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Takeyama M, Wakabayashi H, Fay PJ. Contribution of factor VIII light-chain residues 2007-2016 to an activated protein C-interactive site. Thromb Haemost. 2013 Jan 31; 109(2):187-98.
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Deangelis JP, Wakabayashi H, Fay PJ. Sequences Flanking Arg336 in Factor VIIIa Modulate Factor Xa-catalyzed Cleavage Rates at this Site and Cofactor Function. J Biol Chem. 2012 May 4; 287(19):15409-17.
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Wakabayashi H, Griffiths AE, Fay PJ. Enhancing factor VIII and VIIIa stability by combining mutations at the A2 domain interface and A1-C2 domain interface. J Thromb Haemost. 2012 Mar; 10(3):492-5.
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Takeyama M, Wakabayashi H, Fay PJ. Factor VIII Light Chain Contains a Binding Site for Factor X That Contributes to the Catalytic Efficiency of Factor Xase. Biochemistry. 2012 Jan 24; 51(3):820-8.
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Griffiths AE, Wang W, Hagen FK, Fay PJ. Use of affinity-directed liquid chromatography-mass spectrometry to map the epitopes of a factor VIII inhibitor antibody fraction. J Thromb Haemost. 2011 Aug; 9(8):1534-40.
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Wakabayashi H, Griffiths AE, Fay PJ. Increasing hydrophobicity or disulfide bridging at the factor VIII A1 and C2 domain interface enhances procofactor stability. J Biol Chem. 2011 Jul 22; 286(29):25748-55.
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DeAngelis JP, Varfaj F, Wakabayashi H, Fay PJ. The role of P4-P3' residues flanking Arg336 in facilitating activated protein C-catalyzed cleavage and inactivation of factor VIIIa. Thromb Res. 2011 Nov; 128(5):470-6.
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Novakovic VA, Cullinan DB, Wakabayashi H, Fay PJ, Baleja JD, Gilbert GE. Membrane-binding properties of the Factor VIII C2 domain. Biochem J. 2011 Apr 1; 435(1):187-96.
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Wakabayashi H, Griffiths AE, Fay PJ. Factor VIII lacking the C2 domain retains cofactor activity in vitro. J Biol Chem. 2010 Aug 13; 285(33):25176-84.
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Jagannathan I, Ichikawa HT, Kruger T, Fay PJ. Identification of residues in the 558-loop of factor VIIIa A2 subunit that interact with factor IXa. J Biol Chem. 2009 Nov 20; 284(47):32248-55.
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Newell JL, Fay PJ. Cleavage at Arg-1689 influences heavy chain cleavages during thrombin-catalyzed activation of factor VIII. J Biol Chem. 2009 Apr 24; 284(17):11080-9.
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Wakabayashi H, Griffiths AE, Fay PJ. Combining mutations of charged residues at the A2 domain interface enhances factor VIII stability over single point mutations. J Thromb Haemost. 2009 Mar; 7(3):438-44.
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Wakabayashi H, Varfaj F, Deangelis J, Fay PJ. Generation of enhanced stability factor VIII variants by replacement of charged residues at the A2 domain interface. Blood. 2008 Oct 1; 112(7):2761-9.
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Newell JL, Fay PJ. Acidic residues C-terminal to the A2 domain facilitate thrombin-catalyzed activation of factor VIII. Biochemistry. 2008 Aug 19; 47(33):8786-95.
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Wakabayashi H, Fay PJ. Identification of residues contributing to A2 domain-dependent structural stability in factor VIII and factor VIIIa. J Biol Chem. 2008 Apr 25; 283(17):11645-51.
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Newell JL, Fay PJ. Proteolysis at Arg740 facilitates subsequent bond cleavages during thrombin-catalyzed activation of factor VIII. J Biol Chem. 2007 Aug 31; 282(35):25367-75.
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Varfaj F, Wakabayashi H, Fay PJ. Residues surrounding Arg336 and Arg562 contribute to the disparate rates of proteolysis of factor VIIIa catalyzed by activated protein C. J Biol Chem. 2007 Jul 13; 282(28):20264-72.
