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John Olschowka

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentNeurobiology and Anatomy
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 603
Rochester NY 14642
 
 Awards And Honors
1974     Sigma Xi Honor Society
1978     Outstanding Teaching Award, Graduate Division
1992     George W. Merck Dean's Teaching Scholar Award
1994     Alumni Award for Excellence in Graduate Education
1995     Student (undergraduate) Advisor of the Year
1996     Commendation for excellence in medical education
2000     Commendation for excellence in medical education
2001     Commendation for excellence in medical education
2003     Commendation for excellence in medical education
2004     Commendation for excellence in medical education
2012     Commendation for Excellence in Medical Education  | University of Rochester
 
 Overview
RECENT RESEARCH:

Models of CNS inflammation.

The inflammatory processes that follow injury (trauma, stroke, seizure, infection, radiation, etc.) to the central nervous system (CNS) dramatically amplify the damage. For example, reduction of the inflammatory process following stroke has been shown to limit the volume of damaged tissue by 2/3's. Our laboratory is currently working to better understand the mechanisms of inflammation within the CNS. Currently we are examining several clinically relevant areas of CNS inflammation, most in collaboration with Dr. Kerry O'Banion. First, we are using a model of damage to the CNS caused by gamma-irradiation. Treatment of brain tumors with radiation leads to long-term damage of the normal brain tissue, damage caused by a massive inflammatory response. This model will be expanded beginning in the fall of 2008 by a NIAID funded pilot project as we examine the effects of combined injuries, radiation and a peripheral injury, on the functioning of both brain and lung. In a related model, we are examining the effect of cosmic radiation (similar to the exposure received in space) on the CNS. Third, using several transgenic mouse models of Alzheimer's disease coupled with a model of chronic inflammation, we are exploring the possible beneficial effects of inflammation in the clearing of Aß plaque pathology. Fourth, in a project begun this year, we are examining the potential brain injuring effects of underwater sound exposure. This project funded by the Office of Naval Research is interested in the use of sound exposure as a non-lethal weapon. Our final and newest area of research examines late appearing cytokines following brain injury. While suppression of acute pro-inflammatory cytokines has worked well in animal models, they have not proven useful clinically. We are now examining the late appearing cytokine HMGB-1 and its receptors (RAGE, TLR4 and TLR2) in a model of traumatic brain injury. With a better understanding, we hope to limit the inflammatory response and thus improve the effectiveness of therapy. Using techniques such as light microscopic immunocytochemistry, in situ hybridization, computerized image analysis, quantitative real time RT-PCR, and the immunohistochemical methods for detection of apoptosis, we have begun to unravel the cell types, cytokines, chemokines, apoptotic genes, and adhesion molecules involved in CNS inflammation.
With the aid of a pilot grant from the Schmitt Foundation, we are now beginning to examine to role of CNS inflammation in the development of seizure activity. Following a variety of inflammation models (radiation-induced, Alzheimer's transgenic mice, peripheral inflammation, etc), we have begun to record EEG's from mice to determine alterations in susceptibility to seizure activity.

PUBLICATIONS:

Matousek, S.B., A.M. Hein, S.S. Shaftel, J.A. Olschowka, S. Kyrkanides, and M.K. O'Banion. Cyclooxygenase-1 mediates prostaglandin E2 elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1? expression. J. Neurochem. In press.
Hein AM, Stasko, MR, Matousek SB, Scott-McKean JJ, Maier SF, Olschowka JA, Costa AC, O'Banion MK. Sustained hippocampal IL-1ß overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav. Immun. 2009, PMCID: PMC2818290
Kyrakanides S, Miller AW, Miller JN, Tallents RH, Brouxhon SM, Olschowka ME, O'Banion MK, Olschowka JA. Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration. J Neuroimmunol. 203 (2008):50-57,.
Shaftel, S. S.; Carlson, T. J.; Olschowka, J. A.; Kyrkanides, S.; Matousek, S. B.; O'Banion, M. K.;. "Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration". J Neurosci 27 (2007): 9301-9.

