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Thomas Thatcher

TitleResearch Associate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 692
Rochester NY 14642
 
 Awards And Honors
1984 - 1988Bausch and Lomb Memorial Scholarship  | University of Rochester
1994     Melville A. Hare Award for Excellence in Teaching  | Department of Microbiology and Immunology
2000     Melville A. Hare Award for Excellence in Research  | Department of Microbiology and Immunology
 
 Selected Publications
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  1. Lugade AA, Bogner PN, Thatcher TH, Sime PJ, Phipps RP, Thanavala Y. Cigarette smoke exposure exacerbates lung inflammation and compromises immunity to bacterial infection. J Immunol. 2014 Jun 1; 192(11):5226-35.
    View in: PubMed
  2. Olsen KC, Epa AP, Kulkarni AA, Kottmann RM, McCarthy CE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ. Inhibition of transglutaminase 2, a novel target for pulmonary fibrosis, by two small electrophilic molecules. Am J Respir Cell Mol Biol. 2014 Apr; 50(4):737-47.
    View in: PubMed
  3. Kulkarni AA, Thatcher TH, Hsiao HM, Olsen KC, Kottmann RM, Morrissette J, Wright TW, Phipps RP, Sime PJ. The Triterpenoid CDDO-Me Inhibits Bleomycin-Induced Lung Inflammation and Fibrosis. PLoS One. 2013; 8(5):e63798.
    View in: PubMed
  4. Thatcher TH, Hsiao HM, Pinner E, Laudon M, Pollock SJ, Sime PJ, Phipps RP. Neu-164 and Neu-107, two novel antioxidant and anti-myeloperoxidase compounds, inhibit acute cigarette smoke-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2013 Jul; 305(2):L165-74.
    View in: PubMed
  5. McMillan DH, Woeller CF, Thatcher TH, Spinelli SL, Maggirwar SB, Sime PJ, Phipps RP. Attenuation of inflammatory mediator production by the NF-?B member RelB is mediated by microRNA-146a in lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2013 Jun; 304(11):L774-81.
    View in: PubMed
  6. Hsiao HM, Sapinoro RE, Thatcher TH, Croasdell A, Levy EP, Fulton RA, Olsen KC, Pollock SJ, Serhan CN, Phipps RP, Sime PJ. A novel anti-inflammatory and pro-resolving role for resolvin d1 in acute cigarette smoke-induced lung inflammation. PLoS One. 2013; 8(3):e58258.
    View in: PubMed
  7. Ramon S, Bancos S, Thatcher TH, Murant TI, Moshkani S, Sahler JM, Bottaro A, Sime PJ, Phipps RP. Peroxisome Proliferator-Activated Receptor ? B Cell-Specific-Deficient Mice Have an Impaired Antibody Response. J Immunol. 2012 Nov 15; 189(10):4740-7.
    View in: PubMed
  8. Kulkarni AA, Woeller CF, Thatcher TH, Ramon S, Phipps RP, Sime PJ. Emerging PPAR?-Independent Role of PPAR? Ligands in Lung Diseases. PPAR Res. 2012; 2012:705352.
    View in: PubMed
  9. Davies ER, Haitchi HM, Thatcher TH, Sime PJ, Kottmann RM, Ganesan A, Packham G, O'Reilly KM, Davies DE. Spiruchostatin A inhibits proliferation and differentiation of fibroblasts from patients with pulmonary fibrosis. Am J Respir Cell Mol Biol. 2012 May; 46(5):687-94.
    View in: PubMed
  10. Olsen KC, Sapinoro RE, Kottmann RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ. Transglutaminase 2 and its role in pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Sep 15; 184(6):699-707.
    View in: PubMed
  11. Hogan CM, Thatcher TH, Sapinoro RE, Gurell MN, Ferguson HE, Pollock SJ, Jones C, Phipps RP, Sime PJ. Electrophilic PPAR? Ligands Attenuate IL-1ß and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPAR?-Independent Mechanism. PPAR Res. 2011; 2011:318134.
    View in: PubMed
  12. McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP. Lung-targeted overexpression of the NF-?B member RelB inhibits cigarette smoke-induced inflammation. Am J Pathol. 2011 Jul; 179(1):125-33.
    View in: PubMed
  13. Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ. PPAR-? ligands repress TGFß-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis. PLoS One. 2011; 6(1):e15909.
    View in: PubMed
  14. Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ. Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2009 Nov; 297(5):L912-9.
    View in: PubMed
  15. Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ. Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. Am J Respir Cell Mol Biol. 2009 Dec; 41(6):722-30.
    View in: PubMed
  16. Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB. J Biol Chem. 2008 Oct 24; 283(43):28944-57.
    View in: PubMed