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Wakabayashi H, Zhou Q, Varfaj F, Fay PJ. A3 domain residue Glu1829 contributes to A2 subunit retention in factor VIIIa. J Thromb Haemost. 2007 May; 5(5):996-1001.
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Ansong C, Miles SM, Fay PJ. Factor VIII A1 domain residues 97-105 represent a light chain-interactive site. Biochemistry. 2006 Nov 7; 45(44):13140-9.
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Varfaj F, Neuberg J, Jenkins PV, Wakabayashi H, Fay PJ. Role of P1 residues Arg336 and Arg562 in the activated-Protein-C-catalysed inactivation of Factor VIIIa. Biochem J. 2006 Jun 1; 396(2):355-62.
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Wakabayashi H, Zhou Q, Nogami K, Ansong C, Varfaj F, Miles S, Fay PJ. pH-dependent association of factor VIII chains: enhancement of affinity at physiological pH by Cu2+. Biochim Biophys Acta. 2006 Jun; 1764(6):1094-101.
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Ansong C, Miles SM, Fay PJ. Epitope mapping factor VIII A2 domain by affinity-directed mass spectrometry: residues 497-510 and 584-593 comprise a discontinuous epitope for the monoclonal antibody R8B12. J Thromb Haemost. 2006 Apr; 4(4):842-7.
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Fay PJ. Factor VIII structure and function. Int J Hematol. 2006 Feb; 83(2):103-8.
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Wakabayashi H, Su YC, Ahmad SS, Walsh PN, Fay PJ. A Glu113Ala mutation within a factor VIII Ca2+-binding site enhances cofactor interactions in factor Xase. Biochemistry. 2005 Aug 2; 44(30):10298-304.
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Ansong C, Fay PJ. Factor VIII A3 domain residues 1954-1961 represent an A1 domain-interactive site. Biochemistry. 2005 Jun 21; 44(24):8850-7.
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Nogami K, Zhou Q, Myles T, Leung LL, Wakabayashi H, Fay PJ. Exosite-interactive regions in the A1 and A2 domains of factor VIII facilitate thrombin-catalyzed cleavage of heavy chain. J Biol Chem. 2005 May 6; 280(18):18476-87.
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Nogami K, Zhou Q, Wakabayashi H, Fay PJ. Thrombin-catalyzed activation of factor VIII with His substituted for Arg372 at the P1 site. Blood. 2005 Jun 1; 105(11):4362-8.
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Fay PJ, Jenkins PV. Mutating factor VIII: lessons from structure to function. Blood Rev. 2005 Jan; 19(1):15-27.
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Nogami K, Wakabayashi H, Ansong C, Fay PJ. Localization of a pH-dependent, A2 subunit-interactive surface within the factor VIIIa A1 subunit. Biochim Biophys Acta. 2004 Sep 1; 1701(1-2):25-35.
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Nogami K, Freas J, Manithody C, Wakabayashi H, Rezaie AR, Fay PJ. Mechanisms of interactions of factor X and factor Xa with the acidic region in the factor VIII A1 domain. J Biol Chem. 2004 Aug 6; 279(32):33104-13.
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Jenkins PV, Dill JL, Zhou Q, Fay PJ. Contribution of factor VIIIa A2 and A3-C1-C2 subunits to the affinity for factor IXa in factor Xase. Biochemistry. 2004 May 4; 43(17):5094-101.
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Fay PJ. Activation of factor VIII and mechanisms of cofactor action. Blood Rev. 2004 Mar; 18(1):1-15.
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Jenkins PV, Dill JL, Zhou Q, Fay PJ. Clustered basic residues within segment 484-510 of the factor VIIIa A2 subunit contribute to the catalytic efficiency for factor Xa generation. J Thromb Haemost. 2004 Mar; 2(3):452-8.
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Nogami K, Lapan KA, Zhou Q, Wakabayashi H, Fay PJ. Identification of a factor Xa-interactive site within residues 337-372 of the factor VIII heavy chain. J Biol Chem. 2004 Apr 16; 279(16):15763-71.
