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Deborah Cory-Slechta

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentEnvironmental Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester NY 14642
 
 Awards And Honors
1969     Alpha Lambda Delta, honorary sorority
1979 - 1982National Research Service Award Postdoctoral Fellowship
1982 - 1985National Institute of Environmental Health Sciences New Investigator Award
2001     Honoree, Fourth Annual Women in Science Symposium, Joint Programs of University of Medicine and Dentistry of New Jersey and Rutgers University, sponsored by The Environmental and Occupational Health Sciences Institute, Douglass College Project for Rutgers Women in Math, Science and Engineering, Joint Graduate Program in Toxicology, and the Joint Postdoctoral Program in Exposure Assessment, Piscataway, NJ
 
 Overview
Dr. Deborah Cory-Slechta became a faculty member at the University of Rochester Medical School (URMC) in 1982. She went on to become Chair of its Department of Environmental Medicine and Director of the NIEHS Environmental Health Sciences Center in 1998. She served as Dean for Research at the University of Rochester Medical School from 2000-2002. She then moved to NJ to become Director of the Environmental and Occupational Health Sciences Institute (EOHSI) and Chair of the Department of Environmental and Community Medicine at the UMDNJ-Robert Wood Johnson Medical School from 2003-2007, before returning to URMC as Professor in Environmental Medicine and Pediatrics. Dr. Cory-Slechta has served on numerous national review and advisory panels of the National Institutes of Health, the National Institute of Environmental Health Sciences, the Food and Drug Administration, the National Center for Toxicological Research, the Environmental Protection Agency, the National Academy of Sciences, the Institute of Medicine, and the Agency for Toxic Substances and Disease Registry, Centers for Disease Control. In addition, Dr. Cory-Slechta has served on the editorial boards of the journals Neurotoxicology, Toxicology, Toxicological Sciences, Fundamental and Applied Toxicology, Neurotoxicology and Teratology, and American Journal of Mental Retardation. She has held the elected positions of President of the Neurotoxicology Specialty Section of the Society of Toxicology, President of the Behavioral Toxicology Society, and been named a Fellow of the American Psychological Association. Her research has focused largely on the relationships between brain neurotransmitter systems and children's neurodevelopment, and how such relationships are altered by exposures to environmental toxicants, including the role played by environmental neurotoxicant exposures in developmental disabilities and neurodegenerative diseases. These research efforts have resulted in over 150 papers and book chapters to date.
Dr. Cory-Slechta is the co-director of the Behavioral Sciences Facility Core and director of the Animal Behavior Core which provides consultation and assistance to any investigators seeking to develop or implement a behavioral project aiming advance translational neurobehavioral research and enhance our understanding of human disease. The Behavioral Sciences Facility Core's mission is to advance the field of behavioral science by providing high quality services to scientists performing behavioral studies. Our ability to perform both animal and human behavioral testing allows us to work bi-directionally, applying lessons learned from animal work to human studies and vice versa. For this reason, our facility works on the cutting edge of translational behavioral research.
Dr. Cory-Slechta also directs the K12 WHEEL program at URMC. The Women's Health and the Environment Over the Entire Lifespan program provides career development for promising scientists interested in pursuing a research career in women's environmental health. Environmental exposures can affect males and females differently, often by acting on hormonal systems. These exposures appear to have greatest impact during critical periods across the lifespan (including prenatal, perinatal, childhood, mid-life and late-life).

 
 Selected Publications
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  1. Weston HI, Sobolewski ME, Allen JL, Weston D, Conrad K, Pelkowski S, Watson GE, Zareba G, Cory-Slechta DA. Sex-dependent and non-monotonic enhancement and unmasking of methylmercury neurotoxicity by prenatal stress. Neurotoxicology. 2014 Mar; 41:123-40.
    View in: PubMed
  2. Allen JL, Liu X, Weston D, Conrad K, Oberdörster G, Cory-Slechta DA. Consequences of developmental exposure to concentrated ambient ultrafine particle air pollution combined with the adult paraquat and maneb model of the Parkinson's disease phenotype in male mice. Neurotoxicology. 2014 Mar; 41:80-8.
    View in: PubMed
  3. Kobrosly RW, van Wijngaarden E, Seplaki CL, Cory-Slechta DA, Moynihan J. Depressive symptoms are associated with allostatic load among community-dwelling older adults. Physiol Behav. 2014 Jan 17; 123:223-30.
    View in: PubMed
  4. Nkhoma OW, Duffy ME, Cory-Slechta DA, Davidson PW, McSorley EM, Strain JJ, O'Brien GM. Early-Stage Primary School Children Attending a School in the Malawian School Feeding Program (SFP) Have Better Reversal Learning and Lean Muscle Mass Growth Than Those Attending a Non-SFP School. J Nutr. 2013 Aug; 143(8):1324-30.
    View in: PubMed
  5. Lyngdoh T, Viswanathan B, Kobrosly R, van Wijngaarden E, Huber B, Davidson PW, Cory-Slechta DA, Strain S, Myers GJ, Bovet P. Blood pressure and cognitive function: a prospective analysis among adolescents in Seychelles. J Hypertens. 2013 Jun; 31(6):1175-82.
    View in: PubMed
  6. Bellinger DC, Burger J, Cade TJ, Cory-Slechta DA, Finkelstein M, Hu H, Kosnett M, Landrigan PJ, Lanphear B, Pokras MA, Redig PT, Rideout BA, Silbergeld E, Wright R, Smith DR. Health risks from lead-based ammunition in the environment. Environ Health Perspect. 2013 Jun 1; 121(6):a178-9.
