Charles Francis
| Title | Professor Emeritus |
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| Institution | School of Medicine and Dentistry |
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| Department | Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 610
Rochester NY 14642
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| Phi Beta Kappa | |
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| Alpha Omega Alpha | |
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| Established Investigator, American Heart Association | |
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| Clinical Investigator Award, National Institutes of Health | |
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| Inclusion in "The Best Doctors in America", Woodward/White, Inc, Publishers, 1994, 1995, 1996, 1998, 2000-2006 |
Dr. Francis does both clinical and basic research in the areas of thrombosis, hemostasis and vascular biology. Fibrinogen and fibrin have been an area of extensive research. He first described the structures of plasmic degradation products of crosslinked fibrin and developed a molecular model of fibrinolysis. He identified an important structural variant of fibrinogen that differs at the carboxyl terminus of the gamma chain. He was one of the first to demonstrate that ultrasound accelerates enzymatic fibrinolysis, identified the mechanisms responsible and defined the ultrasound parameters for effective fibrinolysis augmentation. Studies in recent years have characterized the interaction of FGF-2, EGF and IL-² beta with fibrinogen and fibrin. The binding sites for interaction have been identified, and augmented functional activity of FGF-2 and IL-² beta in the bound form demonstrated. Extensive clinical research helped to define the structures of crosslinked fibrin degradation products in fibrinolytic states. Numerous studies have been conducted to improve prophylaxsis of deep vein thrombosis and pulmonary embolism. These have included clinical trials using warfarin, antithrombin, low-molecular-weight heparin and direct thrombin inhibitors. Recent clinical studies have examined risk factors for arterial thrombosis and the effects of thiazolidinediones on lipid and hemostatic risk factors for thrombosis.
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Khorana AA, Spyropoulos AC, Zwicker J, Lyman GH, Francis CW. Preventing VTE in Outpatients With Cancer. Chest. 2012 Jul 1; 142(1):265-6.
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Falck-Ytter Y, Francis CW, Johanson NA, Curley C, Dahl OE, Schulman S, Ortel TL, Pauker SG, Colwell CW. Prevention of VTE in Orthopedic Surgery Patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb; 141(2 Suppl):e278S-325S.
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Guyatt GH, Eikelboom JW, Gould MK, Garcia DA, Crowther M, Murad MH, Kahn SR, Falck-Ytter Y, Francis CW, Lansberg MG, Akl EA, Hirsh J. Approach to Outcome Measurement in the Prevention of Thrombosis in Surgical and Medical Patients: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines. Chest. 2012 Feb; 141(2 Suppl):e185S-94S.
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Hackney DN, Miller RK, Pressman EK, Francis CW, Simhan HN. Vaginal bleeding in early pregnancy and circulating markers of thrombin generation. J Matern Fetal Neonatal Med. 2012 Aug; 25(8):1479-82.
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Balkhy HH, El-Saed A, Al Johani SM, Francis C, Al-Qahtani AA, Al-Ahdal MN, Altayeb HT, Arabi Y, Alothman A, Sallah M. The epidemiology of the first described carbapenem-resistant Klebsiella pneumoniae outbreak in a tertiary care hospital in Saudi Arabia: how far do we go? Eur J Clin Microbiol Infect Dis. 2012 Aug; 31(8):1901-9.
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Gudmundsdottir BR, Francis CW, Bjornsdottir AM, Nellbring M, Onundarson PT. Critical role of factors II and X during coumarin anticoagulation and their combined measurement with a new Fiix-prothrombin time. Thromb Res. 2012 Oct; 130(4):674-81.
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Mongan J, Mieszczanska HZ, Smith BH, Messing SP, Phipps RP, Francis CW. Pioglitazone inhibits platelet function and potentiates the effects of aspirin: A prospective observation study. Thromb Res. 2012 Jun; 129(6):760-4.
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Ragni MV, Moore CG, Bias V, Key NS, Kouides PA, Francis CW. Challenges of rare disease research: limited patients and competing priorities. Haemophilia. 2012 May; 18(3):e192-4.
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Refaai MA, Fialkow LB, Heal JM, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Corsetti JP, Francis CW, Bankey PE, Blumberg N. An association of ABO non-identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients. Vox Sang. 2011 Jul; 101(1):55-60.
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Moss AJ, Francis CW, Ryan D. Collaborative clinical trials. N Engl J Med. 2011 Mar 3; 364(9):789-91.
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Connolly GC, Khorana AA, Kuderer NM, Culakova E, Francis CW, Lyman GH. Leukocytosis, thrombosis and early mortality in cancer patients initiating chemotherapy. Thromb Res. 2010 Aug; 126(2):113-8.
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Friedman RJ, Dahl OE, Rosencher N, Caprini JA, Kurth AA, Francis CW, Clemens A, Hantel S, Schnee JM, Eriksson BI. Dabigatran versus enoxaparin for prevention of venous thromboembolism after hip or knee arthroplasty: a pooled analysis of three trials. Thromb Res. 2010 Sep; 126(3):175-82.
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Refaai MA, Chuang C, Menegus M, Blumberg N, Francis CW. Outcomes after platelet transfusion in patients with heparin-induced thrombocytopenia. J Thromb Haemost. 2010 Jun; 8(6):1419-21.
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Spinelli SL, Casey AE, Pollock SJ, Gertz JM, McMillan DH, Narasipura SD, Mody NA, King MR, Maggirwar SB, Francis CW, Taubman MB, Blumberg N, Phipps RP. Platelets and megakaryocytes contain functional nuclear factor-kappaB. Arterioscler Thromb Vasc Biol. 2010 Mar; 30(3):591-8.
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Candelario GD, Francis CW, Panzer R, McAdam KS, Cockrell D, Baird T, Khorana AA. A computerized prompt for thromboprophylaxis in hospitalized cancer patients. Thromb Res. 2010 Jul; 126(1):32-4.
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Kuderer NM, Ortel TL, Francis CW. Impact of venous thromboembolism and anticoagulation on cancer and cancer survival. J Clin Oncol. 2009 Oct 10; 27(29):4902-11.
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Francis CW. Prevention of venous thromboembolism in hospitalized patients with cancer. J Clin Oncol. 2009 Oct 10; 27(29):4874-80.
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Bernard JJ, Seweryniak KE, Koniski AD, Spinelli SL, Blumberg N, Francis CW, Taubman MB, Palis J, Phipps RP. Foxp3 regulates megakaryopoiesis and platelet function. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1874-82.
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Sandset PM, Francis C. Thrombosis Research: Introduction of e-pages. Thromb Res. 2009 Jul; 124(3):251.
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Springer DL, Miller JH, Spinelli SL, Pasa-Tolic L, Purvine SO, Daly DS, Zangar RC, Jin S, Blumberg N, Francis CW, Taubman MB, Casey AE, Wittlin SD, Phipps RP. Platelet proteome changes associated with diabetes and during platelet storage for transfusion. J Proteome Res. 2009 May; 8(5):2261-72.
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Yao JL, Ryan CK, Francis CW, Kohli M, Taubman MB, Khorana AA. Tissue factor and VEGF expression in prostate carcinoma: a tissue microarray study. Cancer Invest. 2009 May; 27(4):430-4.
