URMC Research Network - Richard Phipps

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Richard Phipps

Title	Professor
Institution	School of Medicine and Dentistry
Department	Environmental Medicine
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 850 Rochester NY 14642

Other Positions


Title	Professor
Institution	School of Medicine and Dentistry
Department	Microbiology and Immunology
Title	Professor
Institution	School of Medicine and Dentistry
Department	Pathology and Laboratory Medicine

Title	Professor
Institution	School of Medicine and Dentistry
Department	Pediatrics

Title	Professor
Institution	School of Medicine and Dentistry
Department	Ophthalmology

Title	Professor
Institution	School of Medicine and Dentistry
Department	Obstetrics and Gynecology

Title	Professor
Institution	School of Medicine and Dentistry
Department	Medicine
Division	Medicine - Pulmonary Diseases and Critical Care

Awards And Honors

1973	-	1977	Loyola College Scholarship, Maryland Senatorial Scholarship, Cummins Engine Company Scholarship, 1973-1977.
1977	-	1979	Predoctoral Fellowship, Infectious Disease
1977			Graduated magna cum laude
1979	-	1980	Predoctoral Fellowship, Training in Cancer Etiology and Treatment
1979	-	1980	Postgraduate Scholar at the Walter & Eliza Hall Institute of Medical Research
1980			First Prize, Virginia Academy of Science, Microbiology Section,
1981	-	1982	Postdoctoral Fellowship
1982	-	1984	Arthritis Foundation Fellowship \| Arthritis Foundation
1984	-	1987	Arthritis Foundation Investigatorship \| Arthritis Foundation
1986			Travel Fellowship: NIH Conf on molecular biological approaches to rheumatic diseases \| National Institute of Arthritis, Arthritis Foundation Travel Fel
1986			Travel Fellowship to attend Amer Rheumatism Asso Mtg \| Arthritis Found/Merck, Sharp & Dohme Travel Fellowship
1992			Featured speaker-Second Interlaken Conf on Prostaglandins & Leukotrienes \| Interlaken Conference Organizers
1993			Distinguished Alumni Award for Excellence in Research and Scholarship \| Medical College of Virginia
1998			Arthur Kornberg Research Prize, University of Rochester \| Rochester, NY
2002			Faculty Award for Mentoring Pre-Doctoral students and Post-Doctoral Fellows
2006			Excellence in Research Award \| University of Rochester
2007			Toxicology Student Award for Teaching \| University of Rochester
2008	-	2012	Dean's Professor of Environmental Medicine \| University of Rochester

Overview

Dr. Phipps has authored or co-authorized over 170 articles, and numerous book chapters and reviews concerning control of normal and malignant B lymphocyte activation, cellular and molecular characterization of fibroblasts as mediators of inflammation, wound healing and fibrosis, Graves' ophthalmopathy, and platelet biology. He is on the editorial board of Clinical Immunology and is an ad hoc reviewer for many journals including the Journal of Clinical Investigation, American J. of Pathology, PNAS, Trends in Immunology, Journal of Biological Chemistry, and Journal of Immunology. Dr. Phipps is a member of the American Association for Cancer Research, The American Physiological Society, The American Association of Immunologists, The American Society of Clinical Pathology, and the American Thoracic Society. He has served on numerous review committees for the NIH and other government agencies.

Dr. Phipps was awarded three patents; immunologic conjugates of gram-negative bacterial autoinducer molecules, antibodies raised against immunogenic conjugates of gram-negative bacterial autoinducer molecules, and method for detecting a gram-negative bacterial autoinducer molecule. Dr. Phipps has received numerous awards and honors including the Arthur Kornberg Research Award, Burroughs-Wellcome Foundation Faculty Scholar, and the University of Rochester Pre and Postdoctoral Student Mentoring Award.

Dr. Phipps has dedicated his career to advancing biomedical research and training pre and postdoctoral students. His research studying prostaglandins, cytokines, and fibroblasts have contributed to a better understanding of B cell lymphoma, Graves' Disease, and inflammatory processes.

Selected Publications

Sahler J, Woeller C, Spinelli S, Blumberg N, Phipps R. A novel method for overexpression of peroxisome proliferator-activated receptor-? in megakaryocyte and platelet microparticles achieves transcellular signaling. J Thromb Haemost. 2012 Dec; 10(12):2563-72.

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Ramon S, Bancos S, Thatcher TH, Murant TI, Moshkani S, Sahler JM, Bottaro A, Sime PJ, Phipps RP. Peroxisome Proliferator-Activated Receptor ? B Cell-Specific-Deficient Mice Have an Impaired Antibody Response. J Immunol. 2012 Nov 15; 189(10):4740-7.

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Lannan KL, Sahler J, Spinelli SL, Phipps RP, Blumberg N. Transfusion immunomodulation - the case for leukoreduced and (perhaps) washed transfusions. Blood Cells Mol Dis. 2013 Jan; 50(1):61-8.

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Kottmann RM, Kulkarni AA, Smolnycki KA, Lyda E, Dahanayake T, Salibi R, Honnons S, Jones C, Isern NG, Hu JZ, Nathan SD, Grant G, Phipps RP, Sime PJ. Lactic Acid Is Elevated in Idiopathic Pulmonary Fibrosis and Induces Myofibroblast Differentiation via pH-Dependent Activation of Transforming Growth Factor-ß. Am J Respir Crit Care Med. 2012 Oct 15; 186(8):740-51.

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Blumberg N, Heal JM, Phillips GL, Phipps RP. Platelets--to transfuse or not to transfuse. Lancet. 2012 Oct 13; 380(9850):1287-9.

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Schäuble CL, Hampel R, Breitner S, Rückerl R, Phipps R, Diaz-Sanchez D, Devlin RB, Carter JD, Soukup J, Silbajoris R, Dailey L, Koenig W, Cyrys J, Geruschkat U, Belcredi P, Kraus U, Peters A, Schneider AE. Short-term effects of air temperature on blood markers of coagulation and inflammation in potentially susceptible individuals. Occup Environ Med. 2012 Sep; 69(9):670-8.

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Kulkarni AA, Woeller CF, Thatcher TH, Ramon S, Phipps RP, Sime PJ. Emerging PPAR?-Independent Role of PPAR? Ligands in Lung Diseases. PPAR Res. 2012; 2012:705352.

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Ramon S, Gao F, Serhan CN, Phipps RP. Specialized proresolving mediators enhance human B cell differentiation to antibody-secreting cells. J Immunol. 2012 Jul 15; 189(2):1036-42.

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Sahler J, Spinelli S, Phipps R, Blumberg N. CD40 ligand (CD154) involvement in platelet transfusion reactions. Transfus Clin Biol. 2012 Jun; 19(3):98-103.

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Refaai MA, Carter J, Henrichs KF, Davidson DC, Pollock SJ, Casey AE, Spinelli SL, Phipps RP, Francis CW, Blumberg N. Alterations of platelet function and clot formation kinetics after in vitro exposure to anti-A and -B. Transfusion. 2013 Feb; 53(2):382-93.

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Cholette JM, Henrichs KF, Alfieris GM, Powers KS, Phipps R, Spinelli SL, Swartz M, Gensini F, Daugherty LE, Nazarian E, Rubenstein JS, Sweeney D, Eaton M, Lerner NB, Blumberg N. Washing red blood cells and platelets transfused in cardiac surgery reduces postoperative inflammation and number of transfusions: Results of a prospective, randomized, controlled clinical trial*. Pediatr Crit Care Med. 2012 May; 13(3):290-9.

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Mongan J, Mieszczanska HZ, Smith BH, Messing SP, Phipps RP, Francis CW. Pioglitazone inhibits platelet function and potentiates the effects of aspirin: A prospective observation study. Thromb Res. 2012 Jun; 129(6):760-4.

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Kuriyan AE, Lehmann GM, Kulkarni AA, Woeller CF, Feldon SE, Hindman HB, Sime PJ, Huxlin KR, Phipps RP. Electrophilic PPAR? ligands inhibit corneal fibroblast to myofibroblast differentiation in vitro: A potentially novel therapy for corneal scarring. Exp Eye Res. 2012 Jan; 94(1):136-45.

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Rico de Souza A, Zago M, Pollock SJ, Sime PJ, Phipps RP, Baglole CJ. Genetic Ablation of the Aryl Hydrocarbon Receptor Causes Cigarette Smoke-induced Mitochondrial Dysfunction and Apoptosis. J Biol Chem. 2011 Dec 16; 286(50):43214-28.

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Blumberg N, Sime PJ, Phipps RP. The mystery of transfusion-related acute lung injury. Transfusion. 2011 Oct; 51(10):2054-7.

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Xi X, McMillan DH, Lehmann GM, Sime PJ, Libby RT, Huxlin KR, Feldon SE, Phipps RP. Ocular fibroblast diversity: implications for inflammation and ocular wound healing. Invest Ophthalmol Vis Sci. 2011 Jun; 52(7):4859-65.

