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William Bowen

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentMicrobiology and Immunology in the Center for Oral Biology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 611
Rochester NY 14642
Other Positions
TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentEnvironmental Medicine

 
 Awards And Honors
1963     Colgate-Palmolive Prize, British Division of IADR
1964     Federation Dentaire Internationale Prize
1965     John Tomes Prize, Royal College of Surgeons, England
1965     Elected Fellow of Faculty of Dentistry, Royal College of Surgeons of Ireland
1969     Served on the Ministry of Health (UK) Panel on Cariogenic Foods (B.D.J. 126: 273)
1970     Postgraduate Lecturer, University of London
1971     Scientific Counsellor to ORCA
1971     Editorial Advisor to Journal of Dental Research
1971     Member of Scientific Board of Paradontologie
1971     Member of the Committee of the Comparative Medical Section of the Royal College of Medicine
1972     Dental Consultant, Pan American Health Organization
1972     Consultant to Dental Health Foundation, American Dental Association
1972     Consultant to Dental Health Foundation, American Dental Association
1974     Elected Fellow of Royal College of Surgeons of England
1977     European Organization for Caries Research Prize
1977     President, Cariology Group, International Association for Dental Research
1977     External Examiner for Ph.D., University of Oslo, Norway (also 1980, 1986, 1990, 1993, 1996)
1980 - 1987Editorial Board, Infection and Immunity
1980     Keynote Speaker at James English Symposium, State University of New York at Buffalo, New York
1980     Honorary D.D.Sc., University of Göteborg
1981     International Association for Dental Research, Cariology Award
1981     Merit Award for Outstanding Service, NIH
1982     Senior Executive Service Award for Excellence, Department of Health and Human Services
1984 - 1985Who's Who in Frontiers of Science and Technology
1985     American Men and Women of Science
1985     Elected Fellow of American Association for Advancement of Science
1986     Who's Who in Technology Today
1986     Who's Who in Science
1986     Who's Who in America
1987     Corresponding Referee, Medical Research Council in the Republic of South Africa (Oral Microbiology/Immunology)
1989     Visiting Professorship in Nutrition, National Dairy Council
1990     Advisory Board, Archives of Oral Biology
1990     Fred Birnberg Alumni Award for Distinguished Dental Research, Columbia University, School of Dental and Oral Surgery, New York, NY
1991     Member, Selection Committee, American Dental Association Gold Medal Award for Excellence in Dental Research
1991     Doctor Odontologiae honoris causa, University of Oslo, Norway
1992     Presidential Citation, American Dental Association, for significant contributions to the oral health of the public and to the profession of dentistry
1993 - 1994Wellcome Visiting Professor in the Microbiological Sciences, University of Maryland
1993     Doctor Odontologiae honoris causa, University of Umeå, Sweden
1995     Doctor of Medicine honoris causa, The National University of Ireland
1997     Swedish Patent Fund and Medical Research Council Award
1997     Member, Institute of Medicine, National Academy of Sciences
1998     Arthur Kornberg Research Award, School of Medicine and Dentistry, University of Rochester Institute of Biomedical Sciences
1999     E.W. Borrow Memorial Award, International Association for Dental Research
1999     Honorary M.D., Trinity College, Dublin, Ireland
2000     American Dental Association Gold Medal for Research
2001 - 2003Council on Scientific Affairs, American Dental Association
2004     Honorary Member of American Dental Association
2006     Lifetime Achievement in Mentoring Award, University of Rochester
 
 Overview
Our research is focused on the molecular mechanisms involved in the colonization of surfaces by microorganisms. We are particularly interested in a group of enzymes, the glucosyltransferases, formed by oral streptococci, and which form glucan from sucrose. These enzymes have distinct properties on surfaces compared with those observed when the enzymes are in solution. For example, glucan with a distinct structure may be formed on a surface compared with the product formed by the same enzyme in solution. Thus highly specific binding sites for bacteria may be formed on a surface.

In addition, we are exploring the influence of low molecular weight oligosaccharides on the formation of glucan by glucosyltransferases. The use of food preservatives has increased enormously over the past several decades. They behave chemically in many respects much like fluoride. We are also exploring the influence of common food preservatives on the development of caries.

 
 Selected Publications
  • Bowen WH. The Stephan Curve revisited. Odontology. 2013 Jan; 101(1):2-8.
    View in: PubMed
  • Bowen WH. Rodent model in caries research. Odontology. 2013 Jan; 101(1):9-14.
    View in: PubMed
  • Bowen WH. Cow milk and caries. J Am Dent Assoc. 2012 Jun; 143(6):554-5.
    View in: PubMed
  • Bowen WH, Koo H. Biology of Streptococcus mutans-derived glucosyltransferases: role in extracellular matrix formation of cariogenic biofilms. Caries Res. 2011; 45(1):69-86.
    View in: PubMed
  • Catalán MA, Scott-Anne K, Klein MI, Koo H, Bowen WH, Melvin JE. Elevated incidence of dental caries in a mouse model of cystic fibrosis. PLoS One. 2011; 6(1):e16549.
    View in: PubMed
  • Hannig C, Ruggeri A, Al-Khayer B, Schmitz P, Spitzmüller B, Deimling D, Huber K, Hoth-Hannig W, Bowen WH, Hannig M. Electron microscopic detection and activity of glucosyltransferase B, C, and D in the in situ formed pellicle. Arch Oral Biol. 2008 Nov; 53(11):1003-10.
    View in: PubMed
  • Duarte S, Klein MI, Aires CP, Cury JA, Bowen WH, Koo H. Influences of starch and sucrose on Streptococcus mutans biofilms. Oral Microbiol Immunol. 2008 Jun; 23(3):206-12.
    View in: PubMed
  • Vacca Smith AM, Scott-Anne KM, Whelehan MT, Berkowitz RJ, Feng C, Bowen WH. Salivary glucosyltransferase B as a possible marker for caries activity. Caries Res. 2007; 41(6):445-50.
    View in: PubMed
  • Duarte S, Gregoire S, Singh AP, Vorsa N, Schaich K, Bowen WH, Koo H. Inhibitory effects of cranberry polyphenols on formation and acidogenicity of Streptococcus mutans biofilms. FEMS Microbiol Lett. 2006 Apr; 257(1):50-6.
    View in: PubMed
  • Koo H, Seils J, Abranches J, Burne RA, Bowen WH, Quivey RG. Influence of apigenin on gtf gene expression in Streptococcus mutans UA159. Antimicrob Agents Chemother. 2006 Feb; 50(2):542-6.
    View in: PubMed
  • Koo H, Nino de Guzman P, Schobel BD, Vacca Smith AV, Bowen WH. Influence of cranberry juice on glucan-mediated processes involved in Streptococcus mutans biofilm development. Caries Res. 2006; 40(1):20-7.
    View in: PubMed
  • Koo H, Schobel B, Scott-Anne K, Watson G, Bowen WH, Cury JA, Rosalen PL, Park YK. Apigenin and tt-farnesol with fluoride effects on S. mutans biofilms and dental caries. J Dent Res. 2005 Nov; 84(11):1016-20.
