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David Oakes

TitleProfessor
InstitutionSchool of Medicine and Dentistry
DepartmentBiostatistics and Computational Biology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 630
Rochester NY 14642
Other Positions
TitleProfessor
InstitutionUniversity of Rochester, River Campus
DepartmentStatistics A&S

 
 Overview
After a period as Assistant Professor of Statistics at Harvard University I returned to London in 1977 as Senior Lecturer in Occupational Health Statistics at the London School of Hygiene and Tropical Medicine, where I became involved in the design and analysis of idemiologic studies of cancer and respiratory diseases, and in the education of occupational health professionals.

Since coming to Rochester in 1983 I have become deeply involved in clinical trials. I direct the Biostatistics Centers of the Parkinson and Huntington Study Groups, two consortia of scientific investigators and researchers, committed to advancing knowledge about these diseases through the planning, implementation and reporting of clinical trials of promising therapeutic interventions. I have also worked in cardiology, infectious diseases and pediatrics, and am the Director of the Biostatistics Core facility for the Environmental Health Science Center at the University of Rochester. I am currently involved in several multicenter clinical trials and other initiatives in Parkinson's disease and Huntington's disease, and in a study of the influence of genetic polymorphisms on the risk of recurrent cardiac events after acute myocardial infarction.

At Rochester, I have taught courses in undergraduate probability and statistics and a variety of graduate level courses, including probability, stochastic processes, statistical inference, statistical modeling techniques and survival analysis. I have been involved in the education of medical students and fellows. I hold a training grant in environmental health sciences biostatistics and am co-director of a training grant in experimental therapeutics in neurology. I have Chaired the Departments of Statistics (1989-95) and of Biostatistics (1995-2002).

I have advised a total of eight graduate students, One (Ben Armstrong) is now a Reader in Epidemiological Statistics at London University, another (Amita Manatunga) is Associate Professor at Emory. Four others hold academic positions.

I am a Fellow of the American Statistical Association and an elected member of the International Statistical Institute. I serve on the NIH Study Section "Biostatistical Methods and Research Design" which reviews many grant applications in biostatistical methodology. I am the longest serving associate editor of the leading journal Biometrika (since 1979), and am one of three Editors of the journal Lifetime Data Analysis. I have authored or co-authored over 120 publications. About half of these are methodologic papers in the statistical and biostatistical literature and half are collaborative works, in recent years mostly in Neurology journals. A selection of the methodologic papers is given below. For a full c.v., which includes a complete list of all my publications, click here.

 
 Selected Publications
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  1. A randomized clinical trial of high-dosage coenzyme q10 in early Parkinson disease: no evidence of benefit. JAMA Neurol. 2014 May 1; 71(5):543-52.
    View in: PubMed
  2. Marek K, Seibyl J, Eberly S, Oakes D, Shoulson I, Lang AE, Hyson C, Jennings D. Longitudinal follow-up of SWEDD subjects in the PRECEPT Study. Neurology. 2014 May 20; 82(20):1791-7.
    View in: PubMed
  3. Tanner CM, Meng CC, Ravina B, Lang A, Kurlan R, Marek K, Oakes D, Seibyl J, Flagg E, Gauger L, Guest DD, Goetz CG, Kieburtz K, Dieuliis D, Fahn S, Elliott RA, Shoulson I. A practical approach to remote longitudinal follow-up of Parkinson's disease: The FOUND study. Mov Disord. 2014 May; 29(6):743-9.
    View in: PubMed
  4. Inosine to increase serum and cerebrospinal fluid urate in Parkinson disease: a randomized clinical trial. JAMA Neurol. 2014 Feb 1; 71(2):141-50.
    View in: PubMed
  5. Marder K, Gu Y, Eberly S, Tanner CM, Scarmeas N, Oakes D, Shoulson I. Relationship of mediterranean diet and caloric intake to phenoconversion in huntington disease. JAMA Neurol. 2013 Nov 1; 70(11):1382-8.
    View in: PubMed
  6. Lang AE, Eberly S, Goetz CG, Stebbins G, Oakes D, Marek K, Ravina B, Tanner CM, Shoulson I. Movement Disorder Society Unified Parkinson Disease Rating Scale experiences in daily living: Longitudinal changes and correlation with other assessments. Mov Disord. 2013 Dec; 28(14):1980-6.
    View in: PubMed
  7. Moscovitch-Lopatin M, Goodman RE, Eberly S, Ritch JJ, Rosas HD, Matson S, Matson W, Oakes D, Young AB, Shoulson I, Hersch SM. HTRF analysis of soluble huntingtin in PHAROS PBMCs. Neurology. 2013 Sep 24; 81(13):1134-40.
