Tony E. Godfrey, Ph.D., has been appointed associate professor in the Department of Surgery, with a forthcoming appointment expected as research associate professor. Godfrey's laboratory focuses on providing physicians with new, molecular analysis tools to improve the accuracy and timeliness of cancer diagnosis and staging, and to predict prognosis. He also plans to establish a large tissue bank with detailed clinical information for oncologists and URMC scientists.
With a reputation as a dedicated and valued collaborator, Godfrey will work with researchers in Surgery, the James P. Wilmot Cancer Center, and Pathology, and with co-investigators on currently funded studies at the University of Pittsburgh Medical Center, where he was formerly on faculty. Godfrey comes to Rochester from the Mt. Sinai School of Medicine, where he was an associate professor of Pathology.
One of Godfrey's primary interests is the study of the gene alterations involved in esophageal cancer. He also uses microarray technology to identify ways to detect the spread of cancer to the lymph nodes.
Godfrey earned a bachelor's of science degree, with honors, in biochemistry from Brunel University in England, followed by a doctorate in molecular biology and biochemistry, also from Brunel. He attended the University of California, San Francisco, for postdoctoral fellowships and managed UCSF's Genome Analysis Core Facility.

• Pennathur A, Xi L, Litle VR, Gooding WE, Krasinskas A, Landreneau RJ, Godfrey TE, Luketich JD. Gene expression profiles in esophageal adenocarcinoma predict survival after resection. J Thorac Cardiovasc Surg. 2013 Feb; 145(2):505-13.
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• Choy B, Bandla S, Xia Y, Tan D, Pennathur A, Luketich JD, Godfrey TE, Peters JH, Sun J, Zhou Z. Clinicopathologic characteristics of high expression of Bmi-1 in esophageal adenocarcinoma and squamous cell carcinoma. BMC Gastroenterol. 2012; 12:146.
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• Dulak AM, Schumacher SE, van Lieshout J, Imamura Y, Fox C, Shim B, Ramos AH, Saksena G, Baca SC, Baselga J, Tabernero J, Barretina J, Enzinger PC, Corso G, Roviello F, Lin L, Bandla S, Luketich JD, Pennathur A, Meyerson M, Ogino S, Shivdasani RA, Beer DG, Godfrey TE, Beroukhim R, Bass AJ. Gastrointestinal adenocarcinomas of the esophagus, stomach, and colon exhibit distinct patterns of genome instability and oncogenesis. Cancer Res. 2012 Sep 1; 72(17):4383-93.
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• Reveiller M, Ghatak S, Toia L, Kalatskaya I, Stein L, D'souza M, Zhou Z, Bandla S, Gooding WE, Godfrey TE, Peters JH. Bile exposure inhibits expression of squamous differentiation genes in human esophageal epithelial cells. Ann Surg. 2012 Jun; 255(6):1113-20.
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• Bandla S, Pennathur A, Luketich JD, Beer DG, Lin L, Bass AJ, Godfrey TE, Litle VR. Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma. Ann Thorac Surg. 2012 Apr; 93(4):1101-6.
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• Ferris RL, Stefanika P, Xi L, Gooding W, Seethala RR, Godfrey TE. Rapid molecular detection of metastatic head and neck squamous cell carcinoma as an intraoperative adjunct to sentinel lymph node biopsy. Laryngoscope. 2012 May; 122(5):1020-30.
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• Barry CT, D'Souza M, McCall M, Safadjou S, Ryan C, Kashyap R, Marroquin C, Orloff M, Almudevar A, Godfrey TE. Micro RNA expression profiles as adjunctive data to assess the risk of hepatocellular carcinoma recurrence after liver transplantation. Am J Transplant. 2012 Feb; 12(2):428-37.
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• Ismail A, Bandla S, Reveiller M, Toia L, Zhou Z, Gooding WE, Kalatskaya I, Stein L, D'Souza M, Litle VR, Peters JH, Pennathur A, Luketich JD, Godfrey TE. Early G1 cyclin-dependent kinases as prognostic markers and potential therapeutic targets in esophageal adenocarcinoma. Clin Cancer Res. 2011 Jul 1; 17(13):4513-22.
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• Hu Y, Bandla S, Godfrey TE, Tan D, Luketich JD, Pennathur A, Qiu X, Hicks DG, Peters JH, Zhou Z. HER2 amplification, overexpression and score criteria in esophageal adenocarcinoma. Mod Pathol. 2011 Jul; 24(7):899-907.