    View in: PubMed
  • Culp DJ, Quivey RQ, Bowen WH, Fallon MA, Pearson SK, Faustoferri R. A mouse caries model and evaluation of aqp5-/- knockout mice. Caries Res. 2005 Nov-Dec; 39(6):448-54.
    View in: PubMed
  • Hayacibara MF, Koo H, Rosalen PL, Duarte S, Franco EM, Bowen WH, Ikegaki M, Cury JA. In vitro and in vivo effects of isolated fractions of Brazilian propolis on caries development. J Ethnopharmacol. 2005 Oct 3; 101(1-3):110-5.
    View in: PubMed
  • Bowen WH, Lawrence RA. Comparison of the cariogenicity of cola, honey, cow milk, human milk, and sucrose. Pediatrics. 2005 Oct; 116(4):921-6.
    View in: PubMed
  • Kho HS, Vacca Smith AM, Koo H, Scott-Anne K, Bowen WH. Interactions of Streptococcus mutans glucosyltransferase B with lysozyme in solution and on the surface of hydroxyapatite. Caries Res. 2005 Sep-Oct; 39(5):411-6.
    View in: PubMed
  • Duarte S, Rosalen PL, Hayacibara MF, Cury JA, Bowen WH, Marquis RE, Rehder VL, Sartoratto A, Ikegaki M, Koo H. The influence of a novel propolis on mutans streptococci biofilms and caries development in rats. Arch Oral Biol. 2006 Jan; 51(1):15-22.
    View in: PubMed
  • Pecharki GD, Cury JA, Paes Leme AF, Tabchoury CP, Del Bel Cury AA, Rosalen PL, Bowen WH. Effect of sucrose containing iron (II) on dental biofilm and enamel demineralization in situ. Caries Res. 2005 Mar-Apr; 39(2):123-9.
    View in: PubMed
  • Hayacibara MF, Koo H, Vacca-Smith AM, Kopec LK, Scott-Anne K, Cury JA, Bowen WH. The influence of mutanase and dextranase on the production and structure of glucans synthesized by streptococcal glucosyltransferases. Carbohydr Res. 2004 Aug 23; 339(12):2127-37.
    View in: PubMed
  • Bowen WH. Henry Klein--a forgotten icon? J Dent Res. 2004 May; 83(5):365-7.
    View in: PubMed
  • Krüger C, Pearson SK, Kodama Y, Vacca Smith A, Bowen WH, Hammarström L. The effects of egg-derived antibodies to glucosyltransferases on dental caries in rats. Caries Res. 2004 Jan-Feb; 38(1):9-14.
    View in: PubMed
  • Koo H, Hayacibara MF, Schobel BD, Cury JA, Rosalen PL, Park YK, Vacca-Smith AM, Bowen WH. Inhibition of Streptococcus mutans biofilm accumulation and polysaccharide production by apigenin and tt-farnesol. J Antimicrob Chemother. 2003 Nov; 52(5):782-9.
    View in: PubMed
  • Duarte S, Koo H, Bowen WH, Hayacibara MF, Cury JA, Ikegaki M, Rosalen PL. Effect of a novel type of propolis and its chemical fractions on glucosyltransferases and on growth and adherence of mutans streptococci. Biol Pharm Bull. 2003 Apr; 26(4):527-31.
    View in: PubMed
  • Koo H, Pearson SK, Scott-Anne K, Abranches J, Cury JA, Rosalen PL, Park YK, Marquis RE, Bowen WH. Effects of apigenin and tt-farnesol on glucosyltransferase activity, biofilm viability and caries development in rats. Oral Microbiol Immunol. 2002 Dec; 17(6):337-43.
    View in: PubMed
  • Bowen WH. Fluorosis: is it really a problem? J Am Dent Assoc. 2002 Oct; 133(10):1405-7.
    View in: PubMed
  • Koo H, Rosalen PL, Cury JA, Park YK, Bowen WH. Effects of compounds found in propolis on Streptococcus mutans growth and on glucosyltransferase activity. Antimicrob Agents Chemother. 2002 May; 46(5):1302-9.
    View in: PubMed
  • Korpela A, Yu X, Loimaranta V, Lenander-Lumikari M, Vacca-Smith A, Wunder D, Bowen WH, Tenovuo J. Lactoperoxidase inhibits glucosyltransferases from Streptococcus mutans in vitro. Caries Res. 2002 Mar-Apr; 36(2):116-21.
    View in: PubMed
  • Kopec LK, Vacca Smith AM, Wunder D, Ng-Evans L, Bowen WH. Influence of antibody on the structure of glucans. Caries Res. 2002 Mar-Apr; 36(2):108-15.
    View in: PubMed
  • Bowen WH. Do we need to be concerned about dental caries in the coming millennium? Crit Rev Oral Biol Med. 2002; 13(2):126-31.
    View in: PubMed
  • Bowen WH. Exposure to metal ions and susceptibility to dental caries. J Dent Educ. 2001 Oct; 65(10):1046-53.
    View in: PubMed
  • Davis BA, Raubertas RF, Pearson SK, Bowen WH. The effects of benzoate and fluoride on dental caries in intact and desalivated rats. Caries Res. 2001 Sep-Oct; 35(5):331-7.
    View in: PubMed
  • Goldhaber P, Greenspan JS, Bowen WH, Genco RJ, Barker B, Greene JC, Allukian M, McCallum CA, Slavkin H. The growing family of NIH institutes. Science. 2001 Jun 8; 292(5523):1835-6.
    View in: PubMed
  • Bowen WH, Quivey RG, Smith AV. Glucosyltransferase inactivation reduces dental caries. J Dent Res. 2001 Jun; 80(6):1505-6.
    View in: PubMed
  • Kopec LK, Vacca Smith AM, Wunder D, Ng-Evans L, Bowen WH. Properties of Streptococcus sanguinis glucans formed under various conditions. Caries Res. 2001 Jan-Feb; 35(1):67-74.
    View in: PubMed
  • Wunder D, Bowen WH. Effects of antibodies to glucosyltransferase on soluble and insolubilized enzymes. Oral Dis. 2000 Sep; 6(5):289-96.
    View in: PubMed
  • Yu D, Pearson SK, Bowen WH, Luo D, Kohut BE, Harper DS. Caries inhibition efficacy of an antiplaque/antigingivitis dentifrice. Am J Dent. 2000 Sep; 13(Spec No):14C-17C.
    View in: PubMed
  • Koo H, Vacca Smith AM, Bowen WH, Rosalen PL, Cury JA, Park YK. Effects of Apis mellifera propolis on the activities of streptococcal glucosyltransferases in solution and adsorbed onto saliva-coated hydroxyapatite. Caries Res. 2000 Sep-Oct; 34(5):418-26.
    View in: PubMed
  • Yu X, Loimaranta V, Lenander-Lumikari M, Wunder D, Bowen WH, Tenuvuo J. Effect of lactoperoxidase system on glucosyltransferase D of Streptococcus mutans. Chin J Dent Res. 2000 Aug; 3(2):61-4.
    View in: PubMed
  • Vacca Smith AM, Ng-Evans L, Wunder D, Bowen WH. Studies concerning the glucosyltransferase of Streptococcus sanguis. Caries Res. 2000 Jul-Aug; 34(4):295-302.