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Brummel-Ziedins KE, Gissel M, Francis C, Queenan J, Mann KG. The effect of high circulating estradiol levels on thrombin generation during in vitro fertilization. Thromb Res. 2009 Sep; 124(4):505-7.
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Ban-Hoefen M, Francis C. Heparin induced thrombocytopenia and thrombosis in a tertiary care hospital. Thromb Res. 2009 Jun; 124(2):189-92.
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Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP. The platelet as an immune cell-CD40 ligand and transfusion immunomodulation. Immunol Res. 2009; 45(2-3):251-60.
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Khorana AA, Francis CW, Blumberg N, Culakova E, Refaai MA, Lyman GH. Blood transfusions, thrombosis, and mortality in hospitalized patients with cancer. Arch Intern Med. 2008 Nov 24; 168(21):2377-81.
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O'Brien JJ, Baglole CJ, Garcia-Bates TM, Blumberg N, Francis CW, Phipps RP. 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. J Thromb Haemost. 2009 Jan; 7(1):182-9.
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Khorana AA, Francis CW, Menzies KE, Wang JG, Hyrien O, Hathcock J, Mackman N, Taubman MB. Plasma tissue factor may be predictive of venous thromboembolism in pancreatic cancer. J Thromb Haemost. 2008 Nov; 6(11):1983-5.
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O'Brien JJ, Spinelli SL, Tober J, Blumberg N, Francis CW, Taubman MB, Palis J, Seweryniak KE, Gertz JM, Phipps RP. 15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes. Blood. 2008 Nov 15; 112(10):4051-60.
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Oral thrombin inhibitor dabigatran etexilate vs North American enoxaparin regimen for prevention of venous thromboembolism after knee arthroplasty surgery. J Arthroplasty. 2009 Jan; 24(1):1-9.
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Khorana AA, Kuderer NM, Culakova E, Lyman GH, Francis CW. Development and validation of a predictive model for chemotherapy-associated thrombosis. Blood. 2008 May 15; 111(10):4902-7.
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Francis CW. Warfarin: an historical perspective. Hematology Am Soc Hematol Educ Program. 2008; 251.
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Spinelli SL, O'Brien JJ, Bancos S, Lehmann GM, Springer DL, Blumberg N, Francis CW, Taubman MB, Phipps RP. The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. PPAR Res. 2008; 2008:328172.
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Francis CW. New issues in oral anticoagulants. Hematology Am Soc Hematol Educ Program. 2008; 259-65.
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Ray DM, Spinelli SL, Pollock SJ, Murant TI, O'Brien JJ, Blumberg N, Francis CW, Taubman MB, Phipps RP. Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb Haemost. 2008 Jan; 99(1):86-95.
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Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Frequency, risk factors, and trends for venous thromboembolism among hospitalized cancer patients. Cancer. 2007 Nov 15; 110(10):2339-46.
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Lyman GH, Khorana AA, Falanga A, Clarke-Pearson D, Flowers C, Jahanzeb M, Kakkar A, Kuderer NM, Levine MN, Liebman H, Mendelson D, Raskob G, Somerfield MR, Thodiyil P, Trent D, Francis CW. American Society of Clinical Oncology guideline: recommendations for venous thromboembolism prophylaxis and treatment in patients with cancer. J Clin Oncol. 2007 Dec 1; 25(34):5490-505.
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Sahni A, Simpson-Haidaris PJ, Sahni SK, Vaday GG, Francis CW. Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2). J Thromb Haemost. 2008 Jan; 6(1):176-83.
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Kuderer NM, Khorana AA, Lyman GH, Francis CW. A meta-analysis and systematic review of the efficacy and safety of anticoagulants as cancer treatment: impact on survival and bleeding complications. Cancer. 2007 Sep 1; 110(5):1149-61.
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Khorana AA, Ahrendt SA, Ryan CK, Francis CW, Hruban RH, Hu YC, Hostetter G, Harvey J, Taubman MB. Tissue factor expression, angiogenesis, and thrombosis in pancreatic cancer. Clin Cancer Res. 2007 May 15; 13(10):2870-5.
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Mieszczanska H, Kaba NK, Francis CW, Gerich JE, Dodis R, Schwarz KQ, Phipps RP, Smith BH, Lee M, Messing S, Taubman MB. Effects of pioglitazone on fasting and postprandial levels of lipid and hemostatic variables in overweight non-diabetic patients with coronary artery disease. J Thromb Haemost. 2007 May; 5(5):942-9.
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Francis CW. Clinical practice. Prophylaxis for thromboembolism in hospitalized medical patients. N Engl J Med. 2007 Apr 5; 356(14):1438-44.
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Khorana AA, Francis CW, Culakova E, Kuderer NM, Lyman GH. Thromboembolism is a leading cause of death in cancer patients receiving outpatient chemotherapy. J Thromb Haemost. 2007 Mar; 5(3):632-4.
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Haulon S, Greenberg RK, Pfaff K, Francis C, Koussa M, West K. Branched grafting for aortoiliac aneurysms. Eur J Vasc Endovasc Surg. 2007 May; 33(5):567-74.
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O'Brien JJ, Ray DM, Spinelli SL, Blumberg N, Taubman MB, Francis CW, Wittlin SD, Phipps RP. The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands. Prostaglandins Other Lipid Mediat. 2007 Jan; 82(1-4):68-76.
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Komrokji RS, Uppal NP, Khorana AA, Lyman GH, Kaplan KL, Fisher RI, Francis CW. Venous thromboembolism in patients with diffuse large B-cell lymphoma. Leuk Lymphoma. 2006 Jun; 47(6):1029-33.
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Khorana AA, Francis CW, Culakova E, Fisher RI, Kuderer NM, Lyman GH. Thromboembolism in hospitalized neutropenic cancer patients. J Clin Oncol. 2006 Jan 20; 24(3):484-90.
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Khorana AA, Francis CW, Culakova E, Lyman GH. Risk factors for chemotherapy-associated venous thromboembolism in a prospective observational study. Cancer. 2005 Dec 15; 104(12):2822-9.
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Almuneef MA, Memish ZA, Balkhy HH, Hijazi O, Cunningham G, Francis C. Rate, risk factors and outcomes of catheter-related bloodstream infection in a paediatric intensive care unit in Saudi Arabia. J Hosp Infect. 2006 Feb; 62(2):207-13.
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Colwell CW, Berkowitz SD, Lieberman JR, Comp PC, Ginsberg JS, Paiement G, McElhattan J, Roth AW, Francis CW. Oral direct thrombin inhibitor ximelagatran compared with warfarin for the prevention of venous thromboembolism after total knee arthroplasty. J Bone Joint Surg Am. 2005 Oct; 87(10):2169-77.
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Sahni A, Khorana AA, Baggs RB, Peng H, Francis CW. FGF-2 binding to fibrin(ogen) is required for augmented angiogenesis. Blood. 2006 Jan 1; 107(1):126-31.
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Sahni A, Sahni SK, Francis CW. Endothelial cell activation by IL-1beta in the presence of fibrinogen requires alphavbeta3. Arterioscler Thromb Vasc Biol. 2005 Oct; 25(10):2222-7.