    View in: PubMed
  7. Cory-Slechta DA, Weston D, Liu S, Allen JL. Brain hemispheric differences in the neurochemical effects of lead, prenatal stress, and the combination and their amelioration by behavioral experience. Toxicol Sci. 2013 Apr; 132(2):419-30.
    View in: PubMed
  8. Nkhoma OW, Duffy ME, Davidson PW, Cory-Slechta DA, McSorley EM, Strain JJ, O'Brien GM. Nutritional and cognitive status of entry-level primary school children in Zomba, rural Malawi. Int J Food Sci Nutr. 2013 May; 64(3):282-91.
    View in: PubMed
  9. Beier EE, Maher JR, Sheu TJ, Cory-Slechta DA, Berger AJ, Zuscik MJ, Puzas JE. Heavy metal lead exposure, osteoporotic-like phenotype in an animal model, and depression of Wnt signaling. Environ Health Perspect. 2013 Jan; 121(1):97-104.
    View in: PubMed
  10. Allen JL, Conrad K, Oberdörster G, Johnston CJ, Sleezer B, Cory-Slechta DA. Developmental exposure to concentrated ambient particles and preference for immediate reward in mice. Environ Health Perspect. 2013 Jan; 121(1):32-8.
    View in: PubMed
  11. Strain JJ, Davidson PW, Thurston SW, Harrington D, Mulhern MS, McAfee AJ, van Wijngaarden E, Shamlaye CF, Henderson J, Watson GE, Zareba G, Cory-Slechta DA, Lynch M, Wallace JM, McSorley EM, Bonham MP, Stokes-Riner A, Sloane-Reeves J, Janciuras J, Wong R, Clarkson TW, Myers GJ. Maternal PUFA Status but Not Prenatal Methylmercury Exposure Is Associated with Children's Language Functions at Age Five Years in the Seychelles. J Nutr. 2012 Nov; 142(11):1943-9.
    View in: PubMed
  12. Kobrosly RW, Seplaki CL, Cory-Slechta DA, Moynihan J, van Wijngaarden E. Multisystem physiological dysfunction is associated with depressive symptoms in a population-based sample of older adults. Int J Geriatr Psychiatry. 2013 Jul; 28(7):718-27.
    View in: PubMed
  13. Block ML, Elder A, Auten RL, Bilbo SD, Chen H, Chen JC, Cory-Slechta DA, Costa D, Diaz-Sanchez D, Dorman DC, Gold DR, Gray K, Jeng HA, Kaufman JD, Kleinman MT, Kirshner A, Lawler C, Miller DS, Nadadur SS, Ritz B, Semmens EO, Tonelli LH, Veronesi B, Wright RO, Wright RJ. The outdoor air pollution and brain health workshop. Neurotoxicology. 2012 Oct; 33(5):972-84.
    View in: PubMed
  14. Cory-Slechta DA, Merchant-Borna K, Allen JL, Liu S, Weston D, Conrad K. Variations in the nature of behavioral experience can differentially alter the consequences of developmental exposures to lead, prenatal stress, and the combination. Toxicol Sci. 2012 Jan; 131(1):194-205.
    View in: PubMed
  15. Cory-Slechta DA, Virgolini MB, Liu S, Weston D. Enhanced stimulus sequence-dependent repeated learning in male offspring after prenatal stress alone or in conjunction with lead exposure. Neurotoxicology. 2012 Oct; 33(5):1188-202.
    View in: PubMed
  16. Fortin MC, Cory-Slechta DA, Ohman-Strickland P, Nwankwo C, Yanger TS, Todd AC, Moynihan J, Walton J, Brooks A, Fiedler N. Increased lead biomarker levels are associated with changes in hormonal response to stress in occupationally exposed male participants. Environ Health Perspect. 2012 Feb; 120(2):278-83.
    View in: PubMed
  17. Lee DW, Notter SA, Thiruchelvam M, Dever DP, Fitzpatrick R, Kostyniak PJ, Cory-Slechta DA, Opanashuk LA. Subchronic polychlorinated biphenyl (Aroclor 1254) exposure produces oxidative damage and neuronal death of ventral midbrain dopaminergic systems. Toxicol Sci. 2012 Feb; 125(2):496-508.
    View in: PubMed
  18. Davidson PW, Cory-Slechta DA, Thurston SW, Huang LS, Shamlaye CF, Gunzler D, Watson G, van Wijngaarden E, Zareba G, Klein JD, Clarkson TW, Strain JJ, Myers GJ. Fish consumption and prenatal methylmercury exposure: cognitive and behavioral outcomes in the main cohort at 17 years from the Seychelles child development study. Neurotoxicology. 2011 Dec; 32(6):711-7.
    View in: PubMed
  19. Kobrosly RW, van Wijngaarden E, Galea S, Cory-Slechta DA, Love T, Hong C, Shamlaye CF, Davidson PW. Socioeconomic position and cognitive function in the Seychelles: a life course analysis. Neuroepidemiology. 2011; 36(3):162-8.
    View in: PubMed
  20. van Wijngaarden E, Winters PC, Cory-Slechta DA. Blood lead levels in relation to cognitive function in older U.S. adults. Neurotoxicology. 2011 Jan; 32(1):110-5.
    View in: PubMed
  21. Rossi-George A, Virgolini MB, Weston D, Thiruchelvam M, Cory-Slechta DA. Interactions of lifetime lead exposure and stress: behavioral, neurochemical and HPA axis effects. Neurotoxicology. 2011 Jan; 32(1):83-99.