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Wakabayashi H, Freas J, Zhou Q, Fay PJ. Residues 110-126 in the A1 domain of factor VIII contain a Ca2+ binding site required for cofactor activity. J Biol Chem. 2004 Mar 26; 279(13):12677-84.
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Peng H, Sahni A, Fay P, Bellum S, Prudovsky I, Maciag T, Francis CW. Identification of a binding site on human FGF-2 for fibrinogen. Blood. 2004 Mar 15; 103(6):2114-20.
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Balakrishnan M, Roques BP, Fay PJ, Bambara RA. Template dimerization promotes an acceptor invasion-induced transfer mechanism during human immunodeficiency virus type 1 minus-strand synthesis. J Virol. 2003 Apr; 77(8):4710-21.
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Nogami K, Wakabayashi H, Fay PJ. Mechanisms of factor Xa-catalyzed cleavage of the factor VIIIa A1 subunit resulting in cofactor inactivation. J Biol Chem. 2003 May 9; 278(19):16502-9.
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Manithody C, Fay PJ, Rezaie AR. Exosite-dependent regulation of factor VIIIa by activated protein C. Blood. 2003 Jun 15; 101(12):4802-7.
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Wakabayashi H, Zhen Z, Schmidt KM, Fay PJ. Mn2+ binding to factor VIII subunits and its effect on cofactor activity. Biochemistry. 2003 Jan 14; 42(1):145-53.
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Chen Y, Balakrishnan M, Roques BP, Fay PJ, Bambara RA. Mechanism of minus strand strong stop transfer in HIV-1 reverse transcription. J Biol Chem. 2003 Mar 7; 278(10):8006-17.
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Nogami K, Wakabayashi H, Schmidt K, Fay PJ. Altered interactions between the A1 and A2 subunits of factor VIIIa following cleavage of A1 subunit by factor Xa. J Biol Chem. 2003 Jan 17; 278(3):1634-41.
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Roda RH, Balakrishnan M, Kim JK, Roques BP, Fay PJ, Bambara RA. Strand transfer occurs in retroviruses by a pause-initiated two-step mechanism. J Biol Chem. 2002 Dec 6; 277(49):46900-11.
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Jenkins PV, Freas J, Schmidt KM, Zhou Q, Fay PJ. Mutations associated with hemophilia A in the 558-565 loop of the factor VIIIa A2 subunit alter the catalytic activity of the factor Xase complex. Blood. 2002 Jul 15; 100(2):501-8.
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Wakabayashi H, Schmidt KM, Fay PJ. Ca(2+) binding to both the heavy and light chains of factor VIII is required for cofactor activity. Biochemistry. 2002 Jul 2; 41(26):8485-92.
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Wisniewski M, Chen Y, Balakrishnan M, Palaniappan C, Roques BP, Fay PJ, Bambara RA. Substrate requirements for secondary cleavage by HIV-1 reverse transcriptase RNase H. J Biol Chem. 2002 Aug 9; 277(32):28400-10.
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Koszelak Rosenblum ME, Schmidt K, Freas J, Mastri M, Fay PJ. Cofactor activities of factor VIIIa and A2 subunit following cleavage of A1 subunit at Arg336. J Biol Chem. 2002 Apr 5; 277(14):11664-9.
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Wakabayashi H, Koszelak ME, Mastri M, Fay PJ. Metal ion-independent association of factor VIII subunits and the roles of calcium and copper ions for cofactor activity and inter-subunit affinity. Biochemistry. 2001 Aug 28; 40(34):10293-300.
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Fay PJ, Mastri M, Koszelak ME. Factor VIIIa cofactor activity shows enhanced ionic strength sensitivity in the absence of phospholipid. Biochim Biophys Acta. 2001 Jul 9; 1548(1):159-68.
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Balakrishnan M, Fay PJ, Bambara RA. The kissing hairpin sequence promotes recombination within the HIV-I 5' leader region. J Biol Chem. 2001 Sep 28; 276(39):36482-92.
