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Soo Ok Lee

TitleResearch Associate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentRadiation Oncology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
 
 Awards And Honors
1976 - 1978Honored Student Award
1986 - 1988Busch Memorial Fellowship
 
 Overview
Dr. Lee's research interest is in the signal transduction effects on androgen receptor.

 
 Selected Publications
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  1. Huang CK, Pang H, Wang L, Niu Y, Luo J, Chang E, Sparks JD, Lee SO, Chang C. New Therapy via Targeting Androgen Receptor in Monocytes/Macrophages to Battle Atherosclerosis. Hypertension. 2014 Jun; 63(6):1345-53.
    View in: PubMed
  2. Cho S, Ge J, Seo SB, Kim K, Lee HY, Lee SD. Age estimation via quantification of signal-joint T cell receptor excision circles in Koreans. Leg Med (Tokyo). 2014 May; 16(3):135-8.
    View in: PubMed
  3. Chen Y, Nowak I, Huang J, Keng PC, Sun H, Xu H, Wei G, Lee SO. Erk/MAP Kinase Signaling Pathway and Neuroendocrine Differentiation of Non-Small-Cell Lung Cancer. J Thorac Oncol. 2014 Jan; 9(1):50-8.
    View in: PubMed
  4. Seo SB, Jin HX, Lee HY, Ge J, King JL, Lyoo SH, Shin DH, Lee SD. Improvement of short tandem repeat analysis of samples highly contaminated by humic acid. J Forensic Leg Med. 2013 Oct; 20(7):922-8.
    View in: PubMed
  5. Soh SF, Huang CK, Lee SO, Xu D, Yeh S, Li J, Yong EL, Gong Y, Chang C. Determination of androgen receptor degradation enhancer ASC-J9(®) in mouse sera and organs with liquid chromatography tandem mass spectrometry. J Pharm Biomed Anal. 2014 Jan; 88:117-22.
    View in: PubMed
  6. Chang C, Yeh S, Lee SO, Chang TM. Androgen receptor (AR) pathophysiological roles in androgen-related diseases in skin, bone/muscle, metabolic syndrome and neuron/immune systems: lessons learned from mice lacking AR in specific cells. Nucl Recept Signal. 2013; 11:e001.
    View in: PubMed
  7. Lin TH, Izumi K, Lee SO, Lin WJ, Yeh S, Chang C. Anti-androgen receptor ASC-J9 versus anti-androgens MDV3100 (Enzalutamide) or Casodex (Bicalutamide) leads to opposite effects on prostate cancer metastasis via differential modulation of macrophage infiltration and STAT3-CCL2 signaling. Cell Death Dis. 2013; 4:e764.
    View in: PubMed
  8. Wen S, Niu Y, Lee SO, Chang C. Androgen receptor (AR) positive vs negative roles in prostate cancer cell deaths including apoptosis, anoikis, entosis, necrosis and autophagic cell death. Cancer Treat Rev. 2014 Feb; 40(1):31-40.
    View in: PubMed
  9. Chang C, Lee SO, Wang RS, Yeh S, Chang TM. Androgen Receptor (AR) Physiological Roles in Male and Female Reproductive Systems: Lessons Learned from AR-Knockout Mice Lacking AR in Selective Cells. Biol Reprod. 2013; 89(1):21.
    View in: PubMed
  10. Luo J, Ok Lee S, Liang L, Huang CK, Li L, Wen S, Chang C. Infiltrating bone marrow mesenchymal stem cells increase prostate cancer stem cell population and metastatic ability via secreting cytokines to suppress androgen receptor signaling. Oncogene. 2014 May 22; 33(21):2768-78.
    View in: PubMed
  11. Huang CK, Lai KP, Luo J, Tsai MY, Kang HY, Chen Y, Lee SO, Chang C. Loss of androgen receptor promotes adipogenesis but suppresses osteogenesis in bone marrow stromal cells. Stem Cell Res. 2013 Sep; 11(2):938-50.
    View in: PubMed
  12. Lin TH, Lee SO, Niu Y, Xu D, Liang L, Li L, Yeh SD, Fujimoto N, Yeh S, Chang C. Differential Androgen Deprivation Therapies with Anti-androgens Casodex/Bicalutamide or MDV3100/Enzalutamide versus Anti-androgen Receptor ASC-J9(R) Lead to Promotion versus Suppression of Prostate Cancer Metastasis. J Biol Chem. 2013 Jul 5; 288(27):19359-69.