    View in: PubMed
  • Clancy KA, Pearson S, Bowen WH, Burne RA. Characterization of recombinant, ureolytic Streptococcus mutans demonstrates an inverse relationship between dental plaque ureolytic capacity and cariogenicity. Infect Immun. 2000 May; 68(5):2621-9.
    View in: PubMed
  • Vacca Smith AM, Bowen WH. In situ studies of pellicle formation on hydroxyapatite discs. Arch Oral Biol. 2000 Apr; 45(4):277-91.
    View in: PubMed
  • Ayad M, Van Wuyckhuyse BC, Minaguchi K, Raubertas RF, Bedi GS, Billings RJ, Bowen WH, Tabak LA. The association of basic proline-rich peptides from human parotid gland secretions with caries experience. J Dent Res. 2000 Apr; 79(4):976-82.
    View in: PubMed
  • Watson GE, Pearson SK, Bowen WH. The effect of chronic clonidine administration on salivary glands and caries in the rat. Caries Res. 2000 Mar-Apr; 34(2):194-200.
    View in: PubMed
  • Frame PS, Sawai R, Bowen WH, Meyerowitz C. Preventive dentistry: practitioners' recommendations for low-risk patients compared with scientific evidence and practice guidelines. Am J Prev Med. 2000 Feb; 18(2):159-62.
    View in: PubMed
  • Vacca Smith AM, Bowen WH. The effects of milk and kappa-casein on salivary pellicle formed on hydroxyapatite discs in situ. Caries Res. 2000 Jan-Feb; 34(1):88-93.
    View in: PubMed
  • Bowen WH, Pearson SK, Jerussi TP. Influence of (S)-ketoprofen and fluoride on caries in rats. Oral Dis. 2000 Jan; 6(1):12-4.
    View in: PubMed
  • Tabchoury CM, Pearson SK, Bowen WH. Influence of lead on the cariostatic effect of fluoride co-crystallized with sucrose in desalivated rats. Oral Dis. 1999 Apr; 5(2):100-3.
    View in: PubMed
  • Wunder D, Bowen WH. Action of agents on glucosyltransferases from Streptococcus mutans in solution and adsorbed to experimental pellicle. Arch Oral Biol. 1999 Mar; 44(3):203-14.
    View in: PubMed
  • Raubertas RF, Davis BA, Bowen WH, Pearson SK, Watson GE. Litter effects on caries in rats and implications for experimental design. Caries Res. 1999; 33(2):164-9.
    View in: PubMed
  • Bowen WH. Wither or whither caries research? Caries Res. 1999; 33(1):1-3.
    View in: PubMed
  • Bowen WH. Developing a research unit and maintaining it. Eur J Dent Educ. 1999; 3 Suppl 1:99-103.
    View in: PubMed
  • Tabchoury CM, Holt T, Pearson SK, Bowen WH. The effects of fluoride concentration and the level of cariogenic challenge on caries development in desalivated rats. Arch Oral Biol. 1998 Dec; 43(12):917-24.
    View in: PubMed
  • Vacca-Smith AM, Bowen WH. Binding properties of streptococcal glucosyltransferases for hydroxyapatite, saliva-coated hydroxyapatite, and bacterial surfaces. Arch Oral Biol. 1998 Feb; 43(2):103-10.
    View in: PubMed
  • Bowen WH. Response to Seow: biological mechanisms of early childhood caries. Community Dent Oral Epidemiol. 1998; 26(1 Suppl):28-31.
    View in: PubMed
  • Kopec LK, Vacca-Smith AM, Bowen WH. Structural aspects of glucans formed in solution and on the surface of hydroxyapatite. Glycobiology. 1997 Oct; 7(7):929-34.
    View in: PubMed
  • Bowen WH. Research revisited: Gunnar Rølla's contribution to oral health. Eur J Oral Sci. 1997 Oct; 105(5 Pt 2):450-3.
    View in: PubMed
  • Watson GE, Davis BA, Raubertas RF, Pearson SK, Bowen WH. Influence of maternal lead ingestion on caries in rat pups. Nat Med. 1997 Sep; 3(9):1024-5.
    View in: PubMed
  • Bowen WH, Pearson SK, Rosalen PL, Miguel JC, Shih AY. Assessing the cariogenic potential of some infant formulas, milk and sugar solutions. J Am Dent Assoc. 1997 Jul; 128(7):865-71.
    View in: PubMed
  • Miguel JC, Bowen WH, Pearson SK. Effects of iron salts in sucrose on dental caries and plaque in rats. Arch Oral Biol. 1997 May; 42(5):377-83.
    View in: PubMed
  • Rosalen PL, Bowen WH, Pearson SK. Influence of fluoride co-cystallized with sugar on caries development in desalivated rats. Arch Oral Biol. 1997 Apr; 42(4):317-22.
    View in: PubMed
  • Miguel JC, Bowen WH, Pearson SK. Effects of frequency of exposure to iron-sucrose on the incidence of dental caries in desalivated rats. Caries Res. 1997; 31(3):238-43.
    View in: PubMed
  • Miguel JC, Bowen WH, Pearson SK. Influence of iron alone or with fluoride on caries development in desalivated and intact rats. Caries Res. 1997; 31(3):244-8.
    View in: PubMed
  • Rosalen PL, Pearson SK, Bowen WH. Effects of copper, iron and fluoride co-crystallized with sugar on caries development and acid formation in deslivated rats. Arch Oral Biol. 1996 Nov; 41(11):1003-10.
    View in: PubMed
  • Steinberg D, Beeman D, Bowen WH. Kinetic properties of glucosyltransferase adsorbed onto saliva-coated hydroxyapatite. Artif Cells Blood Substit Immobil Biotechnol. 1996 Sep; 24(5):553-66.
    View in: PubMed
  • Zhao XJ, McElhaney-Feser GE, Bowen WH, Cole MF, Broedel SE, Cihlar RL. Requirement for the Candida albicans FAS2 gene for infection in a rat model of oropharyngeal candidiasis. Microbiology. 1996 Sep; 142 ( Pt 9):2509-14.
    View in: PubMed
  • Bowen WH. Vaccine against dental caries--a personal view. J Dent Res. 1996 Aug; 75(8):1530-3.
    View in: PubMed
  • Burne RA, Chen YY, Wexler DL, Kuramitsu H, Bowen WH. Cariogenicity of Streptococcus mutans strains with defects in fructan metabolism assessed in a program-fed specific-pathogen-free rat model. J Dent Res. 1996 Aug; 75(8):1572-7.
    View in: PubMed
  • Vacca-Smith AM, Venkitaraman AR, Quivey RG, Bowen WH. Interactions of streptococcal glucosyltransferases with alpha-amylase and starch on the surface of saliva-coated hydroxyapatite. Arch Oral Biol. 1996 Mar; 41(3):291-8.
    View in: PubMed
  • Bowen WH. Clinical relevance of adaptation to sorbitol by plaque bacteria: a review. J Clin Dent. 1996; 7(1):1-5.
    View in: PubMed
  • Vacca-Smith AM, Venkitaraman AR, Schilling KM, Bowen WH. Characterization of glucosyltransferase of human saliva adsorbed onto hydroxyapatite surfaces. Caries Res. 1996; 30(5):354-60.
