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Paul Allen

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentNeurobiology and Anatomy
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester NY 14642
 
 Awards And Honors
1996 - 1999Australian Postgraduate Award
2004     2Glenn/AFAR Research Grant for Postdoctoral Fellows
 
 Overview
RESEARCH INTERESTS:
Central Presbycusis –changes in the brain that contribute to the problems of aging-related hearing loss.
Physiological, anatomical, and molecular biological specializations of the central auditory system that facilitate the high-fidelity transmission of timing information.

PUBLICATIONS:
Leong UC, Barsz K, Allen PD, Walton JP. (2009) Neural correlates of age-related declines in frequency selectivity in the auditory midbrain., Neurobiol Aging. [Epub ahead of print]
Allen PD, Ison JR, Walton JP. (2008) Kv1.1 channel subunits are not necessary for high temporal acuity in behavioural and electrophysiological gap detection. Hear. Res. 246, 52-58
Ison, J.R, Allen, P.D., O'Neill, W.E. (2007) Age-related hearing loss in C57BL/6J mice has both frequency-specific and non-frequency-specific components that produce a hyperacusis-like exaggeration of the acoustic startle reflex. J. Assoc. Res. Otolaryngol., 8, 539-550.
Ison, J.R, Allen, P.D. (2007) Pre- but not post-menopausal female CBA/CaJ mice show less prepulse inhibition than male mice of the same age. Behav. Brain. Res., 185, 76-81
Ison, J.R., Allen, P.D., Rivoli P.J., & Moore, J.T. (2005) The behavioral response of mice to gaps in noise depends on its spectral components and its bandwidth. . J. Acoust. Soc. Am. 117, 3944-3951
Ison, J. R., & Allen, P. D. (2003) Low frequency Tone Pips Elicit Exaggerated Startle Reflexes in C57BL/6J Mice with Hearing Loss. J. Assn. Res. Otolaryngol, 4, 495-504
Allen, P.D., Burkard, R.F, Ison J.R. & Walton, J. P. (2003) Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels. Hear. Res., 186, 17-29
Ison, J. R., & Allen, P. D. (2003) A diminished rate of "physiological decay" at noise offset contributes to age-related changes in temporal acuity in the CBA mouse model of presbycusis. J. Acoust. Soc. Am, 114, 522-528
Allen P.D., Virag T.M., & Ison J.R. (2002). Humans detect gaps in broadband noise according to effective gap duration without additional cues from abrupt envelope changes. J. Acoust. Soc. Am., 112, 2967-2974
St Pierre T.G., Gorham N.T., Allen P.D., Costa-Kràmer J.L. & Rao K.V. (2002). Apparent magnetic energy barrier distribution in horse spleen ferritin: evidence for multiple interacting magnetic entities per ferrihydrite nanoparticle. Phys. Rev. B, 65, 024436
Ison J.R., Castro J., Allen P, Virag T.M., & Walton, J.P. (2002). The relative detectability for mice of gaps having different ramp durations at their onset and offset boundaries. J. Acoust. Soc. Am. 112, 740-747
Ison J.R., Virag T.M., Allen P.D., & Hammond G.R.(2002) The attention filter for tones in noise has the same shape and effective bandwidth in the elderly as it has in young listeners. J. Acoust. Soc. Am., 112, 238-246
Allen P.D., St Pierre T.G., Chua-anusorn W., Strom V. & Rao K.V. (2000) Low-frequency low-field magnetic susceptibility of ferritin and hemosiderin. Biochim. Biophys. Acta. 1500, 186-96
Allen P.D., St Pierre T.G. & Street R. (1998). Magnetic Interactions in Native Horse Spleen Ferritin below the Superparamagnetic Blocking Temperature, J Magn. Magn. Mat., 177-181, 1459-1460

