Faqian Li
| Title | Associate Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pathology and Laboratory Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 626
Rochester NY 14642
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| 2000 |
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| Finalist, Young Investigator Awards | Heart Failure Society of America |
Congestive heart failure is a major health problem in developed countries and incidence increases as the population ages. Cardiac chamber dilatation and poor contractile performance is the structural and functional basis of heart pump dysfunction.
At the cellular level, chamber dilatation in cardiac failure is largely caused by excessive elongation of heart muscle cells with inadequate increase in cell diameter. The Li Laboratory is investigating the molecular mechanisms that regulate cardiac muscle cell shape change and structural remodeling during heart hypertrophy and failure.
Our findings have pointed to a key role for Wnt/beta-catenin signaling in the transition from heart hypertrophy to failure. Currently, we are searching for beta-catenin signaling targets and partners in heart muscle cells with the hope of identifying key molecules involved in the regulation of cardiac muscle cell shape for future therapeutic intervention.
The Li Laboratory found that mammalian heart muscle cells rapidly switched from proliferation to hypertrophy in neonatal period while the cells in other vertebrates like chicken continued to proliferate even in adults. Using animal models and explanted failing human hearts, we showed that Wnt/beta-catenin signaling, an important developmental pathway, was upregulated during heart failure. This pathway can be explored as a potential therapeutic target.
Another impediment for cardiac repair and recovery from injuries is that the main functional cells, cardiac myocytes, lack significant regenerative potential. By investigating the molecular mechanism that control the transition of heart muscle cells from hyperplasia to hypertrophy, we aim at finding key pathways for novel interventions to promote cardiac regeneration. We are especially interested in epigenetic changes during this neonatal transition.
Epigenetics is a new frontier in biology, with far-reaching implications. Modifications of DNA and DNA binding proteins without any change in primary DNA sequences play important roles in aging, cancer, and many chronic diseases. We have shown that epigenetic changes can be used to diagnose and classify cancers.
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Le NT, Heo KS, Takei Y, Lee H, Woo CH, Chang E, McClain C, Hurley C, Wang X, Li F, Xu H, Morrell C, Sullivan MA, Cohen MS, Serafimova IM, Taunton J, Fujiwara K, Abe J. A Crucial Role for p90RSK-Mediated Reduction of ERK5 Transcriptional Activity in Endothelial Dysfunction and Atherosclerosis. Circulation. 2013 Jan 29; 127(4):486-99.
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Klunder A, Subik K, Ye B, Xu H, Li F. Intimal sarcoma of the abdominal aorta presenting as a retroperitoneal mass. Pathology. 2012 Aug; 44(5):485-7.
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Ye B, Ge Y, Perens G, Hong L, Xu H, Fishbein MC, Li F. Canonical Wnt/ß-catenin signaling in epicardial fibrosis of failed pediatric heart allografts with diastolic dysfunction. Cardiovasc Pathol. 2013 Jan; 22(1):54-7.
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Mao W, You T, Ye B, Li X, Dong HH, Hill JA, Li F, Xu H. Reactive Oxygen Species Suppress Cardiac Na(V)1.5 Expression through Foxo1. PLoS One. 2012; 7(2):e32738.
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Li F, Ye B, Hong L, Xu H, Fishbein MC. Epigenetic modifications of histone h4 in lung neuroendocrine tumors. Appl Immunohistochem Mol Morphol. 2011 Oct; 19(5):389-94.
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Ye J, Hameed O, Findeis-Hosey JJ, Fan L, Li F, McMahon LA, Yang Q, Wang HL, Xu H. Diagnostic utility of PAX8, TTF-1 and napsin A for discriminating metastatic carcinoma from primary adenocarcinoma of the lung. Biotech Histochem. 2012 Jan; 87(1):30-4.
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Mentrikoski MJ, Zhao C, Zhang J, Wang HL, McMahon LA, Yang Q, Li F, Xu H. Metastatic endometrial stromal sarcoma of the lung: importance of immunohistochemical staining, clinical history and imaging studies. Biotech Histochem. 2012 Jan; 87(1):35-9.
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Ye J, Findeis-Hosey JJ, Yang Q, McMahon LA, Yao JL, Li F, Xu H. Combination of napsin A and TTF-1 immunohistochemistry helps in differentiating primary lung adenocarcinoma from metastatic carcinoma in the lung. Appl Immunohistochem Mol Morphol. 2011 Jul; 19(4):313-7.
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Findeis-Hosey JJ, Huang J, Li F, Yang Q, McMahon LA, Xu H. High-grade neuroendocrine carcinomas of the lung highly express enhancer of zeste homolog 2, but carcinoids do not. Hum Pathol. 2011 Jun; 42(6):867-72.
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Ferrantino M, Eichelberger J, Burack HR, Li F, Lee FE. A 48-year-old woman with a large mediastinal mass. Chest. 2010 Nov; 138(5):1260-4.
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Li F, Wang X, Xu H, Roggli VL. Small neuroendocrine lesions in intrathoracic lymph nodes of patients with primary lung adenocarcinoma: real metastasis? Am J Surg Pathol. 2010 Nov; 34(11):1701-7.