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• Feber A, Xi L, Pennathur A, Gooding WE, Bandla S, Wu M, Luketich JD, Godfrey TE, Litle VR. MicroRNA prognostic signature for nodal metastases and survival in esophageal adenocarcinoma. Ann Thorac Surg. 2011 May; 91(5):1523-30.
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• Ferris RL, Xi L, Seethala RR, Chan J, Desai S, Hoch B, Gooding W, Godfrey TE. Intraoperative qRT-PCR for detection of lymph node metastasis in head and neck cancer. Clin Cancer Res. 2011 Apr 1; 17(7):1858-66.
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• Filho PA, López-Albaitero A, Xi L, Gooding W, Godfrey T, Ferris RL. Quantitative expression and immunogenicity of MAGE-3 and -6 in upper aerodigestive tract cancer. Int J Cancer. 2009 Oct 15; 125(8):1912-20.
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• Hughes SJ, Xi L, Gooding WE, Cole DJ, Mitas M, Metcalf J, Bhargava R, Dabbs D, Ching J, Kozma L, McMillan W, Godfrey TE. A quantitative reverse transcription-PCR assay for rapid, automated analysis of breast cancer sentinel lymph nodes. J Mol Diagn. 2009 Nov; 11(6):576-82.
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• Gupta VK, Feber A, Xi L, Pennathur A, Wu M, Luketich JD, Godfrey TE. Association between CCND1 G/A870 polymorphism, allele-specific amplification, cyclin D1 expression, and survival in esophageal and lung carcinoma. Clin Cancer Res. 2008 Dec 1; 14(23):7804-12.
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• Hilari JM, Mangas C, Xi L, Paradelo C, Ferrándiz C, Hughes SJ, Yueh C, Altomare I, Gooding WE, Godfrey TE. Molecular staging of pathologically negative sentinel lymph nodes from melanoma patients using multimarker, quantitative real-time rt-PCR. Ann Surg Oncol. 2009 Jan; 16(1):177-85.
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• Xi L, Feber A, Gupta V, Wu M, Bergemann AD, Landreneau RJ, Litle VR, Pennathur A, Luketich JD, Godfrey TE. Whole genome exon arrays identify differential expression of alternatively spliced, cancer-related genes in lung cancer. Nucleic Acids Res. 2008 Nov; 36(20):6535-47.
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• Feber A, Xi L, Luketich JD, Pennathur A, Landreneau RJ, Wu M, Swanson SJ, Godfrey TE, Litle VR. MicroRNA expression profiles of esophageal cancer. J Thorac Cardiovasc Surg. 2008 Feb; 135(2):255-60; discussion 260.
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• Nicastri DG, Doucette JT, Godfrey TE, Hughes SJ. Is occult lymph node disease in colorectal cancer patients clinically significant? A review of the relevant literature. J Mol Diagn. 2007 Nov; 9(5):563-71.
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• Xi L, Nicastri DG, El-Hefnawy T, Hughes SJ, Luketich JD, Godfrey TE. Optimal markers for real-time quantitative reverse transcription PCR detection of circulating tumor cells from melanoma, breast, colon, esophageal, head and neck, and lung cancers. Clin Chem. 2007 Jul; 53(7):1206-15.
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• Huang X, Godfrey TE, Gooding WE, McCarty KS, Gollin SM. Comprehensive genome and transcriptome analysis of the 11q13 amplicon in human oral cancer and synteny to the 7F5 amplicon in murine oral carcinoma. Genes Chromosomes Cancer. 2006 Nov; 45(11):1058-69.
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• Xi L, Coello MC, Litle VR, Raja S, Gooding WE, Yousem SA, El-Hefnawy T, Landreneau RJ, Luketich JD, Godfrey TE. A combination of molecular markers accurately detects lymph node metastasis in non-small cell lung cancer patients. Clin Cancer Res. 2006 Apr 15; 12(8):2484-91.
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• Hughes SJ, Xi L, Raja S, Gooding W, Cole DJ, Gillanders WE, Mikhitarian K, McCarty K, Silver S, Ching J, McMillan W, Luketich JD, Godfrey TE. A rapid, fully automated, molecular-based assay accurately analyzes sentinel lymph nodes for the presence of metastatic breast cancer. Ann Surg. 2006 Mar; 243(3):389-98.
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• Xi L, Gooding W, McCarty K, Godfrey TE, Hughes SJ. Identification of mRNA markers for molecular staging of lymph nodes in colorectal cancer. Clin Chem. 2006 Mar; 52(3):520-3.
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• Khalid A, Finkelstein S, Thompson B, Kelly L, Hanck C, Godfrey TE, Whitcomb DC. A 93 year old man with the PRSS1 R122H mutation, low SPINK1 expression, and no pancreatitis: insights into phenotypic non-penetrance. Gut. 2006 May; 55(5):728-31.