  17. Thatcher TH, Benson RP, Phipps RP, Sime PJ. High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function. Am J Physiol Lung Cell Mol Physiol. 2008 Sep; 295(3):L412-21.
    View in: PubMed
  18. Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Am J Pathol. 2007 Mar; 170(3):855-64.
    View in: PubMed
  19. Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ. The Role of PPARs in Lung Fibrosis. PPAR Res. 2007; 2007:71323.
    View in: PubMed
  20. Lakatos HF, Burgess HA, Thatcher TH, Redonnet MR, Hernady E, Williams JP, Sime PJ. Oropharyngeal aspiration of a silica suspension produces a superior model of silicosis in the mouse when compared to intratracheal instillation. Exp Lung Res. 2006 May; 32(5):181-99.
    View in: PubMed
  21. Thatcher TH, Luzina I, Fishelevich R, Tomai MA, Miller RL, Gaspari AA. Topical imiquimod treatment prevents UV-light induced loss of contact hypersensitivity and immune tolerance. J Invest Dermatol. 2006 Apr; 126(4):821-31.
    View in: PubMed
  22. Feldon SE, Park DJ, O'Loughlin CW, Nguyen VT, Landskroner-Eiger S, Chang D, Thatcher TH, Phipps RP. Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):3913-21.
    View in: PubMed
  23. Thatcher TH, Sime PJ, Barth RK. Sensitivity to bleomycin-induced lung injury is not moderated by an antigen-limited T-cell repertoire. Exp Lung Res. 2005 Sep; 31(7):685-700.
    View in: PubMed
  24. Thatcher TH, McHugh NA, Egan RW, Chapman RW, Hey JA, Turner CK, Redonnet MR, Seweryniak KE, Sime PJ, Phipps RP. Role of CXCR2 in cigarette smoke-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2005 Aug; 289(2):L322-8.
    View in: PubMed
  25. Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1146-53.
    View in: PubMed
  26. O'Reilly KM, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ. Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1010-6.
    View in: PubMed
  27. Gaspari AA, Thatcher T, Burns RP, Ferbel B, Tanck C, Bedi GS, Perrella FW. Bacterial protease treatment of natural rubber latex alters its primary immunogenicity in a mouse model of sensitization. Clin Immunol. 2002 Oct; 105(1):9-16.
    View in: PubMed
  28. Thatcher TH, O'Brien DP, Altuwaijri S, Barth RK. Increasing the frequency of T-cell precursors specific for a cryptic epitope of hen-egg lysozyme converts it to an immunodominant epitope. Immunology. 2000 Feb; 99(2):235-42.
    View in: PubMed
  29. Gaertig J, Thatcher TH, Gu L, Gorovsky MA. Electroporation-mediated replacement of a positively and negatively selectable beta-tubulin gene in Tetrahymena thermophila. Proc Natl Acad Sci U S A. 1994 May 10; 91(10):4549-53.
    View in: PubMed
  30. Thatcher TH, Gorovsky MA. Phylogenetic analysis of the core histones H2A, H2B, H3, and H4. Nucleic Acids Res. 1994 Jan 25; 22(2):174-9.
    View in: PubMed
  31. Thatcher TH, MacGaffey J, Bowen J, Horowitz S, Shapiro DL, Gorovsky MA. Independent evolutionary origin of histone H3.3-like variants of animals and Tetrahymena. Nucleic Acids Res. 1994 Jan 25; 22(2):180-6.
    View in: PubMed
  32. Wu M, Allis CD, Sweet MT, Cook RG, Thatcher TH, Gorovsky MA. Four distinct and unusual linker proteins in a mitotically dividing nucleus are derived from a 71-kilodalton polyprotein, lack p34cdc2 sites, and contain protein kinase A sites. Mol Cell Biol. 1994 Jan; 14(1):10-20.
    View in: PubMed
  33. Thatcher TH, Gorovsky MA. A temperature-sensitive cell cycle arrest mutation affecting H1 phosphorylation and nuclear localization of a small heat shock protein in Tetrahymena thermophila. Exp Cell Res. 1993 Dec; 209(2):261-70.
    View in: PubMed
  34. Gaertig J, Thatcher TH, McGrath KE, Callahan RC, Gorovsky MA. Perspectives on tubulin isotype function and evolution based on the observation that Tetrahymena thermophila microtubules contain a single alpha- and beta-tubulin. Cell Motil Cytoskeleton. 1993; 25(3):243-53.
    View in: PubMed
  35. Pennock DG, Thatcher T, Bowen J, Bruns PJ, Gorovsky MA. A conditional mutant having paralyzed cilia and a block in cytokinesis is rescued by cytoplasmic exchange in Tetrahymena thermophila. Genetics. 1988 Nov; 120(3):697-705.
    View in: PubMed
  36. Pennock DG, Thatcher T, Gorovsky MA. A temperature-sensitive mutation affecting cilia regeneration, nuclear development, and the cell cycle of Tetrahymena thermophila is rescued by cytoplasmic exchange. Mol Cell Biol. 1988 Jul; 8(7):2681-9.
    View in: PubMed

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