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Bajaj SP, Schmidt AE, Mathur A, Padmanabhan K, Zhong D, Mastri M, Fay PJ. Factor IXa:factor VIIIa interaction. helix 330-338 of factor ixa interacts with residues 558-565 and spatially adjacent regions of the a2 subunit of factor VIIIa. J Biol Chem. 2001 May 11; 276(19):16302-9.
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Fay PJ, Mastri M, Koszelak ME, Wakabayashi H. Cleavage of factor VIII heavy chain is required for the functional interaction of a2 subunit with factor IXA. J Biol Chem. 2001 Apr 13; 276(15):12434-9.
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Wisniewski M, Balakrishnan M, Palaniappan C, Fay PJ, Bambara RA. The sequential mechanism of HIV reverse transcriptase RNase H. J Biol Chem. 2000 Dec 1; 275(48):37664-71.
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Wisniewski M, Balakrishnan M, Palaniappan C, Fay PJ, Bambara RA. Unique progressive cleavage mechanism of HIV reverse transcriptase RNase H. Proc Natl Acad Sci U S A. 2000 Oct 24; 97(22):11978-83.
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Koszelak ME, Huggins CF, Fay PJ. Sites in the A2 subunit involved in the interfactor VIIIa interaction. J Biol Chem. 2000 Sep 1; 275(35):27137-44.
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Archer RH, Dykes C, Gerondelis P, Lloyd A, Fay P, Reichman RC, Bambara RA, Demeter LM. Mutants of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase resistant to nonnucleoside reverse transcriptase inhibitors demonstrate altered rates of RNase H cleavage that correlate with HIV-1 replication fitness in cell culture. J Virol. 2000 Sep; 74(18):8390-401.
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O'Brien LM, Mastri M, Fay PJ. Regulation of factor VIIIa by human activated protein C and protein S: inactivation of cofactor in the intrinsic factor Xase. Blood. 2000 Mar 1; 95(5):1714-20.
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Fay PJ, Scandella D. Human inhibitor antibodies specific for the factor VIII A2 domain disrupt the interaction between the subunit and factor IXa. J Biol Chem. 1999 Oct 15; 274(42):29826-30.
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Wisniewski M, Palaniappan C, Fu Z, Le Grice SF, Fay P, Bambara RA. Mutations in the primer grip region of HIV reverse transcriptase can increase replication fidelity. J Biol Chem. 1999 Oct 1; 274(40):28175-84.
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Fay PJ. Regulation of factor VIIIa in the intrinsic factor Xase. Thromb Haemost. 1999 Aug; 82(2):193-200.
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Gerondelis P, Archer RH, Palaniappan C, Reichman RC, Fay PJ, Bambara RA, Demeter LM. The P236L delavirdine-resistant human immunodeficiency virus type 1 mutant is replication defective and demonstrates alterations in both RNA 5'-end- and DNA 3'-end-directed RNase H activities. J Virol. 1999 Jul; 73(7):5803-13.
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Fay PJ, Koshibu K, Mastri M. The A1 and A2 subunits of factor VIIIa synergistically stimulate factor IXa catalytic activity. J Biol Chem. 1999 May 28; 274(22):15401-6.
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Lapan KA, Fay PJ. Interaction of the A1 subunit of factor VIIIa and the serine protease domain of factor X identified by zero-length cross-linking. Thromb Haemost. 1998 Sep; 80(3):418-22.
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Fay PJ, Koshibu K. The A2 subunit of factor VIIIa modulates the active site of factor IXa. J Biol Chem. 1998 Jul 24; 273(30):19049-54.
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Sudhakar K, Fay PJ. Effects of copper on the structure and function of factor VIII subunits: evidence for an auxiliary role for copper ions in cofactor activity. Biochemistry. 1998 May 12; 37(19):6874-82.
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Pieneman WC, Fay P, Briët E, Reitsma PH, Bertina RM. Partial reconstitution of factor VIII activity from a mild Crm+ hemophilia A patient by replacement of the defective A2 domain. Thromb Haemost. 1998 May; 79(5):943-8.
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Siddiqi F, Odrljin TM, Fay PJ, Cox C, Francis CW. Binding of tissue-plasminogen activator to fibrin: effect of ultrasound. Blood. 1998 Mar 15; 91(6):2019-25.