    View in: PubMed
  22. Cory-Slechta DA, Stern S, Weston D, Allen JL, Liu S. Enhanced learning deficits in female rats following lifetime pb exposure combined with prenatal stress. Toxicol Sci. 2010 Oct; 117(2):427-38.
    View in: PubMed
  23. Cory-Slechta DA, Virgolini MB, Rossi-George A, Weston D, Thiruchelvam M. Experimental manipulations blunt time-induced changes in brain monoamine levels and completely reverse stress, but not Pb+/-stress-related modifications to these trajectories. Behav Brain Res. 2009 Dec 14; 205(1):76-87.
    View in: PubMed
  24. van Wijngaarden E, Campbell JR, Cory-Slechta DA. Bone lead levels are associated with measures of memory impairment in older adults. Neurotoxicology. 2009 Jul; 30(4):572-80.
    View in: PubMed
  25. Rossi-George A, Virgolini MB, Weston D, Cory-Slechta DA. Alterations in glucocorticoid negative feedback following maternal Pb, prenatal stress and the combination: a potential biological unifying mechanism for their corresponding disease profiles. Toxicol Appl Pharmacol. 2009 Jan 1; 234(1):117-27.
    View in: PubMed
  26. Virgolini MB, Rossi-George A, Weston D, Cory-Slechta DA. Influence of low level maternal Pb exposure and prenatal stress on offspring stress challenge responsivity. Neurotoxicology. 2008 Nov; 29(6):928-39.
    View in: PubMed
  27. Bronstein J, Carvey P, Chen H, Cory-Slechta D, DiMonte D, Duda J, English P, Goldman S, Grate S, Hansen J, Hoppin J, Jewell S, Kamel F, Koroshetz W, Langston JW, Logroscino G, Nelson L, Ravina B, Rocca W, Ross GW, Schettler T, Schwarzschild M, Scott B, Seegal R, Singleton A, Steenland K, Tanner CM, Van Den Eeden S, Weisskopf M. Meeting report: consensus statement-Parkinson's disease and the environment: collaborative on health and the environment and Parkinson's Action Network (CHE PAN) conference 26-28 June 2007. Environ Health Perspect. 2009 Jan; 117(1):117-21.
    View in: PubMed
  28. Cory-Slechta DA, Weiss B, Cranmer J. The environmental etiologies of neurobehavioral deficits and disorders: weaving complex outcomes and risk modifiers into the equation. Neurotoxicology. 2008 Sep; 29(5):759-60.
    View in: PubMed
  29. Weiss B, Cory-Slechta D, Gilbert SG, Mergler D, Miller E, Miller C, Newland MC, Rice D, Schettler T. The new tapestry of risk assessment. Neurotoxicology. 2008 Sep; 29(5):883-90.
    View in: PubMed
  30. Virgolini MB, Rossi-George A, Lisek R, Weston DD, Thiruchelvam M, Cory-Slechta DA. CNS effects of developmental Pb exposure are enhanced by combined maternal and offspring stress. Neurotoxicology. 2008 Sep; 29(5):812-27.
    View in: PubMed
  31. Lanphear BP, Hornung RW, Khoury J, Dietrich KN, Cory-Slechta DA, Canfield RL. The conundrum of unmeasured confounding: Comment on: "Can some of the detrimental neurodevelopmental effects attributed to lead be due to pesticides? by Brian Gulson". Sci Total Environ. 2008 Jun 25; 396(2-3):196-200.
    View in: PubMed
  32. Cory-Slechta DA, Virgolini MB, Rossi-George A, Thiruchelvam M, Lisek R, Weston D. Lifetime consequences of combined maternal lead and stress. Basic Clin Pharmacol Toxicol. 2008 Feb; 102(2):218-27.
    View in: PubMed
  33. Jusko TA, Henderson CR, Lanphear BP, Cory-Slechta DA, Parsons PJ, Canfield RL. Blood lead concentrations < 10 microg/dL and child intelligence at 6 years of age. Environ Health Perspect. 2008 Feb; 116(2):243-8.
    View in: PubMed
  34. Cory-Slechta DA, Thiruchelvam M, Di Monte DA. Letter regarding: "Paraquat: the red herring of Parkinson's disease research". Toxicol Sci. 2008 May; 103(1):215-6; author reply 217-8.
    View in: PubMed
  35. White LD, Cory-Slechta DA, Gilbert ME, Tiffany-Castiglioni E, Zawia NH, Virgolini M, Rossi-George A, Lasley SM, Qian YC, Basha MR. New and evolving concepts in the neurotoxicology of lead. Toxicol Appl Pharmacol. 2007 Nov 15; 225(1):1-27.
    View in: PubMed
  36. Barlow BK, Cory-Slechta DA, Richfield EK, Thiruchelvam M. The gestational environment and Parkinson's disease: evidence for neurodevelopmental origins of a neurodegenerative disorder. Reprod Toxicol. 2007 Apr-May; 23(3):457-70.
    View in: PubMed
  37. Gray JP, Heck DE, Mishin V, Smith PJ, Hong JY, Thiruchelvam M, Cory-Slechta DA, Laskin DL, Laskin JD. Paraquat increases cyanide-insensitive respiration in murine lung epithelial cells by activating an NAD(P)H:paraquat oxidoreductase: identification of the enzyme as thioredoxin reductase. J Biol Chem. 2007 Mar 16; 282(11):7939-49.
