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Ingrid Sarelius

TitleProfessor (Part-Time)
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester NY 14642
Other Positions
TitleProfessor (Part-Time)
InstitutionSchool of Medicine and Dentistry
DepartmentBiomedical Engineering

 
 Overview
My research focus is on vascular cell communication and signaling. Our lab is specifically interested in how the cells of the blood vessel wall communicate with each other, with the surrounding tissue, and with the blood itself. Basically, we're interested in figuring out how microvessels work! Since cardiovascular disease is a major killer of adult populations, and since much of this is vascular disease or disorder, understanding normal blood vessel function seems like a good place to start.
The major tool that we use to ask our questions is confocal immunofluorescent intravital microscopy; we are one of a handful of labs worldwide that is able to image local events in cells of the vascular wall in real time in blood perfused microvessels in living animals. We also use single microparticle tracking to define the local fluid dynamic environment in vivo, and confocal imaging of signaling molecules and leukocyte populations in the in situ blood vessel.

 
 Selected Publications
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  1. Sumagin R, Sarelius IH. Emerging understanding of roles for arterioles in inflammation. Microcirculation. 2013 Nov; 20(8):679-92.
    View in: PubMed
  2. Corr M, Lerman I, Keubel JM, Ronacher L, Misra R, Lund F, Sarelius IH, Glading AJ. Decreased krev interaction-trapped 1 expression leads to increased vascular permeability and modifies inflammatory responses in vivo. Arterioscler Thromb Vasc Biol. 2012 Nov; 32(11):2702-10.
    View in: PubMed
  3. Hyun YM, Sumagin R, Sarangi PP, Lomakina E, Overstreet MG, Baker CM, Fowell DJ, Waugh RE, Sarelius IH, Kim M. Uropod elongation is a common final step in leukocyte extravasation through inflamed vessels. J Exp Med. 2012 Jul 2; 209(7):1349-62.
    View in: PubMed
  4. Sumagin R, Kuebel JM, Sarelius IH. Leukocyte rolling and adhesion both contribute to regulation of microvascular permeability to albumin via ligation of ICAM-1. Am J Physiol Cell Physiol. 2011 Oct; 301(4):C804-13.
    View in: PubMed
  5. Sumagin R, Prizant H, Lomakina E, Waugh RE, Sarelius IH. LFA-1 and Mac-1 define characteristically different intralumenal crawling and emigration patterns for monocytes and neutrophils in situ. J Immunol. 2010 Dec 1; 185(11):7057-66.
    View in: PubMed
  6. Sumagin R, Sarelius IH. Intercellular adhesion molecule-1 enrichment near tricellular endothelial junctions is preferentially associated with leukocyte transmigration and signals for reorganization of these junctions to accommodate leukocyte passage. J Immunol. 2010 May 1; 184(9):5242-52.
    View in: PubMed
  7. Sarelius I, Pohl U. Control of muscle blood flow during exercise: local factors and integrative mechanisms. Acta Physiol (Oxf). 2010 Aug; 199(4):349-65.
    View in: PubMed
  8. Sumagin R, Lamkin-Kennard KA, Sarelius IH. A separate role for ICAM-1 and fluid shear in regulating leukocyte interactions with straight regions of venular wall and venular convergences. Microcirculation. 2009 Aug; 16(6):508-20.
    View in: PubMed
  9. Lee J, Jirapatnakul AC, Reeves AP, Crowe WE, Sarelius IH. Vessel diameter measurement from intravital microscopy. Ann Biomed Eng. 2009 May; 37(5):913-26.
    View in: PubMed
  10. Sumagin R, Lomakina E, Sarelius IH. Leukocyte-endothelial cell interactions are linked to vascular permeability via ICAM-1-mediated signaling. Am J Physiol Heart Circ Physiol. 2008 Sep; 295(3):H969-H977.
    View in: PubMed
  11. Sumagin R, Brown CW, Sarelius IH, King MR. Microvascular endothelial cells exhibit optimal aspect ratio for minimizing flow resistance. Ann Biomed Eng. 2008 Apr; 36(4):580-5.
    View in: PubMed
  12. Hocking DC, Titus PA, Sumagin R, Sarelius IH. Extracellular matrix fibronectin mechanically couples skeletal muscle contraction with local vasodilation. Circ Res. 2008 Feb 15; 102(3):372-9.
    View in: PubMed
  13. Sumagin R, Sarelius IH. A role for ICAM-1 in maintenance of leukocyte-endothelial cell rolling interactions in inflamed arterioles. Am J Physiol Heart Circ Physiol. 2007 Nov; 293(5):H2786-98.
    View in: PubMed
  14. Huxley VH, Wang JJ, Sarelius IH. Adaptation of coronary microvascular exchange in arterioles and venules to exercise training and a role for sex in determining permeability responses. Am J Physiol Heart Circ Physiol. 2007 Aug; 293(2):H1196-205.