    View in: PubMed
  13. Yang DR, Ding XF, Luo J, Shan YX, Wang R, Lin SJ, Li G, Huang CK, Zhu J, Chen Y, Lee SO, Chang C. Increased Chemosensitivity via Targeting Testicular Nuclear Receptor 4 (TR4)-Oct4-Interleukin 1 Receptor Antagonist (IL1Ra) Axis in Prostate Cancer CD133+ Stem/Progenitor Cells to Battle Prostate Cancer. J Biol Chem. 2013 Jun 7; 288(23):16476-83.
    View in: PubMed
  14. Huang CK, Lee SO, Lai KP, Ma WL, Lin TH, Tsai MY, Luo J, Chang C. Targeting androgen receptor in bone marrow mesenchymal stem cells leads to better transplantation therapy efficacy in liver cirrhosis. Hepatology. 2013 Apr; 57(4):1550-63.
    View in: PubMed
  15. Wang X, Lee SO, Xia S, Jiang Q, Luo J, Li L, Yeh S, Chang C. Endothelial Cells Enhance Prostate Cancer Metastasis via IL-6->Androgen Receptor->TGF-ß->MMP-9 Signals. Mol Cancer Ther. 2013 Jun; 12(6):1026-37.
    View in: PubMed
  16. Huang CK, Tsai MY, Luo J, Kang HY, Lee SO, Chang C. Suppression of Androgen Receptor Enhances the Self-renewal of Mesenchymal Stem Cells Through Elevated Expression of EGFR. Biochim Biophys Acta. 2013 May; 1833(5):1222-34.
    View in: PubMed
  17. Oh CS, Lee SJ, Lee SD, Kim MJ, Kim YS, Lim DS, Shin DH. Amplification of DNA remnants in mummified human brains from medieval Joseon tombs of Korea. Anthropol Anz. 2013; 70(1):57-81.
    View in: PubMed
  18. Lai KP, Huang CK, Chang YJ, Chung CY, Yamashita S, Li L, Lee SO, Yeh S, Chang C. New Therapeutic Approach to Suppress Castration-Resistant Prostate Cancer Using ASC-J9 via Targeting Androgen Receptor in Selective Prostate Cells. Am J Pathol. 2013 Feb; 182(2):460-73.
    View in: PubMed
  19. Li L, Xie H, Liang L, Gao Y, Zhang D, Fang L, Lee SO, Luo J, Chen X, Wang X, Chang LS, Yeh S, Wang Y, He D, Chang C. Increased PrLZ-mediated androgen receptor transactivation promotes prostate cancer growth at castration-resistant stage. Carcinogenesis. 2013 Feb; 34(2):257-67.
    View in: PubMed
  20. Tian J, Lee SO, Liang L, Luo J, Huang CK, Li L, Niu Y, Chang C. Targeting the Unique Methylation Pattern of Androgen Receptor (AR) Promoter in Prostate Stem/Progenitor Cells with 5-Aza-2'-deoxycytidine (5-AZA) Leads to Suppressed Prostate Tumorigenesis. J Biol Chem. 2012 Nov 16; 287(47):39954-66.
    View in: PubMed
  21. Lee SO, Ma Z, Yeh CR, Luo J, Lin TH, Lai KP, Yamashita S, Liang L, Tian J, Li L, Jiang Q, Huang CK, Niu Y, Yeh S, Chang C. New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs. non-stem/progenitor cells. J Mol Cell Biol. 2013 Feb; 5(1):14-26.
    View in: PubMed
  22. Lee SO, Tian J, Huang CK, Ma Z, Lai KP, Hsiao H, Jiang M, Yeh S, Chang C. Suppressor role of androgen receptor in proliferation of prostate basal epithelial and progenitor cells. J Endocrinol. 2012 May; 213(2):173-82.
    View in: PubMed
  23. Oh CS, Lee SJ, Park JB, Lee SD, Seo SB, Kim HY, Kim J, Kim YS, Shin DH. Autosomal short tandem repeat analysis of ancient DNA by coupled use of mini- and conventional STR kits. J Forensic Sci. 2012 May; 57(3):820-5.
    View in: PubMed
  24. Seo SB, Lee HY, Zhang AH, Kim HY, Shin DH, Lee SD. Effects of humic acid on DNA quantification with Quantifiler® Human DNA Quantification kit and short tandem repeat amplification efficiency. Int J Legal Med. 2012 Nov; 126(6):961-8.
    View in: PubMed
  25. Oh CS, Seo M, Lim NJ, Lee SJ, Lee EJ, Lee SD, Shin DH. Paleoparasitological report on Ascaris aDNA from an ancient East Asian sample. Mem Inst Oswaldo Cruz. 2010 Mar; 105(2):225-8.
    View in: PubMed
  26. Seo SB, Zhang A, Kim HY, Yi JA, Lee HY, Shin DH, Lee SD. Technical note: Efficiency of total demineralization and ion-exchange column for DNA extraction from bone. Am J Phys Anthropol. 2010 Jan; 141(1):158-62.