 
 Selected Publications
List All   |   Timeline
  1. Jalabi W, Kopp-Scheinpflug C, Allen PD, Schiavon E, Digiacomo RR, Forsythe ID, Maricich SM. Sound localization ability and glycinergic innervation of the superior olivary complex persist after genetic deletion of the medial nucleus of the trapezoid body. J Neurosci. 2013 Sep 18; 33(38):15044-9.
    View in: PubMed
  2. Ison JR, Allen PD. Deficits in responding to brief noise offsets in Kcna1 -/- mice reveal a contribution of this gene to precise temporal processing seen previously only for stimulus onsets. J Assoc Res Otolaryngol. 2012 Jun; 13(3):351-8.
    View in: PubMed
  3. Allen PD, Ison JR. Kcna1 gene deletion lowers the behavioral sensitivity of mice to small changes in sound location and increases asynchronous brainstem auditory evoked potentials but does not affect hearing thresholds. J Neurosci. 2012 Feb 15; 32(7):2538-43.
    View in: PubMed
  4. Tremblay MÈ, Zettel ML, Ison JR, Allen PD, Majewska AK. Effects of aging and sensory loss on glial cells in mouse visual and auditory cortices. Glia. 2012 Apr; 60(4):541-58.
    View in: PubMed
  5. Yuen B, Boncompagni S, Feng W, Yang T, Lopez JR, Matthaei KI, Goth SR, Protasi F, Franzini-Armstrong C, Allen PD, Pessah IN. Mice expressing T4826I-RYR1 are viable but exhibit sex- and genotype-dependent susceptibility to malignant hyperthermia and muscle damage. FASEB J. 2012 Mar; 26(3):1311-22.
    View in: PubMed
  6. Bogart LJ, Levy AD, Gladstone M, Allen PD, Zettel M, Ison JR, Luebke AE, Majewska AK. Loss of prestin does not alter the development of auditory cortical dendritic spines. Neural Plast. 2011; 2011:305621.
    View in: PubMed
  7. Chen F, Liu Y, Sugiura Y, Allen PD, Gregg RG, Lin W. Neuromuscular synaptic patterning requires the function of skeletal muscle dihydropyridine receptors. Nat Neurosci. 2011 May; 14(5):570-7.
    View in: PubMed
  8. Bannister RA, Estève E, Eltit JM, Pessah IN, Allen PD, López JR, Beam KG. A malignant hyperthermia-inducing mutation in RYR1 (R163C): consequent alterations in the functional properties of DHPR channels. J Gen Physiol. 2010 Jun; 135(6):629-40.
    View in: PubMed
  9. Allen PD, Ison JR. Sensitivity of the mouse to changes in azimuthal sound location: angular separation, spectral composition, and sound level. Behav Neurosci. 2010 Apr; 124(2):265-77.
    View in: PubMed
  10. Allen PD, Eddins DA. Presbycusis phenotypes form a heterogeneous continuum when ordered by degree and configuration of hearing loss. Hear Res. 2010 Jun 1; 264(1-2):10-20.
    View in: PubMed
  11. Leong UC, Barsz K, Allen PD, Walton JP. Neural correlates of age-related declines in frequency selectivity in the auditory midbrain. Neurobiol Aging. 2011 Jan; 32(1):168-78.
    View in: PubMed
  12. Allen PD, Schmuck N, Ison JR, Walton JP. Kv1.1 channel subunits are not necessary for high temporal acuity in behavioral and electrophysiological gap detection. Hear Res. 2008 Dec; 246(1-2):52-8.
    View in: PubMed
  13. Ison JR, Allen PD, O'Neill WE. Age-related hearing loss in C57BL/6J mice has both frequency-specific and non-frequency-specific components that produce a hyperacusis-like exaggeration of the acoustic startle reflex. J Assoc Res Otolaryngol. 2007 Dec; 8(4):539-50.
    View in: PubMed
  14. Fritz N, Morel JL, Jeyakumar LH, Fleischer S, Allen PD, Mironneau J, Macrez N. RyR1-specific requirement for depolarization-induced Ca2+ sparks in urinary bladder smooth muscle. J Cell Sci. 2007 Nov 1; 120(Pt 21):3784-91.