    View in: PubMed
  8. Oakes D. An introduction to survival models: in honor of Ross Prentice. Lifetime Data Anal. 2013 Oct; 19(4):442-62.
    View in: PubMed
  9. Marras C, Oakes D. Author reply to Holford, Vu and Nutt regarding 'piecing together the puzzle of progression and mortality in Parkinson's disease'. Br J Clin Pharmacol. 2013 May; 75(5):1372.
    View in: PubMed
  10. Killoran A, Biglan KM, Jankovic J, Eberly S, Kayson E, Oakes D, Young AB, Shoulson I. Characterization of the Huntington intermediate CAG repeat expansion phenotype in PHAROS. Neurology. 2013 May 28; 80(22):2022-7.
    View in: PubMed
  11. Ravina B, Marek K, Eberly S, Oakes D, Shoulson I. Reply: Unusual DAT scan results. Mov Disord. 2013 Jun; 28(6):847.
    View in: PubMed
  12. Moss AJ, Greenberg H, Dwyer EM, Klein H, Ryan D, Francis C, Marcus F, Eberly S, Benhorin J, Bodenheimer M, Brown M, Case R, Gillespie J, Goldstein R, Haigney M, Krone R, Lichstein E, Locati E, Oakes D, Thomsen PE, Zareba W. Senior academic physicians and retirement considerations. Prog Cardiovasc Dis. 2013 May-Jun; 55(6):611-5.
    View in: PubMed
  13. Wills AM, Eberly S, Tennis M, Lang AE, Messing S, Togasaki D, Tanner CM, Kamp C, Chen JF, Oakes D, McDermott MP, Schwarzschild MA. Caffeine consumption and risk of dyskinesia in CALM-PD. Mov Disord. 2013 Mar; 28(3):380-3.
    View in: PubMed
  14. Moss AJ, Schuger C, Beck CA, Brown MW, Cannom DS, Daubert JP, Estes NA, Greenberg H, Hall WJ, Huang DT, Kautzner J, Klein H, McNitt S, Olshansky B, Shoda M, Wilber D, Zareba W. Reduction in inappropriate therapy and mortality through ICD programming. N Engl J Med. 2012 Dec 13; 367(24):2275-83.
    View in: PubMed
  15. Frampton MW, Bausch J, Chalupa D, Hopke PK, Little EL, Oakes D, Stewart JC, Utell MJ. Effects of outdoor air pollutants on platelet activation in people with type 2 diabetes. Inhal Toxicol. 2012 Oct; 24(12):831-8.
    View in: PubMed
  16. Ravina B, Marek K, Eberly S, Oakes D, Kurlan R, Ascherio A, Beal F, Beck J, Flagg E, Galpern WR, Harman J, Lang AE, Schwarzschild M, Tanner C, Shoulson I. Dopamine transporter imaging is associated with long-term outcomes in Parkinson's disease. Mov Disord. 2012 Sep 15; 27(11):1392-7.
    View in: PubMed
  17. Marras C, Oakes D. Piecing together the puzzle of progression and mortality in Parkinson's disease. Br J Clin Pharmacol. 2012 Aug; 74(2):264-6.
    View in: PubMed
  18. Paumier KL, Siderowf AD, Auinger P, Oakes D, Madhavan L, Espay AJ, Revilla FJ, Collier TJ. Tricyclic antidepressants delay the need for dopaminergic therapy in early Parkinson's disease. Mov Disord. 2012 Jun; 27(7):880-7.
    View in: PubMed
  19. Rich DQ, Zareba W, Beckett W, Hopke PK, Oakes D, Frampton MW, Bisognano J, Chalupa D, Bausch J, O'Shea K, Wang Y, Utell MJ. Are ambient ultrafine, accumulation mode, and fine particles associated with adverse cardiac responses in patients undergoing cardiac rehabilitation? Environ Health Perspect. 2012 Aug; 120(8):1162-9.
    View in: PubMed
  20. Siderowf A, Jennings D, Eberly S, Oakes D, Hawkins KA, Ascherio A, Stern MB, Marek K. Impaired olfaction and other prodromal features in the Parkinson At-Risk Syndrome Study. Mov Disord. 2012 Mar; 27(3):406-12.
    View in: PubMed
  21. Dorsey R, Biglan K, Eberly S, Auinger P, Brocht A, Umeh CC, Oakes D, Clarence-Smith K, Marshall F, Shoulson I, Frank S. Use of Tetrabenazine in Huntington Disease Patients on Antidepressants or with Advanced Disease: Results from the TETRA-HD Study. PLoS Curr. 2011; 3:RRN1283.
    View in: PubMed
  22. Huang X, Auinger P, Eberly S, Oakes D, Schwarzschild M, Ascherio A, Mailman R, Chen H. Serum cholesterol and the progression of Parkinson's disease: results from DATATOP. PLoS One. 2011; 6(8):e22854.
