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Paul Morrow

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentEnvironmental Medicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box EHSC
Rochester NY 14642
 
 Selected Publications
  • Reddy MB, Dobrev ID, McNett DA, Tobin JM, Utell MJ, Morrow PE, Domoradzki JY, Plotzke KP, Andersen ME. Inhalation dosimetry modeling with decamethylcyclopentasiloxane in rats and humans. Toxicol Sci. 2008 Oct; 105(2):275-85.
    View in: PubMed
  • Frampton MW, Stewart JC, Oberdörster G, Morrow PE, Chalupa D, Pietropaoli AP, Frasier LM, Speers DM, Cox C, Huang LS, Utell MJ. Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environ Health Perspect. 2006 Jan; 114(1):51-8.
    View in: PubMed
  • Frampton MW, Utell MJ, Zareba W, Oberdörster G, Cox C, Huang LS, Morrow PE, Lee FE, Chalupa D, Frasier LM, Speers DM, Stewart J. Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma. Res Rep Health Eff Inst. 2004 Dec; (126):1-47; discussion 49-63.
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  • Chalupa DC, Morrow PE, Oberdörster G, Utell MJ, Frampton MW. Ultrafine particle deposition in subjects with asthma. Environ Health Perspect. 2004 Jun; 112(8):879-82.
    View in: PubMed
  • Pietropaoli AP, Frampton MW, Hyde RW, Morrow PE, Oberdörster G, Cox C, Speers DM, Frasier LM, Chalupa DC, Huang LS, Utell MJ. Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhal Toxicol. 2004; 16 Suppl 1:59-72.
    View in: PubMed
  • Daigle CC, Chalupa DC, Gibb FR, Morrow PE, Oberdörster G, Utell MJ, Frampton MW. Ultrafine particle deposition in humans during rest and exercise. Inhal Toxicol. 2003 May; 15(6):539-52.
    View in: PubMed
  • Reddy MB, Andersen ME, Morrow PE, Dobrev ID, Varaprath S, Plotzke KP, Utell MJ. Physiological modeling of inhalation kinetics of octamethylcyclotetrasiloxane in humans during rest and exercise. Toxicol Sci. 2003 Mar; 72(1):3-18.
    View in: PubMed
  • Zareba G, Gelein R, Morrow PE, Utell MJ. Percutaneous absorption studies of octamethylcyclotetrasiloxane using the human skin/nude mouse model. Skin Pharmacol Appl Skin Physiol. 2002 May-Jun; 15(3):184-94.
    View in: PubMed
  • Frampton MW, Boscia J, Roberts NJ, Azadniv M, Torres A, Cox C, Morrow PE, Nichols J, Chalupa D, Frasier LM, Gibb FR, Speers DM, Tsai Y, Utell MJ. Nitrogen dioxide exposure: effects on airway and blood cells. Am J Physiol Lung Cell Mol Physiol. 2002 Jan; 282(1):L155-65.
    View in: PubMed
  • Morrow PE, Bruce MC, Doull J. Louis James Casarett (1927-1972). Toxicol Sci. 2001 Oct; 63(2):151-2.
    View in: PubMed
  • Voter KZ, Whitin JC, Torres A, Morrow PE, Cox C, Tsai Y, Utell MJ, Frampton MW. Ozone exposure and the production of reactive oxygen species by bronchoalveolar cells in humans. Inhal Toxicol. 2001 Jun; 13(6):465-83.
    View in: PubMed
  • Morrow PE, Witschi H, Vore M, Hakkinen PE, MacGregor J, MacGregor J, Anders MW, Willhite C. Profiles in toxicology. Harold Carpenter Hodge (1904-1990). Toxicol Sci. 2000 Feb; 53(2):157-8.
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  • Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ. Aldehydes (nonanal and hexanal) in rat and human bronchoalveolar lavage fluid after ozone exposure. Res Rep Health Eff Inst. 1999 Nov; (90):1-15; discussion 17-8.
    View in: PubMed
  • Frampton MW, Pryor WA, Cueto R, Cox C, Morrow PE, Utell MJ. Ozone exposure increases aldehydes in epithelial lining fluid in human lung. Am J Respir Crit Care Med. 1999 Apr; 159(4 Pt 1):1134-7.
    View in: PubMed
  • Utell MJ, Gelein R, Yu CP, Kenaga C, Geigel E, Torres A, Chalupa D, Gibb FR, Speers DM, Mast RW, Morrow PE. Quantitative exposure of humans to an octamethylcyclotetrasiloxane (D4) vapor. Toxicol Sci. 1998 Aug; 44(2):206-13.