    View in: PubMed
  • Rosalen PL, Bowen WH, Pearson SK. Effect of copper co-crystallized with sugar on caries development in desalivated rats. Caries Res. 1996; 30(5):367-72.
    View in: PubMed
  • Venkitaraman AR, Vacca-Smith AM, Kopec LK, Bowen WH. Characterization of glucosyltransferaseB, GtfC, and GtfD in solution and on the surface of hydroxyapatite. J Dent Res. 1995 Oct; 74(10):1695-701.
    View in: PubMed
  • Bowen WH. The role of fluoride toothpastes in the prevention of dental caries. J R Soc Med. 1995 Sep; 88(9):505-7.
    View in: PubMed
  • Bowen WH. Are current models for preventive programs sufficient for the needs of tomorrow? Adv Dent Res. 1995 Jul; 9(2):77-81.
    View in: PubMed
  • Bowen WH. Research training: past, present, and future. J Dent Educ. 1995 May; 59(5):559-63.
    View in: PubMed
  • Bowen WH, Caton JG, Clarkson BH, Edgar WM, Featherstone JD, Littleton PA, Van Dyke TE. Summary of panel discussion. 1--Is there a conflict between the postgraduate education of the clinician and the academic researcher? J Dent Educ. 1995 May; 59(5):564-6.
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  • Cole MF, Bowen WH, Zhao XJ, Cihlar RL. Avirulence of Candida albicans auxotrophic mutants in a rat model of oropharyngeal candidiasis. FEMS Microbiol Lett. 1995 Feb 15; 126(2):177-80.
    View in: PubMed
  • Van Wuyckhuyse BC, Perinpanayagam HE, Bevacqua D, Raubertas RF, Billings RJ, Bowen WH, Tabak LA. Association of free arginine and lysine concentrations in human parotid saliva with caries experience. J Dent Res. 1995 Feb; 74(2):686-90.
    View in: PubMed
  • Kopec LK, Bowen WH. Adherence of microorganisms to rat salivary pellicles. Caries Res. 1995; 29(6):507-12.
    View in: PubMed
  • Vacca-Smith AM, Bowen WH. The effect of milk and kappa casein on streptococcal glucosyltransferase. Caries Res. 1995; 29(6):498-506.
    View in: PubMed
  • Vacca-Smith AM, Van Wuyckhuyse BC, Tabak LA, Bowen WH. The effect of milk and casein proteins on the adherence of Streptococcus mutans to saliva-coated hydroxyapatite. Arch Oral Biol. 1994 Dec; 39(12):1063-9.
    View in: PubMed
  • Bowen WH. Ethics in dental research. Ethical use of animals. J Dent Res. 1994 Nov; 73(11):1773-7.
    View in: PubMed
  • Bowen WH. Food components and caries. Adv Dent Res. 1994 Jul; 8(2):215-20.
    View in: PubMed
  • O'Connell AC, Pearson SK, Bowen WH. Pilocarpine alters caries development in partially-desalivated rats. J Dent Res. 1994 Mar; 73(3):637-43.
    View in: PubMed
  • O'Connell AC, Bowen WH. Composition and flow rate of saliva and caries development in young rats following administration of lithium. Caries Res. 1994; 28(5):342-7.
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  • Bowen WH, Pearson SK. Residual effects of fluoride on a severe cariogenic challenge in rats. Caries Res. 1994; 28(4):246-50.
    View in: PubMed
  • O'Connell AC, Van Wuyckhuyse BC, Pearson SK, Bowen WH. The effect of propranolol on salivary gland function and dental caries development in young and aged rats. Arch Oral Biol. 1993 Oct; 38(10):853-61.
    View in: PubMed
  • Yamashita Y, Bowen WH, Burne RA, Kuramitsu HK. Role of the Streptococcus mutans gtf genes in caries induction in the specific-pathogen-free rat model. Infect Immun. 1993 Sep; 61(9):3811-7.
    View in: PubMed
  • Steinberg D, Kopec LK, Bowen WH. Adhesion of actinomyces isolates to experimental pellicles. J Dent Res. 1993 Jun; 72(6):1015-20.
    View in: PubMed
  • Bowen WH, Pearson SK. Effect of milk on cariogenesis. Caries Res. 1993; 27(6):461-6.
    View in: PubMed
  • Steinberg D, Beeman D, Bowen WH. Interactions of delmopinol with constituents of experimental pellicle. J Dent Res. 1992 Nov; 71(11):1797-802.
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  • Wexler DL, Penders JE, Bowen WH, Burne RA. Characteristics and cariogenicity of a fructanase-defective Streptococcus mutants strain. Infect Immun. 1992 Sep; 60(9):3673-81.
    View in: PubMed
  • Bowen WH, Pearson SK. The effects of sucralose, xylitol, and sorbitol on remineralization of caries lesions in rats. J Dent Res. 1992 May; 71(5):1166-8.
    View in: PubMed
  • Yamashita Y, Bowen WH, Kuramitsu HK. Molecular analysis of a Streptococcus mutans strain exhibiting polymorphism in the tandem gtfB and gtfC genes. Infect Immun. 1992 Apr; 60(4):1618-24.
    View in: PubMed
  • Steinberg D, Beeman D, Bowen WH. The effect of delmopinol on glucosyltransferase adsorbed on to saliva-coated hydroxyapatite. Arch Oral Biol. 1992 Jan; 37(1):33-8.
    View in: PubMed
  • Schilling KM, Bowen WH. Glucans synthesized in situ in experimental salivary pellicle function as specific binding sites for Streptococcus mutans. Infect Immun. 1992 Jan; 60(1):284-95.
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  • Bowen WH, Schilling K, Giertsen E, Pearson S, Lee SF, Bleiweis A, Beeman D. Role of a cell surface-associated protein in adherence and dental caries. Infect Immun. 1991 Dec; 59(12):4606-9.
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  • Bowen WH. Caries prevention--fluoride: reaction paper. Adv Dent Res. 1991 Dec; 5:46-9.
    View in: PubMed
  • Melvin JE, O'Connell AC, Koek L, Bowen WH. Agonist-induced Ca2+ mobilization in the rat submandibular gland during aging and subsequent to chronic propranolol treatment. Mech Ageing Dev. 1991 Nov 15; 61(1):33-44.
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  • O'Connell AC, Bowen WH. Influence of rampant caries in dams on caries activity in their offspring. Pediatr Dent. 1991 Nov-Dec; 13(6):361-6.
    View in: PubMed
  • Bowen WH. Dental caries: is it an extinct disease? J Am Dent Assoc. 1991 Sep; 122(9):49-52.
    View in: PubMed
  • Giertsen E, Bowen WH, Pearson SK. Combined effects of Zn(2+)-chlorhexidine and Zn(2+)-cetylpyridinium chloride on caries incidence in partially desalivated rats. Scand J Dent Res. 1991 Aug; 99(4):301-9.
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  • Quivey RG, Bowen WH. A computer program designed for the analysis of data from rat caries studies. Caries Res. 1991; 25(3):191-6.
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  • Bowen WH, Pearson SK, VanWuyckhuyse BC, Tabak LA. Influence of milk, lactose-reduced milk, and lactose on caries in desalivated rats. Caries Res. 1991; 25(4):283-6.