    View in: PubMed
  23. Schwarzschild MA, Marek K, Eberly S, Oakes D, Shoulson I, Jennings D, Seibyl J, Ascherio A. Serum urate and probability of dopaminergic deficit in early "Parkinson's disease". Mov Disord. 2011 Aug 15; 26(10):1864-8.
    View in: PubMed
  24. Pietropaoli AP, Glance LG, Oakes D, Fisher SG. Gender differences in mortality in patients with severe sepsis or septic shock. Gend Med. 2010 Oct; 7(5):422-37.
    View in: PubMed
  25. Schwid SR, Bausch J, Oakes D, Schuchter L, Tanner C, Forrest M, Lang AE, Shoulson I. Cancer incidence in a trial of an antiapoptotic agent for Parkinson's disease. Mov Disord. 2010 Sep 15; 25(12):1801-8.
    View in: PubMed
  26. Foster DC, Kotok MB, Huang LS, Watts A, Oakes D, Howard FM, Poleshuck EL, Stodgell CJ, Dworkin RH. Oral desipramine and topical lidocaine for vulvodynia: a randomized controlled trial. Obstet Gynecol. 2010 Sep; 116(3):583-93.
    View in: PubMed
  27. Oakes D, Feng C. Combining stratified and unstratified log-rank tests in paired survival data. Stat Med. 2010 Jul 20; 29(16):1735-45.
    View in: PubMed
  28. Marras C, Lang AE, Eberly SW, Oakes D, Fahn S, Schwid SR, Hyson C, Shoulson I. A comparison of treatment thresholds in two large Parkinson's disease clinical trial cohorts. Mov Disord. 2009 Dec 15; 24(16):2370-8.
    View in: PubMed
  29. Hauser RA, Auinger P, Oakes D. Levodopa response in early Parkinson's disease. Mov Disord. 2009 Dec 15; 24(16):2328-36.
    View in: PubMed
  30. Ascherio A, LeWitt PA, Xu K, Eberly S, Watts A, Matson WR, Marras C, Kieburtz K, Rudolph A, Bogdanov MB, Schwid SR, Tennis M, Tanner CM, Beal MF, Lang AE, Oakes D, Fahn S, Shoulson I, Schwarzschild MA. Urate as a predictor of the rate of clinical decline in Parkinson disease. Arch Neurol. 2009 Dec; 66(12):1460-8.
    View in: PubMed
  31. Ravina B, Tanner C, Dieuliis D, Eberly S, Flagg E, Galpern WR, Fahn S, Goetz CG, Grate S, Kurlan R, Lang AE, Marek K, Kieburtz K, Oakes D, Elliott R, Shoulson I. A longitudinal program for biomarker development in Parkinson's disease: a feasibility study. Mov Disord. 2009 Oct 30; 24(14):2081-90.
    View in: PubMed
  32. Biglan KM, Ross CA, Langbehn DR, Aylward EH, Stout JC, Queller S, Carlozzi NE, Duff K, Beglinger LJ, Paulsen JS. Motor abnormalities in premanifest persons with Huntington's disease: the PREDICT-HD study. Mov Disord. 2009 Sep 15; 24(12):1763-72.
    View in: PubMed
  33. Marder K, Zhao H, Eberly S, Tanner CM, Oakes D, Shoulson I. Dietary intake in adults at risk for Huntington disease: analysis of PHAROS research participants. Neurology. 2009 Aug 4; 73(5):385-92.
    View in: PubMed
  34. Saperstein S, Chen L, Oakes D, Pryhuber G, Finkelstein J. IL-1beta augments TNF-alpha-mediated inflammatory responses from lung epithelial cells. J Interferon Cytokine Res. 2009 May; 29(5):273-84.
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  35. Foster DC, Kotok MB, Huang LS, Watts A, Oakes D, Howard FM, Stodgell CJ, Dworkin RH. The tampon test for vulvodynia treatment outcomes research: reliability, construct validity, and responsiveness. Obstet Gynecol. 2009 Apr; 113(4):825-32.
    View in: PubMed
  36. Constantinescu R, Romer M, Oakes D, Rosengren L, Kieburtz K. Levels of the light subunit of neurofilament triplet protein in cerebrospinal fluid in Huntington's disease. Parkinsonism Relat Disord. 2009 Mar; 15(3):245-8.
    View in: PubMed
  37. Dorsey ER, Beck CA, Adams M, Chadwick G, de Blieck EA, McCallum C, Briner L, Deuel L, Clarke A, Stewart R, Shoulson I. Communicating clinical trial results to research participants. Arch Neurol. 2008 Dec; 65(12):1590-5.
    View in: PubMed
  38. Oster E, Dorsey ER, Bausch J, Shinaman A, Kayson E, Oakes D, Shoulson I, Quaid K. Fear of health insurance loss among individuals at risk for Huntington disease. Am J Med Genet A. 2008 Aug 15; 146A(16):2070-7.