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Palaniappan C, Kim JK, Wisniewski M, Fay PJ, Bambara RA. Control of initiation of viral plus strand DNA synthesis by HIV reverse transcriptase. J Biol Chem. 1998 Feb 13; 273(7):3808-16.
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O'Brien LM, Huggins CF, Fay PJ. Interacting regions in the A1 and A2 subunits of factor VIIIa identified by zero-length cross-linking. Blood. 1997 Nov 15; 90(10):3943-50.
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Kim JK, Palaniappan C, Wu W, Fay PJ, Bambara RA. Evidence for a unique mechanism of strand transfer from the transactivation response region of HIV-1. J Biol Chem. 1997 Jul 4; 272(27):16769-77.
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Lu Y, Planelles V, Li X, Palaniappan C, Day B, Challita-Eid P, Amado R, Stephens D, Kohn DB, Bakker A, Fay P, Bambara RA, Rosenblatt JD. Inhibition of HIV-1 replication using a mutated tRNALys-3 primer. J Biol Chem. 1997 Jun 6; 272(23):14523-31.
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Palaniappan C, Wisniewski M, Jacques PS, Le Grice SF, Fay PJ, Bambara RA. Mutations within the primer grip region of HIV-1 reverse transcriptase result in loss of RNase H function. J Biol Chem. 1997 Apr 25; 272(17):11157-64.
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Lapan KA, Fay PJ. Localization of a factor X interactive site in the A1 subunit of factor VIIIa. J Biol Chem. 1997 Jan 24; 272(4):2082-8.
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Fuentes GM, Palaniappan C, Fay PJ, Bambara RA. Strand displacement synthesis in the central polypurine tract region of HIV-1 promotes DNA to DNA strand transfer recombination. J Biol Chem. 1996 Nov 22; 271(47):29605-11.
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Sudhakar K, Fay PJ. Exposed hydrophobic sites in factor VIII and isolated subunits. J Biol Chem. 1996 Sep 20; 271(38):23015-21.
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Palaniappan C, Wisniewski M, Wu W, Fay PJ, Bambara RA. Misincorporation by HIV-1 reverse transcriptase promotes recombination via strand transfer synthesis. J Biol Chem. 1996 Sep 13; 271(37):22331-8.
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Fuentes GM, Fay PJ, Bambara RA. Relationship between plus strand DNA synthesis removal of downstream segments of RNA by human immunodeficiency virus, murine leukemia virus and avian myeloblastoma virus reverse transcriptases. Nucleic Acids Res. 1996 May 1; 24(9):1719-26.
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Wu W, Palaniappan C, Bambara RA, Fay PJ. Differences in mutagenesis during minus strand, plus strand and strand transfer (recombination) synthesis of the HIV-1 gene in vitro. Nucleic Acids Res. 1996 May 1; 24(9):1710-8.
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Fay PJ, Beattie TL, Regan LM, O'Brien LM, Kaufman RJ. Model for the factor VIIIa-dependent decay of the intrinsic factor Xase. Role of subunit dissociation and factor IXa-catalyzed proteolysis. J Biol Chem. 1996 Mar 15; 271(11):6027-32.
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Regan LM, O'Brien LM, Beattie TL, Sudhakar K, Walker FJ, Fay PJ. Activated protein C-catalyzed proteolysis of factor VIIIa alters its interactions within factor Xase. J Biol Chem. 1996 Feb 23; 271(8):3982-7.
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Palaniappan C, Fuentes GM, Rodríguez-Rodríguez L, Fay PJ, Bambara RA. Helix structure and ends of RNA/DNA hybrids direct the cleavage specificity of HIV-1 reverse transcriptase RNase H. J Biol Chem. 1996 Jan 26; 271(4):2063-70.
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Fuentes GM, Rodríguez-Rodríguez L, Palaniappan C, Fay PJ, Bambara RA. Strand displacement synthesis of the long terminal repeats by HIV reverse transcriptase. J Biol Chem. 1996 Jan 26; 271(4):1966-71.