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Moss AJ, Ryan D, Oakes D, Goldstein RE, Greenberg H, Bodenheimer MM, Brown MW, Case RB, Dwyer EM, Eberly SW, Francis CW, Gillespie JA, Krone RJ, Lichstein E, MacCluer JW, Marcus FI, McCarthy J, Sparks CE, Zareba W. Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction. Am J Cardiol. 2005 Jul 15; 96(2):177-82.
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Rozmus G, Daubert JP, Huang DT, Rosero S, Hall B, Francis C. Venous thrombosis and stenosis after implantation of pacemakers and defibrillators. J Interv Card Electrophysiol. 2005 Jun; 13(1):9-19.
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Fiessinger JN, Huisman MV, Davidson BL, Bounameaux H, Francis CW, Eriksson H, Lundström T, Berkowitz SD, Nyström P, Thorsén M, Ginsberg JS. Ximelagatran vs low-molecular-weight heparin and warfarin for the treatment of deep vein thrombosis: a randomized trial. JAMA. 2005 Feb 9; 293(6):681-9.
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Francis CW. Direct thrombin inhibitors for treatment of heparin induced thrombocytopenia, deep vein thrombosis and atrial fibrillation. Curr Pharm Des. 2005; 11(30):3931-41.
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Siegel RJ, Suchkova VN, Miyamoto T, Luo H, Baggs RB, Neuman Y, Horzewski M, Suorsa V, Kobal S, Thompson T, Echt D, Francis CW. Ultrasound energy improves myocardial perfusion in the presence of coronary occlusion. J Am Coll Cardiol. 2004 Oct 6; 44(7):1454-8.
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Guo M, Sahni SK, Sahni A, Francis CW. Fibrinogen regulates the expression of inflammatory chemokines through NF-kappaB activation of endothelial cells. Thromb Haemost. 2004 Oct; 92(4):858-66.
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Theodore D, Fried MW, Kleiner DE, Kroner BL, Goedert JJ, Eyster ME, Faust SP, Sherman KE, Kessler CM, Francis C, Aledort LM. Liver biopsy in patients with inherited disorders of coagulation and chronic hepatitis C. Haemophilia. 2004 Sep; 10(5):413-21.
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Sahni A, Sahni SK, Simpson-Haidaris PJ, Francis CW. Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells. J Thromb Haemost. 2004 Sep; 2(9):1629-36.
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Sahni A, Francis CW. Stimulation of endothelial cell proliferation by FGF-2 in the presence of fibrinogen requires alphavbeta3. Blood. 2004 Dec 1; 104(12):3635-41.
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Joshi SG, Francis CW, Silverman DJ, Sahni SK. NF-kappaB activation suppresses host cell apoptosis during Rickettsia rickettsii infection via regulatory effects on intracellular localization or levels of apoptogenic and anti-apoptotic proteins. FEMS Microbiol Lett. 2004 May 15; 234(2):333-41.
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Akbiyik F, Ray DM, Gettings KF, Blumberg N, Francis CW, Phipps RP. Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. Blood. 2004 Sep 1; 104(5):1361-8.
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Kaba NK, Francis CW, Moss AJ, Zareba W, Oakes D, Knox KL, Fernández ID, Rainwater DL. Effects of lipids and lipid-lowering therapy on hemostatic factors in patients with myocardial infarction. J Thromb Haemost. 2004 May; 2(5):718-25.
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Altland OD, Dalecki D, Suchkova VN, Francis CW. Low-intensity ultrasound increases endothelial cell nitric oxide synthase activity and nitric oxide synthesis. J Thromb Haemost. 2004 Apr; 2(4):637-43.
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Sahni A, Guo M, Sahni SK, Francis CW. Interleukin-1beta but not IL-1alpha binds to fibrinogen and fibrin and has enhanced activity in the bound form. Blood. 2004 Jul 15; 104(2):409-14.
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Francis CW. Ximelagatran: a new oral anticoagulant. Best Pract Res Clin Haematol. 2004 Mar; 17(1):139-52.
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Peng H, Sahni A, Fay P, Bellum S, Prudovsky I, Maciag T, Francis CW. Identification of a binding site on human FGF-2 for fibrinogen. Blood. 2004 Mar 15; 103(6):2114-20.
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Francis CW, Berkowitz SD, Comp PC, Lieberman JR, Ginsberg JS, Paiement G, Peters GR, Roth AW, McElhattan J, Colwell CW. Comparison of ximelagatran with warfarin for the prevention of venous thromboembolism after total knee replacement. N Engl J Med. 2003 Oct 30; 349(18):1703-12.
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Colwell CW, Berkowitz SD, Davidson BL, Lotke PA, Ginsberg JS, Lieberman JR, Neubauer J, McElhattan JL, Peters GR, Francis CW. Comparison of ximelagatran, an oral direct thrombin inhibitor, with enoxaparin for the prevention of venous thromboembolism following total hip replacement. A randomized, double-blind study. J Thromb Haemost. 2003 Oct; 1(10):2119-30.
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Khorana AA, Sahni A, Altland OD, Francis CW. Heparin inhibition of endothelial cell proliferation and organization is dependent on molecular weight. Arterioscler Thromb Vasc Biol. 2003 Nov 1; 23(11):2110-5.
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Joshi SG, Francis CW, Silverman DJ, Sahni SK. Nuclear factor kappa B protects against host cell apoptosis during Rickettsia rickettsii infection by inhibiting activation of apical and effector caspases and maintaining mitochondrial integrity. Infect Immun. 2003 Jul; 71(7):4127-36.
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Sahni A, Francis CW. Plasmic degradation modulates activity of fibrinogen-bound fibroblast growth factor-2. J Thromb Haemost. 2003 Jun; 1(6):1271-7.
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Sahni A, Altland OD, Francis CW. FGF-2 but not FGF-1 binds fibrin and supports prolonged endothelial cell growth. J Thromb Haemost. 2003 Jun; 1(6):1304-10.
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Kaba NK, Francis CW, Hall WJ, Falsey AR, Smith BH. Protein S declines during winter respiratory infections. J Thromb Haemost. 2003 Apr; 1(4):729-34.
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Alving BM, Francis CW, Hiatt WR, Jackson MR. Consultations on patients with venous or arterial diseases. Hematology Am Soc Hematol Educ Program. 2003; 540-58.
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Gottlieb RH, Voci SL, Syed L, Shyu C, Fultz PJ, Rubens DJ, Strang JG, Carson N, DiGrazio WJ, Francis CW. Randomized prospective study comparing routine versus selective use of sonography of the complete calf in patients with suspected deep venous thrombosis. AJR Am J Roentgenol. 2003 Jan; 180(1):241-5.
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Francis CW. Factor XIII polymorphisms and venous thromboembolism. Arch Pathol Lab Med. 2002 Nov; 126(11):1391-3.
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Francis CW. Plasminogen activator inhibitor-1 levels and polymorphisms. Arch Pathol Lab Med. 2002 Nov; 126(11):1401-4.
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Suchkova VN, Baggs RB, Sahni SK, Francis CW. Ultrasound improves tissue perfusion in ischemic tissue through a nitric oxide dependent mechanism. Thromb Haemost. 2002 Nov; 88(5):865-70.
