Clin Pediatr (Phila). 2003 Jul-Aug; 42(6):519-26.

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Pichichero ME, Stonehocker Quick L. Clinical evaluation of Pediarix: a new pediatric combination vaccine. Clin Pediatr (Phila). 2003 Jun; 42(5):393-400.

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Curtin-Wirt C, Casey JR, Murray PC, Cleary CT, Hoeger WJ, Marsocci SM, Murphy ML, Francis AB, Pichichero ME. Efficacy of penicillin vs. amoxicillin in children with group A beta hemolytic streptococcal tonsillopharyngitis. Clin Pediatr (Phila). 2003 Apr; 42(3):219-25.

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Anderson P, Treanor J, Porcelli S, Pichichero M. Non-interference between two protein carriers when used with the same polysaccharide for pneumococcal conjugate vaccines in 2-year-old children. Vaccine. 2003 Mar 28; 21(13-14):1554-9.

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Casey JR, Marsocci SM, Murphy ML, Francis AB, Pichichero ME. White blood cell count can aid judicious antibiotic prescribing in acute upper respiratory infections in children. Clin Pediatr (Phila). 2003 Mar; 42(2):113-9.

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Pichichero ME. Diagnostic accuracy, tympanocentesis training performance, and antibiotic selection by pediatric residents in management of otitis media. Pediatrics. 2002 Dec; 110(6):1064-70.

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Pichichero ME, Cernichiari E, Lopreiato J, Treanor J. Mercury concentrations and metabolism in infants receiving vaccines containing thiomersal: a descriptive study. Lancet. 2002 Nov 30; 360(9347):1737-41.

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Monto AS, Pichichero ME, Blanckenberg SJ, Ruuskanen O, Cooper C, Fleming DM, Kerr C. Zanamivir prophylaxis: an effective strategy for the prevention of influenza types A and B within households. J Infect Dis. 2002 Dec 1; 186(11):1582-8.

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Novotny LA, Pichichero ME, Denoël PA, Neyt C, Vanderschrick S, Dequesne G, Bakaletz LO. Detection and characterization of pediatric serum antibody to the OMP P5-homologous adhesin of nontypeable Haemophilus influenzae during acute otitis media. Vaccine. 2002 Oct 4; 20(29-30):3590-7.

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Pichichero ME, Blatter MM, Reisinger KS, Harrison CJ, Johnson CE, Steinhoff MC, Senders SD, Rothstein EP, Willems P, Howe BJ. Impact of a birth dose of hepatitis B vaccine on the reactogenicity and immunogenicity of diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus-Haemophilus influenzae type b combination vaccination. Pediatr Infect Dis J. 2002 Sep; 21(9):854-9.

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Pichichero ME, Casey JR. Otitis media. Expert Opin Pharmacother. 2002 Aug; 3(8):1073-90.

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Pichichero ME. Dynamics of antibiotic prescribing for children. JAMA. 2002 Jun 19; 287(23):3133-5.

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Pichichero ME. Penicillin failures?! Pediatrics. 2002 Jun; 109(6):1189-90; author reply 1190-2.

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Rennels MB, Deloria MA, Pichichero ME, Englund JA, Anderson EL, Steinhoff MC, Decker MD, Edwards KM. Lack of consistent relationship between quantity of aluminum in diphtheria-tetanus-acellular pertussis vaccines and rates of extensive swelling reactions. Vaccine. 2002 May 31; 20 Suppl 3:S44-7.

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Greenberg DP, Pickering LK, Senders SD, Bissey JD, Howard RA, Blatter MM, Reisinger K, Pichichero ME, Howe BJ. Interchangeability of 2 diphtheria-tetanus-acellular pertussis vaccines in infancy. Pediatrics. 2002 Apr; 109(4):666-72.

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Murphy ML, Pichichero ME. Prospective identification and treatment of children with pediatric autoimmune neuropsychiatric disorder associated with group A streptococcal infection (PANDAS). Arch Pediatr Adolesc Med. 2002 Apr; 156(4):356-61.

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Kirmani KI, Lofthus G, Pichichero ME, Voloshen T, D'Angio CT. Seven-year follow-up of vaccine response in extremely premature infants. Pediatrics. 2002 Mar; 109(3):498-504.

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Pichichero ME. Assessing diagnostic accuracy and tympanocentesis skills of South African physicians in management of otitis media. S Afr Med J. 2002 Feb; 92(2):137-8.

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Sorrento A, Pichichero ME. Assessing diagnostic accuracy and tympanocentesis skills by nurse practitioners in management of otitis media. J Am Acad Nurse Pract. 2001 Nov; 13(11):524-9.

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Brook I, Aronovitz GH, Pichichero ME. Open-Label, parallel-group, multicenter, randomized study of cefprozil versus erythromycin in children with group A streptococcal pharyngitis/tonsillitis. Clin Ther. 2001 Nov; 23(11):1889-900.

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Pichichero ME, Poole MD. Assessing diagnostic accuracy and tympanocentesis skills in the management of otitis media. Arch Pediatr Adolesc Med. 2001 Oct; 155(10):1137-42.

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Pichichero ME, Marsocci SM, Murphy ML, Hoeger W, Francis AB, Green JL. A prospective observational study of 5-, 7-, and 10-day antibiotic treatment for acute otitis media. Otolaryngol Head Neck Surg. 2001 Apr; 124(4):381-7.