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  • Madison KM, Bowen WH, Pearson SK, Falany JL. Enhancing the virulence of Streptococcus sobrinus in rats. J Dent Res. 1991 Jan; 70(1):38-43.
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  • Young DA, Bowen WH. The influence of sucralose on bacterial metabolism. J Dent Res. 1990 Aug; 69(8):1480-4.
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  • Bowen WH, Young DA, Pearson SK. The effects of sucralose on coronal and root-surface caries. J Dent Res. 1990 Aug; 69(8):1485-7.
    View in: PubMed
  • Meitner SW, Bowen WH, Haidaris CG. Oral and esophageal Candida albicans infection in hyposalivatory rats. Infect Immun. 1990 Jul; 58(7):2228-36.
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  • Bowen WH. Apathy. J Dent Res. 1990 Jul; 69(7):1350-1.
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  • Madison KM, Bowen WH, Pearson SK, Falany JL. Caries incidence in intact rats infected with Streptococcus sobrinus via transmission from desalivated cagemates. J Dent Res. 1990 May; 69(5):1154-9.
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  • Herzberg MC, Gong K, MacFarlane GD, Erickson PR, Soberay AH, Krebsbach PH, Manjula G, Schilling K, Bowen WH. Phenotypic characterization of Streptococcus sanguis virulence factors associated with bacterial endocarditis. Infect Immun. 1990 Feb; 58(2):515-22.
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  • Bowen WH, Pearson SK, Falany JL. Influence of sweetening agents in solution on dental caries in desalivated rats. Arch Oral Biol. 1990; 35(10):839-44.
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  • Allen PZ, Bowen WH. Immunochemical studies on levans from several strains of Actinomyces viscosus. Arch Oral Biol. 1990; 35(1):55-62.
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  • Watson GE, Pearson SK, Falany JL, Tabak LA, Bowen WH. The effect of chronic propranolol treatment on salivary composition and caries in the rat. Arch Oral Biol. 1990; 35(6):435-41.
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  • Page DJ, Gilbert RJ, Bowen WH, Stephen KW. Concentration of antimicrobial proteins in human saliva. The effect of long-term usage of a zinc-containing dentifrice on the protein composition of stimulated saliva from 198 children. Caries Res. 1990; 24(3):216-9.
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  • Watson GE, Pearson SK, Falany JL, Culp DJ, Tabak LA, Bowen WH. The effect of chronic atropine treatment on salivary composition and caries in rats. J Dent Res. 1989 Dec; 68(12):1739-45.
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  • Emilson CG, Ciardi JE, Olsson J, Bowen WH. The influence of saliva on infection of the human mouth by mutans streptococci. Arch Oral Biol. 1989; 34(5):335-40.
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  • Madison KM, Bowen WH, Pearson SK, Young DA. Effect of desalivation and age on susceptibility to infection by Streptococcus sobrinus. Caries Res. 1989; 23(2):70-4.
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  • Bowen WH, Madison KM, Pearson SK. Influence of desalivation in rats on incidence of caries in intact cagemates. J Dent Res. 1988 Oct; 67(10):1316-8.
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  • Allen PZ, Bowen WH. Immunochemical studies on pneumococcal type 37 capsular polysaccharide. Mol Immunol. 1988 Oct; 25(10):1011-7.
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  • Bowen WH, Pearson SK, Young DA. The effect of desalivation on coronal and root surface caries in rats. J Dent Res. 1988 Jan; 67(1):21-3.
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  • Schilling KM, Bowen WH. The activity of glucosyltransferase adsorbed onto saliva-coated hydroxyapatite. J Dent Res. 1988 Jan; 67(1):2-8.
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  • Harrison R, Bowen WH. Periodontal health, dental caries, and metabolic control in insulin-dependent diabetic children and adolescents. Pediatr Dent. 1987 Dec; 9(4):283-6.
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  • Harrison R, Bowen WH. Flow rate and organic constituents of whole saliva in insulin-dependent diabetic children and adolescents. Pediatr Dent. 1987 Dec; 9(4):287-91.
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  • Burne RA, Schilling K, Bowen WH, Yasbin RE. Expression, purification, and characterization of an exo-beta-D-fructosidase of Streptococcus mutans. J Bacteriol. 1987 Oct; 169(10):4507-17.
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  • Bowen WH. Biochemical and microanalytical methods. Adv Dent Res. 1987 Oct; 1(1):88-91.
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  • Shern RJ, Mirth DB, Emilson CG, Adderly DD, Bowen WH. Evaluation of an intraoral controlled release delivery system for fluoride in primates. Community Dent Oral Epidemiol. 1987 Jun; 15(3):113-6.
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  • Krobicka A, Bowen WH, Pearson S, Young DA. The effects of cheese snacks on caries in desalivated rats. J Dent Res. 1987 Jun; 66(6):1116-9.
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  • Burne RA, Rubinfeld B, Bowen WH, Yasbin RE. Tight genetic linkage of a glucosyltransferase and dextranase of Streptococcus mutans GS-5. J Dent Res. 1986 Dec; 65(12):1392-401.
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  • Bowen WH. Interpretation and use of microbiological findings in dental caries. Oral Microbiol Immunol. 1986 Nov; 1(1):82-6.
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  • Burne RA, Rubinfeld B, Bowen WH, Yasbin RE. Cloning and expression of a Streptococcus mutans glucosyltransferase gene in Bacillus subtilis. Gene. 1986; 47(2-3):201-9.
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  • Thibodeau EA, Bowen WH, Marquis RE. pH-dependent fluoride inhibition of peroxidase activity. J Dent Res. 1985 Oct; 64(10):1211-3.
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  • Mirth DB, Adderly DD, Monell-Torrens E, Amsbaugh SM, Li SH, Bowen WH. Comparison of the cariostatic effect of topically and systemically administered controlled-release fluoride in the rat. Caries Res. 1985; 19(5):466-74.
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  • Johansson I, Ericson T, Bowen W, Cole M. The effect of malnutrition on caries development and saliva composition in the rat. J Dent Res. 1985 Jan; 64(1):37-43.
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  • Cole MF, Emilson CG, Hsu SD, Li SH, Bowen WH. Effect of peroral immunization of humans with Streptococcus mutans on induction of salivary and serum antibodies and inhibition of experimental infection. Infect Immun. 1984 Dec; 46(3):703-9.
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  • Emilson CG, Nilsson B, Bowen WH. Carbohydrate composition of dental plaque from primates with irradiation caries. J Oral Pathol. 1984 Jun; 13(3):213-20.
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  • Bowen WH. Use of supporting laboratory or clinical data in caries clinical trials. J Dent Res. 1984 May; 63 Spec No:757-61.
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  • Robrish SA, Curtis MA, Sharer SA, Bowen WH. The analysis of picomole amounts of L(+)- and D(-)-lactic acid in samples of dental plaque using bacterial luciferase. Anal Biochem. 1984 Feb; 136(2):503-8.
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  • Afseth J, Amsbaugh SM, Monell-Torrens E, Bowen WH, Rölla G, Brunelle J, Li S, Dahl E. Effect of topical application of copper in combination with fluoride in drinking water on experimental caries in rats. Caries Res. 1984; 18(2):134-40.
