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Bruce Fenton

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentRadiation Oncology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 704
Rochester NY 14642
 
 Awards And Honors
      1980 Lamport Award: Top Presentation at Microcirculatory Soc. Meeting, Los Angeles, CA
      1992 Invited Presentation, NIH workshop: "Oxygen in human tumors: Correlations Between Methods of Measurement and Response to Therapy", National Cancer Institute
      1992 Invited Presentation, Symposium on "Geographical Physiology of Tumors", Radiation Research Meeting, Salt Lake City, UT
      1996 Distinguished Visitor Series, "Tumor Biology", University of Tennessee Biomedical Engineering Department, Memphis, TN
      1998 Invited Presentation, "Microregional Measurement of Tumor Oxygenation and Vascular Structure", Bristol-Myers/Squibb Pharmaceutical Corp., Princeton, NJ
      1998 Invited Presentation, Symposium on "Cancer Cells and the Microvasculature", Biomedical Engineering Society Annual Meeting, Cleveland, OH
      1999 Radiation Research Society Travel Award to attend 11th International Congress of Radiation Research Meeting in Dublin, Ireland
      2001 Invited Presentation, First Radiation Therapy Oncology Group Workshop for Translational Research, "Effect of Angiogenesis Factor Expression on Tumor Vascular Distribution and Function", Tampa, FL
      2001 Casarett Translational Research Award, Department of Radiation Oncology, University of Rochester Medical Center, Rochester, NY
      2002 Invited Presentation, Banbury Center Meeting: A critical review of endostatin and its biology, "Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas", Cold Spring Harbor Laboratory, NY
      2003 Invited Presentation, Regional Cancer Center Consortium for the Biological Therapy of Cancer, "VEGF Receptor-2-Blocking Antibody Potentiates the Antitumor Effects of Fractionated Radiotherapy", Roswell Park Cancer Center, Buffalo, NY.
2010     Casarett Research Award  | Department of Radiation Oncology
 
 Selected Publications
List All   |   Timeline
  1. Zhang L, Sun W, Wang J, Zhang M, Yang S, Tian Y, Vidyasagar S, Peña LA, Zhang K, Cao Y, Yin L, Wang W, Zhang L, Schaefer KL, Saubermann LJ, Swarts SG, Fenton BM, Keng PC, Okunieff P. Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation. Int J Radiat Oncol Biol Phys. 2010 May 1; 77(1):261-8.
    View in: PubMed
  2. Nott SL, Huang Y, Kalkanoglu A, Harper K, Chen M, Paoni SF, Fenton BM, Muyan M. Designer monotransregulators provide a basis for a transcriptional therapy for de novo endocrine-resistant breast cancer. Mol Med. 2010 Jan-Feb; 16(1-2):10-8.
    View in: PubMed
  3. Zhang H, Zhang SB, Sun W, Yang S, Zhang M, Wang W, Liu C, Zhang K, Swarts S, Fenton BM, Keng P, Maguire D, Okunieff P, Zhang L. B1 sequence-based real-time quantitative PCR: a sensitive method for direct measurement of mouse plasma DNA levels after gamma irradiation. Int J Radiat Oncol Biol Phys. 2009 Aug 1; 74(5):1592-9.
    View in: PubMed
  4. Fenton BM, Paoni SF. Alterations in daily sequencing of axitinib and fractionated radiotherapy do not affect tumor growth inhibition or pathophysiological response. Radiat Res. 2009 May; 171(5):606-14.
    View in: PubMed
  5. Fenton BM, Paoni SF. The addition of AG-013736 to fractionated radiation improves tumor response without functionally normalizing the tumor vasculature. Cancer Res. 2007 Oct 15; 67(20):9921-8.
    View in: PubMed
  6. Wang W, Yang S, Su Y, Xiao Z, Wang C, Li X, Lin L, Fenton BM, Paoni SF, Ding I, Keng P, Okunieff P, Zhang L. Enhanced antitumor effect of combined triptolide and ionizing radiation. Clin Cancer Res. 2007 Aug 15; 13(16):4891-9.