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Pichichero ME, Anderson EL, Rennels MB, Edwards KM, England JA. Fifth vaccination with dipthteria, tetanus and acellular pertussis is beneficial in four- to six-year-olds. Pediatr Infect Dis J. 2001 Apr; 20(4):427-33.

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Mayes T, Pichichero ME. Are follow-up throat cultures necessary when rapid antigen detection tests are negative for group A streptococci? Clin Pediatr (Phila). 2001 Apr; 40(4):191-5.

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Shelly MA, Pichichero ME, Treanor JJ. Low baseline antibody level to diphtheria is associated with poor response to conjugated pneumococcal vaccine in adults. Scand J Infect Dis. 2001; 33(7):542-4.

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Pichichero ME. Evaluating the need, timing and best choice of antibiotic therapy for acute otitis media and tonsillopharyngitis infections in children. Pediatr Infect Dis J. 2000 Dec; 19(12 Suppl):S131-40.

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Pichichero ME, Gooch WM. Comparison of cefdinir and penicillin V in the treatment of pediatric streptococcal tonsillopharyngitis. Pediatr Infect Dis J. 2000 Dec; 19(12 Suppl):S171-3.

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Lee LH, Ayoub E, Pichichero ME. Fewer symptoms occur in same-serotype recurrent streptococcal tonsillopharyngitis. Arch Otolaryngol Head Neck Surg. 2000 Nov; 126(11):1359-62.

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Lee LH, Pichichero ME. Costs of illness due to Bordetella pertussis in families. Arch Fam Med. 2000 Nov-Dec; 9(10):989-96.

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Hoe NP, Kordari P, Cole R, Liu M, Palzkill T, Huang W, McLellan D, Adams GJ, Hu M, Vuopio-Varkila J, Cate TR, Pichichero ME, Edwards KM, Eskola J, Low DE, Musser JM. Human immune response to streptococcal inhibitor of complement, a serotype M1 group A Streptococcus extracellular protein involved in epidemics. J Infect Dis. 2000 Nov; 182(5):1425-36.

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Pichichero ME. Judicious use of antibiotics in pediatric respiratory infections 2000. Pediatr Infect Dis J. 2000 Sep; 19(9):909-10.

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Pichichero ME. Recurrent and persistent otitis media. Pediatr Infect Dis J. 2000 Sep; 19(9):911-6.

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Pichichero ME. Short course antibiotic therapy for respiratory infections: a review of the evidence. Pediatr Infect Dis J. 2000 Sep; 19(9):929-37.

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Pichichero ME, Casey JR, Mayes T, Francis AB, Marsocci SM, Murphy AM, Hoeger W. Penicillin failure in streptococcal tonsillopharyngitis: causes and remedies. Pediatr Infect Dis J. 2000 Sep; 19(9):917-23.

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Pichichero ME, Reiner SA, Brook I, Gooch WM, Yamauchi T, Jenkins SG, Sher L. Controversies in the medical management of persistent and recurrent acute otitis media. Recommendations of a clinical advisory committee. Ann Otol Rhinol Laryngol Suppl. 2000 Aug; 183:1-12.

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Pichichero ME. Eradication of group A streptococci. Pediatrics. 2000 Aug; 106(2 Pt 1):380-2.

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Anderson P, Ingram DL, Pichichero ME, Peter G. A high degree of natural immunologic priming to the capsular polysaccharide may not prevent Haemophilus influenzae type b meningitis. Pediatr Infect Dis J. 2000 Jul; 19(7):589-91.

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Rennels MB, Englund JA, Bernstein DI, Losonsky GA, Anderson EL, Pichichero ME, Munoz FM, Wolff MC. Diminution of the anti-polyribosylribitol phosphate response to a combined diphtheria-tetanus-acellular pertussis/Haemophilus influenzae type b vaccine by concurrent inactivated poliovirus vaccination. Pediatr Infect Dis J. 2000 May; 19(5):417-23.

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Brooks I, Gooch WM, Jenkins SG, Pichichero ME, Reiner SA, Sher L, Yamauchi T. Medical management of acute bacterial sinusitis. Recommendations of a clinical advisory committee on pediatric and adult sinusitis. Ann Otol Rhinol Laryngol Suppl. 2000 May; 182:2-20.

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Pichichero ME. Acute otitis media: part II. Treatment in an era of increasing antibiotic resistance. Am Fam Physician. 2000 Apr 15; 61(8):2410-6.

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Pichichero ME, Green JL, Francis AB, Marsocci SM, Murphy ML. Outcomes after judicious antibiotic use for respiratory tract infections seen in a private pediatric practice. Pediatrics. 2000 Apr; 105(4 Pt 1):753-9.

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Pichichero ME. Acute otitis media: Part I. Improving diagnostic accuracy. Am Fam Physician. 2000 Apr 1; 61(7):2051-6.

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Novotny LA, Jurcisek JA, Pichichero ME, Bakaletz LO. Epitope mapping of the outer membrane protein P5-homologous fimbrin adhesin of nontypeable Haemophilus influenzae. Infect Immun. 2000 Apr; 68(4):2119-28.

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Pichichero ME. New combination vaccines. Pediatr Clin North Am. 2000 Apr; 47(2):407-26.

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Rennels MB, Deloria MA, Pichichero ME, Losonsky GA, Englund JA, Meade BD, Anderson EL, Steinhoff MC, Edwards KM. Extensive swelling after booster doses of acellular pertussis-tetanus-diphtheria vaccines. Pediatrics. 2000 Jan; 105(1):e12.

