Brian Poligone
| Title | Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Dermatology |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 697
Rochester NY 14642
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| Title | Assistant Professor |
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| Institution | University of Rochester Medical Center |
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| Department | Cancer Center |
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| Dean's List and Honors in Biology (All Semesters) | | 1988 |
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| 1996 | Medical Scientist Training Program (Eight Years Scholarship) | University of North Carolina School of Medicine | | 1992 |
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| Eta Sigma Phi (National Classical Studies Honor Society) | | 1993 |
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| Howard Hughes Undergraduate Research Grant | | 1994 |
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| Class of 1938 Scholar (Summer Study) | UNC Alumni Class | | 1994 |
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| Harrisburg Physicians Scholarship | | 1998 |
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| 1999 | Evaluation of a Hereditary Thrombocytopenia in a Family in Coastal North Carolina | Holderness Medical Fellowship | | 1999 |
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| American Society of Hematology, Medical Student Fellowship | | 1999 |
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| National Institutes of Health Summer Research Fellowship | | 1999 |
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| John B. Graham Research Society | | 2002 |
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| www.facultyof1000.com, Journal of Immunology | | 2008 |
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| Dermatology Foundation Career Development Award |
The Poligone Laboratory studies signal transduction in the skin, specifically examining the role of the transcription factor NF kappa B in skin physiology and disease. Using genetic animal models to study the function of NF kappa B, we strive to better understand the molecular mechanisms behind skin inflammation and carcinogenesis. By studying animal models of disease, we are better able to translate our findings into clinically relevant treatments for human disease. Through his past work with Drs. Albert S. Baldwin and Sankar Ghosh, Dr. Poligone has gained expertise in the study of NF kappa B and has focused his attention to the skin. Currently we are examining how NF kappa B is involved in the formation of a type of skin cancer called a keratoacanthoma. Dr. Poligone has also examined the role of NF kappa B in psoriasis and specifically has been examining NF kappa B inhibitors in this disease.
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Poligone B, Heald P. Menus for managing patients with cutaneous T-cell lymphoma. Semin Cutan Med Surg. 2012 Mar; 31(1):25-32.
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Ahern K, Gilmore ES, Poligone B. Pruritus in cutaneous T-cell lymphoma: A review. J Am Acad Dermatol. 2012 Oct; 67(4):760-8.
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Poligone B, Lin J, Chung C. Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma. Core Evid. 2011; 6:1-12.
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Poligone B, Heald P. Innovative therapy of cutaneous T-cell lymphoma: beyond psoralen and ultraviolet light and nitrogen mustard. Dermatol Clin. 2010 Jul; 28(3):501-10.
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Poligone B, Wilson LD, Subtil A, Heald P. Primary cutaneous T-cell lymphoma localized to the lower leg: a distinct, locally aggressive cutaneous T-cell lymphoma. Arch Dermatol. 2009 Jun; 145(6):677-82.
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Zayour M, Gilmore E, Heald P, Rose M, Poligone B, Lazova R. A distinct entity in the spectrum of the CD30+ cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontaneous resolution. Am J Dermatopathol. 2009 Feb; 31(1):37-43.
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Poligone B, Christensen SR, Lazova R, Heald PW. Bazex syndrome (acrokeratosis paraneoplastica). Lancet. 2007 Feb 10; 369(9560):530.
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Sen P, Bhattacharyya S, Wallet M, Wong CP, Poligone B, Sen M, Baldwin AS, Tisch R. NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. J Immunol. 2003 Feb 15; 170(4):1770-80.
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Poligone B, Weaver DJ, Sen P, Baldwin AS, Tisch R. Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J Immunol. 2002 Jan 1; 168(1):188-96.
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Abdel-Motal UM, Friedline R, Poligone B, Pogue-Caley RR, Frelinger JA, Tisch R. Dendritic cell vaccination induces cross-reactive cytotoxic T lymphocytes specific for wild-type and natural variant human immunodeficiency virus type 1 epitopes in HLA-A*0201/Kb transgenic mice. Clin Immunol. 2001 Oct; 101(1):51-8.
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Poligone B, Baldwin AS. Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins. J Biol Chem. 2001 Oct 19; 276(42):38658-64.
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Weaver DJ, Poligone B, Bui T, Abdel-Motal UM, Baldwin AS, Tisch R. Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase. J Immunol. 2001 Aug 1; 167(3):1461-8.
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