    View in: PubMed
  7. Okunieff P, Sun J, Fenton B, Liu W, Ding I. Intratumoral VEGF and FGF1 administration alters tumor growth, vascular density, oxygenation, and expression of MCP-1 and interleukins. Adv Exp Med Biol. 2007; 599:109-16.
    View in: PubMed
  8. Sun J, Ding I, Fenton B, Yi WS, Okunieff P. Immunohistochemical identification and localization of endogenous endostatin and its related peptides in murine tumors. Adv Exp Med Biol. 2007; 599:147-53.
    View in: PubMed
  9. Xiao Z, Su Y, Yang S, Yin L, Wang W, Yi Y, Fenton BM, Zhang L, Okunieff P. Protective effect of esculentoside A on radiation-induced dermatitis and fibrosis. Int J Radiat Oncol Biol Phys. 2006 Jul 1; 65(3):882-9.
    View in: PubMed
  10. Winey BA, Misic V, Liao L, Parker K, Fenton BM, Yu Y. In vivo cancer diagnosis with optical spectroscopy and acoustically induced blood stasis using a murine MCa35 model. Med Phys. 2006 Jun; 33(6):1623-33.
    View in: PubMed
  11. Okunieff P, Fenton B, Chen Y. Past, present, and future of oxygen in cancer research. Adv Exp Med Biol. 2005; 566:213-22.
    View in: PubMed
  12. Winey B, Misic V, Fenton B, Paoni S, Liao L, Okunieff P, Liu H, Parker K, Yu Y. In vivo Optical Spectroscopy of Acoustically Induced Blood Stasis. Conf Proc IEEE Eng Med Biol Soc. 2005; 2:1449-52.
    View in: PubMed
  13. Misic V, Winey B, Liu H, Liao L, Okunieff P, Parker K, Fenton B, Yu Y. Tumor Detection in vivo with Optical Spectroscopy. Conf Proc IEEE Eng Med Biol Soc. 2005; 5:4708-11.
    View in: PubMed
  14. Fenton BM, Paoni SF, Grimwood B, Ding I. Varied response of spontaneous tumors to antiangiogenic agents. Adv Exp Med Biol. 2005; 566:59-65.
    View in: PubMed
  15. Fenton BM, Paoni SF, Ding I. Pathophysiological effects of vascular endothelial growth factor receptor-2-blocking antibody plus fractionated radiotherapy on murine mammary tumors. Cancer Res. 2004 Aug 15; 64(16):5712-9.
    View in: PubMed
  16. Fenton BM, Paoni SF, Ding I. Effect of VEGF receptor-2 antibody on vascular function and oxygenation in spontaneous and transplanted tumors. Radiother Oncol. 2004 Aug; 72(2):221-30.
    View in: PubMed
  17. Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, Finkelstein JN. Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model. Radiat Res. 2004 May; 161(5):560-7.
    View in: PubMed
  18. Fenton BM, Paoni SF, Liu W, Cheng SY, Hu B, Ding I. Overexpression of VEGF121, but not VEGF165 or FGF-1, improves oxygenation in MCF-7 breast tumours. Br J Cancer. 2004 Jan 26; 90(2):430-5.
    View in: PubMed
  19. Fenton BM, Paoni SF, Grimwood BG, Ding I. Disparate effects of endostatin on tumor vascular perfusion and hypoxia in two murine mammary carcinomas. Int J Radiat Oncol Biol Phys. 2003 Nov 15; 57(4):1038-46.
    View in: PubMed
  20. Liu W, Chen Y, Wang W, Keng P, Finkelstein J, Hu D, Liang L, Guo M, Fenton B, Okunieff P, Ding I. Combination of radiation and celebrex (celecoxib) reduce mammary and lung tumor growth. Am J Clin Oncol. 2003 Aug; 26(4):S103-9.
    View in: PubMed
  21. Guo P, Fang Q, Tao HQ, Schafer CA, Fenton BM, Ding I, Hu B, Cheng SY. Overexpression of vascular endothelial growth factor by MCF-7 breast cancer cells promotes estrogen-independent tumor growth in vivo. Cancer Res. 2003 Aug 1; 63(15):4684-91.