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• Kuss I, Schaefer C, Godfrey TE, Ferris RL, Harris JM, Gooding W, Whiteside TL. Recent thymic emigrants and subsets of naive and memory T cells in the circulation of patients with head and neck cancer. Clin Immunol. 2005 Jul; 116(1):27-36.
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• Xi L, Lyons-Weiler J, Coello MC, Huang X, Gooding WE, Luketich JD, Godfrey TE. Prediction of lymph node metastasis by analysis of gene expression profiles in primary lung adenocarcinomas. Clin Cancer Res. 2005 Jun 1; 11(11):4128-35.
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• Ferris RL, Xi L, Raja S, Hunt JL, Wang J, Gooding WE, Kelly L, Ching J, Luketich JD, Godfrey TE. Molecular staging of cervical lymph nodes in squamous cell carcinoma of the head and neck. Cancer Res. 2005 Mar 15; 65(6):2147-56.
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• Raja S, Ching J, Xi L, Hughes SJ, Chang R, Wong W, McMillan W, Gooding WE, McCarty KS, Chestney M, Luketich JD, Godfrey TE. Technology for automated, rapid, and quantitative PCR or reverse transcription-PCR clinical testing. Clin Chem. 2005 May; 51(5):882-90.
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• Lotze MT, Wang E, Marincola FM, Hanna N, Bugelski PJ, Burns CA, Coukos G, Damle N, Godfrey TE, Howell WM, Panelli MC, Perricone MA, Petricoin EF, Sauter G, Scheibenbogen C, Shivers SC, Taylor DL, Weinstein JN, Whiteside TL. Workshop on cancer biometrics: identifying biomarkers and surrogates of cancer in patients: a meeting held at the Masur Auditorium, National Institutes of Health. J Immunother. 2005 Mar-Apr; 28(2):79-119.
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• Xi L, Luketich JD, Raja S, Gooding WE, Litle VR, Coello MC, Finkelstein SD, Chestney ML, Landreneau RJ, Hughes SJ, Godfrey TE. Molecular staging of lymph nodes from patients with esophageal adenocarcinoma. Clin Cancer Res. 2005 Feb 1; 11(3):1099-109.
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• Herrera LJ, El-Hefnawy T, Queiroz de Oliveira PE, Raja S, Finkelstein S, Gooding W, Luketich JD, Godfrey TE, Hughes SJ. The HGF receptor c-Met is overexpressed in esophageal adenocarcinoma. Neoplasia. 2005 Jan; 7(1):75-84.
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• Godfrey TE, Kelly LA. Development of quantitative reverse transcriptase PCR assays for measuring gene expression. Methods Mol Biol. 2005; 291:423-45.
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• Wang J, Xi L, Gooding W, Godfrey TE, Ferris RL. Chemokine receptors 6 and 7 identify a metastatic expression pattern in squamous cell carcinoma of the head and neck. Adv Otorhinolaryngol. 2005; 62:121-33.
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• Herrera LJ, Raja S, Gooding WE, El-Hefnawy T, Kelly L, Luketich JD, Godfrey TE. Quantitative analysis of circulating plasma DNA as a tumor marker in thoracic malignancies. Clin Chem. 2005 Jan; 51(1):113-8.
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• Lyons-Weiler J, Patel S, Becich MJ, Godfrey TE. Tests for finding complex patterns of differential expression in cancers: towards individualized medicine. BMC Bioinformatics. 2004 Aug 12; 5:110.
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• Wang J, Xi L, Hunt JL, Gooding W, Whiteside TL, Chen Z, Godfrey TE, Ferris RL. Expression pattern of chemokine receptor 6 (CCR6) and CCR7 in squamous cell carcinoma of the head and neck identifies a novel metastatic phenotype. Cancer Res. 2004 Mar 1; 64(5):1861-6.
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• El-Hefnawy T, Raja S, Kelly L, Bigbee WL, Kirkwood JM, Luketich JD, Godfrey TE. Characterization of amplifiable, circulating RNA in plasma and its potential as a tool for cancer diagnostics. Clin Chem. 2004 Mar; 50(3):564-73.
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• Coello MC, Luketich JD, Litle VR, Godfrey TE. Prognostic significance of micrometastasis in non-small-cell lung cancer. Clin Lung Cancer. 2004 Jan; 5(4):214-25.
