URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

Theodore Begenisich

TitleProfessor Emeritus
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 711
Rochester NY 14642
 
 Selected Publications
  • Thompson J, Begenisich T. Selectivity filter gating in large-conductance Ca2+-activated K+ channels. J Gen Physiol. 2012 Mar; 139(3):235-44.
    View in: PubMed
  • Almassy J, Won JH, Begenisich TB, Yule DI. Apical Ca2+-activated potassium channels in mouse parotid acinar cells. J Gen Physiol. 2012 Feb; 139(2):121-33.
    View in: PubMed
  • Almassy J, Begenisich T. The LRRC26 Protein Selectively Alters the Efficacy of BK Channel Activators. Mol Pharmacol. 2012 Jan; 81(1):21-30.
    View in: PubMed
  • Romanenko VG, Roser KS, Melvin JE, Begenisich T. The role of cell cholesterol and the cytoskeleton in the interaction between IK1 and maxi-K channels. Am J Physiol Cell Physiol. 2009 Apr; 296(4):C878-88.
    View in: PubMed
  • Nakamoto T, Romanenko VG, Takahashi A, Begenisich T, Melvin JE. Apical maxi-K (KCa1.1) channels mediate K+ secretion by the mouse submandibular exocrine gland. Am J Physiol Cell Physiol. 2008 Mar; 294(3):C810-9.
    View in: PubMed
  • Romanenko VG, Nakamoto T, Srivastava A, Begenisich T, Melvin JE. Regulation of membrane potential and fluid secretion by Ca2+-activated K+ channels in mouse submandibular glands. J Physiol. 2007 Jun 1; 581(Pt 2):801-17.
    View in: PubMed
  • Nakamoto T, Srivastava A, Romanenko VG, Ovitt CE, Perez-Cornejo P, Arreola J, Begenisich T, Melvin JE. Functional and molecular characterization of the fluid secretion mechanism in human parotid acinar cells. Am J Physiol Regul Integr Comp Physiol. 2007 Jun; 292(6):R2380-90.
    View in: PubMed
  • Quinn CC, Begenisich T. Pharmacology and surface electrostatics of the K channel outer pore vestibule. J Membr Biol. 2006; 212(1):51-60.
    View in: PubMed
  • Romanenko V, Nakamoto T, Srivastava A, Melvin JE, Begenisich T. Molecular identification and physiological roles of parotid acinar cell maxi-K channels. J Biol Chem. 2006 Sep 22; 281(38):27964-72.
    View in: PubMed
  • Thompson J, Begenisich T. Membrane-delimited inhibition of maxi-K channel activity by the intermediate conductance Ca2+-activated K channel. J Gen Physiol. 2006 Feb; 127(2):159-69.
    View in: PubMed
  • Thompson J, Begenisich T. Two stable, conducting conformations of the selectivity filter in Shaker K+ channels. J Gen Physiol. 2005 Jun; 125(6):619-29.
    View in: PubMed
  • Melvin JE, Yule D, Shuttleworth T, Begenisich T. Regulation of fluid and electrolyte secretion in salivary gland acinar cells. Annu Rev Physiol. 2005; 67:445-69.
    View in: PubMed
  • Begenisich T, Nakamoto T, Ovitt CE, Nehrke K, Brugnara C, Alper SL, Melvin JE. Physiological roles of the intermediate conductance, Ca2+-activated potassium channel Kcnn4. J Biol Chem. 2004 Nov 12; 279(46):47681-7.
    View in: PubMed
  • Thompson J, Begenisich T. External TEA block of shaker K+ channels is coupled to the movement of K+ ions within the selectivity filter. J Gen Physiol. 2003 Aug; 122(2):239-46.
    View in: PubMed
  • Thompson J, Begenisich T. Functional identification of ion binding sites at the internal end of the pore in Shaker K+ channels. J Physiol. 2003 May 15; 549(Pt 1):107-20.
    View in: PubMed
  • Arreola J, Begenisich T, Nehrke K, Nguyen HV, Park K, Richardson L, Yang B, Schutte BC, Lamb FS, Melvin JE. Secretion and cell volume regulation by salivary acinar cells from mice lacking expression of the Clcn3 Cl- channel gene. J Physiol. 2002 Nov 15; 545(Pt 1):207-16.