 
 Selected Publications
List All   |   Timeline
  1. Cherry JD, Williams JP, O'Banion MK, Olschowka JA. Thermal injury lowers the threshold for radiation-induced neuroinflammation and cognitive dysfunction. Radiat Res. 2013 Oct; 180(4):398-406.
    View in: PubMed
  2. Montgomery SL, Narrow WC, Mastrangelo MA, Olschowka JA, O'Banion MK, Bowers WJ. Chronic Neuron- and Age-Selective Down-Regulation of TNF Receptor Expression in Triple-Transgenic Alzheimer Disease Mice Leads to Significant Modulation of Amyloid- and Tau-Related Pathologies. Am J Pathol. 2013 Jun; 182(6):2285-97.
    View in: PubMed
  3. Wu MD, Montgomery SL, Rivera-Escalera F, Olschowka JA, O'Banion MK. Sustained IL-1ß expression impairs adult hippocampal neurogenesis independent of IL-1 signaling in nestin(+) neural precursor cells. Brain Behav Immun. 2013 Aug; 32:9-18.
    View in: PubMed
  4. Ghosh S, Wu MD, Shaftel SS, Kyrkanides S, Laferla FM, Olschowka JA, O'Banion MK. Sustained interleukin-1ß overexpression exacerbates tau pathology despite reduced amyloid burden in an Alzheimer's mouse model. J Neurosci. 2013 Mar 13; 33(11):5053-64.
    View in: PubMed
  5. Cherry JD, Liu B, Frost JL, Lemere CA, Williams JP, Olschowka JA, O'Banion MK. Galactic cosmic radiation leads to cognitive impairment and increased aß plaque accumulation in a mouse model of Alzheimer's disease. PLoS One. 2012; 7(12):e53275.
    View in: PubMed
  6. Dilmanian FA, Jenkins AL, Olschowka JA, Zhong Z, Park JY, Desnoyers NR, Sobotka S, Fois GR, Messina CR, Morales M, Hurley SD, Trojanczyk L, Ahmad S, Shahrabi N, Coyle PK, Meek AG, O'Banion MK. X-ray microbeam irradiation of the contusion-injured rat spinal cord temporarily improves hind-limb function. Radiat Res. 2013 Jan; 179(1):76-88.
    View in: PubMed
  7. Kyrkanides S, Brouxhon SM, Tallents RH, Miller JN, Olschowka JA, O'Banion MK. Conditional expression of human ß-hexosaminidase in the neurons of Sandhoff disease rescues mice from neurodegeneration but not neuroinflammation. J Neuroinflammation. 2012; 9:186.
    View in: PubMed
  8. Dilmanian FA, Rusek A, Fois GR, Olschowka J, Desnoyers NR, Park JY, Dioszegi I, Dane B, Wang R, Tomasi D, Lee H, Hurley SD, Coyle PK, Meek AG, O'Banion MK. Interleaved carbon minibeams: an experimental radiosurgery method with clinical potential. Int J Radiat Oncol Biol Phys. 2012 Oct 1; 84(2):514-9.
    View in: PubMed
  9. Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, O'Banion MK. Chronic IL-1ß-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration. J Neuroimmune Pharmacol. 2012 Mar; 7(1):156-64.
    View in: PubMed
  10. Wu MD, Hein AM, Moravan MJ, Shaftel SS, Olschowka JA, O'Banion MK. Adult murine hippocampal neurogenesis is inhibited by sustained IL-1ß and not rescued by voluntary running. Brain Behav Immun. 2012 Feb; 26(2):292-300.
    View in: PubMed
  11. Kyrkanides S, Tallents RH, Miller JN, Olschowka ME, Johnson R, Yang M, Olschowka JA, Brouxhon SM, O'Banion MK. Osteoarthritis accelerates and exacerbates Alzheimer's disease pathology in mice. J Neuroinflammation. 2011; 8:112.
    View in: PubMed
  12. Moravan MJ, Olschowka JA, Williams JP, O'Banion MK. Cranial irradiation leads to acute and persistent neuroinflammation with delayed increases in T-cell infiltration and CD11c expression in C57BL/6 mouse brain. Radiat Res. 2011 Oct; 176(4):459-73.