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Olsen KC, Sapinoro RE, Kottmann RM, Kulkarni AA, Iismaa SE, Johnson GV, Thatcher TH, Phipps RP, Sime PJ. Transglutaminase 2 and its role in pulmonary fibrosis. Am J Respir Crit Care Med. 2011 Sep 15; 184(6):699-707.

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Hogan CM, Thatcher TH, Sapinoro RE, Gurell MN, Ferguson HE, Pollock SJ, Jones C, Phipps RP, Sime PJ. Electrophilic PPAR? Ligands Attenuate IL-1ß and Silica-Induced Inflammatory Mediator Production in Human Lung Fibroblasts via a PPAR?-Independent Mechanism. PPAR Res. 2011; 2011:318134.

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McMillan DH, Baglole CJ, Thatcher TH, Maggirwar S, Sime PJ, Phipps RP. Lung-targeted overexpression of the NF-?B member RelB inhibits cigarette smoke-induced inflammation. Am J Pathol. 2011 Jul; 179(1):125-33.

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Grimshaw K, Sahler J, Spinelli SL, Phipps RP, Blumberg N. New frontiers in transfusion biology: identification and significance of mediators of morbidity and mortality in stored red blood cells. Transfusion. 2011 Apr; 51(4):874-80.

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Guo N, Woeller CF, Feldon SE, Phipps RP. Peroxisome proliferator-activated receptor gamma ligands inhibit transforming growth factor-beta-induced, hyaluronan-dependent, T cell adhesion to orbital fibroblasts. J Biol Chem. 2011 May 27; 286(21):18856-67.

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Refaai MA, Fialkow LB, Heal JM, Henrichs KF, Spinelli SL, Phipps RP, Masel E, Smith BH, Corsetti JP, Francis CW, Bankey PE, Blumberg N. An association of ABO non-identical platelet and cryoprecipitate transfusions with altered red cell transfusion needs in surgical patients. Vox Sang. 2011 Jul; 101(1):55-60.

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Lehmann GM, Xi X, Kulkarni AA, Olsen KC, Pollock SJ, Baglole CJ, Gupta S, Casey AE, Huxlin KR, Sime PJ, Feldon SE, Phipps RP. The aryl hydrocarbon receptor ligand ITE inhibits TGFß1-induced human myofibroblast differentiation. Am J Pathol. 2011 Apr; 178(4):1556-67.

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Sahler J, Bernard JJ, Spinelli SL, Blumberg N, Phipps RP. The Feverfew plant-derived compound, parthenolide enhances platelet production and attenuates platelet activation through NF-?B inhibition. Thromb Res. 2011 May; 127(5):426-34.

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Kulkarni AA, Thatcher TH, Olsen KC, Maggirwar SB, Phipps RP, Sime PJ. PPAR-? ligands repress TGFß-induced myofibroblast differentiation by targeting the PI3K/Akt pathway: implications for therapy of fibrosis. PLoS One. 2011; 6(1):e15909.

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Blumberg N, Heal JM, Gettings KF, Phipps RP, Masel D, Refaai MA, Kirkley SA, Fialkow LB. An association between decreased cardiopulmonary complications (transfusion-related acute lung injury and transfusion-associated circulatory overload) and implementation of universal leukoreduction of blood transfusions. Transfusion. 2010 Dec; 50(12):2738-44.

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Davidson DC, Hirschman MP, Spinelli SL, Morrell CN, Schifitto G, Phipps RP, Maggirwar SB. Antiplatelet activity of valproic acid contributes to decreased soluble CD40 ligand production in HIV type 1-infected individuals. J Immunol. 2011 Jan 1; 186(1):584-91.

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Refaai MA, Phipps RP, Spinelli SL, Blumberg N. Platelet transfusions: impact on hemostasis, thrombosis, inflammation and clinical outcomes. Thromb Res. 2011 Apr; 127(4):287-91.

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Phipps RP. Platelets at the interface between thrombosis, inflammation and immunity. Thromb Res. 2011 Mar; 127(3):179.

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Spinelli SL, Maggirwar SB, Blumberg N, Phipps RP. Nuclear emancipation: a platelet tour de force. Sci Signal. 2010; 3(144):pe37.

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Simpson-Haidaris PJ, Seweryniak KE, Spinelli SL, Garcia-Bates TM, Murant TI, Pollock SJ, Sime PJ, Phipps RP. A putative role for platelet-derived PPAR? in vascular homeostasis demonstrated by anti-PPAR? induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis. J Biotechnol. 2010 Nov; 150(3):417-27.

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Bancos S, Phipps RP. Memory B cells from older people express normal levels of cyclooxygenase-2 and produce higher levels of IL-6 and IL-10 upon in vitro activation. Cell Immunol. 2010; 266(1):90-7.

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Woodroof EA, Phipps RP, Greenwood JE, Hickerson W, Herndon D. The Search for an Ideal Temporary Skin Substitute: AWBAT Plus, a Combination Product Wound Dressing Medical Device. Eplasty. 2010; 10.

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Stewart JC, Chalupa DC, Devlin RB, Frasier LM, Huang LS, Little EL, Lee SM, Phipps RP, Pietropaoli AP, Taubman MB, Utell MJ, Frampton MW. Vascular effects of ultrafine particles in persons with type 2 diabetes. Environ Health Perspect. 2010 Dec; 118(12):1692-8.

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Duque G, Li W, Adams M, Xu S, Phipps R. Effects of risedronate on bone marrow adipocytes in postmenopausal women. Osteoporos Int. 2011 May; 22(5):1547-53.

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Ramirez SH, Fan S, Dykstra H, Reichenbach N, Del Valle L, Potula R, Phipps RP, Maggirwar SB, Persidsky Y. Dyad of CD40/CD40 ligand fosters neuroinflammation at the blood-brain barrier and is regulated via JNK signaling: implications for HIV-1 encephalitis. J Neurosci. 2010 Jul 14; 30(28):9454-64.

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Lehmann GM, Woeller CF, Pollock SJ, O'Loughlin CW, Gupta S, Feldon SE, Phipps RP. Novel anti-adipogenic activity produced by human fibroblasts. Am J Physiol Cell Physiol. 2010 Sep; 299(3):C672-81.

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Edirisinghe I, Arunachalam G, Wong C, Yao H, Rahman A, Phipps RP, Jin ZG, Rahman I. Cigarette-smoke-induced oxidative/nitrosative stress impairs VEGF- and fluid-shear-stress-mediated signaling in endothelial cells. Antioxid Redox Signal. 2010 Jun 15; 12(12):1355-69.

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Bjarnsholt T, Jensen PØ, Jakobsen TH, Phipps R, Nielsen AK, Rybtke MT, Tolker-Nielsen T, Givskov M, Høiby N, Ciofu O. Quorum sensing and virulence of Pseudomonas aeruginosa during lung infection of cystic fibrosis patients. PLoS One. 2010; 5(4):e10115.

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Guo N, Baglole CJ, O'Loughlin CW, Feldon SE, Phipps RP. Mast cell-derived prostaglandin D2 controls hyaluronan synthesis in human orbital fibroblasts via DP1 activation: implications for thyroid eye disease. J Biol Chem. 2010 May 21; 285(21):15794-804.

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Simpson-Haidaris PJ, Pollock SJ, Ramon S, Guo N, Woeller CF, Feldon SE, Phipps RP. Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes. PPAR Res. 2010; 2010:814609.

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Blumberg N, Sime PJ, Phipps RP. Leukoreduction of blood transfusions--there is such a thing as a free lunch. Crit Care Med. 2010 Feb; 38(2):720-1.

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Spinelli SL, Casey AE, Pollock SJ, Gertz JM, McMillan DH, Narasipura SD, Mody NA, King MR, Maggirwar SB, Francis CW, Taubman MB, Blumberg N, Phipps RP. Platelets and megakaryocytes contain functional nuclear factor-kappaB. Arterioscler Thromb Vasc Biol. 2010 Mar; 30(3):591-8.

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Bancos S, Baglole CJ, Rahman I, Phipps RP. Induction of heme oxygenase-1 in normal and malignant B lymphocytes by 15-deoxy-Delta(12,14)-prostaglandin J(2) requires Nrf2. Cell Immunol. 2010; 262(1):18-27.

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Bernard MP, Bancos S, Chapman TJ, Ryan EP, Treanor JJ, Rose RC, Topham DJ, Phipps RP. Chronic inhibition of cyclooxygenase-2 attenuates antibody responses against vaccinia infection. Vaccine. 2010 Feb 3; 28(5):1363-72.

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Garcia-Bates TM, Baglole CJ, Bernard MP, Murant TI, Simpson-Haidaris PJ, Phipps RP. Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation. J Immunol. 2009 Dec 1; 183(11):6903-12.