    View in: PubMed
  15. Sumagin R, Sarelius IH. TNF-alpha activation of arterioles and venules alters distribution and levels of ICAM-1 and affects leukocyte-endothelial cell interactions. Am J Physiol Heart Circ Physiol. 2006 Nov; 291(5):H2116-25.
    View in: PubMed
  16. Sarelius IH, Kuebel JM, Wang J, Huxley VH. Macromolecule permeability of in situ and excised rodent skeletal muscle arterioles and venules. Am J Physiol Heart Circ Physiol. 2006 Jan; 290(1):H474-80.
    View in: PubMed
  17. Wojciechowski JC, Sarelius IH. Preferential binding of leukocytes to the endothelial junction region in venules in situ. Microcirculation. 2005 Jun; 12(4):349-59.
    View in: PubMed
  18. Lamkin-Kennard KA, Chuang JY, Kim MB, Sarelius IH, King MR. The distribution of rolling neutrophils in venular convergences. Biorheology. 2005; 42(5):363-83.
    View in: PubMed
  19. Kim MB, Sarelius IH. Role of shear forces and adhesion molecule distribution on P-selectin-mediated leukocyte rolling in postcapillary venules. Am J Physiol Heart Circ Physiol. 2004 Dec; 287(6):H2705-11.
    View in: PubMed
  20. King MR, Bansal D, Kim MB, Sarelius IH. The effect of hematocrit and leukocyte adherence on flow direction in the microcirculation. Ann Biomed Eng. 2004 Jun; 32(6):803-14.
    View in: PubMed
  21. Murrant CL, Duza T, Kim MB, Cohen KD, Sarelius IH. Arteriolar dilations induced by contraction of hamster cremaster muscle are dependent on changes in endothelial cell calcium. Acta Physiol Scand. 2004 Mar; 180(3):231-8.
    View in: PubMed
  22. Duza T, Sarelius IH. Localized transient increases in endothelial cell Ca2+ in arterioles in situ: implications for coordination of vascular function. Am J Physiol Heart Circ Physiol. 2004 Jun; 286(6):H2322-31.
    View in: PubMed
  23. Kim MB, Sarelius IH. Regulation of leukocyte recruitment by local wall shear rate and leukocyte delivery. Microcirculation. 2004 Jan-Feb; 11(1):55-67.
    View in: PubMed
  24. Duza T, Sarelius IH. Increase in endothelial cell Ca(2+) in response to mouse cremaster muscle contraction. J Physiol. 2004 Mar 1; 555(Pt 2):459-69.
    View in: PubMed
  25. King MR, Kim MB, Sarelius IH, Hammer DA. Hydrodynamic interactions between rolling leukocytes in vivo. Microcirculation. 2003 Oct; 10(5):401-9.
    View in: PubMed
  26. Kim MB, Sarelius IH. Distributions of wall shear stress in venular convergences of mouse cremaster muscle. Microcirculation. 2003 Apr; 10(2):167-78.
    View in: PubMed
  27. Duza T, Sarelius IH. Conducted dilations initiated by purines in arterioles are endothelium dependent and require endothelial Ca2+. Am J Physiol Heart Circ Physiol. 2003 Jul; 285(1):H26-37.
    View in: PubMed
  28. Murrant CL, Sarelius IH. Multiple dilator pathways in skeletal muscle contraction-induced arteriolar dilations. Am J Physiol Regul Integr Comp Physiol. 2002 Apr; 282(4):R969-78.
    View in: PubMed
  29. Cohen KD, Sarelius IH. Muscle contraction under capillaries in hamster muscle induces arteriolar dilatation via K(ATP) channels and nitric oxide. J Physiol. 2002 Mar 1; 539(Pt 2):547-55.
    View in: PubMed
  30. Frame MD, Sarelius IH. Flow-induced cytoskeletal changes in endothelial cells growing on curved surfaces. Microcirculation. 2000 Dec; 7(6 Pt 1):419-27.
    View in: PubMed
  31. Murrant CL, Sarelius IH. Local and remote arteriolar dilations initiated by skeletal muscle contraction. Am J Physiol Heart Circ Physiol. 2000 Nov; 279(5):H2285-94.
    View in: PubMed
  32. Murdock RC, Reynolds C, Sarelius IH, Waugh RE. Adaptation and survival of surface-deprived red blood cells in mice. Am J Physiol Cell Physiol. 2000 Oct; 279(4):C970-80.
    View in: PubMed
  33. Sarelius IH, Cohen KD, Murrant CL. Role for capillaries in coupling blood flow with metabolism. Clin Exp Pharmacol Physiol. 2000 Oct; 27(10):826-9.