    View in: PubMed
  • Looney RJ, Frampton MW, Byam J, Kenaga C, Speers DM, Cox C, Mast R, Klykken PC, Morrow PE, Utell MJ. Acute respiratory exposure of human volunteers to octamethylcyclotetrasiloxane (D4): absence of immunological effects. Toxicol Sci. 1998 Aug; 44(2):214-20.
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  • Tong Z, Utell MJ, Morrow PE, Rusch GM, Anders MW. Metabolism of 1,1-dichloro-1-fluoroethane (HCFC-141b) in human volunteers. Drug Metab Dispos. 1998 Jul; 26(7):711-3.
    View in: PubMed
  • Frampton MW, Morrow PE, Torres A, Voter KZ, Whitin JC, Cox C, Speers DM, Tsai Y, Utell MJ. Effects of ozone on normal and potentially sensitive human subjects. Part II: Airway inflammation and responsiveness to ozone in nonsmokers and smokers. Res Rep Health Eff Inst. 1997 Jun; (78):39-72; discussion 81-99.
    View in: PubMed
  • Frampton MW, Morrow PE, Torres A, Cox C, Voter KZ, Utell MJ. Ozone responsiveness in smokers and nonsmokers. Am J Respir Crit Care Med. 1997 Jan; 155(1):116-21.
    View in: PubMed
  • Rahill AA, Weiss B, Morrow PE, Frampton MW, Cox C, Gibb R, Gelein R, Speers D, Utell MJ. Human performance during exposure to toluene. Aviat Space Environ Med. 1996 Jul; 67(7):640-7.
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  • Torres A, Voter KZ, Utell MJ, Whitin JC, Morrow PE, Frampton MW. Production of reactive oxygen intermediates following exposure to ozone. Relative contribution of alveolar macrophages. Chest. 1996 Mar; 109(3 Suppl):8S.
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  • Morrow PE, Haseman JK, Hobbs CH, Driscoll KE, Vu V, Oberdörster G. The maximum tolerated dose for inhalation bioassays: toxicity vs overload. Fundam Appl Toxicol. 1996 Feb; 29(2):155-67.
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  • Culp DJ, Latchney LR, Frampton MW, Jahnke MR, Morrow PE, Utell MJ. Composition of human airway mucins and effects after inhalation of acid aerosol. Am J Physiol. 1995 Sep; 269(3 Pt 1):L358-70.
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  • Frampton MW, Morrow PE, Cox C, Levy PC, Condemi JJ, Speers D, Gibb FR, Utell MJ. Sulfuric acid aerosol followed by ozone exposure in healthy and asthmatic subjects. Environ Res. 1995 Apr; 69(1):1-14.
    View in: PubMed
  • Utell MJ, Frampton MW, Morrow PE, Cox C, Levy PC, Speers DM, Gibb FR. Oxidant and acid aerosol exposure in healthy subjects and subjects with asthma. Part II: Effects of sequential sulfuric acid and ozone exposures on the pulmonary function of healthy subjects and subjects with asthma. Res Rep Health Eff Inst. 1994 Nov; (70):37-93, discussion 95-112.
    View in: PubMed
  • Frampton MW, Voter KZ, Morrow PE, Roberts NJ, Culp DJ, Cox C, Utell MJ. Sulfuric acid aerosol exposure in humans assessed by bronchoalveolar lavage. Am Rev Respir Dis. 1992 Sep; 146(3):626-32.
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  • Smith RJ, Hyde RW, Waldman DL, Freund GG, Weber DA, Utell MJ, Morrow PE. Effect of pattern of aerosol inhalation on clearance of technetium-99m-labeled diethylenetriamine pentaacetic acid from the lungs of normal humans. Am Rev Respir Dis. 1992 May; 145(5):1109-16.
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  • Morrow PE. Dust overloading of the lungs: update and appraisal. Toxicol Appl Pharmacol. 1992 Mar; 113(1):1-12.
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  • Morrow PE, Utell MJ, Bauer MA, Smeglin AM, Frampton MW, Cox C, Speers DM, Gibb FR. Pulmonary performance of elderly normal subjects and subjects with chronic obstructive pulmonary disease exposed to 0.3 ppm nitrogen dioxide. Am Rev Respir Dis. 1992 Feb; 145(2 Pt 1):291-300.
    View in: PubMed
  • Oberdörster G, Ferin J, Morrow PE. Volumetric loading of alveolar macrophages (AM): a possible basis for diminished AM-mediated particle clearance. Exp Lung Res. 1992 Jan-Mar; 18(1):87-104.