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Francis CW, Davidson BL, Berkowitz SD, Lotke PA, Ginsberg JS, Lieberman JR, Webster AK, Whipple JP, Peters GR, Colwell CW. Ximelagatran versus warfarin for the prevention of venous thromboembolism after total knee arthroplasty. A randomized, double-blind trial. Ann Intern Med. 2002 Oct 15; 137(8):648-55.
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Byrne NP, Henry JC, Herrmann DN, Abdelhalim AN, Shrier DA, Francis CW, Powers JM. Neuropathologic findings in a Guillain-Barré patient with strokes after IVIg therapy. Neurology. 2002 Aug 13; 59(3):458-61.
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Kaplan KL, Francis CW. Direct thrombin inhibitors. Semin Hematol. 2002 Jul; 39(3):187-96.
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Suchkova V, Carstensen EL, Francis CW. Ultrasound enhancement of fibrinolysis at frequencies of 27 to 100 kHz. Ultrasound Med Biol. 2002 Mar; 28(3):377-82.
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Setliff RC, Catalano PJ, Catalano LA, Francis C. An anatomic classification of the ethmoidal bulla. Otolaryngol Head Neck Surg. 2001 Dec; 125(6):598-602.
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Horan JT, Francis CW. Fibrin degradation products, fibrin monomer and soluble fibrin in disseminated intravascular coagulation. Semin Thromb Hemost. 2001 Dec; 27(6):657-66.
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Heit JA, Colwell CW, Francis CW, Ginsberg JS, Berkowitz SD, Whipple J, Peters G. Comparison of the oral direct thrombin inhibitor ximelagatran with enoxaparin as prophylaxis against venous thromboembolism after total knee replacement: a phase 2 dose-finding study. Arch Intern Med. 2001 Oct 8; 161(18):2215-21.
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Hull RD, Pineo GF, Stein PD, Mah AF, MacIsaac SM, Dahl OE, Ghali WA, Butcher MS, Brant RF, Bergqvist D, Hamulyák K, Francis CW, Marder VJ, Raskob GE. Timing of initial administration of low-molecular-weight heparin prophylaxis against deep vein thrombosis in patients following elective hip arthroplasty: a systematic review. Arch Intern Med. 2001 Sep 10; 161(16):1952-60.
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Anolik JH, Blumberg N, Snider J, Francis CW. Posttransfusion purpura secondary to an alloantibody reactive with HPA-5a (Br(b)). Transfusion. 2001 May; 41(5):633-6.
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Francis CW. Ultrasound-enhanced thrombolysis. Echocardiography. 2001 Apr; 18(3):239-46.
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Falsey AR, Walsh EE, Francis CW, Looney RJ, Kolassa JE, Hall WJ, Abraham GN. Response of C-reactive protein and serum amyloid A to influenza A infection in older adults. J Infect Dis. 2001 Apr 1; 183(7):995-9.
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Horan JT, Francis CW, Falsey AR, Kolassa J, Smith BH, Hall WJ. Prothrombotic changes in hemostatic parameters and C-reactive protein in the elderly with winter acute respiratory tract infections. Thromb Haemost. 2001 Feb; 85(2):245-9.
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Francis CW, Suchkova VN. Ultrasound and thrombolysis. Vasc Med. 2001; 6(3):181-7.
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Sahni A, Francis CW. Vascular endothelial growth factor binds to fibrinogen and fibrin and stimulates endothelial cell proliferation. Blood. 2000 Dec 1; 96(12):3772-8.
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Bili A, Moss AJ, Francis CW, Zareba W, Watelet LF, Sanz I. Anticardiolipin antibodies and recurrent coronary events: a prospective study of 1150 patients. Thrombogenic Factors, and Recurrent Coronary Events Investigators. Circulation. 2000 Sep 12; 102(11):1258-63.
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Everbach EC, Francis CW. Cavitational mechanisms in ultrasound-accelerated thrombolysis at 1 MHz. Ultrasound Med Biol. 2000 Sep; 26(7):1153-60.
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Hull RD, Pineo GF, Francis C, Bergqvist D, Fellenius C, Soderberg K, Holmqvist A, Mant M, Dear R, Baylis B, Mah A, Brant R. Low-molecular-weight heparin prophylaxis using dalteparin in close proximity to surgery vs warfarin in hip arthroplasty patients: a double-blind, randomized comparison. The North American Fragmin Trial Investigators. Arch Intern Med. 2000 Jul 24; 160(14):2199-207.
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Hull RD, Pineo GF, Francis C, Bergqvist D, Fellenius C, Soderberg K, Holmqvist A, Mant M, Dear R, Baylis B, Mah A, Brant R. Low-molecular-weight heparin prophylaxis using dalteparin extended out-of-hospital vs in-hospital warfarin/out-of-hospital placebo in hip arthroplasty patients: a double-blind, randomized comparison. North American Fragmin Trial Investigators. Arch Intern Med. 2000 Jul 24; 160(14):2208-15.
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Suchkova VN, Baggs RB, Francis CW. Effect of 40-kHz ultrasound on acute thrombotic ischemia in a rabbit femoral artery thrombosis model: enhancement of thrombolysis and improvement in capillary muscle perfusion. Circulation. 2000 May 16; 101(19):2296-301.
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Sahni A, Baker CA, Sporn LA, Francis CW. Fibrinogen and fibrin protect fibroblast growth factor-2 from proteolytic degradation. Thromb Haemost. 2000 May; 83(5):736-41.
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McCarron BI, Marder VJ, Francis CW. Reactivity of soluble fibrin assays with plasmic degradation products of fibrin and in patients receiving fibrinolytic therapy. Thromb Haemost. 1999 Dec; 82(6):1722-9.
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Shortell CK, Francis CW. Thrombolytic therapy for arterial thrombosis. Curr Opin Hematol. 1999 Sep; 6(5):309-13.
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Weisel JW, Veklich Y, Collet JP, Francis CW. Structural studies of fibrinolysis by electron and light microscopy. Thromb Haemost. 1999 Aug; 82(2):277-82.
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McCarron BI, Marder VJ, Kanouse JJ, Francis CW. A soluble fibrin standard: comparable dose-response with immunologic and functional assays. Thromb Haemost. 1999 Jul; 82(1):145-8.
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Sahni A, Sporn LA, Francis CW. Potentiation of endothelial cell proliferation by fibrin(ogen)-bound fibroblast growth factor-2. J Biol Chem. 1999 May 21; 274(21):14936-41.
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Baharloo F, Veyckemans F, Francis C, Biettlot MP, Rodenstein DO. Tracheobronchial foreign bodies: presentation and management in children and adults. Chest. 1999 May; 115(5):1357-62.
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Kaplan KL, Francis CW. Heparin-induced thrombocytopenia. Blood Rev. 1999 Mar; 13(1):1-7.
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Veklich Y, Francis CW, White J, Weisel JW. Structural studies of fibrinolysis by electron microscopy. Blood. 1998 Dec 15; 92(12):4721-9.
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Suchkova V, Siddiqi FN, Carstensen EL, Dalecki D, Child S, Francis CW. Enhancement of fibrinolysis with 40-kHz ultrasound. Circulation. 1998 Sep 8; 98(10):1030-5.
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Felcher A, Commichau C, Cao Q, Brown MJ, Torres A, Francis CW. Disseminated intravascular coagulation and status epilepticus. Neurology. 1998 Aug; 51(2):629-31.