    View in: PubMed
  39. Schifitto G, Friedman JH, Oakes D, Shulman L, Comella CL, Marek K, Fahn S. Fatigue in levodopa-naive subjects with Parkinson disease. Neurology. 2008 Aug 12; 71(7):481-5.
    View in: PubMed
  40. Oakes D, Peterson DR. Survival methods: additional topics. Circulation. 2008 Jun 3; 117(22):2949-55.
    View in: PubMed
  41. Frank S, Ondo W, Fahn S, Hunter C, Oakes D, Plumb S, Marshall F, Shoulson I, Eberly S, Walker F, Factor S, Hunt V, Shinaman A, Jankovic J. A study of chorea after tetrabenazine withdrawal in patients with Huntington disease. Clin Neuropharmacol. 2008 May-Jun; 31(3):127-33.
    View in: PubMed
  42. Schwarzschild MA, Schwid SR, Marek K, Watts A, Lang AE, Oakes D, Shoulson I, Ascherio A. Serum urate as a predictor of clinical and radiographic progression in Parkinson disease. Arch Neurol. 2008 Jun; 65(6):716-23.
    View in: PubMed
  43. Paulsen JS, Langbehn DR, Stout JC, Aylward E, Ross CA, Nance M, Guttman M, Johnson S, MacDonald M, Beglinger LJ, Duff K, Kayson E, Biglan K, Shoulson I, Oakes D, Hayden M. Detection of Huntington's disease decades before diagnosis: the Predict-HD study. J Neurol Neurosurg Psychiatry. 2008 Aug; 79(8):874-80.
    View in: PubMed
  44. Johnson SA, Stout JC, Solomon AC, Langbehn DR, Aylward EH, Cruce CB, Ross CA, Nance M, Kayson E, Julian-Baros E, Hayden MR, Kieburtz K, Guttman M, Oakes D, Shoulson I, Beglinger L, Duff K, Penziner E, Paulsen JS. Beyond disgust: impaired recognition of negative emotions prior to diagnosis in Huntington's disease. Brain. 2007 Jul; 130(Pt 7):1732-44.
    View in: PubMed
  45. Solomon AC, Stout JC, Johnson SA, Langbehn DR, Aylward EH, Brandt J, Ross CA, Beglinger L, Hayden MR, Kieburtz K, Kayson E, Julian-Baros E, Duff K, Guttman M, Nance M, Oakes D, Shoulson I, Penziner E, Paulsen JS. Verbal episodic memory declines prior to diagnosis in Huntington's disease. Neuropsychologia. 2007 Apr 9; 45(8):1767-76.
    View in: PubMed
  46. Elmer L, Schwid S, Eberly S, Goetz C, Fahn S, Kieburtz K, Oakes D, Blindauer K, Salzman P, Oren S, Prisco UL, Stern M, Shoulson I. Rasagiline-associated motor improvement in PD occurs without worsening of cognitive and behavioral symptoms. J Neurol Sci. 2006 Oct 25; 248(1-2):78-83.
    View in: PubMed
  47. Goldman SM, Tanner CM, Oakes D, Bhudhikanok GS, Gupta A, Langston JW. Head injury and Parkinson's disease risk in twins. Ann Neurol. 2006 Jul; 60(1):65-72.
    View in: PubMed
  48. Paulsen JS, Hayden M, Stout JC, Langbehn DR, Aylward E, Ross CA, Guttman M, Nance M, Kieburtz K, Oakes D, Shoulson I, Kayson E, Johnson S, Penziner E. Preparing for preventive clinical trials: the Predict-HD study. Arch Neurol. 2006 Jun; 63(6):883-90.
    View in: PubMed
  49. Goetz CG, Schwid SR, Eberly SW, Oakes D, Shoulson I. Safety of rasagiline in elderly patients with Parkinson disease. Neurology. 2006 May 9; 66(9):1427-9.
    View in: PubMed
  50. Biglan KM, Schwid S, Eberly S, Blindauer K, Fahn S, Goren T, Kieburtz K, Oakes D, Plumb S, Siderowf A, Stern M, Shoulson I. Rasagiline improves quality of life in patients with early Parkinson's disease. Mov Disord. 2006 May; 21(5):616-23.
    View in: PubMed
  51. Blindauer K, Shoulson I, Oakes D, Kieburtz K, Schwid S, Fahn S, Stern M, Goetz C, Nutt J, Goren S, Sayag N, Scolnik M, Levy R, Eyal E, Salzman P, Pagano M. A randomized controlled trial of etilevodopa in patients with Parkinson disease who have motor fluctuations. Arch Neurol. 2006 Feb; 63(2):210-6.