    View in: PubMed
  22. Gerber SA, Moran JP, Frelinger JG, Frelinger JA, Fenton BM, Lord EM. Mechanism of IL-12 mediated alterations in tumour blood vessel morphology: analysis using whole-tissue mounts. Br J Cancer. 2003 May 6; 88(9):1453-61.
    View in: PubMed
  23. Fenton BM, Paoni SF. Oxygenation and vascular perfusion in spontaneous and transplanted tumor models. Adv Exp Med Biol. 2003; 530:165-76.
    View in: PubMed
  24. Ding I, Liu W, Sun J, Paoni SF, Hernady E, Fenton BM, Okunieff P. FGF1 and VEGF mediated angiogenesis in KHT tumor-bearing mice. Adv Exp Med Biol. 2003; 530:603-9.
    View in: PubMed
  25. Fenton BM, Paoni SF, Beauchamp BK, Tran B, Liang L, Grimwood B, Ding I. Evaluation of microregional variations in tumor hypoxia following the administration of endostatin. Adv Exp Med Biol. 2003; 510:19-24.
    View in: PubMed
  26. Okunieff P, Fenton BM, Zhang L, Kern FG, Wu T, Greg JR, Ding I. Fibroblast growth factors (FGFS) increase breast tumor growth rate, metastases, blood flow, and oxygenation without significant change in vascular density. Adv Exp Med Biol. 2003; 530:593-601.
    View in: PubMed
  27. Ding I, Okunieff P, Salnikow K, Liu W, Fenton B. A new intrinsic hypoxia marker in esophageal cancer. Adv Exp Med Biol. 2003; 540:227-33.
    View in: PubMed
  28. Fenton BM, Paoni SF, Beauchamp BK, Ding I. Zonal image analysis of tumour vascular perfusion, hypoxia, and necrosis. Br J Cancer. 2002 Jun 5; 86(11):1831-6.
    View in: PubMed
  29. Ding I, Liu W, Sun J, Fenton B, Okunieff P. Comparison and modulation of angiogenic responses by FGFs, VEGF and SCF in murine and human fibrosarcomas. Comp Biochem Physiol A Mol Integr Physiol. 2002 May; 132(1):17-25.
    View in: PubMed
  30. Fenton BM, Beauchamp BK, Paoni SF, Okunieff P, Ding I. Characterization of the effects of antiangiogenic agents on tumor pathophysiology. Am J Clin Oncol. 2001 Oct; 24(5):453-7.
    View in: PubMed
  31. Okunieff P, Li M, Liu W, Sun J, Fenton B, Zhang L, Ding I. Keratinocyte growth factors radioprotect bowel and bone marrow but not KHT sarcoma. Am J Clin Oncol. 2001 Oct; 24(5):491-5.
    View in: PubMed
  32. Fenton BM, Lord EM, Paoni SF. Intravascular HBO(2) saturations, perfusion and hypoxia in spontaneous and transplanted tumor models. Int J Cancer. 2001 Sep 1; 93(5):693-8.
    View in: PubMed
  33. Fenton BM. Influence of hydralazine administration on oxygenation in spontaneous and transplanted tumor models. Int J Radiat Oncol Biol Phys. 2001 Mar 1; 49(3):799-808.
    View in: PubMed
  34. Fenton BM, Lord EM, Paoni SF. Effects of radiation on tumor intravascular oxygenation, vascular configuration, development of hypoxia, and clonogenic survival. Radiat Res. 2001 Feb; 155(2):360-8.
    View in: PubMed
  35. Ding I, Sun JZ, Fenton B, Liu WM, Kimsely P, Okunieff P, Min W. Intratumoral administration of endostatin plasmid inhibits vascular growth and perfusion in MCa-4 murine mammary carcinomas. Cancer Res. 2001 Jan 15; 61(2):526-31.
    View in: PubMed
  36. Conover DL, Fenton BM, Foster TH, Hull EL. An evaluation of near infrared spectroscopy and cryospectrophotometry estimates of haemoglobin oxygen saturation in a rodent mammary tumour model. Phys Med Biol. 2000 Sep; 45(9):2685-700.
    View in: PubMed
  37. Lee J, Moran JP, Fenton BM, Koch CJ, Frelinger JG, Keng PC, Lord EM. Alteration of tumour response to radiation by interleukin-2 gene transfer. Br J Cancer. 2000 Feb; 82(4):937-44.