    View in: PubMed
  13. Hein AM, Zarcone TJ, Parfitt DB, Matousek SB, Carbonari DM, Olschowka JA, O'Banion MK. Behavioral, structural and molecular changes following long-term hippocampal IL-1ß overexpression in transgenic mice. J Neuroimmune Pharmacol. 2012 Mar; 7(1):145-55.
    View in: PubMed
  14. Matousek SB, Hein AM, Shaftel SS, Olschowka JA, Kyrkanides S, O'Banion MK. Cyclooxygenase-1 mediates prostaglandin E(2) elevation and contextual memory impairment in a model of sustained hippocampal interleukin-1beta expression. J Neurochem. 2010 Jul; 114(1):247-58.
    View in: PubMed
  15. Hein AM, Stasko MR, Matousek SB, Scott-McKean JJ, Maier SF, Olschowka JA, Costa AC, O'Banion MK. Sustained hippocampal IL-1beta overexpression impairs contextual and spatial memory in transgenic mice. Brain Behav Immun. 2010 Feb; 24(2):243-53.
    View in: PubMed
  16. Kyrkanides S, Yang M, Tallents RH, Miller JN, Brouxhon SM, Olschowka JA. The trigeminal retrograde transfer pathway in the treatment of neurodegeneration. J Neuroimmunol. 2009 Apr 30; 209(1-2):139-42.
    View in: PubMed
  17. Kyrkanides S, Miller AW, Miller JN, Tallents RH, Brouxhon SM, Olschowka ME, O'Banion MK, Olschowka JA. Peripheral blood mononuclear cell infiltration and neuroinflammation in the HexB-/- mouse model of neurodegeneration. J Neuroimmunol. 2008 Oct 15; 203(1):50-7.
    View in: PubMed
  18. Shaftel SS, Carlson TJ, Olschowka JA, Kyrkanides S, Matousek SB, O'Banion MK. Chronic interleukin-1beta expression in mouse brain leads to leukocyte infiltration and neutrophil-independent blood brain barrier permeability without overt neurodegeneration. J Neurosci. 2007 Aug 29; 27(35):9301-9.
    View in: PubMed
  19. Kyrkanides S, Miller JN, Tallents RH, Brouxhon SM, Centola GM, Olschowka JA. Intraperitoneal inoculation of Sandhoff mouse neonates with an HIV-1 based lentiviral vector exacerbates the attendant neuroinflammation and disease phenotype. J Neuroimmunol. 2007 Aug; 188(1-2):39-47.
    View in: PubMed
  20. Shaftel SS, Kyrkanides S, Olschowka JA, Miller JN, Johnson RE, O'Banion MK. Sustained hippocampal IL-1 beta overexpression mediates chronic neuroinflammation and ameliorates Alzheimer plaque pathology. J Clin Invest. 2007 Jun; 117(6):1595-604.
    View in: PubMed
  21. Lai YC, Shaftel SS, Miller JN, Tallents RH, Chang Y, Pinkert CA, Olschowka JA, Dickerson IM, Puzas JE, O'Banion MK, Kyrkanides S. Intraarticular induction of interleukin-1beta expression in the adult mouse, with resultant temporomandibular joint pathologic changes, dysfunction, and pain. Arthritis Rheum. 2006 Apr; 54(4):1184-97.
    View in: PubMed
  22. Liu W, Ding I, Chen K, Olschowka J, Xu J, Hu D, Morrow GR, Okunieff P. Interleukin 1beta (IL1B) signaling is a critical component of radiation-induced skin fibrosis. Radiat Res. 2006 Feb; 165(2):181-91.
    View in: PubMed
  23. Lioy DT, Sheridan PA, Hurley SD, Walton JR, Martin AM, Olschowka JA, Moynihan JA. Acute morphine exposure potentiates the development of HSV-1-induced encephalitis. J Neuroimmunol. 2006 Mar; 172(1-2):9-17.