    View in: PubMed
  • Nehrke K, Quinn CC, Begenisich T. Molecular identification of Ca2+-activated K+ channels in parotid acinar cells. Am J Physiol Cell Physiol. 2003 Feb; 284(2):C535-46.
    View in: PubMed
  • Arreola J, Begenisich T, Melvin JE. Conformation-dependent regulation of inward rectifier chloride channel gating by extracellular protons. J Physiol. 2002 May 15; 541(Pt 1):103-12.
    View in: PubMed
  • Quinn CC, Begenisich T. The influence of surface charges on quaternary ammonium block of shaker K+ channels. J Membr Biol. 2001 Aug 1; 182(3):233-43.
    View in: PubMed
  • Park K, Begenisich T, Melvin JE. Protein kinase A activation phosphorylates the rat ClC-2 Cl- channel but does not change activity. J Membr Biol. 2001 Jul 1; 182(1):31-7.
    View in: PubMed
  • Thompson J, Begenisich T. Affinity and location of an internal K+ ion binding site in shaker K channels. J Gen Physiol. 2001 May; 117(5):373-84.
    View in: PubMed
  • Thompson J, Begenisich T. Interaction between quaternary ammonium ions in the pore of potassium channels. Evidence against an electrostatic repulsion mechanism. J Gen Physiol. 2000 Jun; 115(6):769-82.
    View in: PubMed
  • Thompson J, Begenisich T. Electrostatic interaction between charybdotoxin and a tetrameric mutant of Shaker K(+) channels. Biophys J. 2000 May; 78(5):2382-91.
    View in: PubMed
  • Stampe P, Arreola J, Pérez-Cornejo P, Begenisich T. Nonindependent K+ movement through the pore in IRK1 potassium channels. J Gen Physiol. 1998 Oct; 112(4):475-84.
    View in: PubMed
  • Park K, Arreola J, Begenisich T, Melvin JE. Comparison of voltage-activated Cl- channels in rat parotid acinar cells with ClC-2 in a mammalian expression system. J Membr Biol. 1998 May 15; 163(2):87-95.
    View in: PubMed
  • Perez-Cornejo P, Stampe P, Begenisich T. Proton probing of the charybdotoxin binding site of Shaker K+ channels. J Gen Physiol. 1998 Mar; 111(3):441-50.
    View in: PubMed
  • Stampe P, Begenisich T. Unidirectional fluxes through ion channels expressed in Xenopus oocytes. Methods Enzymol. 1998; 293:556-64.
    View in: PubMed
  • Begenisich T. Determining ion channel permeation properties. Methods Enzymol. 1998; 293:383-90.
    View in: PubMed
  • Arreola J, Melvin JE, Begenisich T. Differences in regulation of Ca(2+)-activated Cl- channels in colonic and parotid secretory cells. Am J Physiol. 1998 Jan; 274(1 Pt 1):C161-6.
    View in: PubMed
  • Arreola J, Melvin JE, Begenisich T. Activation of calcium-dependent chloride channels in rat parotid acinar cells. J Gen Physiol. 1996 Jul; 108(1):35-47.
    View in: PubMed
  • Stampe P, Begenisich T. Unidirectional K+ fluxes through recombinant Shaker potassium channels expressed in single Xenopus oocytes. J Gen Physiol. 1996 Apr; 107(4):449-57.
    View in: PubMed
  • Arreola J, Park K, Melvin JE, Begenisich T. Three distinct chloride channels control anion movements in rat parotid acinar cells. J Physiol. 1996 Jan 15; 490 ( Pt 2):351-62.
    View in: PubMed
  • Arreola J, Melvin JE, Begenisich T. Inhibition of Ca(2+)-dependent Cl- channels from secretory epithelial cells by low internal pH. J Membr Biol. 1995 Sep; 147(1):95-104.
    View in: PubMed
  • Arreola J, Melvin JE, Begenisich T. Volume-activated chloride channels in rat parotid acinar cells. J Physiol. 1995 May 1; 484 ( Pt 3):677-87.