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  • Afseth J, Amsbaugh SM, Monell-Torrens E, Bowen WH, Rølla G, Brunelle J, Dahl E. Effect of copper applied topically or in drinking water on experimental caries in rats. Caries Res. 1984; 18(5):434-9.
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  • Curtis MA, Kemp CW, Robrish SA, Bowen WH. Stickland reactions of dental plaque. Infect Immun. 1983 Oct; 42(1):431-3.
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  • Rölla G, Amsbaugh SM, Monell-Torrens E, Ellingsen JE, Afseth J, Ciardi JE, Bowen WH. Effect of topical application of stannous fluoride, stannous chloride and stannous tartrate on rat caries. Scand J Dent Res. 1983 Oct; 91(5):351-5.
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  • Mirth DB, Adderly DD, Amsbaugh SM, Monell-Torrens E, Li SH, Bowen WH. Inhibition of experimental dental caries using an intraoral fluoride-releasing device. J Am Dent Assoc. 1983 Jul; 107(1):55-8.
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  • Rölla G, Ciardi JE, Bowen WH. Identification of IgA, IgG, lysozyme, albumin, alpha-amylase and glucosyltransferase in the protein layer adsorbed to hydroxyapatite from whole saliva. Scand J Dent Res. 1983 Jun; 91(3):186-90.
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  • Kemp CW, Curtis MA, Robrish SA, Bowen WH. Biogenesis of methane in primate dental plaque. FEBS Lett. 1983 May 2; 155(1):61-4.
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  • Kemp CW, Robrish SA, Curtis MA, Sharer SA, Bowen WH. Application of a competition model to the growth of Streptococcus mutans and Streptococcus sanguis in binary continuous culture. Appl Environ Microbiol. 1983 Apr; 45(4):1277-82.
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  • Bowen WH, Amsbaugh SM, Monell-Torrens S, Brunelle J. Effects of varying intervals between meals on dental caries in rats. Caries Res. 1983; 17(5):466-71.
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  • Bowen WH, Amsbaugh SM, Monell-Torrens S, Brunelle JA. Influence of various diets administered by gastric gavage on cariogenicity of foods. Caries Res. 1983; 17(6):525-31.
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  • Mirth DB, Shern RJ, Emilson CG, Adderly DD, Li SH, Gomez IM, Bowen WH. Clinical evaluation of an intraoral device for the controlled release of fluoride. J Am Dent Assoc. 1982 Nov; 105(5):791-7.
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  • Cole MF, Hsu SD, Bowen WH. A fluorescein-linked immunoabsorbent assay for the detection of antibacterial antibodies in secretions and serum. J Immunol Methods. 1982 Sep 30; 53(3):335-43.
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  • Edgar WM, Bowen WH, Cole MF. Protein components in saliva and plaque fluid from irradiated primates. J Oral Pathol. 1982 Jun; 11(3):252-9.
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  • Edgar WM, Bowen WH, Amsbaugh S, Monell-Torrens E, Brunelle J. Effects of different eating patterns on dental caries in the rat. Caries Res. 1982; 16(5):384-9.
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  • Olsson J, Bowen W. Effect of diet on the colonization of the mouth by Actinomyces viscosus (T-6) in Osborne-Mendel rats. Arch Oral Biol. 1982; 27(12):1087-90.
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  • Williams D, Meier PM, Gron P, Hitchcock CJ, Mullins TJ, Bowen WH. Cariostatic microcapsules for aerosol delivery. J Pedod. 1982; 6(3):218-28.
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  • Emilson CG, Bowen WH. Microbial analyses of dental plaque of monkeys (Macaca fascicularis) using fluorescent antibody techniques. Scand J Dent Res. 1981 Dec; 89(6):458-62.
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  • Emilson CG, Bowen WH, Robrish SA, Kemp CW. Effect of the antibacterial agents octenidine and chlorhexidine on the plaque flora in primates. Scand J Dent Res. 1981 Oct; 89(5):384-92.
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  • Edgar WM, Bowen WH, Cole MF. Development of rampant dental caries, and composition of plaque fluid and saliva in irradiated primates. J Oral Pathol. 1981 Aug; 10(4):284-95.
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  • Cole MF, Hsu SD, Baum BJ, Bowen WH, Sierra LI, Aquirre M, Gillespie G. Specific and nonspecific immune factors in dental plaque fluid and saliva from young and old populations. Infect Immun. 1981 Mar; 31(3):998-1002.
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  • Ciardi JE, Rosenthal AB, Bowen WH. Rapid quantitative determination of the effect of antiplaque agents and antisera on the growth, acid production, and adherence of Streptococcus mutans. J Dent Res. 1981 Mar; 60(3):756-62.
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  • Mirth DB, Miller CJ, Kingman A, Bowen WH. Binding of salivary aggregating factors for Streptococcus mutans by concanavalin A and fucose-binding protein. Caries Res. 1981; 15(1):1-8.
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  • Edgar WM, Bowen WH, Amsbaugh S, Monell-Torrens A. Effects on caries in rats of calcium glycerophosphate and sodium fluoride administered separately and together. Caries Res. 1981; 15(6):512-4.
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  • Thomson LA, Little WA, Bowen WH, Sierra LI, Aguirrer M, Gillespie G. Prevalence of Streptococcus mutans serotypes, Actinomyces, and other bacteria in the plaque of children. J Dent Res. 1980 Oct; 59(10):1581-9.
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  • Bowen WH, Amsbaugh SM, Monell-Torrens S, Brunelle J, Kuzmiak-Jones H, Cole MF. A method to assess cariogenic potential of foodstuffs. J Am Dent Assoc. 1980 May; 100(5):677-81.
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  • Ciardi JE, Reilly JA, Bowen WH. Inhibition by sodium fluoride of 3H-glycerol incorporation into lipoteichoic acid in Streptococcus mutans. Caries Res. 1980; 14(1):24-31.
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  • Rølla G, Oppermann RV, Bowen WH, Ciardi JE, Knox KW. High amounts of lipoteichoic acid in sucrose-induced plaque in vivo. Caries Res. 1980; 14(4):235-8.
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  • Cole MF, Eastoe JE, Curtis MA, Korts DC, Bowen WH. Effects of pyridoxine, phytate and invert sugar on plaque composition and caries activity in the monkey (Macaca fascicularis). Caries Res. 1980; 14(1):1-15.
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  • Robrish SA, Kemp CW, Chopp DE, Bowen WH. Viable and total cell masses in dental plaque as measured by bioluminescence methods. Clin Chem. 1979 Sep; 25(9):1649-54.
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  • Little WA, Thomson LA, Bowen WH. Antibiotic susceptibility of Streptococcus mutans: comparison of serotype profiles. Antimicrob Agents Chemother. 1979 Mar; 15(3):440-3.
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  • Thomson LA, Bowen WH, Little WA, Kuzmiak-Jones HM, Gomez IM. Simultaneous implantation of five serotypes of Streptococcus mutans in gnotobiotic rats. Caries Res. 1979; 13(1):9-17.
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  • Mirth DB, Miller CJ, Kingman A, Bowen WH. Inhibition of saliva-induced aggregation of Streptococcus mutans by wheat germ agglutinin. Caries Res. 1979; 13(3):121-31.
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  • Bowen WH. Dental caries. N Y State J Med. 1978 Dec; 78(14):2278-9.