    View in: PubMed
  38. Froehlich TE, Lanphear BP, Dietrich KN, Cory-Slechta DA, Wang N, Kahn RS. Interactive effects of a DRD4 polymorphism, lead, and sex on executive functions in children. Biol Psychiatry. 2007 Aug 1; 62(3):243-9.
    View in: PubMed
  39. Vahter M, Gochfeld M, Casati B, Thiruchelvam M, Falk-Filippson A, Kavlock R, Marafante E, Cory-Slechta D. Implications of gender differences for human health risk assessment and toxicology. Environ Res. 2007 May; 104(1):70-84.
    View in: PubMed
  40. Davidson PW, Weiss B, Beck C, Cory-Slechta DA, Orlando M, Loiselle D, Young EC, Sloane-Reeves J, Myers GJ. Development and validation of a test battery to assess subtle neurodevelopmental differences in children. Neurotoxicology. 2006 Dec; 27(6):951-69.
    View in: PubMed
  41. Virgolini MB, Bauter MR, Weston DD, Cory-Slechta DA. Permanent alterations in stress responsivity in female offspring subjected to combined maternal lead exposure and/or stress. Neurotoxicology. 2006 Jan; 27(1):11-21.
    View in: PubMed
  42. Cory-Slechta DA, Thiruchelvam M, Barlow BK, Richfield EK. Developmental pesticide models of the Parkinson disease phenotype. Environ Health Perspect. 2005 Sep; 113(9):1263-70.
    View in: PubMed
  43. Cory-Slechta DA. Studying toxicants as single chemicals: does this strategy adequately identify neurotoxic risk? Neurotoxicology. 2005 Aug; 26(4):491-510.
    View in: PubMed
  44. Virgolini MB, Chen K, Weston DD, Bauter MR, Cory-Slechta DA. Interactions of chronic lead exposure and intermittent stress: consequences for brain catecholamine systems and associated behaviors and HPA axis function. Toxicol Sci. 2005 Oct; 87(2):469-82.
    View in: PubMed
  45. Rodriguez VM, Thiruchelvam M, Cory-Slechta DA. Sustained exposure to the widely used herbicide atrazine: altered function and loss of neurons in brain monoamine systems. Environ Health Perspect. 2005 Jun; 113(6):708-15.
    View in: PubMed
  46. Mhyre TR, Chesler EJ, Thiruchelvam M, Lungu C, Cory-Slechta DA, Fry JD, Richfield EK. Heritability, correlations and in silico mapping of locomotor behavior and neurochemistry in inbred strains of mice. Genes Brain Behav. 2005 Jun; 4(4):209-28.
    View in: PubMed
  47. Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect. 2005 Jun; 113(6):749-55.
    View in: PubMed
  48. Thiruchelvam M, Prokopenko O, Cory-Slechta DA, Richfield EK, Buckley B, Mirochnitchenko O. Overexpression of superoxide dismutase or glutathione peroxidase protects against the paraquat + maneb-induced Parkinson disease phenotype. J Biol Chem. 2005 Jun 10; 280(23):22530-9.
    View in: PubMed
  49. Cory-Slechta DA, Thiruchelvam M, Richfield EK, Barlow BK, Brooks AI. Developmental pesticide exposures and the Parkinson's disease phenotype. Birth Defects Res A Clin Mol Teratol. 2005 Mar; 73(3):136-9.
    View in: PubMed
  50. Barlow BK, Lee DW, Cory-Slechta DA, Opanashuk LA. Modulation of antioxidant defense systems by the environmental pesticide maneb in dopaminergic cells. Neurotoxicology. 2005 Jan; 26(1):63-75.
    View in: PubMed
  51. Reeves R, Thiruchelvam M, Richfield EK, Cory-Slechta DA. The effect of developmental exposure to the fungicide triadimefon on behavioral sensitization to triadimefon during adulthood. Toxicol Appl Pharmacol. 2004 Oct 1; 200(1):54-63.
    View in: PubMed
  52. Reeves R, Thiruchelvam M, Cory-Slechta DA. Expression of behavioral sensitization to the cocaine-like fungicide triadimefon is blocked by pretreatment with AMPA, NMDA and DA D1 receptor antagonists. Brain Res. 2004 May 22; 1008(2):155-67.
    View in: PubMed
  53. Cory-Slechta DA, Virgolini MB, Thiruchelvam M, Weston DD, Bauter MR. Maternal stress modulates the effects of developmental lead exposure. Environ Health Perspect. 2004 May; 112(6):717-30.
    View in: PubMed
  54. Reeves R, Thiruchelvam M, Cory-Slechta DA. Development of behavioral sensitization to the cocaine-like fungicide triadimefon is prevented by AMPA, NMDa, DA D1 but not DA D2 receptor antagonists. Toxicol Sci. 2004 May; 79(1):123-36.
    View in: PubMed
  55. Thiruchelvam MJ, Powers JM, Cory-Slechta DA, Richfield EK. Risk factors for dopaminergic neuron loss in human alpha-synuclein transgenic mice. Eur J Neurosci. 2004 Feb; 19(4):845-54.
    View in: PubMed
  56. Barlow BK, Richfield EK, Cory-Slechta DA, Thiruchelvam M. A fetal risk factor for Parkinson's disease. Dev Neurosci. 2004 Jan-Feb; 26(1):11-23.
    View in: PubMed
  57. Canfield RL, Gendle MH, Cory-Slechta DA. Impaired neuropsychological functioning in lead-exposed children. Dev Neuropsychol. 2004; 26(1):513-40.