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• Makhija S, Sit A, Edwards R, Aufman K, Weiss H, Kanbour-Shakir A, Gooding W, D'Angelo G, Ferrell R, Raja S, Godfrey TE. Identification of genetic alterations related to chemoresistance in epithelial ovarian cancer. Gynecol Oncol. 2003 Jul; 90(1):3-9.
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• Collins JL, Vodovotz Y, Hierholzer C, Villavicencio RT, Liu S, Alber S, Gallo D, Stolz DB, Watkins SC, Godfrey A, Gooding W, Kelly E, Peitzman AB, Billiar TR. Characterization of the expression of inducible nitric oxide synthase in rat and human liver during hemorrhagic shock. Shock. 2003 Feb; 19(2):117-22.
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• Raja S, Godfrey TE, Luketich JD. The role of tumor suppressor genes in esophageal cancer. Minerva Chir. 2002 Dec; 57(6):767-80.
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• Huang X, Gollin SM, Raja S, Godfrey TE. High-resolution mapping of the 11q13 amplicon and identification of a gene, TAOS1, that is amplified and overexpressed in oral cancer cells. Proc Natl Acad Sci U S A. 2002 Aug 20; 99(17):11369-74.
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• Raja S, El-Hefnawy T, Kelly LA, Chestney ML, Luketich JD, Godfrey TE. Temperature-controlled primer limit for multiplexing of rapid, quantitative reverse transcription-PCR assays: application to intraoperative cancer diagnostics. Clin Chem. 2002 Aug; 48(8):1329-37.
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• Raja S, Luketich JD, Kelly LA, Gooding WE, Finkelstein SD, Godfrey TE. Rapid, quantitative reverse transcriptase-polymerase chain reaction: application to intraoperative molecular detection of occult metastases in esophageal cancer. J Thorac Cardiovasc Surg. 2002 Mar; 123(3):475-82; discussion 482-3.
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• Aldape K, Ginzinger DG, Godfrey TE. Real-time quantitative polymerase chain reaction: a potential tool for genetic analysis in neuropathology. Brain Pathol. 2002 Jan; 12(1):54-66.
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• Godfrey TE, Raja S, Finkelstein SD, Gooding WE, Kelly LA, Luketich JD. Prognostic value of quantitative reverse transcription-polymerase chain reaction in lymph node-negative esophageal cancer patients. Clin Cancer Res. 2001 Dec; 7(12):4041-8.
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• Raja S, Finkelstein SD, Baksh FK, Gooding WE, Swalsky PA, Godfrey TE, Buenaventura PO, Luketich JD. Correlation between dysplasia and mutations of six tumor suppressor genes in Barrett's esophagus. Ann Thorac Surg. 2001 Oct; 72(4):1130-5.
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• Simmons ML, Lamborn KR, Takahashi M, Chen P, Israel MA, Berger MS, Godfrey T, Nigro J, Prados M, Chang S, Barker FG, Aldape K. Analysis of complex relationships between age, p53, epidermal growth factor receptor, and survival in glioblastoma patients. Cancer Res. 2001 Feb 1; 61(3):1122-8.
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• Suzuki S, Moore DH, Ginzinger DG, Godfrey TE, Barclay J, Powell B, Pinkel D, Zaloudek C, Lu K, Mills G, Berchuck A, Gray JW. An approach to analysis of large-scale correlations between genome changes and clinical endpoints in ovarian cancer. Cancer Res. 2000 Oct 1; 60(19):5382-5.
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• Ginzinger DG, Godfrey TE, Nigro J, Moore DH, Suzuki S, Pallavicini MG, Gray JW, Jensen RH. Measurement of DNA copy number at microsatellite loci using quantitative PCR analysis. Cancer Res. 2000 Oct 1; 60(19):5405-9.
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• Raja S, Luketich JD, Kelly LA, Ruff DW, Godfrey TE. Increased sensitivity of one-tube, quantitative RT-PCR. Biotechniques. 2000 Oct; 29(4):702, 704, 706.
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• Weiss WA, Godfrey T, Francisco C, Bishop JM. Genome-wide screen for allelic imbalance in a mouse model for neuroblastoma. Cancer Res. 2000 May 1; 60(9):2483-7.
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• Moore L, Godfrey T, Eng C, Smith A, Ho R, Waldman FM. Validation of fluorescent SSCP analysis for sensitive detection of p53 mutations. Biotechniques. 2000 May; 28(5):986-92.
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• Godfrey TE, Kim SH, Chavira M, Ruff DW, Warren RS, Gray JW, Jensen RH. Quantitative mRNA expression analysis from formalin-fixed, paraffin-embedded tissues using 5' nuclease quantitative reverse transcription-polymerase chain reaction. J Mol Diagn. 2000 May; 2(2):84-91.