    View in: PubMed
  52. Chou KL, Messing S, Oakes D, Feldman PD, Breier A, Friedman JH. Drug-induced psychosis in Parkinson disease: phenomenology and correlations among psychosis rating instruments. Clin Neuropharmacol. 2005 Sep-Oct; 28(5):215-9.
    View in: PubMed
  53. Marras C, Lang AE, Oakes D, McDermott MP, Kieburtz K, Shoulson I, Tanner CM, Fahn S. High-dosage vitamin E supplementation and all-cause mortality. Ann Intern Med. 2005 Jul 19; 143(2):152-3; author reply 156-8.
    View in: PubMed
  54. Moss AJ, Ryan D, Oakes D, Goldstein RE, Greenberg H, Bodenheimer MM, Brown MW, Case RB, Dwyer EM, Eberly SW, Francis CW, Gillespie JA, Krone RJ, Lichstein E, MacCluer JW, Marcus FI, McCarthy J, Sparks CE, Zareba W. Atherosclerotic risk genotypes and recurrent coronary events after myocardial infarction. Am J Cardiol. 2005 Jul 15; 96(2):177-82.
    View in: PubMed
  55. Hogarth P, Kayson E, Kieburtz K, Marder K, Oakes D, Rosas D, Shoulson I, Wexler NS, Young AB, Zhao H. Interrater agreement in the assessment of motor manifestations of Huntington's disease. Mov Disord. 2005 Mar; 20(3):293-7.
    View in: PubMed
  56. Fahn S, Oakes D, Shoulson I, Kieburtz K, Rudolph A, Lang A, Olanow CW, Tanner C, Marek K. Levodopa and the progression of Parkinson's disease. N Engl J Med. 2004 Dec 9; 351(24):2498-508.
    View in: PubMed
  57. Jennings DL, Seibyl JP, Oakes D, Eberly S, Murphy J, Marek K. (123I) beta-CIT and single-photon emission computed tomographic imaging vs clinical evaluation in Parkinsonian syndrome: unmasking an early diagnosis. Arch Neurol. 2004 Aug; 61(8):1224-9.
    View in: PubMed
  58. Shults CW, Haas R, Oakes D, Kieburtz K, Plumb S, Shoulson I, Beal MF, Juncos J, Nutt J. Measuring the effects of therapy in Parkinson disease. JAMA. 2004 May 26; 291(20):2430-1; author reply 2431.
    View in: PubMed
  59. Kaba NK, Francis CW, Moss AJ, Zareba W, Oakes D, Knox KL, Fernández ID, Rainwater DL. Effects of lipids and lipid-lowering therapy on hemostatic factors in patients with myocardial infarction. J Thromb Haemost. 2004 May; 2(5):718-25.
    View in: PubMed
  60. Brooks DJ, Frey KA, Marek KL, Oakes D, Paty D, Prentice R, Shults CW, Stoessl AJ. Assessment of neuroimaging techniques as biomarkers of the progression of Parkinson's disease. Exp Neurol. 2003 Nov; 184 Suppl 1:S68-79.
    View in: PubMed
  61. Howard CR, Howard FM, Lanphear B, Eberly S, deBlieck EA, Oakes D, Lawrence RA. Randomized clinical trial of pacifier use and bottle-feeding or cupfeeding and their effect on breastfeeding. Pediatrics. 2003 Mar; 111(3):511-8.
    View in: PubMed
  62. Reider CR, Halter CA, Castelluccio PF, Oakes D, Nichols WC, Foroud T. Reliability of reported age at onset for Parkinson's disease. Mov Disord. 2003 Mar; 18(3):275-9.
    View in: PubMed
  63. McDermott MP, Hall WJ, Oakes D, Eberly S. Design and analysis of two-period studies of potentially disease-modifying treatments. Control Clin Trials. 2002 Dec; 23(6):635-49.
    View in: PubMed
  64. Shults CW, Oakes D, Kieburtz K, Beal MF, Haas R, Plumb S, Juncos JL, Nutt J, Shoulson I, Carter J, Kompoliti K, Perlmutter JS, Reich S, Stern M, Watts RL, Kurlan R, Molho E, Harrison M, Lew M. Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. Arch Neurol. 2002 Oct; 59(10):1541-50.
    View in: PubMed
  65. Phatak PD, Ryan DH, Cappuccio J, Oakes D, Braggins C, Provenzano K, Eberly S, Sham RL. Prevalence and penetrance of HFE mutations in 4865 unselected primary care patients. Blood Cells Mol Dis. 2002 Jul-Aug; 29(1):41-7.
    View in: PubMed
  66. Shoulson I, Oakes D, Fahn S, Lang A, Langston JW, LeWitt P, Olanow CW, Penney JB, Tanner C, Kieburtz K, Rudolph A. Impact of sustained deprenyl (selegiline) in levodopa-treated Parkinson's disease: a randomized placebo-controlled extension of the deprenyl and tocopherol antioxidative therapy of parkinsonism trial. Ann Neurol. 2002 May; 51(5):604-12.