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Sahni A, Odrljin T, Francis CW. Binding of basic fibroblast growth factor to fibrinogen and fibrin. J Biol Chem. 1998 Mar 27; 273(13):7554-9.
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Siddiqi F, Odrljin TM, Fay PJ, Cox C, Francis CW. Binding of tissue-plasminogen activator to fibrin: effect of ultrasound. Blood. 1998 Mar 15; 91(6):2019-25.
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Ryan DH, Crowther MA, Ginsberg JS, Francis CW. Relation of factor V Leiden genotype to risk for acute deep venous thrombosis after joint replacement surgery. Ann Intern Med. 1998 Feb 15; 128(4):270-6.
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Everbach EC, Makin IR, Francis CW, Meltzer RS. Effect of acoustic cavitation on platelets in the presence of an echo-contrast agent. Ultrasound Med Biol. 1998 Jan; 24(1):129-36.
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Braaten JV, Goss RA, Francis CW. Ultrasound reversibly disaggregates fibrin fibers. Thromb Haemost. 1997 Sep; 78(3):1063-8.
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Francis CW, Pellegrini VD, Totterman S, Boyd AD, Marder VJ, Liebert KM, Stulberg BN, Ayers DC, Rosenberg A, Kessler C, Johanson NA. Prevention of deep-vein thrombosis after total hip arthroplasty. Comparison of warfarin and dalteparin. J Bone Joint Surg Am. 1997 Sep; 79(9):1365-72.
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Messeri P, Workman S, Saunders C, Francis C. The application of meta-analysis in assessing racial differences in the effects of antihypertensive medication. J Natl Med Assoc. 1997 Jul; 89(7):477-85.
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Geigel EJ, Francis CW. Reversal of multiorgan system dysfunction in sickle cell disease with plasma exchange. Acta Anaesthesiol Scand. 1997 May; 41(5):647-50.
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Riggs PN, Francis CW, Bartos SR, Penney DP. Ultrasound enhancement of rabbit femoral artery thrombolysis. Cardiovasc Surg. 1997 Apr; 5(2):201-7.
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Illig KA, Green RM, Ouriel K, Riggs PN, Bartos S, Whorf R, DeWeese JA, Chhibber A, Marder VJ, Francis CW. Primary fibrinolysis during supraceliac aortic clamping. J Vasc Surg. 1997 Feb; 25(2):244-51; discussion 252-4.
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Francis CW, Felcher AH, White J, Braaten JV, Goss R. Thrombin activity associated with indwelling central venous catheters. Thromb Haemost. 1997 Jan; 77(1):48-52.
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Dalecki D, Raeman CH, Child SZ, Cox C, Francis CW, Meltzer RS, Carstensen EL. Hemolysis in vivo from exposure to pulsed ultrasound. Ultrasound Med Biol. 1997; 23(2):307-13.
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Odrljin TM, Francis CW, Sporn LA, Bunce LA, Marder VJ, Simpson-Haidaris PJ. Heparin-binding domain of fibrin mediates its binding to endothelial cells. Arterioscler Thromb Vasc Biol. 1996 Dec; 16(12):1544-51.
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Odrljin TM, Rybarczyk BJ, Francis CW, Lawrence SO, Hamaguchi M, Simpson-Haidaris PJ. Calcium modulates plasmin cleavage of the fibrinogen D fragment gamma chain N-terminus: mapping of monoclonal antibody J88B to a plasmin sensitive domain of the gamma chain. Biochim Biophys Acta. 1996 Nov 14; 1298(1):69-77.
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Blinc A, Francis CW. Transport processes in fibrinolysis and fibrinolytic therapy. Thromb Haemost. 1996 Oct; 76(4):481-91.
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Francis CW, Pellegrini VD, Leibert KM, Totterman S, Azodo MV, Harris CM, Cox C, Marder VJ. Comparison of two warfarin regimens in the prevention of venous thrombosis following total knee replacement. Thromb Haemost. 1996 May; 75(5):706-11.
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Davis BR, Cutler JA, Gordon DJ, Furberg CD, Wright JT, Cushman WC, Grimm RH, LaRosa J, Whelton PK, Perry HM, Alderman MH, Ford CE, Oparil S, Francis C, Proschan M, Pressel S, Black HR, Hawkins CM. Rationale and design for the Antihypertensive and Lipid Lowering Treatment to Prevent Heart Attack Trial (ALLHAT). ALLHAT Research Group. Am J Hypertens. 1996 Apr; 9(4 Pt 1):342-60.
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Sporn LA, Bunce LA, Francis CW. Cell proliferation on fibrin: modulation by fibrinopeptide cleavage. Blood. 1995 Sep 1; 86(5):1802-10.
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Francis CW, Totterman S. Magnetic resonance imaging of deep vein thrombi correlates with response to thrombolytic therapy. Thromb Haemost. 1995 Mar; 73(3):386-91.
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Siddiqi F, Blinc A, Braaten J, Francis CW. Ultrasound increases flow through fibrin gels. Thromb Haemost. 1995 Mar; 73(3):495-8.
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el Khawand C, Marchandise FX, Mayne A, Jamart J, Francis C, Weynants P, Sibille Y, Delaunois L. [Spontaneous pneumothorax. Results of pleural talc therapy using thoracoscopy]. Rev Mal Respir. 1995; 12(3):275-81.
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Francis CW, Blinc A, Lee S, Cox C. Ultrasound accelerates transport of recombinant tissue plasminogen activator into clots. Ultrasound Med Biol. 1995; 21(3):419-24.
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Kashyap A, Blinc A, Marder VJ, Penney DP, Francis CW. Acceleration of fibrinolysis by ultrasound in a rabbit ear model of small vessel injury. Thromb Res. 1994 Dec 1; 76(5):475-85.
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Shammas NW, Cunningham MJ, Pomerantz RM, Francis CW. Markers of hemostatic activation in affected coronary arteries during angioplasty. Thromb Haemost. 1994 Nov; 72(5):672-5.
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Hamaguchi M, Bunce LA, Sporn LA, Francis CW. Plasmic degradation of fibrin rapidly decreases platelet adhesion and spreading. Blood. 1994 Aug 15; 84(4):1143-50.
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Ouriel K, Shortell CK, DeWeese JA, Green RM, Francis CW, Azodo MV, Gutierrez OH, Manzione JV, Cox C, Marder VJ. A comparison of thrombolytic therapy with operative revascularization in the initial treatment of acute peripheral arterial ischemia. J Vasc Surg. 1994 Jun; 19(6):1021-30.
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Sham RL, Francis CW. Evaluation of mild bleeding disorders and easy bruising. Blood Rev. 1994 Jun; 8(2):98-104.
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Harpaz D, Chen X, Francis CW, Meltzer RS. Ultrasound accelerates urokinase-induced thrombolysis and reperfusion. Am Heart J. 1994 May; 127(5):1211-9.
