Laurel Carney
| Title | Professor |
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| Institution | University of Rochester, River Campus |
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| Department | Biomedical Engineering |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester NY 14642
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| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Neurobiology and Anatomy |
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| 1990 |
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| Rose Neuroscience Award | University of Wisconsin-Madison | | 1992 |
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| 1995 | Young Investigator Award | The Whitaker Foundation | | 1995 |
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| Outstanding Professor of the Year Award | Boston University College of Engineering | | 2001 |
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| Outstanding Professor of the Year Award | Boston University, Dept. of Biomedical Engineering | | 2002 |
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| Elected Fellow | Acoustical Society of America | | 2006 |
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| Elected Fellow | American Institute for Medical and Biological Engineering | | 2010 |
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| BME Faculty Member of the Year | Awarded by Students | | 2010 |
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| 2011 | Professor of the Year |
Research Overview:
We combine neurophysiological, behavioral, and computational modeling techniques towards our goal of understanding neural mechanisms underlying the perception of complex sounds. Our work now includes studies of both listeners with normal hearing ability and those with sensorineural hearing loss. We are also interested in applying the results from our laboratory to the design of physiologically based signal-processing strategies to aid listeners with hearing loss.
We are currently studying three specific problems: detection of acoustic signals in background noise, detection of fluctuations in the amplitude of sounds, and neural coding of vowels. These problems are of interest because they are tasks at which the healthy auditory system excels, but they are situations that can present great difficulty for listeners with hearing loss. We study the psychophysical limits of ability in these tasks, and we also study the neural coding and processing of these sounds using stimuli matched to those of our behavioral studies. Computational modeling helps bridge the gap between our behavioral and physiological studies. For example, using computational models derived from neural population recordings, we make predictions of behavioral abilities that can be directly compared to actual behavioral results. The cues and mechanisms used by our computational models can be manipulated to test different hypotheses for neural coding and processing.
By identifying the cues involved in the detection of signals in noise, fluctuations of signals, and coding of vowels, our goal is to direct novel strategies for signal processors to preserve, restore, or enhance these cues for listeners with hearing loss.
Selected Relevant Recent Publications:
Davidson, S.A., Gilkey, R.H., Colburn, H.S. and Carney, L.H. (2006), Binaural detection with narrowband and wideband reproducible noise maskers: III. Models for monaural and diotic detection, J.Acoust. Soc. Am. 119:2258-2275
Anzalone, M.C., Calandruccio, L., Doherty, K.A., Carney, L.H., (2006), Determination of the Potential Benefit of Time-Frequency Gain Manipulation, Ear & Hearing. 27: 480-492.
Nelson, P.C., and Carney, L. H. (2006) Cues for masked amplitude-modulation detection, J. Acoust. Soc. Am. 120, 978-990.
Tan and Carney (2006), Predictions of Formant-Frequency Discrimination in Noise Based on Model Auditory-Nerve Responses, J. Acoust. Soc. Am. 120:1435-1445.
Gai, Y. and Carney, L.H. (2006) Temporal measures and neural strategies for detection of tones in noise based on responses in anteroventral cochlear nucleus, J. Neurophysiol., 96:2451-2464.
Nelson, P.C. and Carney, L. H. (2007) Rate and timing cues for neural detection and discrimination of amplitude-modulated tones in the awake rabbit inferior colliculus. J. Neurophysiol. 97:522-539.
Nelson, P.N. Ewert, S.D., Carney, L.H., and Dau, T. (2007). Comparison of intensity discrimination, increment detection, and comodulation masking release in the audio- and envelope-frequency domains, J. Acoust. Soc. Am. 121:2168-2181.
Deshmukh, O., Espy-Wilson, C., and Carney, L.H. (2007) Speech enhancement using the modified phase-opponency model, J. Acoust. Soc. Am. 121: 3886-3898.
Calandruccio, L., Doherty, K.A., Carney, L.H., Kikkeri, H.N. (2007), Perception of Temporally Processed Speech by Listeners with Hearing Impairment, Ear & Hearing. 28: 512-523
Gai, Y., L.H. Carney, K.S. Abrams, F. Idrobo, J. M. Harrison, R. H. Gilkey (2007) Detection of Tones in Reproducible Noise Maskers by Rabbits and Comparison to Detection by Humans, JARO, 8: 1525-3961.
Gai, Y., L.H. Carney (2008) Influence of Inhibitory Inputs on Rate and Timing of Responses in the Anteroventral Cochlear Nucleus, J. Neurophysiol., 99:1077-1095.
Gai, Y., L.H. Carney (2008) Statistical Analyses of Temporal Information in Auditory Brainstem Responses to Tones in Noise: Correlation Index and Spike-distance Metric, JARO, 9:373-387.