    View in: PubMed
  67. Harb TS, Zareba W, Moss AJ, Ridker PM, Marder VJ, Rifai N, Miller Watelet LF, Arora R, Brown MW, Case RB, Dwyer EM, Gillespie JA, Goldstein RE, Greenberg H, Hochman J, Krone RJ, Liang CS, Lichstein E, Little W, Marcus FI, Oakes D, Sparks CE, VanVoorhees L. Association of C-reactive protein and serum amyloid A with recurrent coronary events in stable patients after healing of acute myocardial infarction. Am J Cardiol. 2002 Jan 15; 89(2):216-21.
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  68. Marek K, Innis R, van Dyck C, Fussell B, Early M, Eberly S, Oakes D, Seibyl J. [123I]beta-CIT SPECT imaging assessment of the rate of Parkinson's disease progression. Neurology. 2001 Dec 11; 57(11):2089-94.
    View in: PubMed
  69. Lichtman MA, Oakes D. The productivity and impact of the Leukemia & Lymphoma Society Scholar Program: the apparent positive effect of peer review. Blood Cells Mol Dis. 2001 Nov-Dec; 27(6):1020-7.
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  70. Factor SA, Friedman JH, Lannon MC, Oakes D, Bourgeois K. Clozapine for the treatment of drug-induced psychosis in Parkinson's disease: results of the 12 week open label extension in the PSYCLOPS trial. Mov Disord. 2001 Jan; 16(1):135-9.
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  71. Watelet LF, Moss AJ, Zareba W, Oakes D, Ryan D. Detection of a group of risk factors in coronary disease using a new carriership analysis approach. Am J Cardiol. 2000 Dec 1; 86(11):1253-6, A6.
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  72. Manatunga AK, Oakes D. Parametric analysis for matched pair survival data. Lifetime Data Anal. 1999 Dec; 5(4):371-87.
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  73. Baggs JG, Schmitt MH, Mushlin AI, Mitchell PH, Eldredge DH, Oakes D, Hutson AD. Association between nurse-physician collaboration and patient outcomes in three intensive care units. Crit Care Med. 1999 Sep; 27(9):1991-8.
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  74. Shetty N, Friedman JH, Kieburtz K, Marshall FJ, Oakes D. The placebo response in Parkinson's disease. Parkinson Study Group. Clin Neuropharmacol. 1999 Jul-Aug; 22(4):207-12.
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  75. Moss AJ, Goldstein RE, Marder VJ, Sparks CE, Oakes D, Greenberg H, Weiss HJ, Zareba W, Brown MW, Liang CS, Lichstein E, Little WC, Gillespie JA, Van Voorhees L, Krone RJ, Bodenheimer MM, Hochman J, Dwyer EM, Arora R, Marcus FI, Watelet LF, Case RB. Thrombogenic factors and recurrent coronary events. Circulation. 1999 May 18; 99(19):2517-22.
    View in: PubMed
  76. Oakes DD, Sherck JP, Cobb LF. Surgical salvage of failed radiocephalic arteriovenous fistulae: techniques and results in 29 patients. Kidney Int. 1998 Feb; 53(2):480-7.
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  77. Oakes D, Jeong JH. Frailty models and rank tests. Lifetime Data Anal. 1998; 4(3):209-28.
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  78. Oakes D. Selegiline and excess mortality. Clin Neuropharmacol. 1997 Dec; 20(6):542.
    View in: PubMed
  79. Baggs JG, Schmitt MH, Mushlin AI, Eldredge DH, Oakes D, Hutson AD. Nurse-physician collaboration and satisfaction with the decision-making process in three critical care units. Am J Crit Care. 1997 Sep; 6(5):393-9.
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  80. Bonnez W, Oakes D, Bailey-Farchione A, Choi A, Hallahan D, Corey L, Barnum G, Pappas PG, Halloway M, Stoler MH, Reichman RC. A randomized, double-blind trial of parenteral low dose versus high dose interferon-beta in combination with cryotherapy for treatment of condyloma acuminatum. Antiviral Res. 1997 Jun; 35(1):41-52.
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  81. LeWitt P, Oakes D, Cui L. The need for levodopa as an end point of Parkinson's disease progression in a clinical trial of selegiline and alpha-tocopherol. Parkinson Study Group. Mov Disord. 1997 Mar; 12(2):183-9.
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  82. Bonnez W, Oakes D, Choi A, d'Arcy SJ, Pappas PG, Corey L, Stoler MH, Demeter LM, Reichman RC. Therapeutic efficacy and complications of excisional biopsy of condyloma acuminatum. Sex Transm Dis. 1996 Jul-Aug; 23(4):273-6.