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Hindman HB, Swanton JN, Phipps RP, Sime PJ, Huxlin KR. Differences in the TGF-{beta}1-induced profibrotic response of anterior and posterior corneal keratocytes in vitro. Invest Ophthalmol Vis Sci. 2010 Apr; 51(4):1935-42.

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Hampel R, Breitner S, Rückerl R, Frampton MW, Koenig W, Phipps RP, Wichmann HE, Peters A, Schneider A. Air temperature and inflammatory and coagulation responses in men with coronary or pulmonary disease during the winter season. Occup Environ Med. 2010 Jun; 67(6):408-16.

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Zhang Q, Hu JZ, Rommereim DN, Murphy MK, Phipps RP, Huso DL, Dicello JF. Application of high-resolution 1H MAS NMR spectroscopy to the analysis of intact bones from mice exposed to gamma radiation. Radiat Res. 2009 Nov; 172(5):607-16.

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Bertram KM, Baglole CJ, Phipps RP, Libby RT. Molecular regulation of cigarette smoke induced-oxidative stress in human retinal pigment epithelial cells: implications for age-related macular degeneration. Am J Physiol Cell Physiol. 2009 Nov; 297(5):C1200-10.

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Ferguson HE, Thatcher TH, Olsen KC, Garcia-Bates TM, Baglole CJ, Kottmann RM, Strong ER, Phipps RP, Sime PJ. Peroxisome proliferator-activated receptor-gamma ligands induce heme oxygenase-1 in lung fibroblasts by a PPARgamma-independent, glutathione-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2009 Nov; 297(5):L912-9.

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Kottmann RM, Hogan CM, Phipps RP, Sime PJ. Determinants of initiation and progression of idiopathic pulmonary fibrosis. Respirology. 2009 Sep; 14(7):917-33.

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Sniderhan LF, Garcia-Bates TM, Burgart M, Bernstein SH, Phipps RP, Maggirwar SB. Neurotrophin signaling through tropomyosin receptor kinases contributes to survival and proliferation of non-Hodgkin lymphoma. Exp Hematol. 2009 Nov; 37(11):1295-309.

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Bernard JJ, Seweryniak KE, Koniski AD, Spinelli SL, Blumberg N, Francis CW, Taubman MB, Palis J, Phipps RP. Foxp3 regulates megakaryopoiesis and platelet function. Arterioscler Thromb Vasc Biol. 2009 Nov; 29(11):1874-82.

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Heal JM, Phipps RP, Blumberg N. One big unhappy family: transfusion alloimmunization, thrombosis, and immune modulation/inflammation. Transfusion. 2009 Jun; 49(6):1032-6.

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Phipps RP, Blumberg N. Statin islands and PPAR ligands in platelets. Arterioscler Thromb Vasc Biol. 2009 May; 29(5):620-1.

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Springer DL, Miller JH, Spinelli SL, Pasa-Tolic L, Purvine SO, Daly DS, Zangar RC, Jin S, Blumberg N, Francis CW, Taubman MB, Casey AE, Wittlin SD, Phipps RP. Platelet proteome changes associated with diabetes and during platelet storage for transfusion. J Proteome Res. 2009 May; 8(5):2261-72.

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Bancos S, Bernard MP, Topham DJ, Phipps RP. Ibuprofen and other widely used non-steroidal anti-inflammatory drugs inhibit antibody production in human cells. Cell Immunol. 2009; 258(1):18-28.

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Ferguson HE, Kulkarni A, Lehmann GM, Garcia-Bates TM, Thatcher TH, Huxlin KR, Phipps RP, Sime PJ. Electrophilic peroxisome proliferator-activated receptor-gamma ligands have potent antifibrotic effects in human lung fibroblasts. Am J Respir Cell Mol Biol. 2009 Dec; 41(6):722-30.

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Blumberg N, Spinelli SL, Francis CW, Taubman MB, Phipps RP. The platelet as an immune cell-CD40 ligand and transfusion immunomodulation. Immunol Res. 2009; 45(2-3):251-60.

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Hwang CJ, Afifiyan N, Sand D, Naik V, Said J, Pollock SJ, Chen B, Phipps RP, Goldberg RA, Smith TJ, Douglas RS. Orbital fibroblasts from patients with thyroid-associated ophthalmopathy overexpress CD40: CD154 hyperinduces IL-6, IL-8, and MCP-1. Invest Ophthalmol Vis Sci. 2009 May; 50(5):2262-8.

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Garcia-Bates TM, Peslak SA, Baglole CJ, Maggirwar SB, Bernstein SH, Phipps RP. Peroxisome proliferator-activated receptor gamma overexpression and knockdown: impact on human B cell lymphoma proliferation and survival. Cancer Immunol Immunother. 2009 Jul; 58(7):1071-83.

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Kuriyan AE, Phipps RP, Feldon SE. The eye and thyroid disease. Curr Opin Ophthalmol. 2008 Nov; 19(6):499-506.

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Phipps RP. CD40: Lord of the endothelial cell. Blood. 2008 Nov 1; 112(9):3531-2.

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Bühren J, Nagy L, Swanton JN, Kenner S, MacRae S, Phipps RP, Huxlin KR. Optical effects of anti-TGFbeta treatment after photorefractive keratectomy in a cat model. Invest Ophthalmol Vis Sci. 2009 Feb; 50(2):634-43.

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Garcia-Bates TM, Bernstein SH, Phipps RP. Peroxisome proliferator-activated receptor gamma overexpression suppresses growth and induces apoptosis in human multiple myeloma cells. Clin Cancer Res. 2008 Oct 15; 14(20):6414-25.

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Tang SY, Allen MR, Phipps R, Burr DB, Vashishth D. Changes in non-enzymatic glycation and its association with altered mechanical properties following 1-year treatment with risedronate or alendronate. Osteoporos Int. 2009 Jun; 20(6):887-94.

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O'Brien JJ, Baglole CJ, Garcia-Bates TM, Blumberg N, Francis CW, Phipps RP. 15-deoxy-Delta12,14 prostaglandin J2-induced heme oxygenase-1 in megakaryocytes regulates thrombopoiesis. J Thromb Haemost. 2009 Jan; 7(1):182-9.

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Smith TJ, Tsai CC, Shih MJ, Tsui S, Chen B, Han R, Naik V, King CS, Press C, Kamat S, Goldberg RA, Phipps RP, Douglas RS, Gianoukakis AG. Unique attributes of orbital fibroblasts and global alterations in IGF-1 receptor signaling could explain thyroid-associated ophthalmopathy. Thyroid. 2008 Sep; 18(9):983-8.

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Lehmann GM, Feldon SE, Smith TJ, Phipps RP. Immune mechanisms in thyroid eye disease. Thyroid. 2008 Sep; 18(9):959-65.

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O'Brien JJ, Spinelli SL, Tober J, Blumberg N, Francis CW, Taubman MB, Palis J, Seweryniak KE, Gertz JM, Phipps RP. 15-deoxy-delta12,14-PGJ2 enhances platelet production from megakaryocytes. Blood. 2008 Nov 15; 112(10):4051-60.

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Baglole CJ, Maggirwar SB, Gasiewicz TA, Thatcher TH, Phipps RP, Sime PJ. The aryl hydrocarbon receptor attenuates tobacco smoke-induced cyclooxygenase-2 and prostaglandin production in lung fibroblasts through regulation of the NF-kappaB family member RelB. J Biol Chem. 2008 Oct 24; 283(43):28944-57.

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Baglole CJ, Sime PJ, Phipps RP. Cigarette smoke-induced expression of heme oxygenase-1 in human lung fibroblasts is regulated by intracellular glutathione. Am J Physiol Lung Cell Mol Physiol. 2008 Oct; 295(4):L624-36.

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Yang SR, Yao H, Rajendrasozhan S, Chung S, Edirisinghe I, Valvo S, Fromm G, McCabe MJ, Sime PJ, Phipps RP, Li JD, Bulger M, Rahman I. RelB is differentially regulated by IkappaB Kinase-alpha in B cells and mouse lung by cigarette smoke. Am J Respir Cell Mol Biol. 2009 Feb; 40(2):147-58.

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Kuriyan AE, Phipps RP, O'Loughlin CW, Feldon SE. Improvement of thyroid eye disease following treatment with the cyclooxygenase-2 selective inhibitor celecoxib. Thyroid. 2008 Aug; 18(8):911-4.

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Skindersoe ME, Alhede M, Phipps R, Yang L, Jensen PO, Rasmussen TB, Bjarnsholt T, Tolker-Nielsen T, Høiby N, Givskov M. Effects of antibiotics on quorum sensing in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 2008 Oct; 52(10):3648-63.

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Thatcher TH, Benson RP, Phipps RP, Sime PJ. High-dose but not low-dose mainstream cigarette smoke suppresses allergic airway inflammation by inhibiting T cell function. Am J Physiol Lung Cell Mol Physiol. 2008 Sep; 295(3):L412-21.

