Lei Xu
| Title | Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Biomedical Genetics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 633
Rochester NY 14642
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| Title | Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Dermatology |
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| Title | Assistant Professor |
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| Institution | University of Rochester Medical Center |
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| Department | Cancer Center |
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| 1991 |
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| Guanghua Award | Nanjing University, China | | 1992 |
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| Gold Medal | Nanjing University, China | | 1992 |
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| 1994 | Excellent Student Award | Nanjing University, China | | 2009 |
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| IDEA Award from NYSTEM | New York State Department of Health | | 2009 |
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| Ruth L. Kirschstein National Research Service Award | NIH |
http://www.urmc.rochester.edu/biomedical-genetics/faculty/xu-lab.cfm
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Yang L, Xu L. GPR56 in cancer progression: current status and future perspective. Future Oncol. 2012 Apr; 8(4):431-40.
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Xu L, Chen J, Yin M, Glaser KJ, Chen Q, Woodrum DA, Ehman RL. Assessment of stiffness changes in the ex vivo porcine aortic wall using magnetic resonance elastography. Magn Reson Imaging. 2012 Jan; 30(1):122-7.
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Yang L, Chen G, Mohanty S, Scott G, Fazal F, Rahman A, Begum S, Hynes RO, Xu L. GPR56 Regulates VEGF production and angiogenesis during melanoma progression. Cancer Res. 2011 Aug 15; 71(16):5558-68.
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Loy RE, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, MacLennan DH, Meissner G, Melzer W, Dirksen RT. Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum. J Gen Physiol. 2011 Jan; 137(1):43-57.
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Chen G, Yang L, Begum S, Xu L. GPR56 is essential for testis development and male fertility in mice. Dev Dyn. 2010 Dec; 239(12):3358-67.
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Mohanty S, Xu L. Experimental metastasis assay. J Vis Exp. 2010; (42).
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Xu L, Begum S, Barry M, Crowley D, Yang L, Bronson RT, Hynes RO. GPR56 plays varying roles in endogenous cancer progression. Clin Exp Metastasis. 2010 Apr; 27(4):241-9.
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Xu L. GPR56 interacts with extracellular matrix and regulates cancer progression. Adv Exp Med Biol. 2010; 706:98-108.
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Xu L, Shen SS, Hoshida Y, Subramanian A, Ross K, Brunet JP, Wagner SN, Ramaswamy S, Mesirov JP, Hynes RO. Gene expression changes in an animal melanoma model correlate with aggressiveness of human melanoma metastases. Mol Cancer Res. 2008 May; 6(5):760-9.
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Xu L, Hynes RO. GPR56 and TG2: possible roles in suppression of tumor growth by the microenvironment. Cell Cycle. 2007 Jan 15; 6(2):160-5.
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Lyfenko AD, Ducreux S, Wang Y, Xu L, Zorzato F, Ferreiro A, Meissner G, Treves S, Dirksen RT. Two central core disease (CCD) deletions in the C-terminal region of RYR1 alter muscle excitation-contraction (EC) coupling by distinct mechanisms. Hum Mutat. 2007 Jan; 28(1):61-8.
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Xu L, Begum S, Hearn JD, Hynes RO. GPR56, an atypical G protein-coupled receptor, binds tissue transglutaminase, TG2, and inhibits melanoma tumor growth and metastasis. Proc Natl Acad Sci U S A. 2006 Jun 13; 103(24):9023-8.
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Xu L, Strome S. Depletion of a novel SET-domain protein enhances the sterility of mes-3 and mes-4 mutants of Caenorhabditis elegans. Genetics. 2001 Nov; 159(3):1019-29.
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Xu L, Paulsen J, Yoo Y, Goodwin EB, Strome S. Caenorhabditis elegans MES-3 is a target of GLD-1 and functions epigenetically in germline development. Genetics. 2001 Nov; 159(3):1007-17.
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Xu L, Fong Y, Strome S. The Caenorhabditis elegans maternal-effect sterile proteins, MES-2, MES-3, and MES-6, are associated in a complex in embryos. Proc Natl Acad Sci U S A. 2001 Apr 24; 98(9):5061-6.
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Williams C, Xu L, Blumenthal T. SL1 trans splicing and 3'-end formation in a novel class of Caenorhabditis elegans operon. Mol Cell Biol. 1999 Jan; 19(1):376-83.
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