    View in: PubMed
  38. Fenton BM, Lord EM, Paoni SF. Enhancement of tumor perfusion and oxygenation by carbogen and nicotinamide during single- and multifraction irradiation. Radiat Res. 2000 Jan; 153(1):75-83.
    View in: PubMed
  39. Lava Kumar P, Fenton B, Jones AT. Identification of cecidophyopsis mites (Acari: Eriophyidae) based on variable simple sequence repeats of ribosomal DNA internal transcribed spacer-1 sequences via multiplex PCR. Insect Mol Biol. 1999 Aug; 8(3):347-57.
    View in: PubMed
  40. Schell MC, Rosenzweig DP, Weaver KA, Fenton BM, Rubin P. Characterization of the dose perturbation by stents as a function of X-ray beam energy. Cardiovasc Radiat Med. 1999 Apr-Jun; 1(2):154-9.
    View in: PubMed
  41. Fenton BM, Paoni SF, Lee J, Koch CJ, Lord EM. Quantification of tumour vasculature and hypoxia by immunohistochemical staining and HbO2 saturation measurements. Br J Cancer. 1999 Feb; 79(3-4):464-71.
    View in: PubMed
  42. Merikangas KR, Stolar M, Stevens DE, Goulet J, Preisig MA, Fenton B, Zhang H, O'Malley SS, Rounsaville BJ. Familial transmission of substance use disorders. Arch Gen Psychiatry. 1998 Nov; 55(11):973-9.
    View in: PubMed
  43. Lee J, Fenton BM, Koch CJ, Frelinger JG, Lord EM. Interleukin 2 expression by tumor cells alters both the immune response and the tumor microenvironment. Cancer Res. 1998 Apr 1; 58(7):1478-85.
    View in: PubMed
  44. Fenton BM, Paoni SF, Koch CJ, Lord EM. Effect of local irradiation on tumor oxygenation, perfused vessel density, and development of hypoxia. Adv Exp Med Biol. 1998; 454:619-28.
    View in: PubMed
  45. Fenton BM. Effects of carbogen plus fractionated irradiation on KHT tumor oxygenation. Radiother Oncol. 1997 Aug; 44(2):183-90.
    View in: PubMed
  46. Kiani MF, Fenton BM, Sporn LA, Siemann DW. Effects of ionizing radiation on the adhesive interaction of human tumor and endothelial cells in vitro. Clin Exp Metastasis. 1997 Jan; 15(1):12-8.
    View in: PubMed
  47. Fenton BM, Kiani MF, Siemann DW. Should direct measurements of tumor oxygenation relate to the radiobiological hypoxic fraction of a tumor? Int J Radiat Oncol Biol Phys. 1995 Sep 30; 33(2):365-73.
    View in: PubMed
  48. Fenton BM. The effects of carbogen and nicotinamide on intravascular oxyhaemoglobin saturations in SCCVII and KHT murine tumours. Br J Cancer. 1995 May; 71(5):945-9.
    View in: PubMed
  49. Kiani MF, Fenton BM. Inherent cellular differences may explain the dissimilar survival of RIF-1 and KHT tumour cells under aerobic and hypoxic conditions. Int J Radiat Biol. 1995 Apr; 67(4):449-52.
    View in: PubMed
  50. Fenton BM, Siemann DW. Are direct measures of tumor oxygenation reflective of changes in tumor radiosensitivity following oxygen manipulation? Acta Oncol. 1995; 34(3):307-11.
    View in: PubMed
  51. Fenton BM, Raubertas RF, Boyce DJ. Quantification of micro-regional heterogeneities in tumor oxygenation using intravascular HbO2 saturations. Radiat Res. 1995 Jan; 141(1):49-56.
    View in: PubMed
  52. Fenton BM, Boyce DJ. Micro-regional mapping of HbO2 saturations and blood flow following nicotinamide administration. Int J Radiat Oncol Biol Phys. 1994 Jun 15; 29(3):459-62.
    View in: PubMed
  53. Fenton BM, Siemann DW. Investigations of perfusion-limited hypoxia and oxygenation in the KHT sarcoma. Adv Exp Med Biol. 1994; 361:627-34.