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Edirisinghe I, Yang SR, Yao H, Rajendrasozhan S, Caito S, Adenuga D, Wong C, Rahman A, Phipps RP, Jin ZG, Rahman I. VEGFR-2 inhibition augments cigarette smoke-induced oxidative stress and inflammatory responses leading to endothelial dysfunction. FASEB J. 2008 Jul; 22(7):2297-310.

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Caito S, Yang SR, Kode A, Edirisinghe I, Rajendrasozhan S, Phipps RP, Rahman I. Rosiglitazone and 15-deoxy-Delta12,14-prostaglandin J2, PPARgamma agonists, differentially regulate cigarette smoke-mediated pro-inflammatory cytokine release in monocytes/macrophages. Antioxid Redox Signal. 2008 Feb; 10(2):253-60.

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Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP. Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies. PPAR Res. 2008; 2008:834612.

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Hu JZ, Rommereim DN, Minard KR, Woodstock A, Harrer BJ, Wind RA, Phipps RP, Sime PJ. Metabolomics in lung inflammation:a high-resolution (1)h NMR study of mice exposedto silica dust. Toxicol Mech Methods. 2008; 18(5):385-98.

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Bernard MP, Bancos S, Sime PJ, Phipps RP. Targeting cyclooxygenase-2 in hematological malignancies: rationale and promise. Curr Pharm Des. 2008; 14(21):2051-60.

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Bjarnsholt T, Kirketerp-Møller K, Jensen PØ, Madsen KG, Phipps R, Krogfelt K, Høiby N, Givskov M. Why chronic wounds will not heal: a novel hypothesis. Wound Repair Regen. 2008 Jan-Feb; 16(1):2-10.

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Ray DM, Spinelli SL, Pollock SJ, Murant TI, O'Brien JJ, Blumberg N, Francis CW, Taubman MB, Phipps RP. Peroxisome proliferator-activated receptor gamma and retinoid X receptor transcription factors are released from activated human platelets and shed in microparticles. Thromb Haemost. 2008 Jan; 99(1):86-95.

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Spinelli SL, O'Brien JJ, Bancos S, Lehmann GM, Springer DL, Blumberg N, Francis CW, Taubman MB, Phipps RP. The PPAR-Platelet Connection: Modulators of Inflammation and Potential Cardiovascular Effects. PPAR Res. 2008; 2008:328172.

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Lehmann GM, Garcia-Bates TM, Smith TJ, Feldon SE, Phipps RP. Regulation of Lymphocyte Function by PPARgamma: Relevance to Thyroid Eye Disease-Related Inflammation. PPAR Res. 2008; 2008:895901.

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Cholette JM, Blumberg N, Phipps RP, McDermott MP, Gettings KF, Lerner NB. Developmental changes in soluble CD40 ligand. J Pediatr. 2008 Jan; 152(1):50-4, 54.e1.

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Bernard MP, Phipps RP. CpG oligodeoxynucleotides induce cyclooxygenase-2 in human B lymphocytes: implications for adjuvant activity and antibody production. Clin Immunol. 2007 Nov; 125(2):138-48.

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Ryan EP, Bushnell TP, Friedman AE, Rahman I, Phipps RP. Cyclooxygenase-2 independent effects of cyclooxygenase-2 inhibitors on oxidative stress and intracellular glutathione content in normal and malignant human B-cells. Cancer Immunol Immunother. 2008 Mar; 57(3):347-58.

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Mieszczanska H, Kaba NK, Francis CW, Gerich JE, Dodis R, Schwarz KQ, Phipps RP, Smith BH, Lee M, Messing S, Taubman MB. Effects of pioglitazone on fasting and postprandial levels of lipid and hemostatic variables in overweight non-diabetic patients with coronary artery disease. J Thromb Haemost. 2007 May; 5(5):942-9.

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Jensen PØ, Bjarnsholt T, Phipps R, Rasmussen TB, Calum H, Christoffersen L, Moser C, Williams P, Pressler T, Givskov M, Høiby N. Rapid necrotic killing of polymorphonuclear leukocytes is caused by quorum-sensing-controlled production of rhamnolipid by Pseudomonas aeruginosa. Microbiology. 2007 May; 153(Pt 5):1329-38.

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Foster DC, Piekarz KH, Murant TI, LaPoint R, Haidaris CG, Phipps RP. Enhanced synthesis of proinflammatory cytokines by vulvar vestibular fibroblasts: implications for vulvar vestibulitis. Am J Obstet Gynecol. 2007 Apr; 196(4):346.e1-8.

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Kaufman J, Spinelli SL, Schultz E, Blumberg N, Phipps RP. Release of biologically active CD154 during collection and storage of platelet concentrates prepared for transfusion. J Thromb Haemost. 2007 Apr; 5(4):788-96.

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Thatcher TH, Maggirwar SB, Baglole CJ, Lakatos HF, Gasiewicz TA, Phipps RP, Sime PJ. Aryl hydrocarbon receptor-deficient mice develop heightened inflammatory responses to cigarette smoke and endotoxin associated with rapid loss of the nuclear factor-kappaB component RelB. Am J Pathol. 2007 Mar; 170(3):855-64.

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Sui Z, Sniderhan LF, Schifitto G, Phipps RP, Gelbard HA, Dewhurst S, Maggirwar SB. Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia. J Immunol. 2007 Mar 1; 178(5):3226-36.

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Brookes PS, Morse K, Ray D, Tompkins A, Young SM, Hilchey S, Salim S, Konopleva M, Andreeff M, Phipps R, Bernstein SH. The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid and its derivatives elicit human lymphoid cell apoptosis through a novel pathway involving the unregulated mitochondrial permeability transition pore. Cancer Res. 2007 Feb 15; 67(4):1793-802.

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Rückerl R, Phipps RP, Schneider A, Frampton M, Cyrys J, Oberdörster G, Wichmann HE, Peters A. Ultrafine particles and platelet activation in patients with coronary heart disease--results from a prospective panel study. Part Fibre Toxicol. 2007; 4:1.

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Lakatos HF, Thatcher TH, Kottmann RM, Garcia TM, Phipps RP, Sime PJ. The Role of PPARs in Lung Fibrosis. PPAR Res. 2007; 2007:71323.

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Ryan EP, Malboeuf CM, Bernard M, Rose RC, Phipps RP. Cyclooxygenase-2 inhibition attenuates antibody responses against human papillomavirus-like particles. J Immunol. 2006 Dec 1; 177(11):7811-9.

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Ray DM, Akbiyik F, Phipps RP. The peroxisome proliferator-activated receptor gamma (PPARgamma) ligands 15-deoxy-Delta12,14-prostaglandin J2 and ciglitazone induce human B lymphocyte and B cell lymphoma apoptosis by PPARgamma-independent mechanisms. J Immunol. 2006 Oct 15; 177(8):5068-76.

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Blumberg N, Gettings KF, Turner C, Heal JM, Phipps RP. An association of soluble CD40 ligand (CD154) with adverse reactions to platelet transfusions. Transfusion. 2006 Oct; 46(10):1813-21.

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Feldon SE, O'loughlin CW, Ray DM, Landskroner-Eiger S, Seweryniak KE, Phipps RP. Activated human T lymphocytes express cyclooxygenase-2 and produce proadipogenic prostaglandins that drive human orbital fibroblast differentiation to adipocytes. Am J Pathol. 2006 Oct; 169(4):1183-93.

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Ray DM, Morse KM, Hilchey SP, Garcia TM, Felgar RE, Maggirwar SB, Phipps RP, Bernstein SH. The novel triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid (CDDO) induces apoptosis of human diffuse large B-cell lymphoma cells through a peroxisome proliferator-activated receptor gamma-independent pathway. Exp Hematol. 2006 Sep; 34(9):1202-11.

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O'Brien JJ, Ray DM, Spinelli SL, Blumberg N, Taubman MB, Francis CW, Wittlin SD, Phipps RP. The platelet as a therapeutic target for treating vascular diseases and the role of eicosanoid and synthetic PPARgamma ligands. Prostaglandins Other Lipid Mediat. 2007 Jan; 82(1-4):68-76.

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Khan SY, Kelher MR, Heal JM, Blumberg N, Boshkov LK, Phipps R, Gettings KF, McLaughlin NJ, Silliman CC. Soluble CD40 ligand accumulates in stored blood components, primes neutrophils through CD40, and is a potential cofactor in the development of transfusion-related acute lung injury. Blood. 2006 Oct 1; 108(7):2455-62.

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Ryan EP, Pollock SJ, Kaur K, Felgar RE, Bernstein SH, Chiorazzi N, Phipps RP. Constitutive and activation-inducible cyclooxygenase-2 expression enhances survival of chronic lymphocytic leukemia B cells. Clin Immunol. 2006 Jul; 120(1):76-90.

