Kate Ackerman
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 703
Rochester NY 14642
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| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Genetics |
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| 1991 |
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| 1995 | Dean's Letters of Commendation | University at Buffalo School of Medicine | | 1992 |
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| Honors Poster Award | University at Buffalo School of Medicine | | 1995 |
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| Glascow Award | | 1995 |
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| Association of Pathology Chairs Honor Society | | 1995 |
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| Honors and Distinction in Research | | 1995 |
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| Thesis Honors | | 2002 |
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| Children's Hospital Fellow Research Award | | 2005 |
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| Children's Hospital Faculty Development Award/Eleanor and Miles Shore Scholar | | 2006 |
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| Harvard Medical School Leadership Development for Physicians and Scientists | Harvard Medical School | | 2008 |
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| 2009 | Henry C. and Bertha H. Buswell Fellow | University of Rochester |
Congenital Diaphragmatic Hernia (CDH) is a relatively common birth defect that results in a high rate of neonatal illness or death. The focus of Dr. Ackerman's laboratory is to identify genes that are necessary for development of the diaphragm and the lung.
Current research projects include:
- To identify mechnisms and pathway genes in Fog2 mediated diaphragm development and Fog2 mediated pulmonary lobar braching
-To investigate mechanisms of development in Barx1 homeobox gene associated posterior medical diaphragmatic hernia.
_To develop models for conditional deletion of genes on mesenchymal tissue of the diaphragm
-To develop new models of abnormal diaphragm and lung development from forward genetic screening
-To characterize human diaphragmatic defects and translate findings in animal models to the human disease with the hopes of modulating outcome in fetuses and neonates with congenital diaphragmatic defects
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Coles GL, Ackerman KG. Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia. Proc Natl Acad Sci U S A. 2013 May 21; 110(21):E1898-905.
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Ackerman KG, Vargas SO, Wilson JA, Jennings RW, Kozakewich HP, Pober BR. Congenital diaphragmatic defects: proposal for a new classification based on observations in 234 patients. Pediatr Dev Pathol. 2012 Jul-Aug; 15(4):265-74.
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Russell MK, Longoni M, Wells J, Maalouf FI, Tracy AA, Loscertales M, Ackerman KG, Pober BR, Lage K, Bult CJ, Donahoe PK. Congenital diaphragmatic hernia candidate genes derived from embryonic transcriptomes. Proc Natl Acad Sci U S A. 2012 Feb 21; 109(8):2978-83.
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Cozzi E, Ackerman KG, Lundequist A, Drazen JM, Boyce JA, Beier DR. The naive airway hyperresponsiveness of the A/J mouse is Kit-mediated. Proc Natl Acad Sci U S A. 2011 Aug 2; 108(31):12787-92.
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Kantarci S, Ackerman KG, Russell MK, Longoni M, Sougnez C, Noonan KM, Hatchwell E, Zhang X, Pieretti Vanmarcke R, Anyane-Yeboa K, Dickman P, Wilson J, Donahoe PK, Pober BR. Characterization of the chromosome 1q41q42.12 region, and the candidate gene DISP1, in patients with CDH. Am J Med Genet A. 2010 Oct; 152A(10):2493-504.
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Zhou B, Ma Q, Kong SW, Hu Y, Campbell PH, McGowan FX, Ackerman KG, Wu B, Zhou B, Tevosian SG, Pu WT. Fog2 is critical for cardiac function and maintenance of coronary vasculature in the adult mouse heart. J Clin Invest. 2009 Jun; 119(6):1462-76.
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Stevens TP, van Wijngaarden E, Ackerman KG, Lally PA, Lally KP. Timing of delivery and survival rates for infants with prenatal diagnoses of congenital diaphragmatic hernia. Pediatrics. 2009 Feb; 123(2):494-502.
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Liu X, Ramjiganesh T, Chen YH, Chung SW, Hall SR, Schissel SL, Padera RF, Liao R, Ackerman KG, Kajstura J, Leri A, Anversa P, Yet SF, Layne MD, Perrella MA. Disruption of striated preferentially expressed gene locus leads to dilated cardiomyopathy in mice. Circulation. 2009 Jan 20; 119(2):261-8.
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Ackerman KG, Greer JJ. Development of the diaphragm and genetic mouse models of diaphragmatic defects. Am J Med Genet C Semin Med Genet. 2007 May 15; 145C(2):109-16.
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Ackerman KG, Pober BR. Congenital diaphragmatic hernia and pulmonary hypoplasia: new insights from developmental biology and genetics. Am J Med Genet C Semin Med Genet. 2007 May 15; 145C(2):105-8.
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Ackerman KG, Wang J, Luo L, Fujiwara Y, Orkin SH, Beier DR. Gata4 is necessary for normal pulmonary lobar development. Am J Respir Cell Mol Biol. 2007 Apr; 36(4):391-7.
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Pober BR, Lin A, Russell M, Ackerman KG, Chakravorty S, Strauss B, Westgate MN, Wilson J, Donahoe PK, Holmes LB. Infants with Bochdalek diaphragmatic hernia: sibling precurrence and monozygotic twin discordance in a hospital-based malformation surveillance program. Am J Med Genet A. 2005 Oct 1; 138A(2):81-8.
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Ackerman KG, Herron BJ, Vargas SO, Huang H, Tevosian SG, Kochilas L, Rao C, Pober BR, Babiuk RP, Epstein JA, Greer JJ, Beier DR. Fog2 is required for normal diaphragm and lung development in mice and humans. PLoS Genet. 2005 Jul; 1(1):58-65.
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Ackerman KG, Huang H, Grasemann H, Puma C, Singer JB, Hill AE, Lander E, Nadeau JH, Churchill GA, Drazen JM, Beier DR. Interacting genetic loci cause airway hyperresponsiveness. Physiol Genomics. 2005 Mar 21; 21(1):105-11.
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Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt B, Szczeklik W, Drazen JM, Serhan CN. Lipoxins and aspirin-triggered lipoxins in airway responses. Adv Exp Med Biol. 2003; 525:19-23.
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Levy BD, De Sanctis GT, Devchand PR, Kim E, Ackerman K, Schmidt BA, Szczeklik W, Drazen JM, Serhan CN. Multi-pronged inhibition of airway hyper-responsiveness and inflammation by lipoxin A(4). Nat Med. 2002 Sep; 8(9):1018-23.
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Finotto S, Neurath MF, Glickman JN, Qin S, Lehr HA, Green FH, Ackerman K, Haley K, Galle PR, Szabo SJ, Drazen JM, De Sanctis GT, Glimcher LH. Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet. Science. 2002 Jan 11; 295(5553):336-8.
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MacLean JA, De Sanctis GT, Ackerman KG, Drazen JM, Sauty A, DeHaan E, Green FH, Charo IF, Luster AD. CC chemokine receptor-2 is not essential for the development of antigen-induced pulmonary eosinophilia and airway hyperresponsiveness. J Immunol. 2000 Dec 1; 165(11):6568-75.
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Grover TR, Ackerman KG, Le Cras TD, Jobe AH, Abman SH. Repetitive prenatal glucocorticoids increase lung endothelial nitric oxide synthase expression in ovine fetuses delivered at term. Pediatr Res. 2000 Jul; 48(1):75-83.
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