URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Joseph Holt

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentOtolaryngology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 629
Rochester NY 14642
Other Positions
TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentNeurobiology and Anatomy

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology

 
 Awards And Honors
1986 - 1991Chancellor's Scholar Program  | University of North Carolina at Pembroke
1989     James F. Ebert Award  | University of North Carolina at Pembroke
1989 - 1990J.P. Stevens Scholarship  | University of North Carolina at Pembroke
1997 - 1999Advanced Predoctoral Fellowship  | Pharmaceutical and Research Manufacturers of America (PhRMA)
 
 Overview
RESEARCH:

Cellular and Molecular Mechanisms of Synaptic Transmission in the Vestibular Periphery.

Many sensory systems are endowed with efferent feedback mechanisms that can modulate their primary input to the brain. That is, incoming information from a peripheral detector is delivered to a way station within the CNS which then modifies the output from that same detector. Everyday examples include the pupillary reflex to bright light entering the eyes, the contraction of middle ear muscles to loud sounds, or the recruitment of additional muscle fibers when first lifting a heavy object. Here, the function of the efferent loop is presumably to optimize or "tune" each sensory modality to its stimulus. Sensory information regarding the position and movement of the head are encoded by the vestibular system, which begins as a number of small detectors located within the inner ear. Like the preceding examples, the peripheral vestibular system is also endowed with a prominent efferent innervation. The functional role of this feedback system, however, is relatively unknown. We do know that when these efferent pathways are electrically stimulated, afferent output from vestibular endorgans is profoundly inhibited or excited, suggesting that vestibular efferents may be involved in both negative and positive feedback. If such efferent activity occurs under physiological conditions, it is almost certain to modify and transform vestibular information traveling to the CNS. Yet, very little information is available as to how and when these efferent actions ultimately impact the processing of vestibular information in an alert animal. Taking a reductionistic approach, my lab is addressing the function of the vestibular efferent system from three vantage points: (1) Identifying the receptor mechanisms by which different efferent responses are generated during activation of their pathways; (2) Characterizing how these efferent receptor mechanisms modulate afferent response properties by pairing afferent recordings during vestibular stimulation with activation of efferent pathways; and (3) Identification of efferent discharge patterns with direct, in vivo recordings from vestibular efferent neurons. Such knowledge is critical in evaluating efferent function in behaving animal models, one of our long term goals.

AREA OF RESEARCH:

Sensory pharmacology with an emphasis on efferent and afferent neurotransmission in the vestibular periphery
Cholinergic mechanisms and systems
Glutamatergic mechanisms and systems

RECENT PUBLICATIONS:

Holt JC, Chatlani S, Lysakowski A, Goldberg JM. Quantal and Non-quantal Transmission in Calyx-Bearing Fibers of the Turtle Posterior Crista. J Neurophysiol. 98:1083-101, 2007.

Holt JC, Lysakowski A, Goldberg JM. Mechanisms of efferent-mediated responses in the turtle posterior crista. J Neurosci. 26:13180-93, 2006.

Holt JC, Xue JT, Brichta AM, Goldberg JM. Transmission between type II hair cells and bouton afferents in the turtle posterior crista. J Neurophysiol. 95: 428-452, 2006.

Holt JC, Lioudyno M, Guth PS. A pharmacologically distinct nicotinic ACh receptor is found in a subset of frog semicircular canal hair cells. J Neurophysiol. 90: 1526-36, 2003.

Lioudyno MI, Verbitsky M, Glowatzki E, Holt JC, Boulter J, Zadina JE, Elgoyhen AB, Guth PS. The alpha9/alpha10-containing nicotinic ACh receptor is directly modulated by opioid peptides, endomorphin-1, and dynorphin B, proposed efferent cotransmitters in the inner ear. Mol Cell Neurosci. 20: 695-711, 2002.

Holt JC, Lioudyno M, Athas GB, Garcia MM, Perin P, Guth PS. The effects of proteolytic enzymes on the alpha9-nicotinic receptor-mediated response in isolated frog vestibular hair cells. Hear Res. 152: 25-42, 2001.