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  83. Bonnez W, Oakes D, Bailey-Farchione A, Choi A, Hallahan D, Pappas P, Holloway M, Corey L, Barnum G, Dunne A, et al. A randomized, double-blind, placebo-controlled trial of systemically administered interferon-alpha, -beta, or -gamma in combination with cryotherapy for the treatment of condyloma acuminatum. J Infect Dis. 1995 May; 171(5):1081-9.
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  84. Oakes D. Multiple time scales in survival analysis. Lifetime Data Anal. 1995; 1(1):7-18.
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  85. A controlled trial of lazabemide (Ro 19-6327) in levodopa-treated Parkinson's disease. Parkinson Study Group. Arch Neurol. 1994 Apr; 51(4):342-7.
    View in: PubMed
  86. Boden WE, Moss AJ, Herbert PN, Saritelli A, Oakes D, Eberly S. Effect of long-term diltiazem administration on serum lipids in post-myocardial infarction survivors. Multicenter Diltiazem Post-Infarction Trial Research Group. Am J Cardiol. 1994 Mar 1; 73(7):513-4.
    View in: PubMed
  87. Oakes D. Antiparkinson efficacy of deprenyl. DATATOP Steering Committee of Parkinson Study Group. Ann Neurol. 1993 Oct; 34(4):634.
    View in: PubMed
  88. A controlled trial of lazabemide (RO19-6327) in untreated Parkinson's disease. Parkinson Study Group. Ann Neurol. 1993 Apr; 33(4):350-6.
    View in: PubMed
  89. Effects of tocopherol and deprenyl on the progression of disability in early Parkinson's disease. The Parkinson Study Group. N Engl J Med. 1993 Jan 21; 328(3):176-83.
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  90. LeWitt PA, Galloway MP, Matson W, Milbury P, McDermott M, Srivastava DK, Oakes D. Markers of dopamine metabolism in Parkinson's disease. The Parkinson Study Group. Neurology. 1992 Nov; 42(11):2111-7.
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  91. Boden WE, Moss AJ, Oakes D. Hypolipidemic effect of type Ia antiarrhythmic agents in postinfarction patients. Circulation. 1992 Jun; 85(6):2039-44.
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  92. Moss AJ, Oakes D, Rubison M, McDermott M, Carleen E, Eberly S, Brown M. Effects of diltiazem on long-term outcome after acute myocardial infarction in patients with and without a history of systemic hypertension. The Multicenter Diltiazem Postinfarction Trial Research Group. Am J Cardiol. 1991 Aug 15; 68(5):429-33.
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  93. Boden WE, Krone RJ, Kleiger RE, Oakes D, Greenberg H, Dwyer EJ, Miller JP, Abrams J, Coromilas J, Goldstein R, et al. Electrocardiographic subset analysis of diltiazem administration on long-term outcome after acute myocardial infarction. The Multicenter Diltiazem Post-Infarction Trial Research Group. Am J Cardiol. 1991 Feb 15; 67(5):335-42.
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  94. Reichman RC, Oakes D, Bonnez W, Brown D, Mattison HR, Bailey-Farchione A, Stoler MH, Demeter LM, Tyring SK, Miller L, et al. Treatment of condyloma acuminatum with three different interferon-alpha preparations administered parenterally: a double-blind, placebo-controlled trial. J Infect Dis. 1990 Dec; 162(6):1270-6.
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  95. Benhorin J, Moss AJ, Oakes D, Marcus F, Greenberg H, Dwyer EM, Algeo S, Hahn E. The prognostic significance of first myocardial infarction type (Q wave versus non-Q wave) and Q wave location. The Multicenter Diltiazem Post-Infarction Research Group. J Am Coll Cardiol. 1990 May; 15(6):1201-7.
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  96. Benhorin J, Moss AJ, Oakes D. Prognostic significance of nonfatal myocardial reinfarction. Multicenter Diltiazem Postinfarction Trial Research Group. J Am Coll Cardiol. 1990 Feb; 15(2):253-8.
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  97. Fleiss JL, Bigger JT, McDermott M, Miller JP, Moon T, Moss AJ, Oakes D, Rolnitzky LM, Therneau TM. Nonfatal myocardial infarction is, by itself, an inappropriate end point in clinical trials in cardiology. Circulation. 1990 Feb; 81(2):684-5.
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  98. Moss AJ, Oakes D, Benhorin J, Carleen E. The interaction between diltiazem and left ventricular function after myocardial infarction. Multicenter Diltiazem Post-Infarction Research Group. Circulation. 1989 Dec; 80(6 Suppl):IV102-6.
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  99. DATATOP: a multicenter controlled clinical trial in early Parkinson's disease. Parkinson Study Group. Arch Neurol. 1989 Oct; 46(10):1052-60.