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  • Utell MJ, Frampton MW, Morrow PE. Air pollution and asthma: clinical studies with sulfuric acid aerosols. Allergy Proc. 1991 Nov-Dec; 12(6):385-8.
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  • Utell MJ, Frampton MW, Roberts NJ, Finkelstein JN, Cox C, Morrow PE. Mechanisms of nitrogen dioxide toxicity in humans. Res Rep Health Eff Inst. 1991 Aug; (43):1-33.
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  • Frampton MW, Morrow PE, Cox C, Gibb FR, Speers DM, Utell MJ. Effects of nitrogen dioxide exposure on pulmonary function and airway reactivity in normal humans. Am Rev Respir Dis. 1991 Mar; 143(3):522-7.
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  • Johnson DA, Frampton MW, Winters RS, Morrow PE, Utell MJ. Inhalation of nitrogen dioxide fails to reduce the activity of human lung alpha-1-proteinase inhibitor. Am Rev Respir Dis. 1990 Oct; 142(4):758-62.
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  • Stöber W, Morrow PE, Morawietz G. Alveolar retention and clearance of insoluble particles in rats simulated by a new physiology-oriented compartmental kinetics model. Fundam Appl Toxicol. 1990 Aug; 15(2):329-49.
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  • Frampton MW, Finkelstein JN, Roberts NJ, Smeglin AM, Morrow PE, Utell MJ. Effects of nitrogen dioxide exposure on bronchoalveolar lavage proteins in humans. Am J Respir Cell Mol Biol. 1989 Dec; 1(6):499-505.
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  • Stöber W, Morrow PE, Hoover MD. Compartmental modeling of the long-term retention of insoluble particles deposited in the alveolar region of the lung. Fundam Appl Toxicol. 1989 Nov; 13(4):823-42.
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  • Yu CP, Chen YK, Morrow PE. An analysis of alveolar macrophage mobility kinetics at dust overloading of the lungs. Fundam Appl Toxicol. 1989 Oct; 13(3):452-9.
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  • Lewis TR, Morrow PE, McClellan RO, Raabe OG, Kennedy GL, Schwetz BA, Goehl TJ, Roycroft JH, Chhabra RS. Establishing aerosol exposure concentrations for inhalation toxicity studies. Toxicol Appl Pharmacol. 1989 Jul; 99(3):377-83.
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  • Diamond GL, Morrow PE, Panner BJ, Gelein RM, Baggs RB. Reversible uranyl fluoride nephrotoxicity in the Long Evans rat. Fundam Appl Toxicol. 1989 Jul; 13(1):65-78.
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  • Frampton MW, Smeglin AM, Roberts NJ, Finkelstein JN, Morrow PE, Utell MJ. Nitrogen dioxide exposure in vivo and human alveolar macrophage inactivation of influenza virus in vitro. Environ Res. 1989 Apr; 48(2):179-92.
    View in: PubMed
  • Morrow PE, Utell MJ. Responses of susceptible subpopulations to nitrogen dioxide. Res Rep Health Eff Inst. 1989 Feb; (23):1-45.
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  • Platner JW, Morrow PE. Altered clearance of inhaled 99mTc-pentetate aerosols following exposure to cadmium chloride aerosols in ferrets. Exp Lung Res. 1989; 15(1):77-91.
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  • Pinkston P, Smeglin A, Roberts NJ, Gibb FR, Morrow PE, Utell MJ. Effects of in vitro exposure to nitrogen dioxide on human alveolar macrophage release of neutrophil chemotactic factor and interleukin-1. Environ Res. 1988 Oct; 47(1):48-58.
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  • Zalups RK, Gelein RM, Morrow PE, Diamond GL. Nephrotoxicity of uranyl fluoride in uninephrectomized and sham-operated rats. Toxicol Appl Pharmacol. 1988 Jun 15; 94(1):11-22.
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  • Morrow PE. Possible mechanisms to explain dust overloading of the lungs. Fundam Appl Toxicol. 1988 Apr; 10(3):369-84.
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  • Greenspan BJ, Morrow PE, Ferin J. Effects of aerosol exposures to cadmium chloride on the clearance of titanium dioxide from the lungs of rats. Exp Lung Res. 1988; 14(4):491-9.
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  • Waldman DL, Weber DA, Oberdörster G, Drago SR, Utell MJ, Hyde RW, Morrow PE. Chemical breakdown of technetium-99m DTPA during nebulization. J Nucl Med. 1987 Mar; 28(3):378-82.