    View in: PubMed
  58. Reeves R, Thiruchelvam M, Baggs RB, Cory-Slechta DA. Interactions of paraquat and triadimefon: behavioral and neurochemical effects. Neurotoxicology. 2003 Dec; 24(6):839-50.
    View in: PubMed
  59. Reeves R, Thiruchelvam M, Richfield EK, Cory-Slechta DA. Behavioral sensitization and long-term neurochemical alterations associated with the fungicide triadimefon. Pharmacol Biochem Behav. 2003 Sep; 76(2):315-26.
    View in: PubMed
  60. Thiruchelvam M, McCormack A, Richfield EK, Baggs RB, Tank AW, Di Monte DA, Cory-Slechta DA. Age-related irreversible progressive nigrostriatal dopaminergic neurotoxicity in the paraquat and maneb model of the Parkinson's disease phenotype. Eur J Neurosci. 2003 Aug; 18(3):589-600.
    View in: PubMed
  61. Barlow BK, Thiruchelvam MJ, Bennice L, Cory-Slechta DA, Ballatori N, Richfield EK. Increased synaptosomal dopamine content and brain concentration of paraquat produced by selective dithiocarbamates. J Neurochem. 2003 May; 85(4):1075-86.
    View in: PubMed
  62. Canfield RL, Henderson CR, Cory-Slechta DA, Cox C, Jusko TA, Lanphear BP. Intellectual impairment in children with blood lead concentrations below 10 microg per deciliter. N Engl J Med. 2003 Apr 17; 348(16):1517-26.
    View in: PubMed
  63. Cory-Slechta DA. Lead-induced impairments in complex cognitive function: offerings from experimental studies. Child Neuropsychol. 2003 Mar; 9(1):54-75.
    View in: PubMed
  64. Bauter MR, Brockel BJ, Pankevich DE, Virgolini MB, Cory-Slechta DA. Glutamate and dopamine in nucleus accumbens core and shell: sequence learning versus performance. Neurotoxicology. 2003 Mar; 24(2):227-43.
    View in: PubMed
  65. Thiruchelvam M, Richfield EK, Goodman BM, Baggs RB, Cory-Slechta DA. Developmental exposure to the pesticides paraquat and maneb and the Parkinson's disease phenotype. Neurotoxicology. 2002 Oct; 23(4-5):621-33.
    View in: PubMed
  66. Cory-Slechta DA, Brockel BJ, O'Mara DJ. Lead exposure and dorsomedial striatum mediation of fixed interval schedule-controlled behavior. Neurotoxicology. 2002 Sep; 23(3):313-27.
    View in: PubMed
  67. McCormack AL, Thiruchelvam M, Manning-Bog AB, Thiffault C, Langston JW, Cory-Slechta DA, Di Monte DA. Environmental risk factors and Parkinson's disease: selective degeneration of nigral dopaminergic neurons caused by the herbicide paraquat. Neurobiol Dis. 2002 Jul; 10(2):119-27.
    View in: PubMed
  68. Richfield EK, Thiruchelvam MJ, Cory-Slechta DA, Wuertzer C, Gainetdinov RR, Caron MG, Di Monte DA, Federoff HJ. Behavioral and neurochemical effects of wild-type and mutated human alpha-synuclein in transgenic mice. Exp Neurol. 2002 May; 175(1):35-48.
    View in: PubMed
  69. Brooks AI, Stein CS, Hughes SM, Heth J, McCray PM, Sauter SL, Johnston JC, Cory-Slechta DA, Federoff HJ, Davidson BL. Functional correction of established central nervous system deficits in an animal model of lysosomal storage disease with feline immunodeficiency virus-based vectors. Proc Natl Acad Sci U S A. 2002 Apr 30; 99(9):6216-21.
    View in: PubMed
  70. Zuch CL, Cory-Slechta DA. Stimulus properties of 7-OH-DPAT versus auto- and postsynaptic receptor-specific doses of quinpirole. Pharmacol Biochem Behav. 2001 Mar; 68(3):469-79.
    View in: PubMed
  71. Cory-Slechta DA, Crofton KM, Foran JA, Ross JF, Sheets LP, Weiss B, Mileson B. Methods to identify and characterize developmental neurotoxicity for human health risk assessment. I: behavioral effects. Environ Health Perspect. 2001 Mar; 109 Suppl 1:79-91.
    View in: PubMed
  72. Thiruchelvam M, Richfield EK, Baggs RB, Tank AW, Cory-Slechta DA. The nigrostriatal dopaminergic system as a preferential target of repeated exposures to combined paraquat and maneb: implications for Parkinson's disease. J Neurosci. 2000 Dec 15; 20(24):9207-14.
    View in: PubMed
  73. Davidson PW, Weiss B, Myers GJ, Cory-Slechta DA, Brockel BJ, Young EC, Orlando M, Loiselle D, Palumbo D, Pittelli R, Sloan-Reeves J. Evaluation of techniques for assessing neurobehavioral development in children. Neurotoxicology. 2000 Dec; 21(6):957-72.
    View in: PubMed
  74. Slikker W, Beck BD, Cory-Slechta DA, Paule MG, Anger WK, Bellinger D. Cognitive tests: interpretation for neurotoxicity? (Workshop summary). Toxicol Sci. 2000 Dec; 58(2):222-34.
    View in: PubMed
  75. Brooks AI, Cory-Slechta DA, Federoff HJ. Gene-experience interaction alters the cholinergic septohippocampal pathway of mice. Proc Natl Acad Sci U S A. 2000 Nov 21; 97(24):13378-83.