    View in: PubMed
  24. Moore AH, Olschowka JA, Williams JP, Okunieff P, O'Banion MK. Regulation of prostaglandin E2 synthesis after brain irradiation. Int J Radiat Oncol Biol Phys. 2005 May 1; 62(1):267-72.
    View in: PubMed
  25. Kyrkanides S, Miller JH, Brouxhon SM, Olschowka JA, Federoff HJ. beta-hexosaminidase lentiviral vectors: transfer into the CNS via systemic administration. Brain Res Mol Brain Res. 2005 Feb 18; 133(2):286-98.
    View in: PubMed
  26. Moore AH, Olschowka JA, O'Banion MK. Intraparenchymal administration of interleukin-1beta induces cyclooxygenase-2-mediated expression of membrane- and cytosolic-associated prostaglandin E synthases in mouse brain. J Neuroimmunol. 2004 Mar; 148(1-2):32-40.
    View in: PubMed
  27. Moore AH, Olschowka JA, Williams JP, Paige SL, O'Banion MK. Radiation-induced edema is dependent on cyclooxygenase 2 activity in mouse brain. Radiat Res. 2004 Feb; 161(2):153-60.
    View in: PubMed
  28. Hurley SD, O'Banion MK, Song DD, Arana FS, Olschowka JA, Haber SN. Microglial response is poorly correlated with neurodegeneration following chronic, low-dose MPTP administration in monkeys. Exp Neurol. 2003 Dec; 184(2):659-68.
    View in: PubMed
  29. Shaftel SS, Olschowka JA, Hurley SD, Moore AH, O'Banion MK. COX-3: a splice variant of cyclooxygenase-1 in mouse neural tissue and cells. Brain Res Mol Brain Res. 2003 Nov 26; 119(2):213-5.
    View in: PubMed
  30. Bowers WJ, Olschowka JA, Federoff HJ. Immune responses to replication-defective HSV-1 type vectors within the CNS: implications for gene therapy. Gene Ther. 2003 Jun; 10(11):941-5.
    View in: PubMed
  31. Olschowka JA, Bowers WJ, Hurley SD, Mastrangelo MA, Federoff HJ. Helper-free HSV-1 amplicons elicit a markedly less robust innate immune response in the CNS. Mol Ther. 2003 Feb; 7(2):218-27.
    View in: PubMed
  32. Kyrkanides S, Moore AH, Olschowka JA, Daeschner JC, Williams JP, Hansen JT, Kerry O'Banion M. Cyclooxygenase-2 modulates brain inflammation-related gene expression in central nervous system radiation injury. Brain Res Mol Brain Res. 2002 Aug 15; 104(2):159-69.
    View in: PubMed
  33. Wang CX, Reece C, Wrathall JR, Shuaib A, Olschowka JA, Hao C. Expression of tumor necrosis factor alpha and its mRNA in the spinal cord following a weight-drop injury. Neuroreport. 2002 Aug 7; 13(11):1391-3.
    View in: PubMed
  34. Hurley SD, Olschowka JA, O'Banion MK. Cyclooxygenase inhibition as a strategy to ameliorate brain injury. J Neurotrauma. 2002 Jan; 19(1):1-15.
    View in: PubMed
  35. Kyrkanides S, Tallents RH, Macher DJ, Olschowka JA, Stevens SY. Temporomandibular joint nociception: effects of capsaicin on substance P-like immunoreactivity in the rabbit brain stem. J Orofac Pain. 2002; 16(3):229-36.
    View in: PubMed
  36. O'Banion MK, Kyrkanides S, Olschowka JA. Selective inhibition of cyclooxygenase-2 attenuates expression of inflammation-related genes in CNS injury. Adv Exp Med Biol. 2002; 507:155-60.
    View in: PubMed
  37. Kyrkanides S, O'Banion MK, Whiteley PE, Daeschner JC, Olschowka JA. Enhanced glial activation and expression of specific CNS inflammation-related molecules in aged versus young rats following cortical stab injury. J Neuroimmunol. 2001 Oct 1; 119(2):269-77.