    View in: PubMed
  27. Lee IS, Lee EJ, Park JB, Baek SH, Oh CS, Lee SD, Kim YS, Bok GD, Hong JW, Lim DS, Shin MH, Seo M, Shin DH. Acute traumatic death of a 17th century general based on examination of mummified remains found in Korea. Ann Anat. 2009 Jun; 191(3):309-20.
    View in: PubMed
  28. Lee SO, Chun JY, Nadiminty N, Lou W, Feng S, Gao AC. Interleukin-4 activates androgen receptor through CBP/p300. Prostate. 2009 Feb 1; 69(2):126-32.
    View in: PubMed
  29. Lee SO, Pinder E, Chun JY, Lou W, Sun M, Gao AC. Interleukin-4 stimulates androgen-independent growth in LNCaP human prostate cancer cells. Prostate. 2008 Jan 1; 68(1):85-91.
    View in: PubMed
  30. Lee SO, Dutt SS, Nadiminty N, Pinder E, Liao H, Gao AC. Development of an androgen-deprivation induced and androgen suppressed human prostate cancer cell line. Prostate. 2007 Sep 1; 67(12):1293-300.
    View in: PubMed
  31. Lee SO, Chun JY, Nadiminty N, Lou W, Gao AC. Interleukin-6 undergoes transition from growth inhibitor associated with neuroendocrine differentiation to stimulator accompanied by androgen receptor activation during LNCaP prostate cancer cell progression. Prostate. 2007 May 15; 67(7):764-73.
    View in: PubMed
  32. Hwang SH, Sohn YH, Oh HB, Hwang CY, Lee SH, Shin ES, Lee KJ. Human leukocyte antigen alleles and haplotypes associated with chronicity of hepatitis B virus infection in Koreans. Arch Pathol Lab Med. 2007 Jan; 131(1):117-21.
    View in: PubMed
  33. Lee SO, Yeon Chun J, Nadiminty N, Trump DL, Ip C, Dong Y, Gao AC. Monomethylated selenium inhibits growth of LNCaP human prostate cancer xenograft accompanied by a decrease in the expression of androgen receptor and prostate-specific antigen (PSA). Prostate. 2006 Jul 1; 66(10):1070-5.
    View in: PubMed
  34. Nadiminty N, Lou W, Lee SO, Lin X, Trump DL, Gao AC. Stat3 activation of NF-{kappa}B p100 processing involves CBP/p300-mediated acetylation. Proc Natl Acad Sci U S A. 2006 May 9; 103(19):7264-9.
    View in: PubMed
  35. Chun JY, Nadiminty N, Lee SO, Onate SA, Lou W, Gao AC. Mechanisms of selenium down-regulation of androgen receptor signaling in prostate cancer. Mol Cancer Ther. 2006 Apr; 5(4):913-8.
    View in: PubMed
  36. Nadiminty N, Lou W, Lee SO, Mehraein-Ghomi F, Kirk JS, Conroy JM, Zhang H, Gao AC. Prostate-specific antigen modulates genes involved in bone remodeling and induces osteoblast differentiation of human osteosarcoma cell line SaOS-2. Clin Cancer Res. 2006 Mar 1; 12(5):1420-30.
    View in: PubMed
  37. Tan D, Wu X, Hou M, Lee SO, Lou W, Wang J, Janarthan B, Nallapareddy S, Trump DL, Gao AC. Interleukin-6 polymorphism is associated with more aggressive prostate cancer. J Urol. 2005 Aug; 174(2):753-6.
    View in: PubMed
  38. Lee SO, Lou W, Nadiminty N, Lin X, Gao AC. Requirement for NF-(kappa)B in interleukin-4-induced androgen receptor activation in prostate cancer cells. Prostate. 2005 Jul 1; 64(2):160-7.
    View in: PubMed
  39. Kim GY, Kim KH, Lee SH, Yoon MS, Lee HJ, Moon DO, Lee CM, Ahn SC, Park YC, Park YM. Curcumin inhibits immunostimulatory function of dendritic cells: MAPKs and translocation of NF-kappa B as potential targets. J Immunol. 2005 Jun 15; 174(12):8116-24.
    View in: PubMed
  40. Lee SO, Nadiminty N, Wu XX, Lou W, Dong Y, Ip C, Onate SA, Gao AC. Selenium disrupts estrogen signaling by altering estrogen receptor expression and ligand binding in human breast cancer cells. Cancer Res. 2005 Apr 15; 65(8):3487-92.