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  • Bauer MA, Utell MJ, Morrow PE, Speers DM, Gibb FR. Inhalation of 0.30 ppm nitrogen dioxide potentiates exercise-induced bronchospasm in asthmatics. Am Rev Respir Dis. 1986 Dec; 134(6):1203-8.
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  • Oberdörster G, Utell MJ, Morrow PE, Hyde RW, Weber DA. Bronchial and alveolar absorption of inhaled 99mTc-DTPA. Am Rev Respir Dis. 1986 Nov; 134(5):944-50.
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  • Morrow PE. Factors determining hygroscopic aerosol deposition in airways. Physiol Rev. 1986 Apr; 66(2):330-76.
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  • Lehnert BE, Morrow PE. The initial lag in phagocytic rate by macrophages in monolayer is related to particle encounters and binding. Immunol Invest. 1985 Dec; 14(6):515-21.
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  • Lehnert BE, Morrow PE. Association of 59iron oxide with alveolar macrophages during alveolar clearance. Exp Lung Res. 1985; 9(1-2):1-16.
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  • Lehnert BE, Morrow PE. Characteristics of alveolar macrophages following the deposition of a low burden or iron oxide in the lung. J Toxicol Environ Health. 1985; 16(6):855-68.
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  • Lehnert BE, Morrow PE. Size, adherence, and phagocytic characteristics of alveolar macrophages harvested 'early' and 'later' during bronchoalveolar lavage. J Immunol Methods. 1984 Oct 26; 73(2):329-35.
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  • Utell MJ, Morrow PE, Hyde RW. Airway reactivity to sulfate and sulfuric acid aerosols in normal and asthmatic subjects. J Air Pollut Control Assoc. 1984 Sep; 34(9):931-5.
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  • Oberdörster G, Utell MJ, Weber DA, Ivanovich M, Hyde RW, Morrow PE. Lung clearance of inhaled 99mTc-DTPA in the dog. J Appl Physiol. 1984 Aug; 57(2):589-95.
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  • Greenspan BJ, Morrow PE. The effects of in vitro and aerosol exposures to cadmium on phagocytosis by rat pulmonary macrophages. Fundam Appl Toxicol. 1984 Feb; 4(1):48-57.
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  • Velasquez DJ, Morrow PE. Estimation of guinea pig tracheobronchial transport rates using a compartmental model. Exp Lung Res. 1984; 7(3-4):163-76.
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  • Lehnert BE, Morrow PE. Preservation of Fc gamma receptor-mediated particle phagocytosis and binding with rat alveolar macrophages adhered to a plastic substrate in a serum free system. Immunol Commun. 1984; 13(4):313-23.
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  • Utell MJ, Morrow PE, Speers DM, Darling J, Hyde RW. Airway responses to sulfate and sulfuric acid aerosols in asthmatics. An exposure-response relationship. Am Rev Respir Dis. 1983 Sep; 128(3):444-50.
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  • Morrow PE, Yuile CL. The disposition of coal dusts in the lungs and tracheobronchial lymph nodes of dogs. Fundam Appl Toxicol. 1982 Nov-Dec; 2(6):300-5.
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  • Morrow PE, Gibb FR, Beiter H, Amato F, Yuile C, Kilpper RW. Pulmonary retention of coal dusts. Ann Occup Hyg. 1982; 26(1-4):291-307.
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  • Utell MJ, Morrow PE, Hyde RW. Comparison of normal and asthmatic subjects' responses to sulphate pollutant aerosols. Ann Occup Hyg. 1982; 26(1-4):691-7.
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  • Morrow PE. An evaluation of the physical properties of monodisperse and heterodisperse aerosols used in the assessment of bronchial function. Chest. 1981 Dec; 80(6 Suppl):809-13.
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  • Leung HW, Morrow PE. Interaction of glutathione and ascorbic acid in guinea pig lungs exposed to nitrogen dioxide. Res Commun Chem Pathol Pharmacol. 1981 Jan; 31(1):111-8.
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  • Morrow PE, Beiter H, Amato F, Gibb FR. Pulmonary retention of lead: an experimental study in man. Environ Res. 1980 Apr; 21(2):373-84.
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  • Utell MJ, Aquilina AT, Hall WJ, Speers DM, Douglas RG, Gibb FR, Morrow PE, Hyde RW. Development of airway reactivity to nitrates in subjects with influenza. Am Rev Respir Dis. 1980 Feb; 121(2):233-41.
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  • Morrow PE, Gibb FR, Beiter H, Kilpper RW. Pulmonary retention of neutron-activated coal dust. Arch Environ Health. 1979 May-Jun; 34(3):178-83.