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Fuentes GM, Rodríguez-Rodríguez L, Fay PJ, Bambara RA. Use of an oligoribonucleotide containing the polypurine tract sequence as a primer by HIV reverse transcriptase. J Biol Chem. 1995 Nov 24; 270(47):28169-76.
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O'Brien LM, Medved LV, Fay PJ. Localization of factor IXa and factor VIIIa interactive sites. J Biol Chem. 1995 Nov 10; 270(45):27087-92.
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Rodríguez-Rodríguez L, Tsuchihashi Z, Fuentes GM, Bambara RA, Fay PJ. Influence of human immunodeficiency virus nucleocapsid protein on synthesis and strand transfer by the reverse transcriptase in vitro. J Biol Chem. 1995 Jun 23; 270(25):15005-11.
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Regan LM, Fay PJ. Cleavage of factor VIII light chain is required for maximal generation of factor VIIIa activity. J Biol Chem. 1995 Apr 14; 270(15):8546-52.
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Palaniappan C, Fay PJ, Bambara RA. Nevirapine alters the cleavage specificity of ribonuclease H of human immunodeficiency virus 1 reverse transcriptase. J Biol Chem. 1995 Mar 3; 270(9):4861-9.
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Wu W, Blumberg BM, Fay PJ, Bambara RA. Strand transfer mediated by human immunodeficiency virus reverse transcriptase in vitro is promoted by pausing and results in misincorporation. J Biol Chem. 1995 Jan 6; 270(1):325-32.
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Bambara RA, Fay PJ, Mallaber LM. Methods of analyzing processivity. Methods Enzymol. 1995; 262:270-80.
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DeStefano JJ, Wu W, Seehra J, McCoy J, Laston D, Albone E, Fay PJ, Bambara RA. Characterization of an RNase H deficient mutant of human immunodeficiency virus-1 reverse transcriptase having an aspartate to asparagine change at position 498. Biochim Biophys Acta. 1994 Oct 18; 1219(2):380-8.
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DeStefano JJ, Mallaber LM, Fay PJ, Bambara RA. Quantitative analysis of RNA cleavage during RNA-directed DNA synthesis by human immunodeficiency and avian myeloblastosis virus reverse transcriptases. Nucleic Acids Res. 1994 Sep 11; 22(18):3793-800.
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Fay PJ, Beattie T, Huggins CF, Regan LM. Factor VIIIa A2 subunit residues 558-565 represent a factor IXa interactive site. J Biol Chem. 1994 Aug 12; 269(32):20522-7.
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Regan LM, Lamphear BJ, Huggins CF, Walker FJ, Fay PJ. Factor IXa protects factor VIIIa from activated protein C. Factor IXa inhibits activated protein C-catalyzed cleavage of factor VIIIa at Arg562. J Biol Chem. 1994 Apr 1; 269(13):9445-52.
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DeStefano JJ, Bambara RA, Fay PJ. The mechanism of human immunodeficiency virus reverse transcriptase-catalyzed strand transfer from internal regions of heteropolymeric RNA templates. J Biol Chem. 1994 Jan 7; 269(1):161-8.
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Buiser RG, Bambara RA, Fay PJ. Pausing by retroviral DNA polymerases promotes strand transfer from internal regions of RNA donor templates to homopolymeric acceptor templates. Biochim Biophys Acta. 1993 Oct 19; 1216(1):20-30.
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Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ. Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma. Blood. 1993 Oct 15; 82(8):2406-13.
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DeStefano JJ, Mallaber LM, Fay PJ, Bambara RA. Determinants of the RNase H cleavage specificity of human immunodeficiency virus reverse transcriptase. Nucleic Acids Res. 1993 Sep 11; 21(18):4330-8.
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Fay PJ, Haidaris PJ, Huggins CF. Role of the COOH-terminal acidic region of A1 subunit in A2 subunit retention in human factor VIIIa. J Biol Chem. 1993 Aug 25; 268(24):17861-6.
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DeStefano JJ, Bambara RA, Fay PJ. Parameters that influence the binding of human immunodeficiency virus reverse transcriptase to nucleic acid structures. Biochemistry. 1993 Jul 13; 32(27):6908-15.