    View in: PubMed
  76. Brooks AI, Cory-Slechta DA, Bowers WJ, Murg SL, Federoff HJ. Enhanced learning in mice parallels vector-mediated nerve growth factor expression in hippocampus. Hum Gene Ther. 2000 Nov 20; 11(17):2341-52.
    View in: PubMed
  77. Brooks AI, Cory-Slechta DA, Murg SL, Federoff HJ. Repeated acquisition and performance chamber for mice: a paradigm for assessment of spatial learning and memory. Neurobiol Learn Mem. 2000 Nov; 74(3):241-58.
    View in: PubMed
  78. Thiruchelvam M, Brockel BJ, Richfield EK, Baggs RB, Cory-Slechta DA. Potentiated and preferential effects of combined paraquat and maneb on nigrostriatal dopamine systems: environmental risk factors for Parkinson's disease? Brain Res. 2000 Aug 11; 873(2):225-34.
    View in: PubMed
  79. Evans SB, Cory-Slechta DA. Prefrontal cortical manipulations alter the effects of intra-ventral striatal dopamine antagonists on fixed-interval performance in the rat. Behav Brain Res. 2000 Jan; 107(1-2):45-58.
    View in: PubMed
  80. Brockel BJ, Cory-Slechta DA. The effects of postweaning low-level Pb exposure on sustained attention: a study of target densities, stimulus presentation rate, and stimulus predictability. Neurotoxicology. 1999 Dec; 20(6):921-33.
    View in: PubMed
  81. Cory-Slechta DA, O'Mara DJ, Brockel BJ. Learning versus performance impairments following regional administration of MK-801 into nucleus accumbens and dorsomedial striatum. Behav Brain Res. 1999 Jul; 102(1-2):181-94.
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  82. Brockel BJ, Cory-Slechta DA. Lead-induced decrements in waiting behavior: involvement of D2-like dopamine receptors. Pharmacol Biochem Behav. 1999 Jul; 63(3):423-34.
    View in: PubMed
  83. Brooks AI, Chadwick CA, Gelbard HA, Cory-Slechta DA, Federoff HJ. Paraquat elicited neurobehavioral syndrome caused by dopaminergic neuron loss. Brain Res. 1999 Mar 27; 823(1-2):1-10.
    View in: PubMed
  84. Cory-Slechta DA, O'Mara DJ, Brockel BJ. Nucleus accumbens dopaminergic medication of fixed interval schedule-controlled behavior and its modulation by low-level lead exposure. J Pharmacol Exp Ther. 1998 Aug; 286(2):794-805.
    View in: PubMed
  85. Brockel BJ, Cory-Slechta DA. Lead, attention, and impulsive behavior: changes in a fixed-ratio waiting-for-reward paradigm. Pharmacol Biochem Behav. 1998 Jun; 60(2):545-52.
    View in: PubMed
  86. Maines MD, Polevoda B, Coban T, Johnson K, Stoliar S, Huang TJ, Panahian N, Cory-Slechta DA, McCoubrey WK. Neuronal overexpression of heme oxygenase-1 correlates with an attenuated exploratory behavior and causes an increase in neuronal NADPH diaphorase staining. J Neurochem. 1998 May; 70(5):2057-69.
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  87. Zuch CL, O'Mara DJ, Cory-Slechta DA. Low-level lead exposure selectively enhances dopamine overflow in nucleus accumbens: an in vivo electrochemistry time course assessment. Toxicol Appl Pharmacol. 1998 May; 150(1):174-85.
    View in: PubMed
  88. McCoy L, Richfield EK, Cory-Slechta DA. Regional decreases in alpha-[3H]amino-3-hydroxy-5-methylisoxazole-4-propionic acid ([3H]AMPA) and 6-[3H]cyano-7-nitroquinoxaline-2,3-dione ([3H]CNQX) binding in response to chronic low-level lead exposure: reversal versus potentiation by chronic dopamine agonist treatment. J Neurochem. 1997 Dec; 69(6):2466-76.
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  89. Cory-Slechta DA, Flaugher CL, Evans SB, Pokora MJ, Greenamyre JT. Susceptibility of adult rats to lead-induced changes in NMDA receptor complex function. Neurotoxicol Teratol. 1997 Nov-Dec; 19(6):517-30.
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  90. Cory-Slechta DA, Pazmino R, Bare C. The critical role of nucleus accumbens dopamine systems in the mediation of fixed interval schedule-controlled operant behavior. Brain Res. 1997 Aug 1; 764(1-2):253-6.
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  91. Cory-Slechta DA, Garcia-Osuna M, Greenamyre JT. Lead-induced changes in NMDA receptor complex binding: correlations with learning accuracy and with sensitivity to learning impairments caused by MK-801 and NMDA administration. Behav Brain Res. 1997 May; 85(2):161-74.
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  92. Cory-Slechta DA, McCoy L, Richfield EK. Time course and regional basis of Pb-induced changes in MK-801 binding: reversal by chronic treatment with the dopamine agonist apomorphine but not the D1 agonist SKF-82958. J Neurochem. 1997 May; 68(5):2012-23.
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  93. Cory-Slechta DA. Relationships between Pb-induced changes in neurotransmitter system function and behavioral toxicity. Neurotoxicology. 1997; 18(3):673-88.
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  94. Cory-Slechta DA. Postnatal lead exposure and MK-801 sensitivity. Neurotoxicology. 1997; 18(1):209-20.