    View in: PubMed
  38. Matsuoka Y, Picciano M, Malester B, LaFrancois J, Zehr C, Daeschner JM, Olschowka JA, Fonseca MI, O'Banion MK, Tenner AJ, Lemere CA, Duff K. Inflammatory responses to amyloidosis in a transgenic mouse model of Alzheimer's disease. Am J Pathol. 2001 Apr; 158(4):1345-54.
    View in: PubMed
  39. Kyrkanides S, Olschowka JA, Williams JP, Hansen JT, O'Banion MK. TNF alpha and IL-1beta mediate intercellular adhesion molecule-1 induction via microglia-astrocyte interaction in CNS radiation injury. J Neuroimmunol. 1999 Mar 1; 95(1-2):95-106.
    View in: PubMed
  40. Park K, Olschowka JA, Richardson LA, Bookstein C, Chang EB, Melvin JE. Expression of multiple Na+/H+ exchanger isoforms in rat parotid acinar and ductal cells. Am J Physiol. 1999 Feb; 276(2 Pt 1):G470-8.
    View in: PubMed
  41. O'Banion MK, Olschowka JA. Localization and distribution of cyclooxygenase-2 in brain tissue by immunohistochemistry. Methods Mol Biol. 1999; 120:55-66.
    View in: PubMed
  42. Blair ML, Want A, Olschowka JA, Piekut D. Role of paraventricular nucleus parvicellular neurons in the compensatory responses to graded hemorrhage. Am J Physiol. 1998 Jul; 275(1 Pt 2):R278-85.
    View in: PubMed
  43. Olschowka JA, Kyrkanides S, Harvey BK, O'Banion MK, Williams JP, Rubin P, Hansen JT. ICAM-1 induction in the mouse CNS following irradiation. Brain Behav Immun. 1997 Dec; 11(4):273-85.
    View in: PubMed
  44. Kaplan MD, Olschowka JA, O'Banion MK. Cyclooxygenase-1 behaves as a delayed response gene in PC12 cells differentiated by nerve growth factor. J Biol Chem. 1997 Jul 25; 272(30):18534-7.
    View in: PubMed
  45. Wang CX, Olschowka JA, Wrathall JR. Increase of interleukin-1beta mRNA and protein in the spinal cord following experimental traumatic injury in the rat. Brain Res. 1997 Jun 13; 759(2):190-6.
    View in: PubMed
  46. Blair ML, Piekut D, Want A, Olschowka JA. Role of the hypothalamic paraventricular nucleus in cardiovascular regulation. Clin Exp Pharmacol Physiol. 1996 Feb; 23(2):161-5.
    View in: PubMed
  47. Dopp JM, Breneman SM, Olschowka JA. Expression of ICAM-1, VCAM-1, L-selectin, and leukosialin in the mouse central nervous system during the induction and remission stages of experimental allergic encephalomyelitis. J Neuroimmunol. 1994 Oct; 54(1-2):129-44.
    View in: PubMed
  48. Romano TA, Felten SY, Olschowka JA, Felten DL. Noradrenergic and peptidergic innervation of lymphoid organs in the beluga, Delphinapterus leucas: an anatomical link between the nervous and immune systems. J Morphol. 1994 Sep; 221(3):243-59.
    View in: PubMed
  49. Sladek CD, Olschowka JA. Dehydration induces Fos, but not increased vasopressin mRNA in the supraoptic nucleus of aged rats. Brain Res. 1994 Aug 1; 652(2):207-15.
    View in: PubMed
  50. Earnest DJ, DiGiorgio S, Olschowka JA. Light induces expression of fos-related proteins within gastrin-releasing peptide neurons in the rat suprachiasmatic nucleus. Brain Res. 1993 Nov 12; 627(2):205-9.
    View in: PubMed
  51. Romano TA, Felten SY, Olschowka JA, Felten DL. A microscopic investigation of the lymphoid organs of the beluga, Delphinapterus leucas. J Morphol. 1993 Mar; 215(3):261-87.
    View in: PubMed
  52. Earnest DJ, Olschowka JA. Circadian regulation of c-fos expression in the suprachiasmatic pacemaker by light. J Biol Rhythms. 1993; 8 Suppl:S65-71.