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Carney LH, Li J, Li T, McDonough JM. Using a computational model for the auditory midbrain to explore the neural representation of vowels. J Acoust Soc Am. 2013 May; 133(5):3245.
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Bergevin C, Dong W, Carney L, Velenovsky DS, Bonine KE, Jarchow JL. Comparative auditory biomechanics probed by otoacoustic emissions. J Acoust Soc Am. 2013 May; 133(5):3509.
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Carney LH, Mao J, Koch KJ, Doherty KA. Modeling detection of 500-hertz tones in reproducible noise for listeners with sensorineural hearing loss. J Acoust Soc Am. 2013 May; 133(5):3559.
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Carney LH, Ketterer AD, Abrams KS, Schwarz DM, Idrobo F. Detection thresholds for amplitude modulations of tones in budgerigar, rabbit, and human. Adv Exp Med Biol. 2013; 787:391-8.
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Schwarz DM, Zilany MS, Skevington M, Huang NJ, Flynn BC, Carney LH. Semi-supervised spike sorting using pattern matching and a scaled Mahalanobis distance metric. J Neurosci Methods. 2012 May 15; 206(2):120-31.
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Wojtczak M, Nelson PC, Viemeister NF, Carney LH. Forward masking in the amplitude-modulation domain for tone carriers: psychophysical results and physiological correlates. J Assoc Res Otolaryngol. 2011 Jun; 12(3):361-73.
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Carney LH, Sarkar S, Abrams KS, Idrobo F. Sound-localization ability of the Mongolian gerbil (Meriones unguiculatus) in a task with a simplified response map. Hear Res. 2011 May; 275(1-2):89-95.
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Zilany MS, Carney LH. Power-law dynamics in an auditory-nerve model can account for neural adaptation to sound-level statistics. J Neurosci. 2010 Aug 4; 30(31):10380-90.
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Zilany MS, Bruce IC, Nelson PC, Carney LH. A phenomenological model of the synapse between the inner hair cell and auditory nerve: long-term adaptation with power-law dynamics. J Acoust Soc Am. 2009 Nov; 126(5):2390-412.
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Davidson SA, Gilkey RH, Colburn HS, Carney LH. Diotic and dichotic detection with reproducible chimeric stimuli. J Acoust Soc Am. 2009 Oct; 126(4):1889-905.
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Davidson SA, Gilkey RH, Colburn HS, Carney LH. An evaluation of models for diotic and dichotic detection in reproducible noises. J Acoust Soc Am. 2009 Oct; 126(4):1906-25.
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Gai Y, Carney LH. Statistical analyses of temporal information in auditory brainstem responses to tones in noise: correlation index and spike-distance metric. J Assoc Res Otolaryngol. 2008 Sep; 9(3):373-87.
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Nichols AJ, Carney LH, Olson EC. Comparison of slow and fast neocortical neuron migration using a new in vitro model. BMC Neurosci. 2008; 9:50.
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Gai Y, Carney LH. Influence of inhibitory inputs on rate and timing of responses in the anteroventral cochlear nucleus. J Neurophysiol. 2008 Mar; 99(3):1077-95.
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Gai Y, Carney LH, Abrams KS, Idrobo F, Harrison JM, Gilkey RH. Detection of tones in reproducible noise maskers by rabbits and comparison to detection by humans. J Assoc Res Otolaryngol. 2007 Dec; 8(4):522-38.
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Calandruccio L, Doherty KA, Carney LH, Kikkeri HN. Perception of temporally processed speech by listeners with hearing impairment. Ear Hear. 2007 Aug; 28(4):512-23.
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Deshmukh OD, Espy-Wilson CY, Carney LH. Speech enhancement using the modified phase-opponency model. J Acoust Soc Am. 2007 Jun; 121(6):3886-98.
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Nelson PC, Ewert SD, Carney LH, Dau T. Comparison of level discrimination, increment detection, and comodulation masking release in the audio- and envelope-frequency domains. J Acoust Soc Am. 2007 Apr; 121(4):2168-81.
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Nelson PC, Carney LH. Neural rate and timing cues for detection and discrimination of amplitude-modulated tones in the awake rabbit inferior colliculus. J Neurophysiol. 2007 Jan; 97(1):522-39.
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Anzalone MC, Calandruccio L, Doherty KA, Carney LH. Determination of the potential benefit of time-frequency gain manipulation. Ear Hear. 2006 Oct; 27(5):480-92.
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Tan Q, Carney LH. Predictions of formant-frequency discrimination in noise based on model auditory-nerve responses. J Acoust Soc Am. 2006 Sep; 120(3):1435-45.
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Gai Y, Carney LH. Temporal measures and neural strategies for detection of tones in noise based on responses in anteroventral cochlear nucleus. J Neurophysiol. 2006 Nov; 96(5):2451-64.