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Pichichero ME, Edwards KM, Anderson EL, Rennels MB, Englund JA, Yerg DE, Blackwelder WC, Jansen DL, Meade BD. Safety and immunogenicity of six acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fifth dose in four- to six-year-old children. Pediatrics. 2000 Jan; 105(1):e11.

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Pichichero ME. Understanding antibiotic overuse for respiratory tract infections in children. Pediatrics. 1999 Dec; 104(6):1384-8.

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Pichichero ME, Voloshen T, Passador S. Kinetics of booster responses to Haemophilus influenzae type B conjugate after combined diphtheria-tetanus-acelluar pertussis-Haemophilus influenzae type b vaccination in infants. Pediatr Infect Dis J. 1999 Dec; 18(12):1106-8.

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Pichichero ME, Voloshen T, Zajac D, Passador S. Avidity maturation of antibody to Haemophilus influenzae type b (Hib) after immunization with diphtheria-tetanus-acellular pertussis-hib-hepatitis B combined vaccine in infants. J Infect Dis. 1999 Oct; 180(4):1390-3.

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Block SL, Pichichero ME, McLinn S, Aronovitz G, Kimball S. Spectral gradient acoustic reflectometry: detection of middle ear effusion in suppurative acute otitis media. Pediatr Infect Dis J. 1999 Aug; 18(8):741-4.

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Pichichero M. Cost-effective management of sore throat: it depends on the perspective. Arch Pediatr Adolesc Med. 1999 Jul; 153(7):672-4.

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Pichichero ME, Hoeger W, Marsocci SM, Murphy AM, Francis AB, Dragalin V. Variables influencing penicillin treatment outcome in streptococcal tonsillopharyngitis. Arch Pediatr Adolesc Med. 1999 Jun; 153(6):565-70.

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Pichichero ME, Marsocci SM, Murphy ML, Hoeger W, Green JL, Sorrento A. Incidence of streptococcal carriers in private pediatric practice. Arch Pediatr Adolesc Med. 1999 Jun; 153(6):624-8.

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Pichichero ME, McLinn S, Rotbart HA, Menegus MA, Cascino M, Reidenberg BE. Clinical and economic impact of enterovirus illness in private pediatric practice. Pediatrics. 1998 Nov; 102(5):1126-34.

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Pichichero ME, Green JL, Francis AB, Marsocci SM, Murphy AM, Hoeger W, Noriega C, Sorrento A, Gootnick J. Recurrent group A streptococcal tonsillopharyngitis. Pediatr Infect Dis J. 1998 Sep; 17(9):809-15.

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Pichichero ME. Group A beta-hemolytic streptococcal infections. Pediatr Rev. 1998 Sep; 19(9):291-302.

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Pichichero ME. Cefprozil and respiratory tract infections in children. Pediatr Infect Dis J. 1998 Aug; 17(8 Suppl):S53-4.

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Pichichero ME. Changing the treatment paradigm for acute otitis media in children. JAMA. 1998 Jun 3; 279(21):1748-50.

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Block SL, Mandel E, McLinn S, Pichichero ME, Bernstein S, Kimball S, Kozikowski J. Spectral gradient acoustic reflectometry for the detection of middle ear effusion by pediatricians and parents. Pediatr Infect Dis J. 1998 Jun; 17(6):560-4; discussion 580.

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Khalak R, Pichichero ME, D'Angio CT. Three-year follow-up of vaccine response in extremely preterm infants. Pediatrics. 1998 Apr; 101(4 Pt 1):597-603.

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Pichichero ME, Porcelli S, Treanor J, Anderson P. Serum antibody responses of weanling mice and two-year-old children to pneumococcal-type 6A-protein conjugate vaccines of differing saccharide chain lengths. Vaccine. 1998 Jan; 16(1):83-91.

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Pichichero ME, Pichichero DM. Diagnosis of penicillin, amoxicillin, and cephalosporin allergy: reliability of examination assessed by skin testing and oral challenge. J Pediatr. 1998 Jan; 132(1):137-43.

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Pichichero ME, Passador S. Administration of combined diphtheria and tetanus toxoids and pertussis vaccine, hepatitis B vaccine, and Haemophilus influenzae type b (Hib) vaccine to infants and response to a booster dose of Hib conjugate vaccine. Clin Infect Dis. 1997 Dec; 25(6):1378-84.

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Pichichero ME, Deloria MA, Rennels MB, Anderson EL, Edwards KM, Decker MD, Englund JA, Steinhoff MC, Deforest A, Meade BD. A safety and immunogenicity comparison of 12 acellular pertussis vaccines and one whole-cell pertussis vaccine given as a fourth dose in 15- to 20-month-old children. Pediatrics. 1997 Nov; 100(5):772-88.

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Pichichero ME, Latiolais T, Bernstein DI, Hosbach P, Christian E, Vidor E, Meschievitz C, Daum RS. Vaccine antigen interactions after a combination diphtheria-tetanus toxoid-acellular pertussis/purified capsular polysaccharide of Haemophilus influenzae type b-tetanus toxoid vaccine in two-, four- and six-month-old infants. Pediatr Infect Dis J. 1997 Sep; 16(9):863-70.

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Pichichero ME, Cohen R. Shortened course of antibiotic therapy for acute otitis media, sinusitis and tonsillopharyngitis. Pediatr Infect Dis J. 1997 Jul; 16(7):680-95.