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  • Mäkinen KK, Bowen WH, Dalgard D, Fitzgerald G. Effect of peroral administration of xylitol on exocrine secretions of monkeys. J Nutr. 1978 May; 108(5):779-89.
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  • Robrish SA, Kemp CW, Bowen WH. Use of extractable adenosine triphosphate to estimate the viable cell mass in dental plaque samples obtained from monkeys. Appl Environ Microbiol. 1978 Apr; 35(4):743-9.
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  • Cole MF, Bowen WH, Sierra L, Espinal F, Aguirra M, Kingman A, Kemp LJ, Gomez I, Reilly JA, Hsu D, Ciardi JE, Gillespie G. Immunoglobulins and antibodies in plaque fluid and saliva in two populations with contrasting levels of caries. Adv Exp Med Biol. 1978; 107:383-92.
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  • Mäkinen KK, Tenovuo J, Bowen WH. Lactoperoxidases of monkey saliva. Acta Chem Scand B. 1978; 32(5):387-90.
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  • Bowen WH, Guggenheim B. Therapeutics of caries prevention--concepts and prospects. Acta Odontol Scand. 1978; 36(4):185-98.
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  • Rölla G, Bowen WH. Surface adsorption of fluoride and ionic exchange reactions on hydroxyapatite. Acta Odontol Scand. 1978; 36(4):219-24.
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  • Robrish SA, Kemp C, Bowen WH. The use of the o-phthalaldehyde reaction as a sensitive assay for protein and to determine protein in bacterial cells and dental plaque. Anal Biochem. 1978 Jan; 84(1):196-204.
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  • Cole MF, Bowden GH, Korts DC, Bowen WH. The effect of pyridoxine, phytate and invert sugar on production of plaque acids in situ in the monkey (M. fascicularis). Caries Res. 1978; 12(4):190-201.
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  • Ciardi JE, Bowen WH, Reilly JA, Hsu SD, Gomez I, Kuzmiak-Jones H, Cole MF. Antigens of Streptococcus mutans implicated in virulence--production of antibodies. Adv Exp Med Biol. 1978; 107:281-92.
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  • Ciardi JE, Bowen WH, Rölla G. The effect of antibacterial compounds on glucosyltransferase activity from Streptococcus mutans. Arch Oral Biol. 1978; 23(4):301-5.
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  • Bowen WH. Dental caries. J Am Pharm Assoc. 1977 Nov; 17(11):709-10.
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  • Bowen WH, Velez H, Aguila M, Velasquez H, Sierra LI, Gillespie G. The microbiology and biochemistry of plaque, saliva, and drinking water from two communities with contrasting levels of caries in Colombia, S.A. J Dent Res. 1977 Oct; 56 Spec No:C32-9.
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  • Rölla G, Robrish SA, Bowen WH. Interaction of hydroxyapatite and protein-coated hydroxyapatite with Streptococcus mutans and Streptococcus sanguis. Acta Pathol Microbiol Scand B. 1977 Oct; 85B(5):341-6.
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  • Bird JL, Baum BJ, Makinen KK, Bowen WH, Longton RW. Xylitol associated changes in amylase and protein content of monkey parotid saliva. J Nutr. 1977 Oct; 107(10):1763-7.
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  • Ciardi JE, Rölla G, Bowen WH, Reilly JA. Adsorption of Streptococcus mutans lipoteichoic acid to hydroxyapatite. Scand J Dent Res. 1977 Sep; 85(6):387-91.
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  • Little WA, Korts DC, Thomson LA, Bowen WH. Comparative recovery of Streptococcus mutans on ten isolation media. J Clin Microbiol. 1977 Jun; 5(6):578-83.
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  • Colman G, Bowen WH, Cole MF. The effects of sucrose, fructose, and a mixture of glucose and fructose on the incidence of dental caries in monkeys (M. fascicularis). Br Dent J. 1977 Apr 5; 142(7):217-21.
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  • Cole MF, Curtis MA, Bowen WH. Ornithine decarboxylase activity in tooth surface plaque from monkeys (Macaca fascicularis) fed pyridoxine, phytate and invert sugar. Arch Oral Biol. 1977; 22(8-9):503-6.
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  • Hellsing G, Giblin AG, Gray CJ, Bowen WH. Absorption of a dextranase--concanavalin a conjugate on to hydroxyapatite. Arch Oral Biol. 1977; 22(3):163-6.
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  • Rölla G, Bowen WH. Concentration of fluoride in plaque - a possible mechanism. Scand J Dent Res. 1977 Jan-Feb; 85(2):149-51.
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  • Rölla G, Hsu SD, Bowen WH. The influence of fluoride on the uptake of protein by hydroxyapatite. Caries Res. 1977; 11(6):308-12.
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  • Polyzois S, Baum BJ, Bowen WH, Longton RW. Differences in the pH activity profile of human and monkey salivary lysozyme. J Dent Res. 1976 Nov-Dec; 55(6):1137.
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  • Bowen WH. "Caries immunization through ingestion of Streptococcus mutans--a critique.". Dent Abstr. 1976 Nov; 21(11):650-1.
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  • Cole MF, Bowen WH. Immunoglobulins A, G, and M in serum and in some secretions of monkeys (Macaca fascicularis syn. irus). Infect Immun. 1976 May; 13(5):1354-9.
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  • Bowen WH, Cohen B, Cole M, Colman G. Immunization against dental caries: summary. J Dent Res. 1976 Apr; 55 Spec No:UNKNOWN.
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  • Bowen WH. Identification of cariogenic bacteria by fluorescent antibody and other techniques: an international symposium. New York City, April 3-4, 1975. A summary and view of the future. J Dent Res. 1976 Jan; 55:A205-6.
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  • Bowen WH. Nature of plaque. Oral Sci Rev. 1976; 9:3-21.
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  • Bowen WH, Cohen B, Cole MF, Colman G. Immunization against dental caries. Br Dent J. 1975 Jul 15; 139(2):45-58.
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  • Cole MF, Bowen WH. Effect of sodium phytate on the chemical and microbial composition of dental plaque in the monkey (Macaca fascicularis) J Dent Res. 1975 May-Jun; 54(3):449-57.
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  • Bowen WH. A search for caries-free teeth. Dent Health (London). 1974 Sep; 13(2):13-21.
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  • Barker SA, Giblin AG, Gray CJ, Bowen WH. Preparation and properties of a conjugate containing dextranase and concanavalin A. Carbohydr Res. 1974 Aug; 36(1):23-33.
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  • Cole MF, Bowen WH. The effect of calcium beta glycerophosphate on phosphatase activity in plaque from monkeys (Macaca fascicularis). Arch Oral Biol. 1974 Apr; 19(4):335-7.
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  • Bowen WH. Effect of restricting oral intake to invert sugar or casein on the microbiology of plaque in Macaca fascicularis (irus). Arch Oral Biol. 1974 Mar; 19(3):231-9.
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  • Bowen WH. Defense mechanisms in the mouth and their possible role in the prevention of dental caries: a review. J Oral Pathol. 1974; 3(6):266-78.
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  • Bowen WH. The effect of fluoride and molybdate on caries activity in monkeys (Macaca fascicularis). Br Dent J. 1973 Dec 4; 135(11):489-93.