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  95. Brooks AI, Muhkerjee B, Panahian N, Cory-Slechta D, Federoff HJ. Nerve growth factor somatic mosaicism produced by herpes virus-directed expression of cre recombinase. Nat Biotechnol. 1997 Jan; 15(1):57-62.
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  96. Cory-Slechta DA, Zuch CL, Fox RA. Comparison of the stimulus properties of a pre- vs. a putative postsynaptic dose of quinpirole. Pharmacol Biochem Behav. 1996 Nov; 55(3):423-32.
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  97. Pokora MJ, Richfield EK, Cory-Slechta DA. Preferential vulnerability of nucleus accumbens dopamine binding sites to low-level lead exposure: time course of effects and interactions with chronic dopamine agonist treatments. J Neurochem. 1996 Oct; 67(4):1540-50.
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  98. Cory-Slechta DA, Pokora MJ, Preston RA. The effects of dopamine agonists on fixed interval schedule-controlled behavior are selectively altered by low-level lead exposure. Neurotoxicol Teratol. 1996 Sep-Oct; 18(5):565-75.
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  99. Hicks DG, O'Keefe RJ, Reynolds KJ, Cory-Slechta DA, Puzas JE, Judkins A, Rosier RN. Effects of lead on growth plate chondrocyte phenotype. Toxicol Appl Pharmacol. 1996 Sep; 140(1):164-72.
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  100. Kulig B, Alleva E, Bignami G, Cohn J, Cory-Slechta D, Landa V, O'Donoghue J, Peakall D. Animal behavioral methods in neurotoxicity assessment: SGOMSEC joint report. Environ Health Perspect. 1996 Apr; 104 Suppl 2:193-204.
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  101. Cory-Slechta DA. Legacy of lead exposure: consequences for the central nervous system. Otolaryngol Head Neck Surg. 1996 Feb; 114(2):224-6.
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  102. Cory-Slechta DA, Pokora MJ, Johnson JL. Postweaning lead exposure enhances the stimulus properties of N-methyl-D-aspartate: possible dopaminergic involvement? Neurotoxicology. 1996; 17(2):509-21.
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  103. Cory-Slechta DA, Pokora MJ, Fox RA, O'Mara DJ. Lead-induced changes in dopamine D1 sensitivity: modulation by drug discrimination training. Neurotoxicology. 1996; 17(2):445-57.
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  104. Cory-Slechta DA. Bridging human and experimental animal studies of lead neurotoxicity: moving beyond IQ. Neurotoxicol Teratol. 1995 May-Jun; 17(3):219-21; discussion 249-51.
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  105. Cory-Slechta DA, Pokora MJ. Lead-induced changes in muscarinic cholinergic sensitivity. Neurotoxicology. 1995; 16(2):337-47.
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  106. Cory-Slechta DA. Relationships between lead-induced learning impairments and changes in dopaminergic, cholinergic, and glutamatergic neurotransmitter system functions. Annu Rev Pharmacol Toxicol. 1995; 35:391-415.
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  107. Cory-Slechta DA. MK-801 subsensitivity following postweaning lead exposure. Neurotoxicology. 1995; 16(1):83-95.
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  108. Cohn J, Cory-Slechta DA. Lead exposure potentiates the effects of NMDA on repeated learning. Neurotoxicol Teratol. 1994 Sep-Oct; 16(5):455-65.
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  109. Chisholm J, Goldstein G, Cory-Slechta D, Weiss B, Landrigan P, Mushak P, Needleman HL, Rice D, Rosen J, Silbergeld E. Lead debate goes on. Pediatrics. 1994 Sep; 94(3):408-10.
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  110. Widzowski DV, Finkelstein JN, Pokora MJ, Cory-Slechta DA. Time course of postnatal lead-induced changes in dopamine receptors and their relationship to changes in dopamine sensitivity. Neurotoxicology. 1994; 15(4):853-65.
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  111. Cory-Slechta DA. The impact of NMDA receptor antagonists on learning and memory functions. Psychopharmacol Bull. 1994; 30(4):601-12.
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  112. Widzowski DV, Cory-Slechta DA. Homogeneity of regional brain lead concentrations. Neurotoxicology. 1994; 15(2):295-307.
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  113. Cohn J, Cory-Slechta DA. Assessment of the role of dopaminergic systems in lead-induced learning impairments using a repeated acquisition and performance baseline. Neurotoxicology. 1994; 15(4):913-26.
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  114. Widzowski DV, Cory-Slechta DA. Apparent mediation of the stimulus properties of a low dose of quinpirole by dopaminergic autoreceptors. J Pharmacol Exp Ther. 1993 Aug; 266(2):526-34.
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  115. Cory-Slechta DA, Widzowski DV, Pokora MJ. Functional alterations in dopamine systems assessed using drug discrimination procedures. Neurotoxicology. 1993 Summer-Fall; 14(2-3):105-14.
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  116. Cohn J, Cox C, Cory-Slechta DA. The effects of lead exposure on learning in a multiple repeated acquisition and performance schedule. Neurotoxicology. 1993 Summer-Fall; 14(2-3):329-46.
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  117. Pounds JG, Cory-Slechta DA. New dimensions of lead neurotoxicity: redefining mechanisms and effects. Neurotoxicology. 1993 Summer-Fall; 14(2-3):4-6.