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Fay PJ. Factor VIII structure and function. Thromb Haemost. 1993 Jul 1; 70(1):63-7.
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Lollar P, Fay PJ, Fass DN. Factor VIII and factor VIIIa. Methods Enzymol. 1993; 222:128-43.
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Lamphear BJ, Fay PJ. Proteolytic interactions of factor IXa with human factor VIII and factor VIIIa. Blood. 1992 Dec 15; 80(12):3120-6.
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Lollar P, Parker ET, Fay PJ. Coagulant properties of hybrid human/porcine factor VIII molecules. J Biol Chem. 1992 Nov 25; 267(33):23652-7.
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DeStefano JJ, Mallaber LM, Rodriguez-Rodriguez L, Fay PJ, Bambara RA. Requirements for strand transfer between internal regions of heteropolymer templates by human immunodeficiency virus reverse transcriptase. J Virol. 1992 Nov; 66(11):6370-8.
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DeStefano JJ, Buiser RG, Mallaber LM, Fay PJ, Bambara RA. Parameters that influence processive synthesis and site-specific termination by human immunodeficiency virus reverse transcriptase on RNA and DNA templates. Biochim Biophys Acta. 1992 Jul 15; 1131(3):270-80.
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Fay PJ, Smudzin TM. Characterization of the interaction between the A2 subunit and A1/A3-C1-C2 dimer in human factor VIIIa. J Biol Chem. 1992 Jul 5; 267(19):13246-50.
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Walker FJ, Fay PJ. Regulation of blood coagulation by the protein C system. FASEB J. 1992 May; 6(8):2561-7.
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Lamphear BJ, Fay PJ. Factor IXa enhances reconstitution of factor VIIIa from isolated A2 subunit and A1/A3-C1-C2 dimer. J Biol Chem. 1992 Feb 25; 267(6):3725-30.
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DeStefano JJ, Buiser RG, Mallaber LM, Bambara RA, Fay PJ. Human immunodeficiency virus reverse transcriptase displays a partially processive 3' to 5' endonuclease activity. J Biol Chem. 1991 Dec 25; 266(36):24295-301.
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Fay PJ, Smudzin TM, Walker FJ. Activated protein C-catalyzed inactivation of human factor VIII and factor VIIIa. Identification of cleavage sites and correlation of proteolysis with cofactor activity. J Biol Chem. 1991 Oct 25; 266(30):20139-45.
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Buiser RG, DeStefano JJ, Mallaber LM, Fay PJ, Bambara RA. Requirements for the catalysis of strand transfer synthesis by retroviral DNA polymerases. J Biol Chem. 1991 Jul 15; 266(20):13103-9.
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Fay PJ, Haidaris PJ, Smudzin TM. Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit. J Biol Chem. 1991 May 15; 266(14):8957-62.
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DeStefano JJ, Buiser RG, Mallaber LM, Myers TW, Bambara RA, Fay PJ. Polymerization and RNase H activities of the reverse transcriptases from avian myeloblastosis, human immunodeficiency, and Moloney murine leukemia viruses are functionally uncoupled. J Biol Chem. 1991 Apr 25; 266(12):7423-31.
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Fay PJ, Coumans JV, Walker FJ. von Willebrand factor mediates protection of factor VIII from activated protein C-catalyzed inactivation. J Biol Chem. 1991 Feb 5; 266(4):2172-7.
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Fowler WE, Fay PJ, Arvan DS, Marder VJ. Electron microscopy of human factor V and factor VIII: correlation of morphology with domain structure and localization of factor V activation fragments. Proc Natl Acad Sci U S A. 1990 Oct; 87(19):7648-52.
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Fay PJ, Smudzin TM. Topography of the human factor VIII-von Willebrand factor complex. J Biol Chem. 1990 Apr 15; 265(11):6197-202.
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Walker FJ, Fay PJ. Characterization of an interaction between protein C and ceruloplasmin. J Biol Chem. 1990 Feb 5; 265(4):1834-6.
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Walker FJ, Scandella D, Fay PJ. Identification of the binding site for activated protein C on the light chain of factors V and VIII. J Biol Chem. 1990 Jan 25; 265(3):1484-9.