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Shi LF, Carney LH, Doherty KA. Correction of the peripheral spatiotemporal response pattern: a potential new signal-processing strategy. J Speech Lang Hear Res. 2006 Aug; 49(4):848-55.
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Nelson PC, Carney LH. Cues for masked amplitude-modulation detection. J Acoust Soc Am. 2006 Aug; 120(2):978-90.
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Davidson SA, Gilkey RH, Colburn HS, Carney LH. Binaural detection with narrowband and wideband reproducible noise maskers. III. Monaural and diotic detection and model results. J Acoust Soc Am. 2006 Apr; 119(4):2258-75.
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Zhang X, Carney LH. Response properties of an integrate-and-fire model that receives subthreshold inputs. Neural Comput. 2005 Dec; 17(12):2571-601.
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Zhang X, Carney LH. Analysis of models for the synapse between the inner hair cell and the auditory nerve. J Acoust Soc Am. 2005 Sep; 118(3 Pt 1):1540-53.
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Jackson BS, Carney LH. The spontaneous-rate histogram of the auditory nerve can be explained by only two or three spontaneous rates and long-range dependence. J Assoc Res Otolaryngol. 2005 Jun; 6(2):148-59.
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Tyler MJ, Carney LH, Cameron DA. Control of cellular pattern formation in the vertebrate inner retina by homotypic regulation of cell-fate decisions. J Neurosci. 2005 May 4; 25(18):4565-76.
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Zhou Y, Carney LH, Colburn HS. A model for interaural time difference sensitivity in the medial superior olive: interaction of excitatory and inhibitory synaptic inputs, channel dynamics, and cellular morphology. J Neurosci. 2005 Mar 23; 25(12):3046-58.
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Dasika VK, White JA, Carney LH, Colburn HS. Effects of inhibitory feedback in a network model of avian brain stem. J Neurophysiol. 2005 Jul; 94(1):400-14.
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Tan Q, Carney LH. Encoding of vowel-like sounds in the auditory nerve: model predictions of discrimination performance. J Acoust Soc Am. 2005 Mar; 117(3 Pt 1):1210-22.
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Nelson PC, Carney LH. A phenomenological model of peripheral and central neural responses to amplitude-modulated tones. J Acoust Soc Am. 2004 Oct; 116(4 Pt 1):2173-86.
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Cameron DA, Carney LH. Cellular patterns in the inner retina of adult zebrafish: quantitative analyses and a computational model of their formation. J Comp Neurol. 2004 Mar 22; 471(1):11-25.
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Tan Q, Carney LH. A phenomenological model for the responses of auditory-nerve fibers. II. Nonlinear tuning with a frequency glide. J Acoust Soc Am. 2003 Oct; 114(4 Pt 1):2007-20.
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Colburn HS, Carney LH, Heinz MG. Quantifying the information in auditory-nerve responses for level discrimination. J Assoc Res Otolaryngol. 2003 Sep; 4(3):294-311.
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Mason CR, Idrobo F, Early SJ, Abibi A, Zheng L, Harrison JM, Carney LH. CS-dependent response probability in an auditory masked-detection task: considerations based on models of Pavlovian conditioning. Q J Exp Psychol B. 2003 May; 56(2):193-205.
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Heinz MG, Colburn HS, Carney LH. Quantifying the implications of nonlinear cochlear tuning for auditory-filter estimates. J Acoust Soc Am. 2002 Feb; 111(2):996-1011.
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Evilsizer ME, Gilkey RH, Mason CR, Colburn HS, Carney LH. Binaural detection with narrowband and wideband reproducible noise maskers: I. Results for human. J Acoust Soc Am. 2002 Jan; 111(1 Pt 1):336-45.
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Zheng L, Early SJ, Mason CR, Idrobo F, Harrison JM, Carney LH. Binaural detection with narrowband and wideband reproducible noise maskers: II. Results for rabbit. J Acoust Soc Am. 2002 Jan; 111(1 Pt 1):346-56.
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Heinz MG, Colburn HS, Carney LH. Evaluating auditory performance limits: II. One-parameter discrimination with random-level variation. Neural Comput. 2001 Oct; 13(10):2317-38.
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Heinz MG, Colburn HS, Carney LH. Evaluating auditory performance limits: i. one-parameter discrimination using a computational model for the auditory nerve. Neural Comput. 2001 Oct; 13(10):2273-316.
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Heinz MG, Colburn HS, Carney LH. Rate and timing cues associated with the cochlear amplifier: level discrimination based on monaural cross-frequency coincidence detection. J Acoust Soc Am. 2001 Oct; 110(4):2065-84.