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Baglole CJ, Bushinsky SM, Garcia TM, Kode A, Rahman I, Sime PJ, Phipps RP. Differential induction of apoptosis by cigarette smoke extract in primary human lung fibroblast strains: implications for emphysema. Am J Physiol Lung Cell Mol Physiol. 2006 Jul; 291(1):L19-29.

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Baglole CJ, Ray DM, Bernstein SH, Feldon SE, Smith TJ, Sime PJ, Phipps RP. More than structural cells, fibroblasts create and orchestrate the tumor microenvironment. Immunol Invest. 2006; 35(3-4):297-325.

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Ishri RK, Menzies S, Halliday GM. Verapamil induces upregulation of P-glycoprotein expression on human monocyte derived dendritic cells. Immunol Invest. 2006; 35(1):1-18.

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Ray DM, Spinelli SL, O'Brien JJ, Blumberg N, Phipps RP. Platelets as a novel target for PPARgamma ligands : implications for inflammation, diabetes, and cardiovascular disease. BioDrugs. 2006; 20(4):231-41.

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Feldon SE, Park DJ, O'Loughlin CW, Nguyen VT, Landskroner-Eiger S, Chang D, Thatcher TH, Phipps RP. Autologous T-lymphocytes stimulate proliferation of orbital fibroblasts derived from patients with Graves' ophthalmopathy. Invest Ophthalmol Vis Sci. 2005 Nov; 46(11):3913-21.

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Purkerson JM, Smith RS, Pollock SJ, Phipps RP. The TRAF6, but not the TRAF2/3, binding domain of CD40 is required for cytokine production in human lung fibroblasts. Eur J Immunol. 2005 Oct; 35(10):2920-8.

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Martey CA, Baglole CJ, Gasiewicz TA, Sime PJ, Phipps RP. The aryl hydrocarbon receptor is a regulator of cigarette smoke induction of the cyclooxygenase and prostaglandin pathways in human lung fibroblasts. Am J Physiol Lung Cell Mol Physiol. 2005 Sep; 289(3):L391-9.

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Thatcher TH, McHugh NA, Egan RW, Chapman RW, Hey JA, Turner CK, Redonnet MR, Seweryniak KE, Sime PJ, Phipps RP. Role of CXCR2 in cigarette smoke-induced lung inflammation. Am J Physiol Lung Cell Mol Physiol. 2005 Aug; 289(2):L322-8.

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Ray DM, Akbiyik F, Bernstein SH, Phipps RP. CD40 engagement prevents peroxisome proliferator-activated receptor gamma agonist-induced apoptosis of B lymphocytes and B lymphoma cells by an NF-kappaB-dependent mechanism. J Immunol. 2005 Apr 1; 174(7):4060-9.

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Ryan EP, Pollock SJ, Pollack SJ, Murant TI, Bernstein SH, Felgar RE, Phipps RP. Activated human B lymphocytes express cyclooxygenase-2 and cyclooxygenase inhibitors attenuate antibody production. J Immunol. 2005 Mar 1; 174(5):2619-26.

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Burgess HA, Daugherty LE, Thatcher TH, Lakatos HF, Ray DM, Redonnet M, Phipps RP, Sime PJ. PPARgamma agonists inhibit TGF-beta induced pulmonary myofibroblast differentiation and collagen production: implications for therapy of lung fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1146-53.

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O'Reilly KM, Phipps RP, Thatcher TH, Graf BA, Van Kirk J, Sime PJ. Crystalline and amorphous silica differentially regulate the cyclooxygenase-prostaglandin pathway in pulmonary fibroblasts: implications for pulmonary fibrosis. Am J Physiol Lung Cell Mol Physiol. 2005 Jun; 288(6):L1010-6.

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Baglole CJ, Reddy SY, Pollock SJ, Feldon SE, Sime PJ, Smith TJ, Phipps RP. Isolation and phenotypic characterization of lung fibroblasts. Methods Mol Med. 2005; 117:115-27.

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Ray DM, Bernstein SH, Phipps RP. Human multiple myeloma cells express peroxisome proliferator-activated receptor gamma and undergo apoptosis upon exposure to PPARgamma ligands. Clin Immunol. 2004 Nov; 113(2):203-13.

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Turner CK, Blieden TM, Smith TJ, Feldon SE, Foster DC, Sime PJ, Phipps RP. A novel ELISpot method for adherent cells. J Immunol Methods. 2004 Aug; 291(1-2):63-70.

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Martey CA, Pollock SJ, Turner CK, O'Reilly KM, Baglole CJ, Phipps RP, Sime PJ. Cigarette smoke induces cyclooxygenase-2 and microsomal prostaglandin E2 synthase in human lung fibroblasts: implications for lung inflammation and cancer. Am J Physiol Lung Cell Mol Physiol. 2004 Nov; 287(5):L981-91.

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Akbiyik F, Ray DM, Gettings KF, Blumberg N, Francis CW, Phipps RP. Human bone marrow megakaryocytes and platelets express PPARgamma, and PPARgamma agonists blunt platelet release of CD40 ligand and thromboxanes. Blood. 2004 Sep 1; 104(5):1361-8.

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Nieves DS, Phipps RP, Pollock SJ, Ochs HD, Zhu Q, Scott GA, Ryan CK, Kobayashi I, Rossi TM, Goldsmith LA. Dermatologic and immunologic findings in the immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome. Arch Dermatol. 2004 Apr; 140(4):466-72.

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Phipps RP, Ryan E, Bernstein SH. Inhibition of cyclooxygenase-2: a new targeted therapy for B-cell lymphoma? Leuk Res. 2004 Feb; 28(2):109-11.

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Kaufman J, Sime PJ, Phipps RP. Expression of CD154 (CD40 ligand) by human lung fibroblasts: differential regulation by IFN-gamma and IL-13, and implications for fibrosis. J Immunol. 2004 Feb 1; 172(3):1862-71.

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Elder A, Gelein R, Finkelstein J, Phipps R, Frampton M, Utell M, Kittelson DB, Watts WF, Hopke P, Jeong CH, Kim E, Liu W, Zhao W, Zhuo L, Vincent R, Kumarathasan P, Oberdörster G. On-road exposure to highway aerosols. 2. Exposures of aged, compromised rats. Inhal Toxicol. 2004; 16 Suppl 1:41-53.

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Koumas L, Smith TJ, Feldon S, Blumberg N, Phipps RP. Thy-1 expression in human fibroblast subsets defines myofibroblastic or lipofibroblastic phenotypes. Am J Pathol. 2003 Oct; 163(4):1291-300.

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Blumberg N, Phipps RP, Kaufman J, Heal JM. The causes and treatment of reactions to platelet transfusions. Transfusion. 2003 Feb; 43(2):291-2; author reply 292.

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Roper RL, Graf B, Phipps RP. Prostaglandin E2 and cAMP promote B lymphocyte class switching to IgG1. Immunol Lett. 2002 Dec 3; 84(3):191-8.

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Smith RS, Kelly R, Iglewski BH, Phipps RP. The Pseudomonas autoinducer N-(3-oxododecanoyl) homoserine lactone induces cyclooxygenase-2 and prostaglandin E2 production in human lung fibroblasts: implications for inflammation. J Immunol. 2002 Sep 1; 169(5):2636-42.

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Koumas L, Phipps RP. Differential COX localization and PG release in Thy-1(+) and Thy-1(-) human female reproductive tract fibroblasts. Am J Physiol Cell Physiol. 2002 Aug; 283(2):C599-608.

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Padilla J, Leung E, Phipps RP. Human B lymphocytes and B lymphomas express PPAR-gamma and are killed by PPAR-gamma agonists. Clin Immunol. 2002 Apr; 103(1):22-33.

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Harris SG, Padilla J, Koumas L, Ray D, Phipps RP. Prostaglandins as modulators of immunity. Trends Immunol. 2002 Mar; 23(3):144-50.

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Koumas L, Smith TJ, Phipps RP. Fibroblast subsets in the human orbit: Thy-1+ and Thy-1- subpopulations exhibit distinct phenotypes. Eur J Immunol. 2002 Feb; 32(2):477-85.

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Smith RS, Harris SG, Phipps R, Iglewski B. The Pseudomonas aeruginosa quorum-sensing molecule N-(3-oxododecanoyl)homoserine lactone contributes to virulence and induces inflammation in vivo. J Bacteriol. 2002 Feb; 184(4):1132-9.

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Harris SG, Smith RS, Phipps RP. 15-deoxy-Delta 12,14-PGJ2 induces IL-8 production in human T cells by a mitogen-activated protein kinase pathway. J Immunol. 2002 Feb 1; 168(3):1372-9.