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Lei D, Li F, Su H, Tian Z, Ye B, Wei N, Wang X. COP9 signalosome subunit 8 is required for postnatal hepatocyte survival and effective proliferation. Cell Death Differ. 2011 Feb; 18(2):259-70.
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Parikh SS, Li F, Fong MW. Cardiac arteriovenous malformation. J Am Coll Cardiol. 2010 Apr 20; 55(16):e133.
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Perens G, Li F, Meier S, Kaur R, Alejos JC, Fishbein M. Clinico-pathologic findings in end-stage pediatric heart transplant grafts. Pediatr Transplant. 2009 Nov; 13(7):887-91.
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Qu J, Zhou J, Yi XP, Dong B, Zheng H, Miller LM, Wang X, Schneider MD, Li F. Cardiac-specific haploinsufficiency of beta-catenin attenuates cardiac hypertrophy but enhances fetal gene expression in response to aortic constriction. J Mol Cell Cardiol. 2007 Sep; 43(3):319-26.
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Zhou J, Qu J, Yi XP, Graber K, Huber L, Wang X, Gerdes AM, Li F. Upregulation of gamma-catenin compensates for the loss of beta-catenin in adult cardiomyocytes. Am J Physiol Heart Circ Physiol. 2007 Jan; 292(1):H270-6.
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Yi XP, Zhou J, Huber L, Qu J, Wang X, Gerdes AM, Li F. Nuclear compartmentalization of FAK and FRNK in cardiac myocytes. Am J Physiol Heart Circ Physiol. 2006 Jun; 290(6):H2509-15.
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Chen Q, Liu JB, Horak KM, Zheng H, Kumarapeli AR, Li J, Li F, Gerdes AM, Wawrousek EF, Wang X. Intrasarcoplasmic amyloidosis impairs proteolytic function of proteasomes in cardiomyocytes by compromising substrate uptake. Circ Res. 2005 Nov 11; 97(10):1018-26.
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Yi XP, Zhou J, Baker J, Wang X, Gerdes AM, Li F. Myocardial expression and redistribution of GRKs in hypertensive hypertrophy and failure. Anat Rec A Discov Mol Cell Evol Biol. 2005 Jan; 282(1):13-23.
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Dong X, Liu J, Zheng H, Glasford JW, Huang W, Chen QH, Harden NR, Li F, Gerdes AM, Wang X. In situ dynamically monitoring the proteolytic function of the ubiquitin-proteasome system in cultured cardiac myocytes. Am J Physiol Heart Circ Physiol. 2004 Sep; 287(3):H1417-25.
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Li F, Wang X, Yi XP, Gerdes AM. Structural basis of ventricular remodeling: role of the myocyte. Curr Heart Fail Rep. 2004 Apr-May; 1(1):5-8.
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Wang X, Klevitsky R, Huang W, Glasford J, Li F, Robbins J. AlphaB-crystallin modulates protein aggregation of abnormal desmin. Circ Res. 2003 Nov 14; 93(10):998-1005.
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Yi XP, Wang X, Gerdes AM, Li F. Subcellular redistribution of focal adhesion kinase and its related nonkinase in hypertrophic myocardium. Hypertension. 2003 Jun; 41(6):1317-23.
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Yi XP, Gerdes AM, Li F. Myocyte redistribution of GRK2 and GRK5 in hypertensive, heart-failure-prone rats. Hypertension. 2002 Jun; 39(6):1058-63.
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Wang X, Li F, Gerdes AM. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: I. Regional hemodynamics and myocyte remodeling. J Mol Cell Cardiol. 1999 Feb; 31(2):307-17.
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Wang X, Li F, Campbell SE, Gerdes AM. Chronic pressure overload cardiac hypertrophy and failure in guinea pigs: II. Cytoskeletal remodeling. J Mol Cell Cardiol. 1999 Feb; 31(2):319-31.
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Li F, McNelis MR, Lustig K, Gerdes AM. Hyperplasia and hypertrophy of chicken cardiac myocytes during posthatching development. Am J Physiol. 1997 Aug; 273(2 Pt 2):R518-26.
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Li F, Wang X, Bunger PC, Gerdes AM. Formation of binucleated cardiac myocytes in rat heart: I. Role of actin-myosin contractile ring. J Mol Cell Cardiol. 1997 Jun; 29(6):1541-51.
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Li F, Wang X, Gerdes AM. Formation of binucleated cardiac myocytes in rat heart: II. Cytoskeletal organisation. J Mol Cell Cardiol. 1997 Jun; 29(6):1553-65.
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Wang X, Li F, Said S, Capasso JM, Gerdes AM. Measurement of regional myocardial blood flow in rats by unlabeled microspheres and Coulter channelyzer. Am J Physiol. 1996 Oct; 271(4 Pt 2):H1656-65.
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Li F, Wang X, Capasso JM, Gerdes AM. Rapid transition of cardiac myocytes from hyperplasia to hypertrophy during postnatal development. J Mol Cell Cardiol. 1996 Aug; 28(8):1737-46.
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