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Pichichero ME, McLinn S, Aronovitz G, Fiddes R, Blumer J, Nelson K, Dashefsky B. Cefprozil treatment of persistent and recurrent acute otitis media. Pediatr Infect Dis J. 1997 May; 16(5):471-8.

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Pichichero ME. Empiric antibiotic selection criteria for respiratory infections in pediatric practice. Pediatr Infect Dis J. 1997 Mar; 16(3 Suppl):S60-4.

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Pichichero ME, Shelly MA, Treanor JJ. Evaluation of a pentavalent conjugated pneumococcal vaccine in toddlers. Pediatr Infect Dis J. 1997 Jan; 16(1):72-4.

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Shelly MA, Jacoby H, Riley GJ, Graves BT, Pichichero M, Treanor JJ. Comparison of pneumococcal polysaccharide and CRM197-conjugated pneumococcal oligosaccharide vaccines in young and elderly adults. Infect Immun. 1997 Jan; 65(1):242-7.

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Pichichero ME, Treanor J. Economic impact of pertussis. Arch Pediatr Adolesc Med. 1997 Jan; 151(1):35-40.

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Tack KJ, Hedrick JA, Rothstein E, Nemeth MA, Keyserling C, Pichichero ME. A study of 5-day cefdinir treatment for streptococcal pharyngitis in children. Cefdinir Pediatric Pharyngitis Study Group. Arch Pediatr Adolesc Med. 1997 Jan; 151(1):45-9.

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Pichichero ME. Sore throat after sore throat after sore throat. Are you asking the critical questions? Postgrad Med. 1997 Jan; 101(1):205-6, 209-12, 215-8, passim.

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Pichichero ME. Streptococcal pharyngitis: is penicillin still the right choice? Compr Ther. 1996 Dec; 22(12):782-7.

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Pichichero ME. Acellular pertussis vaccines. Towards an improved safety profile. Drug Saf. 1996 Nov; 15(5):311-24.

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Clark HF, Offit PA, Ellis RW, Eiden JJ, Krah D, Shaw AR, Pichichero M, Treanor JJ, Borian FE, Bell LM, Plotkin SA. The development of multivalent bovine rotavirus (strain WC3) reassortant vaccine for infants. J Infect Dis. 1996 Sep; 174 Suppl 1:S73-80.

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Pichichero ME, Green JL, Francis AB, Marsocci SM, Murphy AM, Buscarino C. Antibody response and reactions to completion of a four-dose series with a two- or three-component acellular pertussis vaccine compared to whole cell pertussis vaccine. Scand J Infect Dis. 1996; 28(2):159-63.

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Rennels MB, Glass RI, Dennehy PH, Bernstein DI, Pichichero ME, Zito ET, Mack ME, Davidson BL, Kapikian AZ. Safety and efficacy of high-dose rhesus-human reassortant rotavirus vaccines--report of the National Multicenter Trial. United States Rotavirus Vaccine Efficacy Group. Pediatrics. 1996 Jan; 97(1):7-13.

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Clark HF, Offit PA, Ellis RW, Krah D, Shaw AR, Eiden JJ, Pichichero M, Treanor JJ. WC3 reassortant vaccines in children. Arch Virol Suppl. 1996; 12:187-98.

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Bernstein HH, Rothstein EP, Pichichero ME, Green JL, Reisinger KS, Blatter MM, Halpern J, Arbeter AM, Bernstein DI, Smith V, et al. Reactogenicity and immunogenicity of a three-component acellular pertussis vaccine administered as the primary series to 2, 4 and 6 month old infants in the United States. Vaccine. 1995 Dec; 13(17):1631-5.

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Pichichero ME. Resistant respiratory pathogens and extended-spectrum antibiotics. Am Fam Physician. 1995 Nov 1; 52(6):1739-46.

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Pichichero ME, Christy C, Decker MD, Steinhoff MC, Edwards KM, Rennels MB, Anderson EL, Englund JA. Defining the key parameters for comparing reactions among acellular and whole-cell pertussis vaccines. Pediatrics. 1995 Sep; 96(3 Pt 2):588-92.

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Steinhoff MC, Reed GF, Decker MD, Edwards KM, Englund JA, Pichichero ME, Rennels MB, Anderson EL, Deloria MA, Meade BD. A randomized comparison of reactogenicity and immunogenicity of two whole-cell pertussis vaccines. Pediatrics. 1995 Sep; 96(3 Pt 2):567-70.

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Deloria MA, Blackwelder WC, Decker MD, Englund JA, Steinhoff MC, Pichichero ME, Rennels MB, Anderson EL, Edwards KM. Association of reactions after consecutive acellular or whole-cell pertussis vaccine immunizations. Pediatrics. 1995 Sep; 96(3 Pt 2):592-4.

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Decker MD, Edwards KM, Steinhoff MC, Rennels MB, Pichichero ME, Englund JA, Anderson EL, Deloria MA, Reed GF. Comparison of 13 acellular pertussis vaccines: adverse reactions. Pediatrics. 1995 Sep; 96(3 Pt 2):557-66.

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Englund JA, Anderson EL, Reed GF, Decker MD, Edwards KM, Pichichero ME, Steinhoff MC, Rennels MB, Deforest A, Meade BD. The effect of maternal antibody on the serologic response and the incidence of adverse reactions after primary immunization with acellular and whole-cell pertussis vaccines combined with diphtheria and tetanus toxoids. Pediatrics. 1995 Sep; 96(3 Pt 2):580-4.