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Harris SG, Phipps RP. Induction of apoptosis in mouse T cells upon peroxisome proliferator-activated receptor gamma (PPAR-gamma) binding. Adv Exp Med Biol. 2002; 507:421-5.

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Harris SG, Phipps RP. Prostaglandin D(2), its metabolite 15-d-PGJ(2), and peroxisome proliferator activated receptor-gamma agonists induce apoptosis in transformed, but not normal, human T lineage cells. Immunology. 2002 Jan; 105(1):23-34.

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Smith TJ, Koumas L, Gagnon A, Bell A, Sempowski GD, Phipps RP, Sorisky A. Orbital fibroblast heterogeneity may determine the clinical presentation of thyroid-associated ophthalmopathy. J Clin Endocrinol Metab. 2002 Jan; 87(1):385-92.

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Koumas L, King AE, Critchley HO, Kelly RW, Phipps RP. Fibroblast heterogeneity: existence of functionally distinct Thy 1(+) and Thy 1(-) human female reproductive tract fibroblasts. Am J Pathol. 2001 Sep; 159(3):925-35.

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Smith RS, Fedyk ER, Springer TA, Mukaida N, Iglewski BH, Phipps RP. IL-8 production in human lung fibroblasts and epithelial cells activated by the Pseudomonas autoinducer N-3-oxododecanoyl homoserine lactone is transcriptionally regulated by NF-kappa B and activator protein-2. J Immunol. 2001 Jul 1; 167(1):366-74.

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Kaufman J, Graf BA, Leung EC, Pollock SJ, Koumas L, Reddy SY, Blieden TM, Smith TJ, Phipps RP. Fibroblasts as sentinel cells: role of the CDcd40-CDcd40 ligand system in fibroblast activation and lung inflammation and fibrosis. Chest. 2001 Jul; 120(1 Suppl):53S-55S.

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Phipps RP, Kaufman J, Blumberg N. Platelet derived CD154 (CD40 ligand) and febrile responses to transfusion. Lancet. 2001 Jun 23; 357(9273):2023-4.

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Phipps RP, Koumas L, Leung E, Reddy SY, Blieden T, Kaufman J. The CD40-CD40 ligand system: a potential therapeutic target in atherosclerosis. Curr Opin Investig Drugs. 2001 Jun; 2(6):773-7.

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Fedyk ER, Jones D, Critchley HO, Phipps RP, Blieden TM, Springer TA. Expression of stromal-derived factor-1 is decreased by IL-1 and TNF and in dermal wound healing. J Immunol. 2001 May 1; 166(9):5749-54.

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Harris SG, Phipps RP. The nuclear receptor PPAR gamma is expressed by mouse T lymphocytes and PPAR gamma agonists induce apoptosis. Eur J Immunol. 2001 Apr; 31(4):1098-105.

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Borrello MA, Palis J, Phipps RP. The relationship of CD5+ B lymphocytes to macrophages: insights from normal biphenotypic B/macrophage cells. Int Rev Immunol. 2001 Feb; 20(1):137-55.

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King AE, Kelly RW, Critchley HO, Malmstrom A, Sennstrom M, Phipps RP. Cd40 expression in uterine tissues: a key regulator of cytokine expression by fibroblasts. J Clin Endocrinol Metab. 2001 Jan; 86(1):405-12.

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Padilla J, Kaur K, Cao HJ, Smith TJ, Phipps RP. Peroxisome proliferator activator receptor-gamma agonists and 15-deoxy-Delta(12,14)(12,14)-PGJ(2) induce apoptosis in normal and malignant B-lineage cells. J Immunol. 2000 Dec 15; 165(12):6941-8.

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Phipps RP. Atherosclerosis: the emerging role of inflammation and the CD40-CD40 ligand system. Proc Natl Acad Sci U S A. 2000 Jun 20; 97(13):6930-2.

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Pryhuber GS, O'Brien DP, Baggs R, Phipps R, Huyck H, Sanz I, Nahm MH. Ablation of tumor necrosis factor receptor type I (p55) alters oxygen-induced lung injury. Am J Physiol Lung Cell Mol Physiol. 2000 May; 278(5):L1082-90.

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Graf BA, Nazarenko DA, Borrello MA, Roberts LJ, Morrow JD, Phipps RP. Proinflammatory signals upregulate COX-2 and increase PGE2 production in biphenotypic B/macrophage cells. Ann N Y Acad Sci. 2000 Apr; 905:294-6.

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Harris SG, Phipps RP. Peroxisome proliferator-activated receptor gamma (PPAR-gamma) activation in naive mouse T cells induces cell death. Ann N Y Acad Sci. 2000 Apr; 905:297-300.

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Padilla J, Kaur K, Phipps RP. Effects of 15-deoxy-delta 12,14-PGJ2 on B lineage cells. Ann N Y Acad Sci. 2000 Apr; 905:322-5.

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Padilla J, Kaur K, Harris SG, Phipps RP. PPAR-gamma-mediated regulation of normal and malignant B lineage cells. Ann N Y Acad Sci. 2000 Apr; 905:97-109.

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Phipps RP, Pollock SJ, Kaur K, Kaufman J, Borrello MA, Graf BA, Nazarenko D, Roberts LJ, Morrow JD, Palis J, Ryan DJ, Bennett JM. Expression of cyclooxygenase-2 and prostaglandins by B-1 cells and B-CLL cells. Curr Top Microbiol Immunol. 2000; 252:293-300.

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Phipps RP. The Second International Scientific Symposium on Tea & Human Health, September 14th, 1998. Nutrition. 1999 Nov-Dec; 15(11-12):968-71.

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Graf BA, Nazarenko DA, Borrello MA, Roberts LJ, Morrow JD, Palis J, Phipps RP. Biphenotypic B/macrophage cells express COX-1 and up-regulate COX-2 expression and prostaglandin E(2) production in response to pro-inflammatory signals. Eur J Immunol. 1999 Nov; 29(11):3793-803.

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Borrello MA, Phipps RP. Fibroblast-secreted macrophage colony-stimulating factor is responsible for generation of biphenotypic B/macrophage cells from a subset of mouse B lymphocytes. J Immunol. 1999 Oct 1; 163(7):3605-11.

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Smith TJ, Sciaky D, Phipps RP, Jennings TA. CD40 expression in human thyroid tissue: evidence for involvement of multiple cell types in autoimmune and neoplastic diseases. Thyroid. 1999 Aug; 9(8):749-55.

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Kaur K, Harris SG, Padilla J, Graf BA, Phipps RP. Prostaglandin E2 as a modulator of lymphocyte mediated inflammatory and humoral responses. Adv Exp Med Biol. 1999; 469:409-12.

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Adawi A, Zhang Y, Baggs R, Rubin P, Williams J, Finkelstein J, Phipps RP. Blockade of CD40-CD40 ligand interactions protects against radiation-induced pulmonary inflammation and fibrosis. Clin Immunol Immunopathol. 1998 Dec; 89(3):222-30.

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Cao HJ, Wang HS, Zhang Y, Lin HY, Phipps RP, Smith TJ. Activation of human orbital fibroblasts through CD40 engagement results in a dramatic induction of hyaluronan synthesis and prostaglandin endoperoxide H synthase-2 expression. Insights into potential pathogenic mechanisms of thyroid-associated ophthalmopathy. J Biol Chem. 1998 Nov 6; 273(45):29615-25.

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Adawi A, Zhang Y, Baggs R, Finkelstein J, Phipps RP. Disruption of the CD40-CD40 ligand system prevents an oxygen-induced respiratory distress syndrome. Am J Pathol. 1998 Mar; 152(3):651-7.

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Sempowski GD, Rozenblit J, Smith TJ, Phipps RP. Human orbital fibroblasts are activated through CD40 to induce proinflammatory cytokine production. Am J Physiol. 1998 Mar; 274(3 Pt 1):C707-14.

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Zhang Y, Cao HJ, Graf B, Meekins H, Smith TJ, Phipps RP. CD40 engagement up-regulates cyclooxygenase-2 expression and prostaglandin E2 production in human lung fibroblasts. J Immunol. 1998 Feb 1; 160(3):1053-7.

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Smith TJ, Sempowski GD, Berenson CS, Cao HJ, Wang HS, Phipps RP. Human thyroid fibroblasts exhibit a distinctive phenotype in culture: characteristic ganglioside profile and functional CD40 expression. Endocrinology. 1997 Dec; 138(12):5576-88.

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Ostberg JR, Dragone LL, Borrello MA, Phipps RP, Barth RK, Frelinger JG. Expression of mouse CD43 in the B cell lineage of transgenic mice causes impaired immune responses to T-independent antigens. Eur J Immunol. 1997 Sep; 27(9):2152-9.

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Smith RS, Smith TJ, Blieden TM, Phipps RP. Fibroblasts as sentinel cells. Synthesis of chemokines and regulation of inflammation. Am J Pathol. 1997 Aug; 151(2):317-22.