    View in: PubMed
  41. Lee SO, Gao AC. STAT3 and transactivation of steroid hormone receptors. Vitam Horm. 2005; 70:333-57.
    View in: PubMed
  42. Lee SO, Lou W, Qureshi KM, Mehraein-Ghomi F, Trump DL, Gao AC. RNA interference targeting Stat3 inhibits growth and induces apoptosis of human prostate cancer cells. Prostate. 2004 Sep 1; 60(4):303-9.
    View in: PubMed
  43. Lee SO, Lou W, Johnson CS, Trump DL, Gao AC. Interleukin-6 protects LNCaP cells from apoptosis induced by androgen deprivation through the Stat3 pathway. Prostate. 2004 Aug 1; 60(3):178-86.
    View in: PubMed
  44. Lee SD, Kim MR, Hwang PG, Shim SS, Yoon BH, Kim CJ. Chorionic plate vessels as an origin of amniotic fluid neutrophils. Pathol Int. 2004 Jul; 54(7):516-22.
    View in: PubMed
  45. Dong Y, Lee SO, Zhang H, Marshall J, Gao AC, Ip C. Prostate specific antigen expression is down-regulated by selenium through disruption of androgen receptor signaling. Cancer Res. 2004 Jan 1; 64(1):19-22.
    View in: PubMed
  46. Yoo SH, Park YS, Kim HR, Sung SW, Kim JH, Shim YS, Lee SD, Choi YL, Kim MK, Chung DH. Expression of caveolin-1 is associated with poor prognosis of patients with squamous cell carcinoma of the lung. Lung Cancer. 2003 Nov; 42(2):195-202.
    View in: PubMed
  47. Lee SO, Lou W, Hou M, Onate SA, Gao AC. Interleukin-4 enhances prostate-specific antigen expression by activation of the androgen receptor and Akt pathway. Oncogene. 2003 Sep 11; 22(39):7981-8.
    View in: PubMed
  48. Lee SO, Lou W, Hou M, de Miguel F, Gerber L, Gao AC. Interleukin-6 promotes androgen-independent growth in LNCaP human prostate cancer cells. Clin Cancer Res. 2003 Jan; 9(1):370-6.
    View in: PubMed
  49. Son JY, Lee YS, Choung CM, Lee SD. Polymorphism of nine X chromosomal STR loci in Koreans. Int J Legal Med. 2002 Dec; 116(6):317-21.
    View in: PubMed
  50. DeMiguel F, Lee SO, Lou W, Xiao X, Pflug BR, Nelson JB, Gao AC. Stat3 enhances the growth of LNCaP human prostate cancer cells in intact and castrated male nude mice. Prostate. 2002 Jul 1; 52(2):123-9.
    View in: PubMed
  51. Ni Z, Lou W, Lee SO, Dhir R, DeMiguel F, Grandis JR, Gao AC. Selective activation of members of the signal transducers and activators of transcription family in prostate carcinoma. J Urol. 2002 Apr; 167(4):1859-62.
    View in: PubMed
  52. Lee SD, Lee YS, Lee JB. Polymorphism in the mitochondrial cytochrome B gene in Koreans. An additional marker for individual identification. Int J Legal Med. 2002 Apr; 116(2):74-8.
    View in: PubMed
  53. Cho SC, Lee SH, Shinn JJ, Han SH, Roh BJ, Sohn JH, Lee DH, Kee CS. [HBV DNA levels, aminotransferase and histological activity in young male patients with HBeAg positive chronic hepatitis B]. Taehan Kan Hakhoe Chi. 2002 Mar; 8(1):44-51.
    View in: PubMed
  54. Kim HW, Choi E, Yoo B, Choi JR, Park YM, Lee SO, Moon HB, Na DS. Lipocortin 1 binding sites on human T-cells: the population of cells with the binding sites is larger in CD8+ T-lymphocytes than in CD4+ T-lymphocytes. Biochem Mol Biol Int. 1996 Dec; 40(6):1167-73.
    View in: PubMed
  55. Kim SB, Yang WS, Lee OS, Lee KP, Park JS, Na DS. Lipocortin-1 inhibits proliferation of cultured human mesangial cells. Nephron. 1996; 74(1):39-44.
    View in: PubMed
  56. Lee SO, Poretz RD. Hybrid myeloma cells which secrete heterodimeric IgG: a model to study the N-linked glycan. Immunol Cell Biol. 1991 Jun; 69 ( Pt 3):151-7.
    View in: PubMed
  57. Lee SO, Connolly JM, Ramirez-Soto D, Poretz RD. The polypeptide of immunoglobulin G influences its galactosylation in vivo. J Biol Chem. 1990 Apr 5; 265(10):5833-9.
    View in: PubMed

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