    View in: PubMed
  34. Cohen KD, Berg BR, Sarelius IH. Remote arteriolar dilations in response to muscle contraction under capillaries. Am J Physiol Heart Circ Physiol. 2000 Jun; 278(6):H1916-23.
    View in: PubMed
  35. Murrant CL, Sarelius IH. Coupling of muscle metabolism and muscle blood flow in capillary units during contraction. Acta Physiol Scand. 2000 Apr; 168(4):531-41.
    View in: PubMed
  36. Lau KS, Grange RW, Isotani E, Sarelius IH, Kamm KE, Huang PL, Stull JT. nNOS and eNOS modulate cGMP formation and vascular response in contracting fast-twitch skeletal muscle. Physiol Genomics. 2000 Jan 24; 2(1):21-7.
    View in: PubMed
  37. Lau KS, Grange RW, Chang WJ, Kamm KE, Sarelius I, Stull JT. Skeletal muscle contractions stimulate cGMP formation and attenuate vascular smooth muscle myosin phosphorylation via nitric oxide. FEBS Lett. 1998 Jul 10; 431(1):71-4.
    View in: PubMed
  38. Frame MD, Chapman GB, Makino Y, Sarelius IH. Shear stress gradient over endothelial cells in a curved microchannel system. Biorheology. 1998 Jul-Oct; 35(4-5):245-61.
    View in: PubMed
  39. Berg BR, Cohen KD, Sarelius IH. Direct coupling between blood flow and metabolism at the capillary level in striated muscle. Am J Physiol. 1997 Jun; 272(6 Pt 2):H2693-700.
    View in: PubMed
  40. Waugh RE, Sarelius IH. Effects of lost surface area on red blood cells and red blood cell survival in mice. Am J Physiol. 1996 Dec; 271(6 Pt 1):C1847-52.
    View in: PubMed
  41. Berg BR, Sarelius IH. Erythrocyte flux in capillary networks during maturation: implications for oxygen delivery. Am J Physiol. 1996 Dec; 271(6 Pt 2):H2263-73.
    View in: PubMed
  42. Frame MD, Sarelius IH. Endothelial cell dilatory pathways link flow and wall shear stress in an intact arteriolar network. J Appl Physiol. 1996 Nov; 81(5):2105-14.
    View in: PubMed
  43. Frame MD, Sarelius IH. Vascular communication and endothelial cell function in the control of arteriolar flow distribution. Microcirculation. 1996 Jun; 3(2):233-5.
    View in: PubMed
  44. Waugh RE, Hwang WC, Sarelius IH. Combined use of fluorescence microscopy and micromechanical measurement to assess cell and membrane properties. Pflugers Arch. 1996; 431(6 Suppl 2):R271-2.
    View in: PubMed
  45. Frame MD, Sarelius IH. A system for culture of endothelial cells in 20-50-microns branching tubes. Microcirculation. 1995 Dec; 2(4):377-85.
    View in: PubMed
  46. Frame MD, Sarelius IH. Energy optimization and bifurcation angles in the microcirculation. Microvasc Res. 1995 Nov; 50(3):301-10.
    View in: PubMed
  47. Frame MD, Sarelius IH. L-arginine-induced conducted signals alter upstream arteriolar responsivity to L-arginine. Circ Res. 1995 Oct; 77(4):695-701.
    View in: PubMed
  48. Berg BR, Sarelius IH. Functional capillary organization in striated muscle. Am J Physiol. 1995 Mar; 268(3 Pt 2):H1215-22.
    View in: PubMed
  49. Sarelius IH. Invited editorial on "Effect of RBC shape and deformability on pulmonary O2 diffusing capacity and resistance to flow in rabbit lungs". J Appl Physiol. 1995 Mar; 78(3):763-4.
    View in: PubMed
  50. Kiani MF, Pries AR, Hsu LL, Sarelius IH, Cokelet GR. Fluctuations in microvascular blood flow parameters caused by hemodynamic mechanisms. Am J Physiol. 1994 May; 266(5 Pt 2):H1822-8.
    View in: PubMed
  51. Sarelius IH. Cell and oxygen flow in arterioles controlling capillary perfusion. Am J Physiol. 1993 Nov; 265(5 Pt 2):H1682-7.
    View in: PubMed
  52. Frame MD, Sarelius IH. Arteriolar bifurcation angles vary with position and when flow is changed. Microvasc Res. 1993 Sep; 46(2):190-205.
    View in: PubMed
  53. Frame MD, Sarelius IH. Regulation of capillary perfusion by small arterioles is spatially organized. Circ Res. 1993 Jul; 73(1):155-63.
    View in: PubMed
  54. Kiani MF, Cokelet GR, Sarelius IH. Effect of diameter variability along a microvessel segment on pressure drop. Microvasc Res. 1993 May; 45(3):219-32.