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Sempowski GD, Chess PR, Phipps RP. CD40 is a functional activation antigen and B7-independent T cell costimulatory molecule on normal human lung fibroblasts. J Immunol. 1997 May 15; 158(10):4670-7.

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Sempowski GD, Chess PR, Moretti AJ, Padilla J, Phipps RP, Blieden TM. CD40 mediated activation of gingival and periodontal ligament fibroblasts. J Periodontol. 1997 Mar; 68(3):284-92.

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Fedyk ER, Brown DM, Phipps RP. PGE2 regulation of B lymphocytes and T helper 1 and T helper 2 cells: induction of inflammatory versus allergic responses. Adv Exp Med Biol. 1997; 407:237-42.

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Phipps RP, Borrello MA, Blieden TM. Fibroblast heterogeneity in the periodontium and other tissues. J Periodontal Res. 1997 Jan; 32(1 Pt 2):159-65.

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Brown DM, Phipps RP. Prostaglandin E2 mediated apoptosis in subsets of malignant B lymphoma cells. Adv Exp Med Biol. 1997; 400B:565-70.

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Fedyk ER, Harris SG, Padilla J, Phipps RP. Prostaglandin receptors of the EP2 and EP4 subtypes regulate B lymphocyte activation and differentiation to IgE-secreting cells. Adv Exp Med Biol. 1997; 433:153-7.

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Ostberg JR, Dragone LL, Driskell T, Moynihan JA, Phipps R, Barth RK, Frelinger JG. Disregulated expression of CD43 (leukosialin, sialophorin) in the B cell lineage leads to immunodeficiency. J Immunol. 1996 Dec 1; 157(11):4876-84.

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Fedyk ER, Adawi A, Looney RJ, Phipps RP. Regulation of IgE and cytokine production by cAMP: implications for extrinsic asthma. Clin Immunol Immunopathol. 1996 Nov; 81(2):101-13.

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Borrello MA, Phipps RP. Differential Thy-1 expression by splenic fibroblasts defines functionally distinct subsets. Cell Immunol. 1996 Nov 1; 173(2):198-206.

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Borrello MA, Phipps RP. The B/macrophage cell: an elusive link between CD5+ B lymphocytes and macrophages. Immunol Today. 1996 Oct; 17(10):471-5.

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Fedyk ER, Phipps RP. Prostaglandin E2 receptors of the EP2 and EP4 subtypes regulate activation and differentiation of mouse B lymphocytes to IgE-secreting cells. Proc Natl Acad Sci U S A. 1996 Oct 1; 93(20):10978-83.

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Cameron EM, Zhuang J, Menconi MJ, Phipps R, Fink MP. Dantrolene, an inhibitor of intracellular calcium release, fails to increase survival in a rat model of intra-abdominal sepsis. Crit Care Med. 1996 Sep; 24(9):1537-42.

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Brown DM, Phipps RP. Bcl-2 expression inhibits prostaglandin E2-mediated apoptosis in B cell lymphomas. J Immunol. 1996 Aug 15; 157(4):1359-70.

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Gaspari AA, Sempowski GD, Chess P, Gish J, Phipps RP. Human epidermal keratinocytes are induced to secrete interleukin-6 and co-stimulate T lymphocyte proliferation by a CD40-dependent mechanism. Eur J Immunol. 1996 Jun; 26(6):1371-7.

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Sempowski GD, Derdak S, Phipps RP. Interleukin-4 and interferon-gamma discordantly regulate collagen biosynthesis by functionally distinct lung fibroblast subsets. J Cell Physiol. 1996 May; 167(2):290-6.

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Fedyk ER, Ripper JM, Brown DM, Phipps RP. A molecular analysis of PGE receptor (EP) expression on normal and transformed B lymphocytes: coexpression of EP1, EP2, EP3beta and EP4. Mol Immunol. 1996 Jan; 33(1):33-45.

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Borrello MA, Phipps RP. Fibroblasts support outgrowth of splenocytes simultaneously expressing B lymphocyte and macrophage characteristics. J Immunol. 1995 Nov 1; 155(9):4155-61.

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Fries KM, Sempowski GD, Gaspari AA, Blieden T, Looney RJ, Phipps RP. CD40 expression by human fibroblasts. Clin Immunol Immunopathol. 1995 Oct; 77(1):42-51.

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Smith TJ, Sempowski GD, Wang HS, Del Vecchio PJ, Lippe SD, Phipps RP. Evidence for cellular heterogeneity in primary cultures of human orbital fibroblasts. J Clin Endocrinol Metab. 1995 Sep; 80(9):2620-5.

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Sempowski GD, Borrello MA, Blieden TM, Barth RK, Phipps RP. Fibroblast heterogeneity in the healing wound. Wound Repair Regen. 1995 Apr-Jun; 3(2):120-31.

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Brown DM, Phipps RP. Characterization and regulation of prostaglandin E2 receptors on normal and malignant murine B lymphocytes. Cell Immunol. 1995 Mar; 161(1):79-87.

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Keng PC, Phipps R, Penney DP. In vitro radiation sensitivity of mouse lung fibroblasts isolated by flow cytometry. Int J Radiat Oncol Biol Phys. 1995 Feb 1; 31(3):519-23.

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Brown DM, Phipps RP. Characterization of prostaglandin E2 receptors on normal and malignant B lymphocytes. Adv Prostaglandin Thromboxane Leukot Res. 1995; 23:299-301.

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Roper RL, Brown DM, Phipps RP. Prostaglandin E2 promotes B lymphocyte Ig isotype switching to IgE. J Immunol. 1995 Jan 1; 154(1):162-70.

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Silvera MR, Phipps RP. Synthesis of interleukin-1 receptor antagonist by Thy-1+ and Thy-1- murine lung fibroblast subsets. J Interferon Cytokine Res. 1995 Jan; 15(1):63-70.

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Fries KM, Felch ME, Phipps RP. Interleukin-6 is an autocrine growth factor for murine lung fibroblast subsets. Am J Respir Cell Mol Biol. 1994 Nov; 11(5):552-60.

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Silvera MR, Sempowski GD, Phipps RP. Expression of TGF-beta isoforms by Thy-1+ and Thy-1- pulmonary fibroblast subsets: evidence for TGF-beta as a regulator of IL-1-dependent stimulation of IL-6. Lymphokine Cytokine Res. 1994 Oct; 13(5):277-85.

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Fries KM, Blieden T, Looney RJ, Sempowski GD, Silvera MR, Willis RA, Phipps RP. Evidence of fibroblast heterogeneity and the role of fibroblast subpopulations in fibrosis. Clin Immunol Immunopathol. 1994 Sep; 72(3):283-92.

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Fedyk ER, Phipps RP. Reactive oxygen species and not lipoxygenase products are required for mouse B-lymphocyte activation and differentiation. Int J Immunopharmacol. 1994 Jul; 16(7):533-46.

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Willis RA, Nussler AK, Fries KM, Geller DA, Phipps RP. Induction of nitric oxide synthase in subsets of murine pulmonary fibroblasts: effect on fibroblast interleukin-6 production. Clin Immunol Immunopathol. 1994 May; 71(2):231-9.

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Sempowski GD, Beckmann MP, Derdak S, Phipps RP. Subsets of murine lung fibroblasts express membrane-bound and soluble IL-4 receptors. Role of IL-4 in enhancing fibroblast proliferation and collagen synthesis. J Immunol. 1994 Apr 1; 152(7):3606-14.

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Roper RL, Ludlow JW, Phipps RP. Prostaglandin E2 inhibits B lymphocyte activation by a cAMP-dependent mechanism: PGE-inducible regulatory proteins. Cell Immunol. 1994 Apr 1; 154(1):296-308.

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Roper RL, Phipps RP. Prostaglandin E2 regulation of the immune response. Adv Prostaglandin Thromboxane Leukot Res. 1994; 22:101-11.

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Fedyk ER, Borrello MA, Brown DM, Phipps RP. Regulation of B cell tolerance and triggering by immune complexes. Chem Immunol. 1994; 58:67-91.

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Stein-Streilein J, Phipps RP. Horses and zebras. Reg Immunol. 1993 May-Aug; 5(3-4):127-33.

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Roper RL, Phipps RP. Prostaglandin E2 and cAMP inhibit B lymphocyte activation and simultaneously promote IgE and IgG1 synthesis. J Immunol. 1992 Nov 1; 149(9):2984-91.

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Felch ME, Willis RA, Penney DP, Keng PC, Phipps RP. Expression of alpha 6 beta 1 integrin, the laminin receptor, on subsets of normal murine lung fibroblasts and its upregulation by the inflammatory cytokines IFN-gamma and TNF-alpha. Reg Immunol. 1992 Nov-Dec; 4(6):363-70.