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Christy C, Pichichero ME, Reed GF, Decker MD, Anderson EL, Rennels MB, Englund JA, Edwards KM, Steinhoff MC. Effect of gender, race, and parental education on immunogenicity and reported reactogenicity of acellular and whole-cell pertussis vaccines. Pediatrics. 1995 Sep; 96(3 Pt 2):584-7.

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Edwards KM, Meade BD, Decker MD, Reed GF, Rennels MB, Steinhoff MC, Anderson EL, Englund JA, Pichichero ME, Deloria MA. Comparison of 13 acellular pertussis vaccines: overview and serologic response. Pediatrics. 1995 Sep; 96(3 Pt 2):548-57.

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Rennels MB, Reed GF, Decker MD, Edwards KM, Pichichero ME, Deloria MA, Englund JA, Anderson EL, Steinhoff MC, Deforest A, et al. Simultaneous administration of Haemophilus influenzae type b vaccine with acellular or whole-cell pertussis vaccine: effects on reactogenicity and immune responses to pertussis vaccines. Pediatrics. 1995 Sep; 96(3 Pt 2):576-9.

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Pichichero ME, Mclinn SE, Gooch WM, Rodriguez W, Goldfarb J, Reidenberg BE. Ceftibuten vs. penicillin V in group A beta-hemolytic streptococcal pharyngitis. Members of the Ceftibuten Pharyngitis International Study Group. Pediatr Infect Dis J. 1995 Jul; 14(7 Suppl):S102-7.

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Mclinn SE, Mccarty JM, Perrotta R, Pichichero ME, Reidenberg BE. Multicenter controlled trial comparing ceftibuten with amoxicillin/clavulanate in the empiric treatment of acute otitis media. Members of the Ceftibuten Otitis Media United States Study Group. Pediatr Infect Dis J. 1995 Jul; 14(7 Suppl):S108-14.

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D'Angio CT, Maniscalco WM, Pichichero ME. Immunologic response of extremely premature infants to tetanus, Haemophilus influenzae, and polio immunizations. Pediatrics. 1995 Jul; 96(1 Pt 1):18-22.

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Treanor JJ, Clark HF, Pichichero M, Christy C, Gouvea V, Shrager D, Palazzo S, Offit P. Evaluation of the protective efficacy of a serotype 1 bovine-human rotavirus reassortant vaccine in infants. Pediatr Infect Dis J. 1995 Apr; 14(4):301-7.

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Pichichero ME, Pichichero CL. Persistent acute otitis media: I. Causative pathogens. Pediatr Infect Dis J. 1995 Mar; 14(3):178-83.

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Pichichero ME, Pichichero CL. Persistent acute otitis media: II. Antimicrobial treatment. Pediatr Infect Dis J. 1995 Mar; 14(3):183-8.

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Pichichero ME. Group A streptococcal tonsillopharyngitis: cost-effective diagnosis and treatment. Ann Emerg Med. 1995 Mar; 25(3):390-403.

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Pichichero ME. Empiric antibiotic treatment of acute bacterial infections of the lower respiratory tract in children in an era of changing etiology. Pediatr Pulmonol Suppl. 1995; 11:12-3.

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Pichichero ME, Gooch WM, Rodriguez W, Blumer JL, Aronoff SC, Jacobs RF, Musser JM. Effective short-course treatment of acute group A beta-hemolytic streptococcal tonsillopharyngitis. Ten days of penicillin V vs 5 days or 10 days of cefpodoxime therapy in children. Arch Pediatr Adolesc Med. 1994 Oct; 148(10):1053-60.

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Annunziato PW, Rothstein EP, Bernstein HH, Blatter MM, Reisinger KS, Pichichero ME. Comparison of a three-component acellular pertussis vaccine with a whole-cell pertussis vaccine in 4- through 6-year-old children. Elmwood Pediatric Associates, Pennridge Pediatric Associates. Arch Pediatr Adolesc Med. 1994 May; 148(5):503-7.

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Pichichero ME, Green JL, Francis AB, Marsocci SM, Lynd AM, Litteer T. Comparison of a three-component acellular pertussis vaccine with whole cell pertussis vaccine in two-month-old children. Pediatr Infect Dis J. 1994 Mar; 13(3):193-6.

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Insel RA, Amstey M, Woodin K, Pichichero M. Maternal immunization to prevent infectious diseases in the neonate or infant. Int J Technol Assess Health Care. 1994; 10(1):143-53.

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Englund JA, Decker MD, Edwards KM, Pichichero ME, Steinhoff MC, Anderson EL. Acellular and whole-cell pertussis vaccines as booster doses: a multicenter study. Pediatrics. 1994 Jan; 93(1):37-43.

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Pichichero ME. Assessing the treatment alternatives for acute otitis media. Pediatr Infect Dis J. 1994 Jan; 13(1 Suppl 1):S27-34; discussion S50-4.

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Pichichero ME. Recurrent streptococcal pharyngitis: indications for tonsillectomy and penicillin prophylaxis. Pediatr Infect Dis J. 1994 Jan; 13(1):83-4.

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Rodewald LE, Pichichero ME. Compliance with antibiotic therapy: a comparison of deuterium oxide tracer, urine bioassay, bottle weights, and parental reports. J Pediatr. 1993 Jul; 123(1):143-7.

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Pichichero ME, Francis AB, Marsocci SM, Green JL, Disney FA, Meschievitz C. Safety and immunogenicity of an acellular pertussis vaccine booster in 15- to 20-month-old children previously immunized with acellular or whole-cell pertussis vaccine as infants. Pediatrics. 1993 Apr; 91(4):756-60.

