URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Gregory Tall

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester NY 14642
 
 Overview
In canonical G protein signaling, G protein coupled receptors (GPCRs) activate heterotrimeric G proteins, which in turn regulate intracellular effector enzymes. Our lab studies G protein signaling and new classes of enzymes that activate heterotrimeric G proteins apart from GPCR-initiated activation. We found the biochemical function of one new G protein activator, Ric-8. Ric-8A activates G protein alpha subunits by serving as a guanine nucleotide exchange catalyst. A major focus of our research group is to investigate the physiological roles that Ric-8 proteins have in directing non-traditional G protein signaling pathways in the cell. Observations made in genetic model systems suggest that Ric-8 proteins work with G proteins to regulate asymmetric cell division, the subcellular localization of G protein subunits, and as modulators of traditional GPCR signaling.

 
 Selected Publications
List All   |   Timeline
  1. Alzayady KJ, Wagner LE, Chandrasekhar R, Monteagudo A, Godiska R, Tall GG, Joseph SK, Yule DI. Functional inositol 1,4,5-trisphosphate receptors assembled from concatenated homo- and heteromeric subunits. J Biol Chem. 2013 Oct 11; 288(41):29772-84.
    View in: PubMed
  2. Tall GG, Patel BR, Chan P. Ric-8 folding of G proteins better explains Ric-8 apparent amplification of G protein-coupled receptor signaling. Proc Natl Acad Sci U S A. 2013 Aug 20; 110(34):E3148.
    View in: PubMed
  3. Chan P, Thomas CJ, Sprang SR, Tall GG. Molecular chaperoning function of Ric-8 is to fold nascent heterotrimeric G protein a subunits. Proc Natl Acad Sci U S A. 2013 Mar 5; 110(10):3794-9.
    View in: PubMed
  4. Tall GG. Ric-8 regulation of heterotrimeric G proteins. J Recept Signal Transduct Res. 2013 Jun; 33(3):139-43.
    View in: PubMed
  5. Oner SS, Maher EM, Gabay M, Tall GG, Blumer JB, Lanier SM. Regulation of the G-protein Regulatory-Gai Signaling Complex by Nonreceptor Guanine Nucleotide Exchange Factors. J Biol Chem. 2013 Feb 1; 288(5):3003-15.
    View in: PubMed
  6. Gabay M, Pinter ME, Wright FA, Chan P, Murphy AJ, Valenzuela DM, Yancopoulos GD, Tall GG. Ric-8 proteins are molecular chaperones that direct nascent G protein a subunit membrane association. Sci Signal. 2011; 4(200):ra79.
    View in: PubMed
  7. Thomas CJ, Briknarová K, Hilmer JK, Movahed N, Bothner B, Sumida JP, Tall GG, Sprang SR. The nucleotide exchange factor Ric-8A is a chaperone for the conformationally dynamic nucleotide-free state of Gai1. PLoS One. 2011; 6(8):e23197.
    View in: PubMed
  8. Chan P, Gabay M, Wright FA, Tall GG. Ric-8B is a GTP-dependent G protein alphas guanine nucleotide exchange factor. J Biol Chem. 2011 Jun 3; 286(22):19932-42.
    View in: PubMed
  9. Pashkov V, Huang J, Parameswara VK, Kedzierski W, Kurrasch DM, Tall GG, Esser V, Gerard RD, Uyeda K, Towle HC, Wilkie TM. Regulator of G protein signaling (RGS16) inhibits hepatic fatty acid oxidation in a carbohydrate response element-binding protein (ChREBP)-dependent manner. J Biol Chem. 2011 Apr 29; 286(17):15116-25.
    View in: PubMed
  10. Vellano CP, Shu FJ, Ramineni S, Yates CK, Tall GG, Hepler JR. Activation of the regulator of G protein signaling 14-Gai1-GDP signaling complex is regulated by resistance to inhibitors of cholinesterase-8A. Biochemistry. 2011 Feb 8; 50(5):752-62.