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Blombäck M, Abildgaard U, van den Besselaar AM, Clementson KJ, Dahlbäck B, Exner T, Francis CW, Gaffney P, Gralnick H, Hoyer LW, et al. Nomenclature of quantities and units in thrombosis and haemostasis (recommendation 1993). A Collaborative project of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (ISTH/SSC) and the Commission/Committee on Quantities and Units (in Clinical Chemistry) of the International Union of Pure and Applied Chemistry-International Federation of Clinical Chemistry (IUPAC-IFCC/CQU(CC)). Thromb Haemost. 1994 Mar; 71(3):375-94.
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Blinc A, Kennedy SD, Bryant RG, Marder VJ, Francis CW. Flow through clots determines the rate and pattern of fibrinolysis. Thromb Haemost. 1994 Feb; 71(2):230-5.
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Onundarson PT, Haraldsson HM, Bergmann L, Francis CW, Marder VJ. Plasminogen depletion during streptokinase treatment or two-chain urokinase incubation correlates with decreased clot lysability ex vivo and in vitro. Thromb Haemost. 1993 Dec 20; 70(6):998-1004.
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Weisel JW, Francis CW, Nagaswami C, Marder VJ. Determination of the topology of factor XIIIa-induced fibrin gamma-chain cross-links by electron microscopy of ligated fragments. J Biol Chem. 1993 Dec 15; 268(35):26618-24.
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Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ. Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma. Blood. 1993 Oct 15; 82(8):2406-13.
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Pellegrini VD, Langhans MJ, Totterman S, Marder VJ, Francis CW. Embolic complications of calf thrombosis following total hip arthroplasty. J Arthroplasty. 1993 Oct; 8(5):449-57.
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Kornberg A, Francis CW, Pellegrini VD, Gabriel KR, Marder VJ. Comparison of native prothrombin antigen with the prothrombin time for monitoring oral anticoagulant prophylaxis. Circulation. 1993 Aug; 88(2):454-60.
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Blinc A, Francis CW, Trudnowski JL, Carstensen EL. Characterization of ultrasound-potentiated fibrinolysis in vitro. Blood. 1993 May 15; 81(10):2636-43.
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Harpaz D, Chen X, Francis CW, Marder VJ, Meltzer RS. Ultrasound enhancement of thrombolysis and reperfusion in vitro. J Am Coll Cardiol. 1993 May; 21(6):1507-11.
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Hamaguchi M, Bunce LA, Sporn LA, Francis CW. Spreading of platelets on fibrin is mediated by the amino terminus of the beta chain including peptide beta 15-42. Blood. 1993 May 1; 81(9):2348-56.
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Dustan HP, Francis CW, Allen HD, Cunningham SL, Dulany W, Hay J, Kaiser GA, Lee TH, Mattson P, Ness DA, et al. Principles of access to health care. Access to Health Care Task Force, American Heart Association. Circulation. 1993 Feb; 87(2):657-8.
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Francis CW, Bunce LA, Sporn LA. Endothelial cell responses to fibrin mediated by FPB cleavage and the amino terminus of the beta chain. Blood Cells. 1993; 19(2):291-306; discussion 306-7.
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Marchandise FX, Vandenplas O, Wallon J, Francis C. Thoracoscopy in the diagnosis and management of chronic pleural effusions. Acta Clin Belg. 1993; 48(1):5-10.
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Francis CW, Kornberg A. Fibrinogen- and fibrin-degradation products during fibrinolytic therapy. Ann N Y Acad Sci. 1992 Dec 4; 667:310-23.
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Francis CW, Onundarson PT, Carstensen EL, Blinc A, Meltzer RS, Schwarz K, Marder VJ. Enhancement of fibrinolysis in vitro by ultrasound. J Clin Invest. 1992 Nov; 90(5):2063-8.
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Kornberg A, Francis CW, Marder VJ. Plasma crosslinked fibrin polymers: quantitation based on tissue plasminogen activator conversion to D-dimer and measurement in normal and patients with acute thrombotic disorders. Blood. 1992 Aug 1; 80(3):709-17.
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Onundarson PT, Francis CW, Marder VJ. Depletion of plasminogen in vitro or during thrombolytic therapy limits fibrinolytic potential. J Lab Clin Med. 1992 Jul; 120(1):120-8.
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Francis CW, Pellegrini VD, Marder VJ, Totterman S, Harris CM, Gabriel KR, Azodo MV, Leibert KM. Comparison of warfarin and external pneumatic compression in prevention of venous thrombosis after total hip replacement. JAMA. 1992 Jun 3; 267(21):2911-5.
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Marder VJ, Brenner B, Totterman S, Francis CW, Rubin R, Rao AK, Kessler CM, Kwaan HC, Sharma GV, Fong KL. Comparison of dosage schedules of rt-PA in the treatment of proximal deep vein thrombosis. J Lab Clin Med. 1992 May; 119(5):485-95.
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Onundarson PT, Rowe JM, Heal JM, Francis CW. Response to plasma exchange and splenectomy in thrombotic thrombocytopenic purpura. A 10-year experience at a single institution. Arch Intern Med. 1992 Apr; 152(4):791-6.
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Bunce LA, Sporn LA, Francis CW. Endothelial cell spreading on fibrin requires fibrinopeptide B cleavage and amino acid residues 15-42 of the beta chain. J Clin Invest. 1992 Mar; 89(3):842-50.
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Owens MR, Ribes JA, Marder VJ, Francis CW. Effects of ionic and nonionic radiographic contrast agents on endothelial cells in vitro. J Lab Clin Med. 1992 Mar; 119(3):315-9.
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Francis CW, Marder VJ. Fibrinolytic therapy for venous thrombosis. Prog Cardiovasc Dis. 1991 Nov-Dec; 34(3):193-204.
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Francis CW, Brenner B, Leddy JP, Marder VJ. Angioedema during therapy with recombinant tissue plasminogen activator. Br J Haematol. 1991 Apr; 77(4):562-3.
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Francis CW, Pellegrini VD, Harris CM, Stulberg B, Gabriel KR, Marder VJ. Prophylaxis of venous thrombosis following total hip and total knee replacement using antithrombin III and heparin. Semin Hematol. 1991 Jan; 28(1):39-45.
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Blackmore CC, Francis CW, Bryant RG, Brenner B, Marder VJ. Magnetic resonance imaging of blood and clots in vitro. Invest Radiol. 1990 Dec; 25(12):1316-24.
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Francis CW, Pellegrini VD, Stulberg BN, Miller ML, Totterman S, Marder VJ. Prevention of venous thrombosis after total knee arthroplasty. Comparison of antithrombin III and low-dose heparin with dextran. J Bone Joint Surg Am. 1990 Aug; 72(7):976-82.
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Brenner B, Francis CW, Totterman S, Kessler CM, Rao AK, Rubin R, Kwaan HC, Gabriel KR, Marder VJ. Quantitation of venous clot lysis with the D-dimer immunoassay during fibrinolytic therapy requires correction for soluble fibrin degradation. Circulation. 1990 Jun; 81(6):1818-25.
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Ribes JA, Francis CW. Multimer size dependence of von Willebrand factor binding to crosslinked or noncrosslinked fibrin. Blood. 1990 Apr 1; 75(7):1460-5.
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Mehta RL, Scott G, Sloand JA, Francis CW. Skin necrosis associated with acquired protein C deficiency in patients with renal failure and calciphylaxis. Am J Med. 1990 Mar; 88(3):252-7.