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Pichichero ME. Cephalosporins are superior to penicillin for treatment of streptococcal tonsillopharyngitis: is the difference worth it? Pediatr Infect Dis J. 1993 Apr; 12(4):268-74.

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Pichichero ME, Francis AB, Marsocci SM, Green JL, Disney FA. Comparison of a diphtheria and tetanus toxoids and bicomponent acellular pertussis vaccine with diphtheria and tetanus toxoids and whole-cell pertussis vaccine in infants. Am J Dis Child. 1993 Mar; 147(3):295-9.

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Gooch WM, McLinn SE, Aronovitz GH, Pichichero ME, Kumar A, Kaplan EL, Ossi MJ. Efficacy of cefuroxime axetil suspension compared with that of penicillin V suspension in children with group A streptococcal pharyngitis. Antimicrob Agents Chemother. 1993 Feb; 37(2):159-63.

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Pichichero ME, Marsocci SM, Francis AB, Green JL, Disney FA, Rennels MB, Lewis ED, Sugarman L, Losonsky GA, Zito E, et al. A comparative evaluation of the safety and immunogenicity of a single dose of unbuffered oral rhesus rotavirus serotype 3, rhesus/human reassortant serotypes 1, 2 and 4 and combined (tetravalent) vaccines in healthy infants. Vaccine. 1993; 11(7):747-53.

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Harrison CJ, Chartrand SA, Pichichero ME. Microbiologic and clinical aspects of a trial of once daily cefixime compared with twice daily cefaclor for treatment of acute otitis media in infants and children. Pediatr Infect Dis J. 1993 Jan; 12(1):62-9.

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Pichichero ME, Losonsky GA. Asymptomatic infections due to wild-type rotavirus may prime for a heterotypic response to vaccination with rhesus rotavirus. Clin Infect Dis. 1993 Jan; 16(1):86-92.

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Pichichero ME. The development of immunity sequelae or the carrier state following streptococcal pharyngitis. Pediatr Ann. 1992 Dec; 21(12):829-34.

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Pichichero ME, Disney FA, Green JL, Francis AB, Marsocci SM, Lynd AM, Wood GC. Comparative reliability of clinical, culture, and antigen detection methods for the diagnosis of group A beta-hemolytic streptococcal tonsillopharyngitis. Pediatr Ann. 1992 Dec; 21(12):798-805.

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Pichichero ME. Explanations and therapies for penicillin failure in streptococcal pharyngitis. Clin Pediatr (Phila). 1992 Nov; 31(11):642-9.

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Anderson P, Porcelli S, Pichichero M. Natural maternal and cord serum antibodies to pneumococcal serotypes 6A, 14, 19F and 23F polysaccharides. Pediatr Infect Dis J. 1992 Aug; 11(8):677-9.

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Madore HP, Christy C, Pichichero M, Long C, Pincus P, Vosefsky D, Kapikian AZ, Dolin R. Field trial of rhesus rotavirus or human-rhesus rotavirus reassortant vaccine of VP7 serotype 3 or 1 specificity in infants. The Elmwood, Panorama, and Westfall Pediatric Groups. J Infect Dis. 1992 Aug; 166(2):235-43.

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Anderson P, Porcelli S, Pichichero ME. Effect of phosphate ester residues on the immunogenicity of CRM197-coupled Haemophilus influenzae type b capsular saccharides in 2-month-old infants. J Infect Dis. 1992 Jun; 165 Suppl 1:S160-1.

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Rimer HC, Wasserman SS, Flores J, Pichichero ME, Losonsky GA. Rotavirus-specific breast milk antibody in two populations and possible correlates of interference with rhesus rotavirus vaccine seroconversion. J Infect Dis. 1992 May; 165(5):826-30.

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Bernstein HH, Rothstein EP, Pichichero ME, Francis AB, Kovel AJ, Disney FA, Green JL, Marsocci SM, Lynd AM, Wood GC, et al. Clinical reactions and immunogenicity of the BIKEN acellular diphtheria and tetanus toxoids and pertussis vaccine in 4- through 6-year-old US children. Am J Dis Child. 1992 May; 146(5):556-9.

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Pichichero ME, Francis AB, Blatter MM, Reisinger KS, Green JL, Marsocci SM, Disney FA. Acellular pertussis vaccination of 2-month-old infants in the United States. Pediatrics. 1992 May; 89(5 Pt 1):882-7.

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Musser JM, Gray BM, Schlievert PM, Pichichero ME. Streptococcus pyogenes pharyngitis: characterization of strains by multilocus enzyme genotype, M and T protein serotype, and pyrogenic exotoxin gene probing. J Clin Microbiol. 1992 Mar; 30(3):600-3.

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Pichichero ME. Culture and antigen detection tests for streptococcal tonsillopharyngitis. Am Fam Physician. 1992 Jan; 45(1):199-205.

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Pichichero ME. The rising incidence of penicillin treatment failures in group A streptococcal tonsillopharyngitis: an emerging role for the cephalosporins? Pediatr Infect Dis J. 1991 Oct; 10(10 Suppl):S50-5.

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Pichichero ME, Margolis PA. A comparison of cephalosporins and penicillins in the treatment of group A beta-hemolytic streptococcal pharyngitis: a meta-analysis supporting the concept of microbial copathogenicity. Pediatr Infect Dis J. 1991 Apr; 10(4):275-81.