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  100. Shoulson I, Odoroff C, Oakes D, Behr J, Goldblatt D, Caine E, Kennedy J, Miller C, Bamford K, Rubin A, et al. A controlled clinical trial of baclofen as protective therapy in early Huntington's disease. Ann Neurol. 1989 Mar; 25(3):252-9.
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  101. Dubach P, Froelicher VF, Klein J, Oakes D, Grover-McKay M, Friis R. Exercise-induced hypotension in a male population. Criteria, causes, and prognosis. Circulation. 1988 Dec; 78(6):1380-7.
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  102. The effect of diltiazem on mortality and reinfarction after myocardial infarction. The Multicenter Diltiazem Postinfarction Trial Research Group. N Engl J Med. 1988 Aug 18; 319(7):385-92.
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  103. Stewart S, Alexson C, Manning J, Oakes D, Eberly SW. Long-term palliation with the classic Blalock-Taussig shunt. J Thorac Cardiovasc Surg. 1988 Jul; 96(1):117-21.
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  104. Reichman RC, Oakes D, Bonnez W, Greisberger C, Tyring S, Miller L, Whitley R, Carveth H, Weidner M, Krueger G, et al. Treatment of condyloma acuminatum with three different interferons administered intralesionally. A double-blind, placebo-controlled trial. Ann Intern Med. 1988 May; 108(5):675-9.
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  105. Newhouse ML, Matthews G, Sheikh K, Knight KL, Oakes D, Sullivan KR. Mortality of workers at acetylene production plants. Br J Ind Med. 1988 Jan; 45(1):63-9.
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  106. Oakes D. An approximate likelihood procedure for censored data. Biometrics. 1986 Mar; 42(1):177-82.
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  107. Bazas T, Oakes D, Gilson JC, Bazas B, McDonald JC. Pleural calcification in northwest Greece. Environ Res. 1985 Dec; 38(2):239-47.
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  108. Newhouse ML, Oakes D, Woolley AJ. Mortality of welders and other craftsmen at a shipyard in NE England. Br J Ind Med. 1985 Jun; 42(6):406-10.
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  109. Douglas DB, Douglas RB, Oakes D, Scott G. Pulmonary function of London firemen. Br J Ind Med. 1985 Jan; 42(1):55-8.
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  110. Sherck JP, McCort JJ, Oakes DD. Computed tomography in thoracoabdominal trauma. J Trauma. 1984 Dec; 24(12):1015-21.
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  111. Harrington JM, Oakes D. Mortality study of British pathologists 1974-80. Br J Ind Med. 1984 May; 41(2):188-91.
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  112. Oakes DD, Sherck JP, Brodsky JB, Mark JB. Therapeutic thoracoscopy. J Thorac Cardiovasc Surg. 1984 Feb; 87(2):269-73.
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  113. Oakes D. Comparison of models for survival data. Stat Med. 1983 Apr-Jun; 2(2):305-11.
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  114. Pont A, Fox M, Merrell RC, Goldman E, Lee H, Oakes DD. Hyperparathyroidism in twins. Ann Intern Med. 1982 Nov; 97(5):721-2.
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  115. Oakes DD, Sherck JP, Maloney JR, Charters AC. Prognosis and management of victims of near-drowning. J Trauma. 1982 Jul; 22(7):544-9.
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  116. Oakes D. A concordance test for independence in the presence of censoring. Biometrics. 1982 Jun; 38(2):451-5.
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  117. Fawer RF, Gardner AW, Oakes D. Absences attributed to respiratory diseases in welders. Br J Ind Med. 1982 May; 39(2):149-52.
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  118. Spees EK, Light JA, Smith EJ, Mostofi FK, Oakes DD. Transplantation in patients with a history of renal cell carcinoma: long-term results and clinical considerations. Surgery. 1982 Mar; 91(3):282-7.
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  119. Oakes DD, Sherck JP, Mark JB. Lye ingestion. Clinical patterns and therapeutic implications. J Thorac Cardiovasc Surg. 1982 Feb; 83(2):194-204.
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  120. Oakes D, Douglas R, Knight K, Wusteman M, McDonald JC. Respiratory effects of prolonged exposure to gypsum dust. Ann Occup Hyg. 1982; 26(1-4):833-40.
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  121. Oakes D, McDonald JC. Restricted cohort study designs. Scand J Work Environ Health. 1982; 8 Suppl 1:30-3.
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  122. Allibone A, Oakes D, Shannon HS. The health and health care of doctors. J R Coll Gen Pract. 1981 Dec; 31(233):728-34.
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  123. Wall LM, Oakes D, Rycroft RJ. Virus warts in meat handlers. Contact Dermatitis. 1981 Sep; 7(5):259-67.
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  124. Oakes DD, Charters AC. Changing concepts in the management of splenic trauma. Surg Gynecol Obstet. 1981 Aug; 153(2):181-5.
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