    View in: PubMed
  53. Inglefield JR, Bitran D, Olschowka JA, Kellogg CK. Selective effects on CRF neurons and catecholamine terminals in two stress-responsive regions of adult rat brain after prenatal exposure to diazepam. Brain Res Bull. 1993; 31(3-4):353-9.
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  54. Earnest DJ, Ouyang S, Olschowka JA. Rhythmic expression of Fos-related proteins within the rat suprachiasmatic nucleus during constant retinal illumination. Neurosci Lett. 1992 Jun 8; 140(1):19-24.
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  55. Fitzsimmons MD, Olschowka JA, Wiegand SJ, Hoffman GE. Interaction of opioid peptide-containing terminals with dopaminergic perikarya in the rat hypothalamus. Brain Res. 1992 May 22; 581(1):10-8.
    View in: PubMed
  56. Felten SY, Felten DL, Bellinger DL, Olschowka JA. Noradrenergic and peptidergic innervation of lymphoid organs. Chem Immunol. 1992; 52:25-48.
    View in: PubMed
  57. Romano TA, Felten SY, Felten DL, Olschowka JA. Neuropeptide-Y innervation of the rat spleen: another potential immunomodulatory neuropeptide. Brain Behav Immun. 1991 Mar; 5(1):116-31.
    View in: PubMed
  58. Higgins GA, Olschowka JA. Induction of interleukin-1 beta mRNA in adult rat brain. Brain Res Mol Brain Res. 1991 Jan; 9(1-2):143-8.
    View in: PubMed
  59. Earnest DJ, Iadarola M, Yeh HH, Olschowka JA. Photic regulation of c-fos expression in neural components governing the entrainment of circadian rhythms. Exp Neurol. 1990 Sep; 109(3):353-61.
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  60. Date I, Felten SY, Olschowka JA, Felten DL. Limited recovery of striatal dopaminergic fibers by adrenal medullary grafts in MPTP-treated aging mice. Exp Neurol. 1990 Mar; 107(3):197-207.
    View in: PubMed
  61. Bellinger DL, Lorton D, Romano TD, Olschowka JA, Felten SY, Felten DL. Neuropeptide innervation of lymphoid organs. Ann N Y Acad Sci. 1990; 594:17-33.
    View in: PubMed
  62. Yeh HH, Olschowka JA. A system of corticotropin releasing factor-containing amacrine cells in the rat retina. Neuroscience. 1989; 33(1):229-40.
    View in: PubMed
  63. Olschowka JA. A simple embedding method for optimizing the thin sectioning of pre-embedded immunocytochemically stained tissue. J Electron Microsc Tech. 1988 Dec; 10(4):373-4.
    View in: PubMed
  64. Felten SY, Felten DL, Bellinger DL, Carlson SL, Ackerman KD, Madden KS, Olschowka JA, Livnat S. Noradrenergic sympathetic innervation of lymphoid organs. Prog Allergy. 1988; 43:14-36.
    View in: PubMed
  65. Sladek CD, Olschowka JA. Regulation of vasopressin and oxytocin release in vitro. Adv Exp Med Biol. 1988; 245:157-65.
    View in: PubMed
  66. Silverman WF, Aravich PF, Collier TJ, Olschowka JA, Sladek JR. Reinnervation of transplanted hypothalamic neurons by host aminergic fibers in rats. Brain Res. 1987 Jun 2; 412(2):375-80.
    View in: PubMed
  67. Felten SY, Olschowka J. Noradrenergic sympathetic innervation of the spleen: II. Tyrosine hydroxylase (TH)-positive nerve terminals form synapticlike contacts on lymphocytes in the splenic white pulp. J Neurosci Res. 1987; 18(1):37-48.
    View in: PubMed
  68. Crawley JN, Olschowka JA, Diz DI, Jacobowitz DM. Behavioral investigation of the coexistence of substance P, corticotropin releasing factor, and acetylcholinesterase in lateral dorsal tegmental neurons projecting to the medial frontal cortex of the rat. Peptides. 1985 Sep-Oct; 6(5):891-901.