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  • Bowen WH. A search for caries-free teeth. Dent Update. 1973 Nov-Dec; 1(4):191-7.
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  • Bowen WH. Aetiology of dental caries. Nurs Mirror Midwives J. 1973 Oct 19; 137(16):14-5.
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  • Brown WA, Bowen WH. The occurrence of anterior open bites in captive- and wild-born monkeys (Macaca fascicularis). Br Dent J. 1973 Aug 21; 135(4):149-52.
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  • Bowen WH. The effect of single daily doses of fluoride on saliva, plaque, and urine in monkeys (Macaca fascicularis). J Int Assoc Dent Child. 1973 Jul; 4(1):11-4.
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  • Bowen WH. [3d report on a dental caries study in 2 communities in Colombia]. Temas Odontol. 1973; 12(113):174-84.
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  • Bowen WH. Dental caries. Arch Dis Child. 1972 Dec; 47(256):849-53.
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  • Cornick DE, Bowen WH. The effect of sorbitol on the microbiology of the dental plaque in monkeys (Macaca irus). Arch Oral Biol. 1972 Dec; 17(12):1637-48.
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  • Bowen WH. Aetiology of dental caries. Midwife Health Visit. 1972 Nov; 8(11):385-7.
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  • Bowen WH. The effect of dextranase on caries activity in monkeys (macaca irus). Caries Res. 1972; 6(1):75-6.
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  • Bowen WH. The cariostatic effect of calcium glycerophosphate in monkeys. Caries Res. 1972; 6(1):43-51.
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  • Cornick DE, Bowen WH. The effect of sorbitol on the microbiology of dental plaque in monkeys. (M. irus). Caries Res. 1972; 6(1):76-7.
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  • Bowen WH. The search for a caries preventive. Health Visit. 1971 Dec; 44(12):409.
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  • Bowen WH. The effect of dextranase on caries activity in monkeys (Macaca irus). Br Dent J. 1971 Nov 16; 131(10):445-9.
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  • Sidebotham RL, Weigel H, Bowen WH. Studies on dextrans and destranases. IX. Dextrans elaborated by cariogenic organisms. Carbohydr Res. 1971 Sep; 19(2):151-9.
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  • Cornick DE, Bowen WH. Development of the oral flora in new born monkeys (Macaca irus). Br Dent J. 1971 Mar 16; 130(6):231-4.
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  • Bowen WH. The effects of calcium, magnesium and manganese on dextran production by a cariogenic streptococcus. Arch Oral Biol. 1971 Jan; 16(1):115-9.
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  • Bowen WH. The cariostatic effect of calcium glycerophosphate in monkeys (M. irus). Caries Res. 1971; 5(1):7.
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  • Eastoe JE, Bowen WH. Effects of changes in feeding on the amino acid composition of protein in dental plaque from the monkey, Macaca irus. Caries Res. 1971; 5(2):101-10.
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  • Eastoe JE, Bowen WH. Effects of changes in feeding on the amino acid composition of protein in dental plaque from the monkey Macaca irus. Caries Res. 1971; 5(1):29.
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  • Bowen WH. Effects of foods on oral bacterial populations in man and animals. J Dent Res. 1970 Nov-Dec; 49(6):1276-82.
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  • Bowen WH, Cornick DE. The microbiology of gingival-dental plaque recent findings from primate research. Int Dent J. 1970 Sep; 20(3):382-95.
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  • Bowen WH, Koch G. Determination of age in monkeys (Macaca irus) on the basis of dental development. Lab Anim. 1970 Apr; 4(1):113-24.
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  • Bowen WH. Dental diseases in primates. Proc R Soc Med. 1969 Dec 12; 62(12):1295.
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  • Bowen WH. The monitoring of acid production in dental plaque in monkeys. Br Dent J. 1969 Jun 3; 126(11):506-8.
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  • Bowen WH. Caries activity tests. Int Dent J. 1969 Jun; 19(2):267-72.
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  • Bowen WH. A vaccine against dental caries. A pilot experiment in monkeys (Macaca irus). Br Dent J. 1969 Feb 18; 126(4):159-60.
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  • Bowen WH. The development and application of dextranase in the prevention of dental caries. Proc Int Acad Oral Pathol. 1969; 21-7.
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  • Bowen WH. The induction of rampant dental caries in monkeys (Macaca irus). Caries Res. 1969; 3(3):227-37.
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  • Bowen WH. The trace element requirements of cariogenic and non-cariogenic streptococci. Arch Oral Biol. 1968 Jun; 13(6):713-4.
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  • Bowen WH. Effects of dextranase on cariogenic and non-cariogenic dextrans. Br Dent J. 1968 Apr 16; 124(8):347-9.
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  • Bowen WH. Dental caries in monkeys. Adv Oral Biol. 1968; 3:185-216.
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  • Bowen WH. The lactobacilli in the saliva, plaque and carious dentine in Macaca irus. J Pathol Bacteriol. 1967 Jul; 94(1):55-61.
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  • Bowen WH, Cornick DE. Effects of carbohydrate restriction in monkeys (M. irus) with active caries. Helv Odontol Acta. 1967 Apr; 11(1):27-31.
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  • Cock DJ, Bowen WH. Occurrence of Bacterionema matruchotii and Bacteroides melaninogenicus in gingival plaque from monkeys. J Periodontal Res. 1967; 2(1):36-9.
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  • Eastoe JE, Bowen WH. Some factors affecting pH measurements on tooth surfaces in monkeys. Caries Res. 1967; 1(1):59-68.
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  • Bowen WH, Eastoe JE. The effect of sugar solutions containing fluoride and molybdate ions on the pH of plaque in monkeys. Caries Res. 1967; 1(2):130-6.
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  • Cohen B, Bowen WH. Dental caries in experimental monkeys. A pilot study. Br Dent J. 1966 Sep 20; 121(6):269-76.
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  • Bowen WH, Eastoe JE, Cock DJ. The effect of sugar solutions on the pH of plaque in caries-active monkeys (macaca irus). Arch Oral Biol. 1966 Aug; 11(8):833-8.
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  • BOWEN WH. A BACTERIOLOGICAL STUDY OF EXPERIMENTAL DENTAL CARIES IN MONKEYS. Int Dent J. 1965 Mar; 15:12-53.
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  • BOWEN WH, GILMOUR MN. The formation of calculus-like deposits by pure cultures of bacteria. Arch Oral Biol. 1961 Nov; 5:145-8.
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  • Bowen WH. Congenital Naevoid Condition of the Left Thigh. Proc R Soc Med. 1911; 4(Sect Study Dis Child):193-5.
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  • Bowen WH. Congenital Nævoid Condition of the Left Thigh. Proc R Soc Med. 1911; 4(Sect Study Dis Child):193-5.
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  • Bowen WH. Glandular Fever. Proc R Soc Med. 1911; 4(Sect Study Dis Child):195.
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  • Robinson HB, Bowen WH. Inherited Congenital Claw Foot shown in Mother and Child. Proc R Soc Med. 1909; 2(Clin Sect):206-10.
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  • Bowen WH. Spontaneous Occurrence of Congenital Deaf-mutism in Three Members of one Family without any previous history of a similar condition. Proc R Soc Med. 1909; 2(Otol Sect):81-3.
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