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Early SJ, Mason CR, Zheng L, Evilsizer M, Idrobo F, Harrison JM, Carney LH. Studies of binaural detection in the rabbit (Oryctolagus cuniculus) with Pavlovian conditioning. Behav Neurosci. 2001 Jun; 115(3):650-60.
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Stenkamp DL, Powers MK, Carney LH, Cameron DA. Evidence for two distinct mechanisms of neurogenesis and cellular pattern formation in regenerated goldfish retinas. J Comp Neurol. 2001 Mar 19; 431(4):363-81.
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Zhang X, Heinz MG, Bruce IC, Carney LH. A phenomenological model for the responses of auditory-nerve fibers: I. Nonlinear tuning with compression and suppression. J Acoust Soc Am. 2001 Feb; 109(2):648-70.
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Cameron DA, Carney LH. Cell mosaic patterns in the native and regenerated inner retina of zebrafish: implications for retinal assembly. J Comp Neurol. 2000 Jan 17; 416(3):356-67.
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Carney LH. Temporal response properties of neurons in the auditory pathway. Curr Opin Neurobiol. 1999 Aug; 9(4):442-6.
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Carney LH, McDuffy MJ, Shekhter I. Frequency glides in the impulse responses of auditory-nerve fibers. J Acoust Soc Am. 1999 Apr; 105(4):2384-91.
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Carney LH, Friedman M. Spatiotemporal tuning of low-frequency cells in the anteroventral cochlear nucleus. J Neurosci. 1998 Feb 1; 18(3):1096-104.
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Cai H, Carney LH, Colburn HS. A model for binaural response properties of inferior colliculus neurons. II. A model with interaural time difference-sensitive excitatory and inhibitory inputs and an adaptation mechanism. J Acoust Soc Am. 1998 Jan; 103(1):494-506.
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Cai H, Carney LH, Colburn HS. A model for binaural response properties of inferior colliculus neurons. I. A model with interaural time difference-sensitive excitatory and inhibitory inputs. J Acoust Soc Am. 1998 Jan; 103(1):475-93.
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Carney LH, Friedman M. Nonlinear feedback models for the tuning of auditory nerve fibers. Ann Biomed Eng. 1996 May-Jun; 24(3):440-50.
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Litvack DA, Oberlander TF, Carney LH, Saul JP. Time and frequency domain methods for heart rate variability analysis: a methodological comparison. Psychophysiology. 1995 Sep; 32(5):492-504.
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Carney LH. Spatiotemporal encoding of sound level: models for normal encoding and recruitment of loudness. Hear Res. 1994 Jun 1; 76(1-2):31-44.
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Joris PX, Carney LH, Smith PH, Yin TC. Enhancement of neural synchronization in the anteroventral cochlear nucleus. I. Responses to tones at the characteristic frequency. J Neurophysiol. 1994 Mar; 71(3):1022-36.
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Carney LH. A model for the responses of low-frequency auditory-nerve fibers in cat. J Acoust Soc Am. 1993 Jan; 93(1):401-17.
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Carney LH. Modelling the sensitivity of cells in the anteroventral cochlear nucleus to spatiotemporal discharge patterns. Philos Trans R Soc Lond B Biol Sci. 1992 Jun 29; 336(1278):403-6.
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Smith PH, Joris PX, Carney LH, Yin TC. Projections of physiologically characterized globular bushy cell axons from the cochlear nucleus of the cat. J Comp Neurol. 1991 Feb 15; 304(3):387-407.
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Carney LH. Sensitivities of cells in anteroventral cochlear nucleus of cat to spatiotemporal discharge patterns across primary afferents. J Neurophysiol. 1990 Aug; 64(2):437-56.
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Yin TC, Carney LH, Joris PX. Interaural time sensitivity in the inferior colliculus of the albino cat. J Comp Neurol. 1990 May 15; 295(3):438-48.
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Carney LH, Yin TC. Responses of low-frequency cells in the inferior colliculus to interaural time differences of clicks: excitatory and inhibitory components. J Neurophysiol. 1989 Jul; 62(1):144-61.
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Carney LH, Yin TC. Temporal coding of resonances by low-frequency auditory nerve fibers: single-fiber responses and a population model. J Neurophysiol. 1988 Nov; 60(5):1653-77.
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Rosowski JJ, Carney LH, Peake WT. The radiation impedance of the external ear of cat: measurements and applications. J Acoust Soc Am. 1988 Nov; 84(5):1695-708.
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Yin TC, Chan JC, Carney LH. Effects of interaural time delays of noise stimuli on low-frequency cells in the cat's inferior colliculus. III. Evidence for cross-correlation. J Neurophysiol. 1987 Sep; 58(3):562-83.
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Carney LH, Geisler CD. A temporal analysis of auditory-nerve fiber responses to spoken stop consonant-vowel syllables. J Acoust Soc Am. 1986 Jun; 79(6):1896-914.
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