    View in: PubMed
  55. Cokelet GR, Sarelius IH. Perceived vessel lumen and cell-blood velocity ratio: impact on in vivo blood flow rate determination. Am J Physiol. 1992 Apr; 262(4 Pt 2):H1156-63.
    View in: PubMed
  56. Sweeney TE, Sarelius IH. Spatial heterogeneity in striated muscle arteriolar tone, cell flow, and capillarity. Am J Physiol. 1990 Jul; 259(1 Pt 2):H124-36.
    View in: PubMed
  57. Sarelius IH. An analysis of microcirculatory flow heterogeneity using measurements of transit time. Microvasc Res. 1990 Jul; 40(1):88-98.
    View in: PubMed
  58. Sarelius IH, Huxley VH. A direct effect of atrial peptide on arterioles of the terminal microvasculature. Am J Physiol. 1990 May; 258(5 Pt 2):R1224-9.
    View in: PubMed
  59. Sarelius IH. Microcirculation in striated muscle after acute reduction in systemic hematocrit. Respir Physiol. 1989 Oct; 78(1):7-17.
    View in: PubMed
  60. Sweeney TE, Sarelius IH. Arteriolar control of capillary cell flow in striated muscle. Circ Res. 1989 Jan; 64(1):112-20.
    View in: PubMed
  61. Sarelius IH, Nealey TA, Sweeney TE. Variability in microvascular estimates of capillary surface area for exchange. Adv Exp Med Biol. 1988; 242:17-21.
    View in: PubMed
  62. Sarelius IH. Cell flow path influences transit time through striated muscle capillaries. Am J Physiol. 1986 Jun; 250(6 Pt 2):H899-907.
    View in: PubMed
  63. Sweeney TE, Sarelius IH. Use of flow cytometry to extend and improve in vivo determinations of microvessel hematocrit and cell flux. Microvasc Res. 1986 Mar; 31(2):184-96.
    View in: PubMed
  64. Sarelius IH, McKinlay SM. Statistical constraints on microvascular measurements using fluorescent erythrocytes. Am J Physiol. 1985 Apr; 248(4 Pt 2):H577-86.
    View in: PubMed
  65. Federspiel WJ, Sarelius IH. An examination of the contribution of red cell spacing to the uniformity of oxygen flux at the capillary wall. Microvasc Res. 1984 May; 27(3):273-85.
    View in: PubMed
  66. Sarelius IH, Maxwell LC, Gray SD, Duling BR. Capillarity and fiber types in the cremaster muscle of rat and hamster. Am J Physiol. 1983 Aug; 245(2):H368-74.
    View in: PubMed
  67. Sarelius IH, Duling BR. Direct measurement of microvessel hematocrit, red cell flux, velocity, and transit time. Am J Physiol. 1982 Dec; 243(6):H1018-26.
    View in: PubMed
  68. Hughes EW, Martin-Body RL, Sarelius IH, Sinclair JD. Effects of urethane-chloralose anaesthesia on respiration in the rat. Clin Exp Pharmacol Physiol. 1982 Mar-Apr; 9(2):119-27.
    View in: PubMed
  69. Duling BR, Sarelius IH, Jackson WF. A comparison of microvascular estimates of capillary blood flow with direct measurements of total striated muscle flow. Int J Microcirc Clin Exp. 1982; 1(4):409-24.
    View in: PubMed
  70. Sarelius IH, Damon DN, Duling BR. Microvascular adaptations during maturation of striated muscle. Am J Physiol. 1981 Sep; 241(3):H317-24.
    View in: PubMed
  71. Sarelius IH, Sinclair JD. Effects of small changes of blood volume on oxygen delivery and tissue oxygenation. Am J Physiol. 1981 Feb; 240(2):H177-84.
    View in: PubMed
  72. Malcolm JL, Sarelius IH, Sinclair JD. The respiratory role of the ventral surface of the medulla studied in the anaesthetized rat. J Physiol. 1980 Oct; 307:503-15.
    View in: PubMed
  73. Sinclair JD, Sarelius IH. The marathon man: the physiology of the long-distance runner. N Z Med J. 1979 Nov 14; 90(647):383-7.
    View in: PubMed
  74. Sarelius IH. Plasma volume shifts during moderate exercise in splenectomized greyhounds. J Physiol. 1979 Jul; 292:391-405.
    View in: PubMed
  75. Sarelius IH. Blood volume and exercise in dogs. N Z Med J. 1976 Oct 13; 84(573):275-6.
    View in: PubMed
  76. Sarelius IH, Quinn JP. Estimation of maximal oxygen uptake in New Zealanders of three age groups. N Z Med J. 1975 Jun 25; 81(542):549-52.
    View in: PubMed
  77. Sarelius IH, Greenway RM. Rhythmic fluctuations in the urine composition of sheep: separation of feed-dependent from other rhythms. Pflugers Arch. 1975 Mar 26; 355(3):243-59.
    View in: PubMed

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