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Pichichero ME, Green JL, Francis AB, Marsocci SM, Disney FA. New vaccines and vaccination policies. Pediatr Ann. 1990 Dec; 19(12):686-8, 690-1, 694.

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Pichichero ME. Controversies in the treatment of streptococcal pharyngitis. Am Fam Physician. 1990 Dec; 42(6):1567-76.

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Pichichero M, Aronovitz GH, Gooch WM, McLinn SE, Maddern B, Johnson C, Darden PM. Comparison of cefuroxime axetil, cefaclor, and amoxicillin-clavulanate potassium suspensions in acute otitis media in infants and children. South Med J. 1990 Oct; 83(10):1174-7.

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Pichichero ME. Effect of breast-feeding on oral rhesus rotavirus vaccine seroconversion: a metaanalysis. J Infect Dis. 1990 Sep; 162(3):753-5.

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Pichichero ME, Losonsky GA, Rennels MB, Disney FA, Green JL, Francis AB, Marsocci SM. Effect of dose and a comparison of measures of vaccine take for oral rhesus rotavirus vaccine. The Maryland Clinical Studies Group. Pediatr Infect Dis J. 1990 May; 9(5):339-44.

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Margolis PA, Litteer T, Hare N, Pichichero M. Effects of unrestricted diet on mild infantile diarrhea. A practice-based study. Am J Dis Child. 1990 Feb; 144(2):162-4.

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Pichichero ME, Berghash LR, Hengerer AS. Anatomic and audiologic sequelae after tympanostomy tube insertion or prolonged antibiotic therapy for otitis media. Pediatr Infect Dis J. 1989 Nov; 8(11):780-7.

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Anderson PW, Pichichero ME, Stein EC, Porcelli S, Betts RF, Connuck DM, Korones D, Insel RA, Zahradnik JM, Eby R. Effect of oligosaccharide chain length, exposed terminal group, and hapten loading on the antibody response of human adults and infants to vaccines consisting of Haemophilus influenzae type b capsular antigen unterminally coupled to the diphtheria protein CRM197. J Immunol. 1989 Apr 1; 142(7):2464-8.

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Anderson P, Pichichero ME. Haemophilus influenzae type b vaccine. Pediatrics. 1989 Jan; 83(1):145-6.

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Pichichero ME, Bracikowski A, Sullivan R, Madore D, Anderson P. Haemophilus influenzae b polysaccharide revaccination: a continued role for the unconjugated vaccine. Pediatr Infect Dis J. 1989 Jan; 8(1):20-3.

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Christy C, Madore HP, Pichichero ME, Gala C, Pincus P, Vosefski D, Hoshino Y, Kapikian A, Dolin R. Field trial of rhesus rotavirus vaccine in infants. Pediatr Infect Dis J. 1988 Sep; 7(9):645-50.

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Anderson P, Pichichero M, Edwards K, Porch CR, Insel R. Priming and induction of Haemophilus influenzae type b capsular antibodies in early infancy by Dpo20, an oligosaccharide-protein conjugate vaccine. J Pediatr. 1987 Nov; 111(5):644-50.

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Pichichero ME, Disney FA, Aronovitz GH, Ginsburg C, Stillerman M. A multicenter, randomized, single-blind evaluation of cefuroxime axetil and phenoxymethyl penicillin in the treatment of streptococcal pharyngitis. Clin Pediatr (Phila). 1987 Sep; 26(9):453-8.

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Pichichero ME, Disney FA, Talpey WB, Green JL, Francis AB, Roghmann KJ, Hoekelman RA. Adverse and beneficial effects of immediate treatment of Group A beta-hemolytic streptococcal pharyngitis with penicillin. Pediatr Infect Dis J. 1987 Jul; 6(7):635-43.

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Pichichero ME, Disney FA, Aronovitz GH, Talpey WB, Green JL, Francis AB. Randomized, single-blind evaluation of cefadroxil and phenoxymethyl penicillin in the treatment of streptococcal pharyngitis. Antimicrob Agents Chemother. 1987 Jun; 31(6):903-6.

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Pichichero ME, Badgett JT, Rodgers GC, McLinn S, Trevino-Scatterday B, Nelson JD. Acellular pertussis vaccine: immunogenicity and safety of an acellular pertussis vs. a whole cell pertussis vaccine combined with diphtheria and tetanus toxoids as a booster in 18- to 24-month old children. Pediatr Infect Dis J. 1987 Apr; 6(4):352-63.

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Anderson PW, Pichichero ME, Insel RA, Betts R, Eby R, Smith DH. Vaccines consisting of periodate-cleaved oligosaccharides from the capsule of Haemophilus influenzae type b coupled to a protein carrier: structural and temporal requirements for priming in the human infant. J Immunol. 1986 Aug 15; 137(4):1181-6.

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Pichichero ME, Barkin RM, Samuelson JS. Pediatric diphtheria and tetanus toxoids-adsorbed vaccine: immune response to the first booster following the diphtheria and tetanus toxoids vaccine primary series. Pediatr Infect Dis. 1986 Jul-Aug; 5(4):428-30.

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Amstey MS, Insel R, Munoz J, Pichichero M. Fetal-neonatal passive immunization against Hemophilus influenzae, type b. Am J Obstet Gynecol. 1985 Nov 15; 153(6):607-11.

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Pichichero M, Anderson P, Gotschlich E, Kamm J, McMullen A, Nielsen S. Immunogenicity of O-acetyl-negative and -positive polysaccharide vaccines for infections with Neisseria meningitidis group C in infants. J Infect Dis. 1985 Oct; 152(4):850-1.