 
 Selected Publications
List All   |   Timeline
  1. Goldberg JM, Holt JC. Discharge regularity in the turtle posterior crista: comparisons between experiment and theory. J Neurophysiol. 2013 Dec; 110(12):2830-48.
    View in: PubMed
  2. Jordan PM, Parks XX, Contini D, Holt JC. A review of synaptic mechanisms of vestibular efferent signaling in turtles: Extrapolation to efferent actions in mammals. J Vestib Res. 2013 Jan 1; 23(3):161-75.
    View in: PubMed
  3. Holt JC, Chatlani S, Lysakowski A, Goldberg JM. Quantal and nonquantal transmission in calyx-bearing fibers of the turtle posterior crista. J Neurophysiol. 2007 Sep; 98(3):1083-101.
    View in: PubMed
  4. Holt JC, Lysakowski A, Goldberg JM. Mechanisms of efferent-mediated responses in the turtle posterior crista. J Neurosci. 2006 Dec 20; 26(51):13180-93.
    View in: PubMed
  5. Holt JC, Xue JT, Brichta AM, Goldberg JM. Transmission between type II hair cells and bouton afferents in the turtle posterior crista. J Neurophysiol. 2006 Jan; 95(1):428-52.
    View in: PubMed
  6. Holt JC, Lioudyno M, Guth PS. A pharmacologically distinct nicotinic ACh receptor is found in a subset of frog semicircular canal hair cells. J Neurophysiol. 2003 Sep; 90(3):1526-36.
    View in: PubMed
  7. Lioudyno MI, Verbitsky M, Glowatzki E, Holt JC, Boulter J, Zadina JE, Elgoyhen AB, Guth PS. The alpha9/alpha10-containing nicotinic ACh receptor is directly modulated by opioid peptides, endomorphin-1, and dynorphin B, proposed efferent cotransmitters in the inner ear. Mol Cell Neurosci. 2002 Aug; 20(4):695-711.
    View in: PubMed
  8. Holt JC, Lioudyno M, Athas G, Garcia MM, Perin P, Guth PS. The effect of proteolytic enzymes on the alpha9-nicotinic receptor-mediated response in isolated frog vestibular hair cells. Hear Res. 2001 Feb; 152(1-2):25-42.
    View in: PubMed
  9. Lioudyno MI, Verbitsky M, Holt JC, Elgoyhen AB, Guth PS. Morphine inhibits an alpha9-acetylcholine nicotinic receptor-mediated response by a mechanism which does not involve opioid receptors. Hear Res. 2000 Nov; 149(1-2):167-77.
    View in: PubMed
  10. Holt JC, Pantoja AM, Athas GB, Guth PS. A role for chloride in the hyperpolarizing effect of acetylcholine in isolated frog vestibular hair cells. Hear Res. 2000 Aug; 146(1-2):17-27.
    View in: PubMed
  11. Guth PS, Holt JC, Perin P, Athas G, Garcia M, Puri A, Zucca G, Botta L, Valli P. The metabotropic glutamate receptors of the vestibular organs. Hear Res. 1998 Nov; 125(1-2):154-62.
    View in: PubMed
  12. Norris CH, Miller AJ, Perin P, Holt JC, Guth PS. Mechanisms and effects of transepithelial polarization in the isolated semicircular canal. Hear Res. 1998 Sep; 123(1-2):31-40.
    View in: PubMed
  13. Pantoja AM, Holt JC, Guth PS. A role for chloride in the suppressive effect of acetylcholine on afferent vestibular activity. Hear Res. 1997 Oct; 112(1-2):21-32.
    View in: PubMed
  14. Michel RE, Holt JC, Domer FR. Ketorolac causes the release of methionine-enkephalin in rats. Res Commun Mol Pathol Pharmacol. 1996 Feb; 91(2):249-52.
    View in: PubMed

Visualizations


Holt's Networks

Concepts
_
Similar People
_
Same Department