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  • Utell MJ, Swinburne AJ, Hyde RW, Speers DM, Gibb FR, Morrow PE. Airway reactivity to nitrates in normal and mild asthmatic subjects. J Appl Physiol. 1979 Jan; 46(1):189-96.
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  • Oberdörster G, Gibb FR, Beiter H, Lu ST, Morrow PE. Studies of the lymphatic drainage of dog lungs. J Toxicol Environ Health. 1978 Jul; 4(4):571-86.
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  • Morrow PE, Kilpper RW, Beiter HE, Gibb FR. Pulmonary retention and translocation of insufflated tantalum. Radiology. 1976 Nov; 121(2):415-21.
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  • Morrow PE. An evaluation of recent NOx toxicity data and an attempt to derive an ambient air standard for NOx by established toxicological procedures. Environ Res. 1975 Aug; 10(1):92-112.
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  • Beiter H, Gibb FR, Morrow PE. Intramuscular retention of UO3 and UO2. Health Phys. 1975 Aug; 29(2):273-7.
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  • Notter RH, Morrow PE. Pulmonary surfactant: a surface chemistry viewpoint. Ann Biomed Eng. 1975 Jun; 3(2):119-59.
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  • Morrow PE. Conference on the scientific basis of respiratory therapy. Aerosol therapy. Aerosol characterization and deposition. Am Rev Respir Dis. 1974 Dec; 110(6 Pt 2):88-99.
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  • Bianco A, Gibb FR, Kilpper RW, Landman S, Morrow PE. Studies of tantalum dust in the lungs. Radiology. 1974 Sep; 112(3):549-56.
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  • Fisher MV, Morrow PE, Yuile CL. Effect of Freund's complete adjuvant upon clearance of iron-59 oxide from rat lungs. J Reticuloendothel Soc. 1973 Jun; 13(6):536-56.
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  • Morrow PE. Alveolar clearance of aerosols. Arch Intern Med. 1973 Jan; 131(1):101-8.
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  • Morrow PE. Lymphatic drainage of the lung in dust clearance. Ann N Y Acad Sci. 1972 Dec 29; 200:46-65.
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  • Giordano AM, Morrow PE. Chronic low-level nitrogen dioxide exposure and mucociliary clearance. Arch Environ Health. 1972 Dec; 25(6):443-9.
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  • Morrow PE, Gibb FR, Beiter HD. Inhalation studies of uranium trioxide. Health Phys. 1972 Sep; 23(3):273-80.
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  • Yuile CL, Gibb FR, Morrow PE. Dose-related local and systemic effects of inhaled plutonium-238 and plutonium-239 dioxide in dogs. Radiat Res. 1970 Dec; 44(3):821-34.
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  • Morrow PE. Experimental studies of inhaled materials. A basis for respiratory models. Arch Intern Med. 1970 Sep; 126(3):466-70.
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  • Morrow PE, Gibb FR, Davies H, Fisher M. Dust removal from the lung parenchyma: an investigation of clearance stimulants. Toxicol Appl Pharmacol. 1968 May; 12(3):372-96.
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  • Morrow PE, Gibb FR, Gazioglu KM. A study of particulate clearance from the human lungs. Am Rev Respir Dis. 1967 Dec; 96(6):1209-21.
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  • Morrow PE, Gibb FR, Davies H, Mitola J, Wood D, Wraight N, Campbell HS. The retention and fate of inhaled plutonium dioxide in dogs. Health Phys. 1967 Feb; 13(2):113-33.
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  • Morrow PE. [Studies on the elimination of solid particles from the human respiratory system]. Poumon Coeur. 1967; 23(10):1255-78.
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  • MORROW PE, GIBB FR, JOHNSON L. CLEARANCE OF INSOLUBLE DUST FROM THE LOWER RESPIRATORY TRACT. Health Phys. 1964 Aug; 10:543-55.
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  • MORROW PE. EVALUATION OF INHALATION HAZARDS BASED UPON THE RESPIRABLE DUST CONCEPT AND THE PHILOSOPHY AND APPLICATION OF SELECTIVE SAMPLING. Am Ind Hyg Assoc J. 1964 May-Jun; 25:213-36.
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  • GIBB FR, MORROW PE. Alveolar clearance in dogs after inhalation of an iron 59 oxide aerosol. J Appl Physiol. 1962 May; 17:429-32.
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  • MORROW PE, GIBB FR. The deposition of a submicronic aerosol in the respiratory tract of dogs. Am Ind Hyg Assoc J. 1958 Jun; 19(3):196-200.
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