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Anderson P, Pichichero M, Insel R, Farsad P, Santosham M. Capsular antigens noncovalently or covalently associated with protein as vaccines to Haemophilus influenzae type b: comparison in two-year-old children. J Infect Dis. 1985 Sep; 152(3):634-6.

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Anderson P, Pichichero ME, Insel RA. Immunization of 2-month-old infants with protein-coupled oligosaccharides derived from the capsule of Haemophilus influenzae type b. J Pediatr. 1985 Sep; 107(3):346-51.

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Pichichero ME. Immunological paralysis to pneumococcal polysaccharide in man. Lancet. 1985 Aug 31; 2(8453):468-71.

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Insel RA, Amstey M, Pichichero ME. Postimmunization antibody to the Haemophilus influenzae type b capsule in breast milk. J Infect Dis. 1985 Aug; 152(2):407-8.

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Anderson P, Pichichero ME, Insel RA. Immunogens consisting of oligosaccharides from the capsule of Haemophilus influenzae type b coupled to diphtheria toxoid or the toxin protein CRM197. J Clin Invest. 1985 Jul; 76(1):52-9.

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Anderson PW, Pichichero ME, Connor EM. Enhanced nasopharyngeal colonization of rats by piliated Haemophilus influenzae type b. Infect Immun. 1985 May; 48(2):565-8.

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Barkin RM, Pichichero ME, Samuelson JS, Barkin SZ. Pediatric diphtheria and tetanus toxoids vaccine: clinical and immunologic response when administered as the primary series. J Pediatr. 1985 May; 106(5):779-81.

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Redmond SR, Pichichero ME. Hemophilus influenzae type b disease. An epidemiologic study with special reference to day-care centers. JAMA. 1984 Nov 9; 252(18):2581-4.

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Inzana TJ, Pichichero ME. Lipopolysaccharide subtypes of Haemophilus influenzae type b from an outbreak of invasive disease. J Clin Microbiol. 1984 Aug; 20(2):145-50.

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Pichichero ME. Adherence of Haemophilus influenzae to human buccal and pharyngeal epithelial cells: relationship to pilation. J Med Microbiol. 1984 Aug; 18(1):107-16.

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Amstey MS, Insel RA, Pichichero ME. Neonatal passive immunization by maternal vaccination. Obstet Gynecol. 1984 Jan; 63(1):105-9.

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Pichichero ME, Insel RA. Mucosal antibody response to parenteral vaccination with Haemophilus influenzae type b capsule. J Allergy Clin Immunol. 1983 Nov; 72(5 Pt 1):481-6.

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Disney FA, Pichichero ME. Treatment of Staphylococcus aureus infections in children in office practice. Am J Dis Child. 1983 Apr; 137(4):361-4.

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Pichichero ME, Loeb M. Do pili play a role in pathogenicity of Haemophilus influenzae type B? Lancet. 1982 Oct 30; 2(8305):960-2.

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Pichichero ME, Insel RA. Relationship between naturally occurring human mucosal and serum antibody to the capsular polysaccharide of Haemophilus influenzae type b. J Infect Dis. 1982 Aug; 146(2):243-8.

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Pichichero ME, Friesen HA. Polymicrobial osteomyelitis: report of three cases and review of the literature. Rev Infect Dis. 1982 Jan-Feb; 4(1):86-96.

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Gray BM, Converse GM, Huhta N, Johnston RB, Pichichero ME, Schiffman G, Dillon HC. Epidemiologic studies of Streptococcus pneumoniae in infants: antibody response to nasopharyngeal carriage of types 3, 19, and 23. J Infect Dis. 1981 Oct; 144(4):312-8.

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Pichichero ME, Hall CB, Insel RA. A mucosal antibody response following systemic Haemophilus influenzae type B infection in children. J Clin Invest. 1981 May; 67(5):1482-9.

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Pichichero ME, Sommerfelt AE, Steinhoff MC, Insel RA. Breast milk antibody to the capsular polysaccharide of Haemophilus influenzae type b. J Infect Dis. 1980 Nov; 142(5):694-8.

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Pichichero ME, Todd JK. Detection of neonatal bacteremia. J Pediatr. 1979 Jun; 94(6):958-60.

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Barkin RM, Pichichero ME. Diphtheria-pertussis-tetanus vaccine: reactogenicity of commercial products. Pediatrics. 1979 Feb; 63(2):256-60.

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Pichichero ME, McCabe ER. Recurrent Reye's syndrome. Am J Dis Child. 1978 Nov; 132(11):1097-9.

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Pichichero M, Beer B, Clody DE. Effects of dibutyryl cyclic AMP on restoration of function of damaged sciatic nerve in rats. Science. 1973 Nov 16; 182(113):724-5.

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Pichichero ME, Avers CJ. The evolution of cellular movement in eukaryotes: the role of microfilaments and microtubules. Subcell Biochem. 1973 Jan; 2(1):97-105.

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Roisen FJ, Murphy RA, Pichichero ME, Braden WG. Cyclic adenosine monophosphate stimulation of axonal elongation. Science. 1972 Jan 7; 175(17):73-4.

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Pretlow TG, Pichichero ME, Hyams L. Separation of lymphocytes and macrophages from suspensions of guinea pig peritonitis exudate cells using programmed gradient sedimentation. Am J Pathol. 1971 May; 63(2):255-76.

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