    View in: PubMed
  54. Fenton BM, Way BA. Vascular morphometry of KHT and RIF-1 murine sarcomas. Radiother Oncol. 1993 Jul; 28(1):57-62.
    View in: PubMed
  55. Fenton BM, Sutherland RM. Effect of flunarizine on micro-regional distributions of intravascular HbO2 saturations in RIF-1 and KHT sarcomas. Int J Radiat Oncol Biol Phys. 1992; 22(3):447-50.
    View in: PubMed
  56. Fenton BM, Sutherland RM. Effects of anaesthetic agent on [31P]NMR high-energy phosphates and regional distributions of intravascular oxyhaemoglobin saturations. Int J Radiat Biol. 1991 Jul-Aug; 60(1-2):115-9.
    View in: PubMed
  57. Fenton BM, Raubertas RF, Sutherland RM. Time-dependent effects of anesthetic agents on 31P NMR high-energy phosphates in KHT and RIF-1 fibrosarcomas. NMR Biomed. 1991 Jun; 4(3):137-41.
    View in: PubMed
  58. Fenton BM, Gayeski TE. Determination of microvascular oxyhemoglobin saturations using cryospectrophotometry. Am J Physiol. 1990 Dec; 259(6 Pt 2):H1912-20.
    View in: PubMed
  59. Mueller-Klieser W, Schaefer C, Walenta S, Rofstad EK, Fenton BM, Sutherland RM. Assessment of tumor energy and oxygenation status by bioluminescence, nuclear magnetic resonance spectroscopy, and cryospectrophotometry. Cancer Res. 1990 Mar 15; 50(6):1681-5.
    View in: PubMed
  60. Rofstad EK, DeMuth P, Fenton BM, Ceckler TL, Sutherland RM. 31P NMR spectroscopy and HbO2 cryospectrophotometry in prediction of tumor radioresistance caused by hypoxia. Int J Radiat Oncol Biol Phys. 1989 Apr; 16(4):919-23.
    View in: PubMed
  61. Fenton BM, Rofstad EK, Degner FL, Sutherland RM. Cryospectrophotometric determination of tumor intravascular oxyhemoglobin saturations: dependence on vascular geometry and tumor growth. J Natl Cancer Inst. 1988 Dec 21; 80(20):1612-9.
    View in: PubMed
  62. Rofstad EK, DeMuth P, Fenton BM, Sutherland RM. 31P nuclear magnetic resonance spectroscopy studies of tumor energy metabolism and its relationship to intracapillary oxyhemoglobin saturation status and tumor hypoxia. Cancer Res. 1988 Oct 1; 48(19):5440-6.
    View in: PubMed
  63. Rofstad EK, Fenton BM, Sutherland RM. Intracapillary HbO2 saturations in murine tumours and human tumour xenografts measured by cryospectrophotometry: relationship to tumour volume, tumour pH and fraction of radiobiologically hypoxic cells. Br J Cancer. 1988 May; 57(5):494-502.
    View in: PubMed
  64. Fenton BM, Wilson DW, Cokelet GR. Analysis of the effects of measured white blood cell entrance times on hemodynamics in a computer model of a microvascular bed. Pflugers Arch. 1985 Apr; 403(4):396-401.
    View in: PubMed
  65. Fenton BM, Carr RT, Cokelet GR. Nonuniform red cell distribution in 20 to 100 micrometers bifurcations. Microvasc Res. 1985 Jan; 29(1):103-26.
    View in: PubMed
  66. Fenton BM, Cokelet GR, la Celle PL. Influence of wall surface on the flow of blood through endothelial-lined glass tubes. Int J Microcirc Clin Exp. 1982; 1(2):157-62.
    View in: PubMed
  67. Worthen DM, Fenton BM, Rosen P, Zweifach B. Morphometry of diabetic conjunctival blood vessels. Ophthalmology. 1981 Jul; 88(7):655-7.
    View in: PubMed
  68. Fenton BM, Zweifach BW, Worthen DM. Quantitative morphometry of conjunctival microcirculation in diabetes mellitus. Microvasc Res. 1979 Sep; 18(2):153-66.
    View in: PubMed

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