    View in: PubMed
  15. Ison JR, Allen PD. Pre- but not post-menopausal female CBA/CaJ mice show less prepulse inhibition than male mice of the same age. Behav Brain Res. 2007 Dec 28; 185(2):76-81.
    View in: PubMed
  16. Paolini C, Quarta M, Nori A, Boncompagni S, Canato M, Volpe P, Allen PD, Reggiani C, Protasi F. Reorganized stores and impaired calcium handling in skeletal muscle of mice lacking calsequestrin-1. J Physiol. 2007 Sep 1; 583(Pt 2):767-84.
    View in: PubMed
  17. Ison JR, Allen PD, Rivoli PJ, Moore JT. The behavioral response of mice to gaps in noise depends on its spectral components and its bandwidth. J Acoust Soc Am. 2005 Jun; 117(6):3944-51.
    View in: PubMed
  18. Rivier F, Alkan O, Flint AF, Muskiewicz K, Allen PD, Leboulch P, Gussoni E. Role of bone marrow cell trafficking in replenishing skeletal muscle SP and MP cell populations. J Cell Sci. 2004 Apr 15; 117(Pt 10):1979-88.
    View in: PubMed
  19. Allen PD, Burkard RF, Ison JR, Walton JP. Impaired gap encoding in aged mouse inferior colliculus at moderate but not high stimulus levels. Hear Res. 2003 Dec; 186(1-2):17-29.
    View in: PubMed
  20. Ison JR, Allen P. A diminished rate of "physiological decay" at noise offset contributes to age-related changes in temporal acuity in the CBA mouse model of presbycusis. J Acoust Soc Am. 2003 Jul; 114(1):522-8.
    View in: PubMed
  21. Ison JR, Allen PD. Low-frequency tone pips elicit exaggerated startle reflexes in C57BL/6J mice with hearing loss. J Assoc Res Otolaryngol. 2003 Dec; 4(4):495-504.
    View in: PubMed
  22. Allen PD, Virag TM, Ison JR. Humans detect gaps in broadband noise according to effective gap duration without additional cues from abrupt envelope changes. J Acoust Soc Am. 2002 Dec; 112(6):2967-74.
    View in: PubMed
  23. Ison JR, Castro J, Allen P, Virag TM, Walton JP. The relative detectability for mice of gaps having different ramp durations at their onset and offset boundaries. J Acoust Soc Am. 2002 Aug; 112(2):740-7.
    View in: PubMed
  24. Ison JR, Virag TM, Allen PD, Hammond GR. The attention filter for tones in noise has the same shape and effective bandwidth in the elderly as it has in young listeners. J Acoust Soc Am. 2002 Jul; 112(1):238-46.
    View in: PubMed
  25. Allen PD, St Pierre TG, Chua-anusorn W, Ström V, Rao KV. Low-frequency low-field magnetic susceptibility of ferritin and hemosiderin. Biochim Biophys Acta. 2000 Feb 21; 1500(2):186-96.
    View in: PubMed
  26. Oppenheim RW, Prevette D, Houenou LJ, Pincon-Raymond M, Dimitriadou V, Donevan A, O'Donovan M, Wenner P, Mckemy DD, Allen PD. Neuromuscular development in the avian paralytic mutant crooked neck dwarf (cn/cn): further evidence for the role of neuromuscular activity in motoneuron survival. J Comp Neurol. 1997 May 12; 381(3):353-72.
    View in: PubMed
  27. Buck ED, Nguyen HT, Pessah IN, Allen PD. Dyspedic mouse skeletal muscle expresses major elements of the triadic junction but lacks detectable ryanodine receptor protein and function. J Biol Chem. 1997 Mar 14; 272(11):7360-7.
    View in: PubMed
  28. Kim DH, Sreter FA, Ohnishi ST, Ryan JF, Roberts J, Allen PD, Meszaros LG, Antoniu B, Ikemoto N. Kinetic studies of Ca2+ release from sarcoplasmic reticulum of normal and malignant hyperthermia susceptible pig muscles. Biochim Biophys Acta. 1984 Sep 5; 775(3):320-7.
    View in: PubMed

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