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Fay PJ, Smudzin TM. Intersubunit fluorescence energy transfer in human factor VIII. J Biol Chem. 1989 Aug 25; 264(24):14005-10.
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Fay PJ, Walker FJ. Inactivation of human factor VIII by activated protein C: evidence that the factor VIII light chain contains the activated protein C binding site. Biochim Biophys Acta. 1989 Feb 2; 994(2):142-8.
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Fay PJ. Reconstitution of human factor VIII from isolated subunits. Arch Biochem Biophys. 1988 May 1; 262(2):525-31.
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Fay PJ. Subunit structure of thrombin-activated human factor VIIIa. Biochim Biophys Acta. 1988 Jan 29; 952(2):181-90.
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Wagner DD, Fay PJ, Sporn LA, Sinha S, Lawrence SO, Marder VJ. Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells. Proc Natl Acad Sci U S A. 1987 Apr; 84(7):1955-9.
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Walker FJ, Chavin SI, Fay PJ. Inactivation of factor VIII by activated protein C and protein S. Arch Biochem Biophys. 1987 Jan; 252(1):322-8.
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Wagner DD, Lawrence SO, Ohlsson-Wilhelm BM, Fay PJ, Marder VJ. Topology and order of formation of interchain disulfide bonds in von Willebrand factor. Blood. 1987 Jan; 69(1):27-32.
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Fay PJ, Anderson MT, Chavin SI, Marder VJ. The size of human factor VIII heterodimers and the effects produced by thrombin. Biochim Biophys Acta. 1986 Jun 23; 871(3):268-78.
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Fay PJ, Kawai Y, Wagner DD, Ginsburg D, Bonthron D, Ohlsson-Wilhelm BM, Chavin SI, Abraham GN, Handin RI, Orkin SH, et al. Propolypeptide of von Willebrand factor circulates in blood and is identical to von Willebrand antigen II. Science. 1986 May 23; 232(4753):995-8.
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Fay PJ, Cavallaro C, Marder VJ, Pancham N, Fournel MA, Schroeder DD. Comparison of the in vivo survival of human factor VIII with and without von Willebrand factor in the hemophilic dog. Thromb Res. 1986 Feb 1; 41(3):425-9.
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Fay PJ, Chavin SI, Malone JE, Schroeder D, Young FE, Marder VJ. The effect of carbohydrate depletion on procoagulant activity and in vivo survival of highly purified human factor VIII. Biochim Biophys Acta. 1984 Jul 30; 800(2):152-8.
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LaDuca RJ, Fay PJ, Chuang C, McHenry CS, Bambara RA. Site-specific pausing of deoxyribonucleic acid synthesis catalyzed by four forms of Escherichia coli DNA polymerase III. Biochemistry. 1983 Oct 25; 22(22):5177-88.
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Fay PJ, Chavin SI, Schroeder D, Young FE, Marder VJ. Purification and characterization of a highly purified human factor VIII consisting of a single type of polypeptide chain. Proc Natl Acad Sci U S A. 1982 Dec; 79(23):7200-204.
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Fay PJ, Johanson KO, McHenry CS, Bambara RA. Size classes of products synthesized processively by two subassemblies of Escherichia coli DNA polymerase III holoenzyme. J Biol Chem. 1982 May 25; 257(10):5692-9.
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Villani G, Fay PJ, Bambara RA, Lehman IR. Elongation of RNA-primed DNA templates by DNA polymerase alpha from Drosophila melanogaster embryos. J Biol Chem. 1981 Aug 10; 256(15):8202-7.
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Fay PJ, Johanson KO, McHenry CS, Bambara RA. Size classes of products synthesized processively by DNA polymerase III and DNA polymerase III holoenzyme of Escherichia coli. J Biol Chem. 1981 Jan 25; 256(2):976-83.
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Matson SW, Fay PJ, Bambara RA. Mechanism of inhibition of the avian myeloblastosis virus deoxyribonucleic acid polymerase by adriamycin. Biochemistry. 1980 May 13; 19(10):2089-96.