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Derdak S, Penney DP, Keng P, Felch ME, Brown D, Phipps RP. Differential collagen and fibronectin production by Thy 1+ and Thy 1- lung fibroblast subpopulations. Am J Physiol. 1992 Aug; 263(2 Pt 1):L283-90.

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Stein SH, Phipps RP. Anti-class II antibodies potentiate IgG2a production by lipopolysaccharide-stimulated B lymphocytes treated with prostaglandin E2 and IFN-gamma. J Immunol. 1992 Jun 15; 148(12):3943-9.

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Brown DM, Warner GL, Alés-Martínez JE, Scott DW, Phipps RP. Prostaglandin E2 induces apoptosis in immature normal and malignant B lymphocytes. Clin Immunol Immunopathol. 1992 Jun; 63(3):221-9.

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Alés-Martinez JE, Scott DW, Phipps RP, Casnellie JE, Kroemer G, Martinez C, Pezzi L. Cross-linking of surface IgM or IgD causes differential biological effects in spite of overlap in tyrosine (de)phosphorylation profile. Eur J Immunol. 1992 Mar; 22(3):845-50.

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Penney DP, Keng PC, Derdak S, Phipps RP. Morphologic and functional characteristics of subpopulations of murine lung fibroblasts grown in vitro. Anat Rec. 1992 Mar; 232(3):432-43.

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Stein SH, Phipps RP. Antigen-specific IGG2A production in response to prostaglandin E2, immune complexes, and IFN-gamma. J Immunol. 1991 Oct 15; 147(8):2500-6.

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Phipps RP, Stein SH, Roper RL. A new view of prostaglandin E regulation of the immune response. Immunol Today. 1991 Oct; 12(10):349-52.

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Derdak S, Dixon P, Watts H, Penney D, Phipps R. CD4 expression in lung fibroblasts. Lancet. 1991 Feb 9; 337(8737):374.

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Stein SH, Phipps RP. Elevated levels of intracellular cAMP sensitize resting B lymphocytes to immune complex-induced unresponsiveness. Eur J Immunol. 1991 Feb; 21(2):313-8.

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Roper RL, Conrad DH, Brown DM, Warner GL, Phipps RP. Prostaglandin E2 promotes IL-4-induced IgE and IgG1 synthesis. J Immunol. 1990 Oct 15; 145(8):2644-51.

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Phipps RP, Roper RL, Stein SH. Regulation of B-cell tolerance and triggering by macrophages and lymphoid dendritic cells. Immunol Rev. 1990 Oct; 117:135-58.

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Phipps RP, Baecher C, Frelinger JG, Penney DP, Keng P, Brown D. Differential expression of interleukin 1 alpha by Thy-1+ and Thy-1- lung fibroblast subpopulations: enhancement of interleukin 1 alpha production by tumor necrosis factor-alpha. Eur J Immunol. 1990 Aug; 20(8):1723-7.

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Stein SH, Phipps RP. Macrophage-secreted prostaglandin E2 potentiates immune complex-induced B cell unresponsiveness. Eur J Immunol. 1990 Feb; 20(2):403-7.

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Phipps RP, Penney DP, Keng P, Silvera M, Harkins S, Derdak S. Immune functions of subpopulations of lung fibroblasts. Immunol Res. 1990; 9(4):275-86.

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Schad V, Phipps RP. Prostaglandin E2-dependent induction of B cell unresponsiveness. Role of surface Ig and Fc receptors. J Immunol. 1989 Oct 1; 143(7):2127-32.

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Quill H, Gaur A, Brown D, Infante AJ, Phipps RP. Synergistic activation of granulocyte-macrophage colony-stimulating factor production by IL-1 and IL-2 in murine Th1 cells. J Immunol. 1989 Oct 1; 143(7):2242-7.

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Phipps RP, Roper RL, Stein SH. Alternative antigen presentation pathways: accessory cells which down-regulate immune responses. Reg Immunol. 1989 Sep-Oct; 2(5):326-39.

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Phipps RP, Penney DP, Keng P, Quill H, Paxhia A, Derdak S, Felch ME. Characterization of two major populations of lung fibroblasts: distinguishing morphology and discordant display of Thy 1 and class II MHC. Am J Respir Cell Mol Biol. 1989 Jul; 1(1):65-74.

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Phipps RP, Lee D, Schad V, Warner GL. E-series prostaglandins are potent growth inhibitors for some B lymphomas. Eur J Immunol. 1989 Jun; 19(6):995-1001.

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Quill H, Gaur A, Phipps RP. Prostaglandin E2-dependent induction of granulocyte-macrophage colony-stimulating factor secretion by cloned murine helper T cells. J Immunol. 1989 Feb 1; 142(3):813-8.

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Schad VC, Phipps RP. Two signals are required for accessory cells to induce B cell unresponsiveness. Tolerogenic Ig and prostaglandin. J Immunol. 1988 Jul 1; 141(1):79-84.

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Cogswell JP, Phipps RP, Scott DW. Role of self carriers in the immune response and tolerance. XI. Correlation of Ia expression and interleukin-1 production with delivery of immunogenic signals in vivo by hapten-modified accessory cell-like tumor lines. Cell Immunol. 1988 Jun; 114(1):55-70.

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Phipps RP, Spaulding M, Szakos J. DNA is a potent immunogen for spleen cells and for guanosine-binding B lymphocytes. Cell Immunol. 1988 Apr 15; 113(1):202-13.

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Phipps RP, Illig K, Schad V, Bhimani K. Differential presentation of tolerogenic immunoglobulin in vivo by macrophages and by a lymphoid dendritic cell-like tumor line. J Leukoc Biol. 1988 Mar; 43(3):271-8.

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Sadegh-Nasseri S, Phipps RP. Immunogenic presentation of an immunoglobulin "tolerogen" requires interleukin 2. Eur J Immunol. 1988 Mar; 18(3):417-23.

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Cogswell JP, Phipps RP, Scott DW. Role of self carriers in the immune response and tolerance. X. A lymphoid dendritic-like tumor, P388AD.2, acts as a novel immunogenic carrier for hapten. J Immunol. 1986 Aug 1; 137(3):777-83.

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Phipps RP, Szakos J, Illig K. A method for the isolation of autoreactive B cells. J Immunol Methods. 1986 Apr 17; 88(2):163-70.

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Tew JG, Mandel TE, Phipps RP, Szakal AK. Tissue localization and retention of antigen in relation to the immune response. Am J Anat. 1984 Jul; 170(3):407-20.

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Phipps RP, Pillai PS, Scott DW. Conversion of a tolerogenic to an immunogenic signal by P388AD.2 cells, a lymphoid dendritic cell-like tumor line. J Immunol. 1984 May; 132(5):2273-8.

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Phipps RP, Mandel TE, Schnizlein CT, Tew JG. Anamnestic responses induced by antigen persisting on follicular dendritic cells from cyclophosphamide-treated mice. Immunology. 1984 Feb; 51(2):387-97.

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Phipps RP, Scott DW. Function of IgD in B cell triggering and tolerance: an overview of recent advances. Surv Immunol Res. 1984; 3(2-3):195-7.

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Phipps RP, Scott DW. A novel role for macrophages: the ability of macrophages to tolerize B cells. J Immunol. 1983 Nov; 131(5):2122-7.

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Duffett C, Pell J, Phipps R, Wells U, Widdicombe J. Stimulation of nasal mucus secretion in the rabbit. Adv Exp Med Biol. 1982; 144:431-2.

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Mandel TE, Phipps RP, Abbot AP, Tew JG. Long-term antigen retention by dendritic cells in the popliteal lymph node of immunized mice. Immunology. 1981 Jun; 43(2):353-62.

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Phipps RP, Mandel TE, Tew JG. Effect of immunosuppressive agents on antigen retained in lymphoid follicles and collagenous tissue of immune mice. Cell Immunol. 1981 Jan 15; 57(2):505-16.

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Phipps RP, Mitchell GF, Mandel TE, Tew JG. Antibody isotypes mediating antigen retention in passively immunized mice. Immunology. 1980 Jul; 40(3):459-66.

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Phipps RP, Tew JG, Miller GA, Mandel TE. A murine model for analysis of spontaneous induction and feedback regulation of specific antibody synthesis. Immunol Commun. 1980; 9(1):55-70.

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Tew JG, Phipps RP, Mandel TE. The maintenance and regulation of the humoral immune response: persisting antigen and the role of follicular antigen-binding dendritic cells as accessory cells. Immunol Rev. 1980; 53:175-201.

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Mandel TE, Phipps RP, Abbot A, Tew JG. The follicular dendritic cell: long term antigen retention during immunity. Immunol Rev. 1980; 53:29-59.

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Gallagher JT, Kent PW, Phipps R, Richardson P. Influence of pilocarpine and ammonia vapour on the secretion and structure of cat tracheal mucins: differentiation of goblet and submucosal gland cell secretions. Adv Exp Med Biol. 1977; 89:91-102.

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