    View in: PubMed
  11. Chan P, Gabay M, Wright FA, Kan W, Oner SS, Lanier SM, Smrcka AV, Blumer JB, Tall GG. Purification of heterotrimeric G protein alpha subunits by GST-Ric-8 association: primary characterization of purified G alpha(olf). J Biol Chem. 2011 Jan 28; 286(4):2625-35.
    View in: PubMed
  12. Woodard GE, Huang NN, Cho H, Miki T, Tall GG, Kehrl JH. Ric-8A and Gi alpha recruit LGN, NuMA, and dynein to the cell cortex to help orient the mitotic spindle. Mol Cell Biol. 2010 Jul; 30(14):3519-30.
    View in: PubMed
  13. Thomas CJ, Tall GG, Adhikari A, Sprang SR. Ric-8A catalyzes guanine nucleotide exchange on G alphai1 bound to the GPR/GoLoco exchange inhibitor AGS3. J Biol Chem. 2008 Aug 22; 283(34):23150-60.
    View in: PubMed
  14. Johnston CA, Afshar K, Snyder JT, Tall GG, Gönczy P, Siderovski DP, Willard FS. Structural determinants underlying the temperature-sensitive nature of a Galpha mutant in asymmetric cell division of Caenorhabditis elegans. J Biol Chem. 2008 Aug 1; 283(31):21550-8.
    View in: PubMed
  15. Kumar P, Wu Q, Chambliss KL, Yuhanna IS, Mumby SM, Mineo C, Tall GG, Shaul PW. Direct interactions with G a i and G ß? mediate nongenomic signaling by estrogen receptor a . Mol Endocrinol. 2007 Jun; 21(6):1370-80.
    View in: PubMed
  16. Tall GG, Gilman AG. Resistance to inhibitors of cholinesterase 8A catalyzes release of Galphai-GTP and nuclear mitotic apparatus protein (NuMA) from NuMA/LGN/Galphai-GDP complexes. Proc Natl Acad Sci U S A. 2005 Nov 15; 102(46):16584-9.
    View in: PubMed
  17. Malik S, Ghosh M, Bonacci TM, Tall GG, Smrcka AV. Ric-8 enhances G protein betagamma-dependent signaling in response to betagamma-binding peptides in intact cells. Mol Pharmacol. 2005 Jul; 68(1):129-36.
    View in: PubMed
  18. Tall GG, Gilman AG. Purification and functional analysis of Ric-8A: a guanine nucleotide exchange factor for G-protein alpha subunits. Methods Enzymol. 2004; 390:377-88.
    View in: PubMed
  19. Davies BA, Topp JD, Sfeir AJ, Katzmann DJ, Carney DS, Tall GG, Friedberg AS, Deng L, Chen Z, Horazdovsky BF. Vps9p CUE domain ubiquitin binding is required for efficient endocytic protein traffic. J Biol Chem. 2003 May 30; 278(22):19826-33.
    View in: PubMed
  20. Tall GG, Krumins AM, Gilman AG. Mammalian Ric-8A (synembryn) is a heterotrimeric Galpha protein guanine nucleotide exchange factor. J Biol Chem. 2003 Mar 7; 278(10):8356-62.
    View in: PubMed
  21. Tall GG, Barbieri MA, Stahl PD, Horazdovsky BF. Ras-activated endocytosis is mediated by the Rab5 guanine nucleotide exchange activity of RIN1. Dev Cell. 2001 Jul; 1(1):73-82.
    View in: PubMed
  22. Tall GG, Hama H, DeWald DB, Horazdovsky BF. The phosphatidylinositol 3-phosphate binding protein Vac1p interacts with a Rab GTPase and a Sec1p homologue to facilitate vesicle-mediated vacuolar protein sorting. Mol Biol Cell. 1999 Jun; 10(6):1873-89.
    View in: PubMed
  23. Hama H, Tall GG, Horazdovsky BF. Vps9p is a guanine nucleotide exchange factor involved in vesicle-mediated vacuolar protein transport. J Biol Chem. 1999 May 21; 274(21):15284-91.
    View in: PubMed

Visualizations


Tall's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department