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Bryant RG, Marill K, Blackmore C, Francis C. Magnetic relaxation in blood and blood clots. Magn Reson Med. 1990 Jan; 13(1):133-44.
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Totterman S, Francis CW, Foster TH, Brenner B, Marder VJ, Bryant RG. Diagnosis of femoropopliteal venous thrombosis with MR imaging: a comparison of four MR pulse sequences. AJR Am J Roentgenol. 1990 Jan; 154(1):175-8.
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Haidaris PJ, Peerschke EI, Marder VJ, Francis CW. The C-terminal sequences of the gamma 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin. Blood. 1989 Nov 15; 74(7):2437-44.
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Stulberg BN, Francis CW, Pellegrini VD, Miller ML, Shull S, deSwart R, Easley K, Totterman S, Marder VJ. Antithrombin III/low-dose heparin in the prevention of deep-vein thrombosis after total knee arthroplasty. A preliminary report. Clin Orthop Relat Res. 1989 Nov; (248):152-7.
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Francis CW, Mosesson MW. Terminology for fibrinogen gamma-chains differing in carboxyl terminal amino acid sequence. Thromb Haemost. 1989 Sep 29; 62(2):813-4.
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Francis CW, Pellegrini VD, Harris CM, Marder VJ. Antithrombin III prophylaxis of venous thromboembolic disease after total hip or total knee replacement. Am J Med. 1989 Sep 11; 87(3B):61S-66S.
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Haidaris PJ, Francis CW, Sporn LA, Arvan DS, Collichio FA, Marder VJ. Megakaryocyte and hepatocyte origins of human fibrinogen biosynthesis exhibit hepatocyte-specific expression of gamma chain-variant polypeptides. Blood. 1989 Aug 1; 74(2):743-50.
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Ribes JA, Ni F, Wagner DD, Francis CW. Mediation of fibrin-induced release of von Willebrand factor from cultured endothelial cells by the fibrin beta chain. J Clin Invest. 1989 Aug; 84(2):435-42.
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Francis CW, Foster TH, Totterman S, Brenner B, Marder VJ, Bryant RG. Monitoring of therapy for deep vein thrombosis using magnetic resonance imaging. Acta Radiol. 1989 Jul-Aug; 30(4):445-6.
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Brenner B, Francis CW, Marder VJ. The role of soluble cross-linked fibrin in D dimer immunoreactivity of plasmic digests. J Lab Clin Med. 1989 Jun; 113(6):682-8.
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Brenner B, Francis CW, Fitzpatrick PG, Rothbard RL, Cox C, Hackworthy RA, Anderson JL, Sorensen SG, Marder VJ. Relation of plasma D-dimer concentrations to coronary artery reperfusion before and after thrombolytic treatment in patients with acute myocardial infarction. Am J Cardiol. 1989 May 15; 63(17):1179-84.
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Martinot JB, Wallaert B, Hatron PY, Francis C, Voisin C, Sibille Y. Clinical and subclinical alveolitis in collagen vascular diseases: contribution of alpha 2-macroglobulin levels in BAL fluid. Eur Respir J. 1989 May; 2(5):437-43.
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Francis CW, Doughney K, Brenner B, Klingbiel K, Marder VJ. Increased immunoreactivity of plasma after fibrinolytic activation in an anti-DD ELISA system. Role of soluble crosslinked fibrin polymers. Circulation. 1989 Mar; 79(3):666-73.
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Francis CW, Pellegrini VD, Marder VJ, Harris CM, Totterman S, Gabriel KR, Baughman DJ, Roemer S, Burke J, Goodman TL, et al. Prevention of venous thrombosis after total hip arthroplasty. Antithrombin III and low-dose heparin compared with dextran 40. J Bone Joint Surg Am. 1989 Mar; 71(3):327-35.
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Humblet Y, Weynants P, Bosly A, Majois F, Duprez P, Francis C, Beauduin M, Machiels J, Gailly C, Delaunois L, et al. Carboplatin in association with etoposide and either adriamycin or epirubicin for untreated small cell lung cancer: a dose escalation study of carboplatin. UCL Clinical Oncology Group. Med Oncol Tumor Pharmacother. 1989; 6(3):207-12.
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Francis CW, Ricotta JJ, Evarts CM, Marder VJ. Long-term clinical observations and venous functional abnormalities after asymptomatic venous thrombosis following total hip or knee arthroplasty. Clin Orthop Relat Res. 1988 Jul; (232):271-8.
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Francis CW, Marder VJ. Increased resistance to plasmic degradation of fibrin with highly crosslinked alpha-polymer chains formed at high factor XIII concentrations. Blood. 1988 May; 71(5):1361-5.
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Francis CW, Müller E, Henschen A, Simpson PJ, Marder VJ. Carboxyl-terminal amino acid sequences of two variant forms of the gamma chain of human plasma fibrinogen. Proc Natl Acad Sci U S A. 1988 May; 85(10):3358-62.
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Woodlock TJ, Francis CW, Rowe JM, Brown MJ, Marder VJ. Prolonged remission after life-threatening gastrointestinal hemorrhage from coexistent angiodysplasia and acquired bleeding diathesis. Am J Hematol. 1988 Feb; 27(2):125-31.
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Humblet Y, Symann M, Bosly A, Delaunois L, Francis C, Machiels J, Beauduin M, Doyen C, Weynants P, Longueville J, et al. Late intensification chemotherapy with autologous bone marrow transplantation in selected small-cell carcinoma of the lung: a randomized study. J Clin Oncol. 1987 Dec; 5(12):1864-73.
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Francis CW, Marder VJ. Rapid formation of large molecular weight alpha-polymers in cross-linked fibrin induced by high factor XIII concentrations. Role of platelet factor XIII. J Clin Invest. 1987 Nov; 80(5):1459-65.
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Francis CW, Connaghan DG, Scott WL, Marder VJ. Increased plasma concentration of cross-linked fibrin polymers in acute myocardial infarction. Circulation. 1987 Jun; 75(6):1170-7.
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Francis CW, Marder VJ. Physiologic regulation and pathologic disorders of fibrinolysis. Hum Pathol. 1987 Mar; 18(3):263-74.
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Francis CW, Alkjaersig N, Galanakis DK, Graeff H, Owen J, Gaffney P, Marder VJ. Terminology for macromolecular plasmic derivatives of crosslinked fibrin. Thromb Haemost. 1987 Feb 3; 57(1):110-1.
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Marder VJ, Rothbard RL, Fitzpatrick PG, Francis CW, Norry EC. Dose-ranging studies of anisoylated plasminogen streptokinase activator complex. Studies in healthy volunteers and in patients with acute myocardial infarction. Drugs. 1987; 33 Suppl 3:124-32.
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Ribes JA, Francis CW, Wagner DD. Fibrin induces release of von Willebrand factor from endothelial cells. J Clin Invest. 1987 Jan; 79(1):117-23.
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Mader VJ, Francis CW. Two-step warfarin therapy for the prophylaxis of venous thrombosis after elective surgery. Adv Exp Med Biol. 1987; 214:159-63.
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Marder VJ, Francis CW. Physiological balance of haemostasis and bleeding. Drugs. 1987; 33 Suppl 3:13-21.
