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Brian Poligone

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentDermatology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 697
Rochester NY 14642
Other Positions
TitleAssistant Professor
InstitutionUniversity of Rochester Medical Center
DepartmentCancer Center

 
 Awards And Honors
      Dean's List and Honors in Biology (All Semesters)
1988 - 1996Medical Scientist Training Program (Eight Years Scholarship)  | University of North Carolina School of Medicine
1992     Eta Sigma Phi (National Classical Studies Honor Society)
1993     Howard Hughes Undergraduate Research Grant
1994     Class of 1938 Scholar (Summer Study)  | UNC Alumni Class
1994     Harrisburg Physicians Scholarship
1998 - 1999Evaluation of a Hereditary Thrombocytopenia in a Family in Coastal North Carolina  | Holderness Medical Fellowship
1999     American Society of Hematology, Medical Student Fellowship
1999     National Institutes of Health Summer Research Fellowship
1999     John B. Graham Research Society
2002     www.facultyof1000.com, Journal of Immunology
2008     Dermatology Foundation Career Development Award
 
 Overview
The Poligone Laboratory studies signal transduction in the skin, specifically examining the role of the transcription factor NF kappa B in skin physiology and disease. Using genetic animal models to study the function of NF kappa B, we strive to better understand the molecular mechanisms behind skin inflammation and carcinogenesis. By studying animal models of disease, we are better able to translate our findings into clinically relevant treatments for human disease. Through his past work with Drs. Albert S. Baldwin and Sankar Ghosh, Dr. Poligone has gained expertise in the study of NF kappa B and has focused his attention to the skin. Currently we are examining how NF kappa B is involved in the formation of a type of skin cancer called a keratoacanthoma. Dr. Poligone has also examined the role of NF kappa B in psoriasis and specifically has been examining NF kappa B inhibitors in this disease.

 
 Selected Publications
List All   |   Timeline
  1. Poligone B, Hayden MS, Chen L, Pentland AP, Jimi E, Ghosh S. A Role for NF-?B Activity in Skin Hyperplasia and the Development of Keratoacanthomata in Mice. PLoS One. 2013; 8(8):e71887.
    View in: PubMed
  2. Poligone B, Heald P. Menus for managing patients with cutaneous T-cell lymphoma. Semin Cutan Med Surg. 2012 Mar; 31(1):25-32.
    View in: PubMed
  3. Ahern K, Gilmore ES, Poligone B. Pruritus in cutaneous T-cell lymphoma: a review. J Am Acad Dermatol. 2012 Oct; 67(4):760-8.
    View in: PubMed
  4. Poligone B, Lin J, Chung C. Romidepsin: evidence for its potential use to manage previously treated cutaneous T cell lymphoma. Core Evid. 2011; 6:1-12.
    View in: PubMed
  5. Poligone B, Heald P. Innovative therapy of cutaneous T-cell lymphoma: beyond psoralen and ultraviolet light and nitrogen mustard. Dermatol Clin. 2010 Jul; 28(3):501-10.
    View in: PubMed
  6. Poligone B, Wilson LD, Subtil A, Heald P. Primary cutaneous T-cell lymphoma localized to the lower leg: a distinct, locally aggressive cutaneous T-cell lymphoma. Arch Dermatol. 2009 Jun; 145(6):677-82.
    View in: PubMed
  7. Zayour M, Gilmore E, Heald P, Rose M, Poligone B, Lazova R. A distinct entity in the spectrum of the CD30+ cutaneous lymphoproliferative diseases: oligolesional nodules with pseudoepitheliomatous hyperplasia followed by spontaneous resolution. Am J Dermatopathol. 2009 Feb; 31(1):37-43.
    View in: PubMed
  8. Poligone B, Christensen SR, Lazova R, Heald PW. Bazex syndrome (acrokeratosis paraneoplastica). Lancet. 2007 Feb 10; 369(9560):530.
    View in: PubMed
  9. Sen P, Bhattacharyya S, Wallet M, Wong CP, Poligone B, Sen M, Baldwin AS, Tisch R. NF-kappa B hyperactivation has differential effects on the APC function of nonobese diabetic mouse macrophages. J Immunol. 2003 Feb 15; 170(4):1770-80.
    View in: PubMed
  10. Poligone B, Weaver DJ, Sen P, Baldwin AS, Tisch R. Elevated NF-kappaB activation in nonobese diabetic mouse dendritic cells results in enhanced APC function. J Immunol. 2002 Jan 1; 168(1):188-96.
    View in: PubMed
  11. Abdel-Motal UM, Friedline R, Poligone B, Pogue-Caley RR, Frelinger JA, Tisch R. Dendritic cell vaccination induces cross-reactive cytotoxic T lymphocytes specific for wild-type and natural variant human immunodeficiency virus type 1 epitopes in HLA-A*0201/Kb transgenic mice. Clin Immunol. 2001 Oct; 101(1):51-8.
    View in: PubMed
  12. Poligone B, Baldwin AS. Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins. J Biol Chem. 2001 Oct 19; 276(42):38658-64.
    View in: PubMed
  13. Weaver DJ, Poligone B, Bui T, Abdel-Motal UM, Baldwin AS, Tisch R. Dendritic cells from nonobese diabetic mice exhibit a defect in NF-kappa B regulation due to a hyperactive I kappa B kinase. J Immunol. 2001 Aug 1; 167(3):1461-8.
    View in: PubMed

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