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• Bastian BC, Kashani-Sabet M, Hamm H, Godfrey T, Moore DH, Bröcker EB, LeBoit PE, Pinkel D. Gene amplifications characterize acral melanoma and permit the detection of occult tumor cells in the surrounding skin. Cancer Res. 2000 Apr 1; 60(7):1968-73.
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• Tassone F, Hagerman RJ, Taylor AK, Gane LW, Godfrey TE, Hagerman PJ. Elevated levels of FMR1 mRNA in carrier males: a new mechanism of involvement in the fragile-X syndrome. Am J Hum Genet. 2000 Jan; 66(1):6-15.
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• Kim SH, Godfrey T, Jensen RH. Whole genome amplification and molecular genetic analysis of DNA from paraffin-embedded prostate adenocarcinoma tumor tissue. J Urol. 1999 Oct; 162(4):1512-8.
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• Shayesteh L, Lu Y, Kuo WL, Baldocchi R, Godfrey T, Collins C, Pinkel D, Powell B, Mills GB, Gray JW. PIK3CA is implicated as an oncogene in ovarian cancer. Nat Genet. 1999 Jan; 21(1):99-102.
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• Collins C, Rommens JM, Kowbel D, Godfrey T, Tanner M, Hwang SI, Polikoff D, Nonet G, Cochran J, Myambo K, Jay KE, Froula J, Cloutier T, Kuo WL, Yaswen P, Dairkee S, Giovanola J, Hutchinson GB, Isola J, Kallioniemi OP, Palazzolo M, Martin C, Ericsson C, Pinkel D, Albertson D, Li WB, Gray JW. Positional cloning of ZNF217 and NABC1: genes amplified at 20q13.2 and overexpressed in breast carcinoma. Proc Natl Acad Sci U S A. 1998 Jul 21; 95(15):8703-8.
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• Fejzo MS, Godfrey T, Chen C, Waldman F, Gray JW. Molecular cytogenetic analysis of consistent abnormalities at 8q12-q22 in breast cancer. Genes Chromosomes Cancer. 1998 Jun; 22(2):105-13.
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• Hiraguri S, Godfrey T, Nakamura H, Graff J, Collins C, Shayesteh L, Doggett N, Johnson K, Wheelock M, Herman J, Baylin S, Pinkel D, Gray J. Mechanisms of inactivation of E-cadherin in breast cancer cell lines. Cancer Res. 1998 May 1; 58(9):1972-7.
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• Godfrey TE, Cher ML, Chhabra V, Jensen RH. Allelic imbalance mapping of chromosome 16 shows two regions of common deletion in prostate adenocarcinoma. Cancer Genet Cytogenet. 1997 Oct 1; 98(1):36-42.
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• Godfrey TE, Ikebuchi M, Reynolds RJ, Hill CK. Characterization of a mammalian cell line that exhibits spontaneous and ultraviolet light-induced hypermutability while retaining resistance to cell killing by ultraviolet light. Int J Radiat Biol. 1995 Jun; 67(6):661-70.
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• Godfrey TE. Mitomycin C in advanced breast cancer: an update. Semin Oncol. 1988 Jun; 15(3 Suppl 4):71-3.
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• Fisher RD, Rentschler RE, Nelson JC, Godfrey TE, Wilbur DW. Elevation of plasma antidiuretic hormones (ADH) associated with chemotherapy-induced emesis in man. Cancer Treat Rep. 1982 Jan; 66(1):25-9.
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• Chlebowski RT, Weiner JM, Luce J, Hestorff R, Lang JE, Reynolds R, Godfrey T, Ryden VM, Bateman JR. Significance of relapse after adjuvant treatment with combination chemotherapy or 5-fluorouracil alone in high-risk breast cancer. A Western Cancer Study Group Project. Cancer Res. 1981 Nov; 41(11 Pt 1):4399-403.
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• Wise GR, Kuhn IN, Godfrey TE. Mitomycin C in large infrequent doses in breast cancer. Med Pediatr Oncol. 1976; 2(1):55-60.
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• Godfrey TE, King A, Rentschler R. 1,3-Bis (2-chloroethyl)-1-nitrosourea: effects on advanced ovarian carcinoma. Am J Obstet Gynecol. 1973 Feb 15; 115(4):576-7.
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• Godfrey TE, Wilbur DW. Clinical experience with mitomycin C in large infrequent doses. Cancer. 1972 Jun; 29(6):1647-52.
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• Godfrey TE. Mithramycin for hypercalcemia of malignant disease. Calif Med. 1971 Oct; 115(4):1-4.
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