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  118. Cohn J, Cory-Slechta DA. Subsensitivity of lead-exposed rats to the accuracy-impairing and rate-altering effects of MK-801 on a multiple schedule of repeated learning and performance. Brain Res. 1993 Jan 15; 600(2):208-18.
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  119. Cory-Slechta DA, Pokora MJ, Widzowski DV. Postnatal lead exposure induces supersensitivity to the stimulus properties of a D2-D3 agonist. Brain Res. 1992 Dec 11; 598(1-2):162-72.
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  120. Cohn J, Widzowski DV, Cory-Slechta DA. Lead retards development of Drosophila melanogaster. Comp Biochem Physiol C. 1992 May; 102(1):45-9.
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  121. Cohn J, Ziriax JM, Cox C, Cory-Slechta DA. Comparison of error patterns produced by scopolamine and MK-801 on repeated acquisition and transition baselines. Psychopharmacology (Berl). 1992; 107(2-3):243-54.
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  122. Cory-Slechta DA, Widzowski DV. Low level lead exposure increases sensitivity to the stimulus properties of dopamine D1 and D2 agonists. Brain Res. 1991 Jul 5; 553(1):65-74.
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  123. Cory-Slechta DA, Pokora MJ. Behavioral manifestations of prolonged lead exposure initiated at different stages of the life cycle: I. Schedule-controlled responding. Neurotoxicology. 1991; 12(4):745-60.
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  124. Cory-Slechta DA, Pokora MJ, Widzowski DV. Behavioral manifestations of prolonged lead exposure initiated at different stages of the life cycle: II. Delayed spatial alternation. Neurotoxicology. 1991; 12(4):761-76.
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  125. Weiss B, Cory-Slechta DA, Cox C. Modification of lead distribution by diethyldithiocarbamate. Fundam Appl Toxicol. 1990 Nov; 15(4):791-9.
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  126. Cory-Slechta DA. Lead exposure during advanced age: alterations in kinetics and biochemical effects. Toxicol Appl Pharmacol. 1990 Jun 1; 104(1):67-78.
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  127. Cory-Slechta DA. Alterations in tissue Pb distribution and hematopoietic indices during advanced age. Arch Toxicol. 1990; 64(1):31-7.
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  128. Cory-Slechta DA. Exposure duration modifies the effects of low level lead of fixed-interval performance. Neurotoxicology. 1990; 11(3):427-41.
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  129. Cory-Slechta DA, Weiss B, Cox C. Tissue distribution of Pb in adult vs. old rats: a pilot study. Toxicology. 1989 Dec 1; 59(2):139-50.
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  130. Cory-Slechta DA, Widzowski DV, Newland MC. Behavioral differentiation of the stimulus properties of a dopaminergic D1 agonist from a D2 agonist. J Pharmacol Exp Ther. 1989 Sep; 250(3):800-8.
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  131. Cory-Slechta DA, Weiss B. Efficacy of the chelating agent CaEDTA in reversing lead-induced changes in behavior. Neurotoxicology. 1989; 10(4):685-97.
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  132. Cory-Slechta DA. Behavioral measures of neurotoxicity. Neurotoxicology. 1989; 10(2):271-95.
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  133. Cory-Slechta DA. Mobilization of lead over the course of DMSA chelation therapy and long-term efficacy. J Pharmacol Exp Ther. 1988 Jul; 246(1):84-91.
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  134. Cory-Slechta DA, Weiss B, Cox C. Mobilization and redistribution of lead over the course of calcium disodium ethylenediamine tetraacetate chelation therapy. J Pharmacol Exp Ther. 1987 Dec; 243(3):804-13.
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  135. Cox C, Cory-Slechta DA. Analysis of longitudinal "time series" data in toxicology. Fundam Appl Toxicol. 1987 Feb; 8(2):159-69.
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  136. Cory-Slechta DA. Prolonged lead exposure and fixed ratio performance. Neurobehav Toxicol Teratol. 1986 May-Jun; 8(3):237-44.
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  137. Boyer IJ, Cory-Slechta DA, DiStefano V. Lead induction of crop dysfunction in pigeons through a direct action on neural or smooth muscle components of crop tissue. J Pharmacol Exp Ther. 1985 Sep; 234(3):607-15.
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  138. Cory-Slechta DA, Weiss B, Cox C. Performance and exposure indices of rats exposed to low concentrations of lead. Toxicol Appl Pharmacol. 1985 Apr; 78(2):291-9.
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  139. Cory-Slechta DA, Weiss B, Cox C. Delayed behavioral toxicity of lead with increasing exposure concentration. Toxicol Appl Pharmacol. 1983 Dec; 71(3):342-52.
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  140. Cory-Slechta DA, Weiss B. Aversiveness of cadmium in solution. Neurotoxicology. 1981 Dec; 2(4):711-24.
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  141. Cory-Slechta DA, Bissen ST, Young AM, Thompson T. Chronic postweaning lead exposure and response duration performance. Toxicol Appl Pharmacol. 1981 Aug; 60(1):78-84.
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  142. Cory-Slechta DA, Garman RH, Seidman D. Lead-induced crop dysfunction in the pigeon. Toxicol Appl Pharmacol. 1980 Mar 15; 52(3):462-7.
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  143. Cory-Slechta DA, Thompson T. Behavioral toxicity of chronic postweaning lead exposure in the rat. Toxicol Appl Pharmacol. 1979 Jan; 47(1):151-9.
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  144. Laties VG, Cory-Slechta DA. Some problems in interpreting the behavioral effects of lead and methylmercury. Neurobehav Toxicol. 1979; 1 Suppl 1:129-35.
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