    View in: PubMed
  69. Felten DL, Felten SY, Carlson SL, Olschowka JA, Livnat S. Noradrenergic and peptidergic innervation of lymphoid tissue. J Immunol. 1985 Aug; 135(2 Suppl):755s-765s.
    View in: PubMed
  70. Hamill GS, Olschowka JA, Lenn NJ, Jacobowitz DM. The subnuclear distribution of substance P, cholecystokinin, vasoactive intestinal peptide, somatostatin, leu-enkephalin, dopamine-beta-hydroxylase, and serotonin in the rat interpeduncular nucleus. J Comp Neurol. 1984 Jul 10; 226(4):580-96.
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  71. Chronwall BM, Olschowka JA, O'Donohue TL. Histochemical localization of FMRFamide-like immunoreactivity in the rat brain. Peptides. 1984 May-Jun; 5(3):569-84.
    View in: PubMed
  72. Ebner FF, Olschowka JA, Jacobowitz DM. The development of peptide-containing neurons within neocortical transplants in adult mice. Peptides. 1984 Jan-Feb; 5(1):103-13.
    View in: PubMed
  73. Ohhashi T, Olschowka JA, Jacobowitz DM. Vasoactive intestinal peptide inhibitory innervation in bovine mesenteric lymphatics. A histochemical and pharmacological study. Circ Res. 1983 Oct; 53(4):535-8.
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  74. Kobayashi S, Olschowka JA, Jacobowitz DM. Bovine pancreatic polypeptide-like immunoreactive nerves in the rat major cerebral arteries. Brain Res Bull. 1983 Mar; 10(3):373-6.
    View in: PubMed
  75. Olschowka JA, Jacobowitz DM. The coexistence and release of bovine pancreatic polypeptide-like immunoreactivity from noradrenergic superior cervical ganglia neurons. Peptides. 1983 Mar-Apr; 4(2):231-8.
    View in: PubMed
  76. Kobayashi S, Kyoshima K, Olschowka JA, Jacobowitz DM. Vasoactive intestinal polypeptide immunoreactive and cholinergic nerves in the whole mount preparation of the major cerebral arteries of the rat. Histochemistry. 1983; 79(3):377-81.
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  77. Olschowka JA, O'Donohue TL, Mueller GP, Jacobowitz DM. The distribution of corticotropin releasing factor-like immunoreactive neurons in rat brain. Peptides. 1982 Nov-Dec; 3(6):995-1015.
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  78. Olschowka JA, O'Donohue TL, Mueller GP, Jacobowitz DM. Hypothalamic and extrahypothalamic distribution of CRF-like immunoreactive neurons in the rat brain. Neuroendocrinology. 1982 Oct; 35(4):305-8.
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  79. Jacobowitz DM, Olschowka JA. Coexistence of bovine pancreatic polypeptide-like immunoreactivity and catecholamine in neurons of the ventral aminergic pathway of the rat brain. Brain Res Bull. 1982 Jul-Dec; 9(1-6):391-406.
    View in: PubMed
  80. Jacobowitz DM, Olschowka JA. Bovine pancreatic polypeptide-like immunoreactivity in brain and peripheral nervous system: coexistence with catecholaminergic nerves. Peptides. 1982 May-Jun; 3(3):569-90.
    View in: PubMed
  81. Olschowka JA, Molliver ME, Grzanna R, Rice FL, Coyle JT. Ultrastructural demonstration of noradrenergic synapses in the rat central nervous system by dopamine-beta-hydroxylase immunocytochemistry. J Histochem Cytochem. 1981 Feb; 29(2):271-80.
    View in: PubMed
  82. Olschowka JA, O'Donohue TL, Jacobowitz DM. The distribution of bovine pancreatic polypeptide-like immunoreactive neurons in rat brain. Peptides. 1981; 2(3):309-31.
    View in: PubMed
  83. Olschowka JA, Vijayan VK. Postnatal development of cholinergic neurotransmitter enzymes in the mouse cerebellum. Biochemical, light microscopic and electron microscopic cytochemical investigations. J Comp Neurol. 1980 May 1; 191(1):77-101.
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