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Francis CW, Connaghan DG, Marder VJ. Assessment of fibrin degradation products during fibrinolytic therapy for acute myocardial infarction. Circulation. 1986 Nov; 74(5):1027-36.
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Connaghan DG, Francis CW, Ryan DH, Marder VJ. Prevalence and clinical implications of heparin-associated false positive tests for serum fibrin(ogen) degradation products. Am J Clin Pathol. 1986 Sep; 86(3):304-10.
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Scott WL, Francis CW, Knutson DW, Marder VJ. Specific identification of urinary fibrinogen, fibrinogen degradation products, and cross-linked fibrin degradation products in renal diseases and after renal allotransplantation. J Lab Clin Med. 1986 Jun; 107(6):534-43.
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Francis CW, Marder VJ, Evarts CM. Lower risk of thromboembolic disease after total hip replacement with non-cemented than with cemented prostheses. Lancet. 1986 Apr 5; 1(8484):769-71.
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Francis CW, Marder VJ. Degradation of cross-linked fibrin by human leukocyte proteases. J Lab Clin Med. 1986 Apr; 107(4):342-52.
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Marder VJ, Rothbard RL, Fitzpatrick PG, Francis CW. Rapid lysis of coronary artery thrombi with anisoylated plasminogen: streptokinase activator complex. Treatment by bolus intravenous injection. Ann Intern Med. 1986 Mar; 104(3):304-10.
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Peerschke EI, Francis CW, Marder VJ. Fibrinogen binding to human blood platelets: effect of gamma chain carboxyterminal structure and length. Blood. 1986 Feb; 67(2):385-90.
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Francis CW, Marder VJ. Concepts of clot lysis. Annu Rev Med. 1986; 37:187-204.
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Francis CW, Malone JE, Marder VJ. Comparison of a chromogenic prothrombin time with clotting prothrombin time in the assessment of clinical coagulation deficiencies. Am J Clin Pathol. 1985 Dec; 84(6):724-9.
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Rowe JM, Francis CW, Cyran EM, Marder VJ. Thrombotic thrombocytopenic purpura: recovery after splenectomy associated with persistence of abnormally large von Willebrand factor multimers. Am J Hematol. 1985 Oct; 20(2):161-8.
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Rothbard RL, Fitzpatrick PG, Francis CW, Caton DM, Hood WB, Marder VJ. Relationship of the lytic state to successful reperfusion with standard- and low-dose intracoronary streptokinase. Circulation. 1985 Mar; 71(3):562-70.
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Connaghan DG, Francis CW, Lane DA, Marder VJ. Specific identification of fibrin polymers, fibrinogen degradation products, and crosslinked fibrin degradation products in plasma and serum with a new sensitive technique. Blood. 1985 Mar; 65(3):589-97.
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Marder VJ, Francis CW. Thrombolytic therapy for acute transmural myocardial infarction. Intracoronary versus intravenous. Am J Med. 1984 Nov; 77(5):921-8.
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Hanna LS, Scheraga HA, Francis CW, Marder VJ. Comparison of structures of various human fibrinogens and a derivative thereof by a study of the kinetics of release of fibrinopeptides. Biochemistry. 1984 Sep 25; 23(20):4681-7.
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Francis CW, Markham RE, Marder VJ. Demonstration of in situ fibrin degradation in pathologic thrombi. Blood. 1984 May; 63(5):1216-24.
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Francis CW, Keele EM, Marder VJ. Purification of three gamma-chains with different molecular weights from normal human plasma fibrinogen. Biochim Biophys Acta. 1984 Mar 1; 797(3):328-35.
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Francis CW, Nachman RL, Marder VJ. Plasma and platelet fibrinogen differ in gamma chain content. Thromb Haemost. 1984 Feb 28; 51(1):84-8.
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Marder VJ, Francis CW. An assessment of regional versus systemic thrombolytic treatment of peripheral and coronary artery thrombosis. Prog Hemost Thromb. 1984; 7:325-56.
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Francis CW, Markham RE, Barlow GH, Florack TM, Dobrzynski DM, Marder VJ. Thrombin activity of fibrin thrombi and soluble plasmic derivatives. J Lab Clin Med. 1983 Aug; 102(2):220-30.
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Martin SE, Francis CW, Marder VJ. Potentiation of wheat germ agglutinin aggregation of platelets by von Willebrand protein and by a 116,000 molecular weight tryptic fragment. Thromb Res. 1983 Aug 1; 31(3):437-49.
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Marder VJ, Francis CW. Plasmin degradation of cross-linked fibrin. Ann N Y Acad Sci. 1983 Jun 27; 408:397-406.
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Francis CW, Marder VJ. Heterogeneity of normal human fibrinogen due to two high molecular weight variant gamma chains. Ann N Y Acad Sci. 1983 Jun 27; 408:118-20.
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Francis CW, Kraus DH, Marder VJ. Structural and chromatographic heterogeneity of normal plasma fibrinogen associated with the presence of three gamma-chain types with distinct molecular weights. Biochim Biophys Acta. 1983 Apr 28; 744(2):155-64.
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Francis CW, Marder VJ, Evarts CM, Yaukoolbodi S. Two-step warfarin therapy. Prevention of postoperative venous thrombosis without excessive bleeding. JAMA. 1983 Jan 21; 249(3):374-8.
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Barlow GH, Brennan JK, Abboud CN, Francis CW, Lichtman AH, Lichtman MA. Secretion of plasminogen activator by the human macrophage-like cell line, GCT: separation from colony-stimulating and erythropoiesis-enhancing activities. Br J Haematol. 1982 Dec; 52(4):645-55.
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Francis CW, Marder VJ. A molecular model of plasmic degradation of crosslinked fibrin. Semin Thromb Hemost. 1982 Jan; 8(1):25-35.
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Barlow GH, Francis CW, Marder VJ. On the conversion of high molecular weight urokinase to the low molecular weight form by plasmin. Thromb Res. 1981 Sep 15; 23(6):541-7.
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Martin SE, Marder VJ, Francis CW, Barlow GH. Structural studies of the functional heterogeneity of von Willebrand protein polymers. Blood. 1981 Feb; 57(2):313-23.
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Francis CW, Marder VJ, Barlow GH. Plasmic degradation of crosslinked fibrin. Characterization of new macromolecular soluble complexes and a model of their structure. J Clin Invest. 1980 Nov; 66(5):1033-43.
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Francis CW, Marder VJ, Martin SE. Plasmic degradation of crosslinked fibrin. I. Structural analysis of the particulate clot and identification of new macromolecular-soluble complexes. Blood. 1980 Sep; 56(3):456-64.
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Francis CW, Marder VJ, Martin SE. Demonstration of a large molecular weight variant of the gamma chain of normal human plasma fibrinogen. J Biol Chem. 1980 Jun 25; 255(12):5599-604.
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Martin SE, Marder VJ, Francis CW, Loftus LS, Barlow GH. Enzymatic degradation of the factor-VIII-von-Willebrand protein: a unique tryptic fragment with ristocetin cofactor activity. Blood. 1980 May; 55(5):848-58.
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Francis CW, Marder VJ, Martin SE. Detection of circulating crosslinked fibrin derivatives by a heat extraction-SDS gradient gel electrophoretic technique. Blood. 1979 Dec; 54(6):1282-95.
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