    View in: PubMed
  • Spires S, Begenisich T. Voltage-independent gating transitions in squid axon potassium channels. Biophys J. 1995 Feb; 68(2):491-500.
    View in: PubMed
  • Spires S, Begenisich T. Modulation of potassium channel gating by external divalent cations. J Gen Physiol. 1994 Oct; 104(4):675-92.
    View in: PubMed
  • Pérez-Cornejo P, Begenisich T. The multi-ion nature of the pore in Shaker K+ channels. Biophys J. 1994 Jun; 66(6):1929-38.
    View in: PubMed
  • Arreola J, Spires S, Begenisich T. Na+ channels in cardiac and neuronal cells derived from a mouse embryonal carcinoma cell line. J Physiol. 1993 Dec; 472:289-303.
    View in: PubMed
  • Nealey T, Spires S, Eatock RA, Begenisich T. Potassium channels in squid neuron cell bodies: comparison to axonal channels. J Membr Biol. 1993 Feb; 132(1):13-25.
    View in: PubMed
  • Spires S, Begenisich T. Chemical properties of the divalent cation binding site on potassium channels. J Gen Physiol. 1992 Aug; 100(2):181-93.
    View in: PubMed
  • Spires S, Begenisich T. Modification of potassium channel kinetics by amino group reagents. J Gen Physiol. 1992 Jan; 99(1):109-29.
    View in: PubMed
  • Begenisich T. Ion channel selectivity, permeation, and block. Methods Enzymol. 1992; 207:92-100.
    View in: PubMed
  • Smith-Maxwell CJ, Eatock RA, Begenisich T. Induction of K-channel expression in a neuroblastoma cell line. J Neurobiol. 1991 Jun; 22(4):327-41.
    View in: PubMed
  • Spires S, Begenisich T. Modification of potassium channel kinetics by histidine-specific reagents. J Gen Physiol. 1990 Oct; 96(4):757-75.
    View in: PubMed
  • Walsh KB, Begenisich TB, Kass RS. Beta-adrenergic modulation of cardiac ion channels. Differential temperature sensitivity of potassium and calcium currents. J Gen Physiol. 1989 May; 93(5):841-54.
    View in: PubMed
  • Bennett PB, Kass R, Begenisich T. Nonstationary fluctuation analysis of the delayed rectifier K channel in cardiac Purkinje fibers. Actions of norepinephrine on single-channel current. Biophys J. 1989 Apr; 55(4):731-8.
    View in: PubMed
  • Spires S, Begenisich T. Pharmacological and kinetic analysis of K channel gating currents. J Gen Physiol. 1989 Feb; 93(2):263-83.
    View in: PubMed
  • Walsh KB, Begenisich TB, Kass RS. Beta-adrenergic modulation in the heart. Independent regulation of K and Ca channels. Pflugers Arch. 1988 Feb; 411(2):232-4.
    View in: PubMed
  • Smith-Maxwell C, Begenisich T. Guanidinium analogues as probes of the squid axon sodium pore. Evidence for internal surface charges. J Gen Physiol. 1987 Sep; 90(3):361-74.
    View in: PubMed
  • Bennett PB, Begenisich TB. Catecholamines modulate the delayed rectifying potassium current (IK) in guinea pig ventricular myocytes. Pflugers Arch. 1987 Sep; 410(1-2):217-9.
    View in: PubMed
  • Chabala LD, Morello RS, Busath D, Danko M, Smith-Maxwell CJ, Begenisich T. Capture, transport, and maintenance of live squid (Loligo pealei) for electrophysiological studies. Pflugers Arch. 1986 Jul; 407(1):105-8.
    View in: PubMed
  • Bennett P, McKinney L, Begenisich T, Kass RS. Adrenergic modulation of the delayed rectifier potassium channel in calf cardiac Purkinje fibers. Biophys J. 1986 Apr; 49(4):839-48.
    View in: PubMed
  • Danko M, Smith-Maxwell C, McKinney L, Begenisich T. Block of sodium channels by internal mono- and divalent guanidinium analogues. Modulation by sodium ion concentration. Biophys J. 1986 Feb; 49(2):509-19.
    View in: PubMed
  • Bennett PB, McKinney LC, Kass RS, Begenisich T. Delayed rectification in the calf cardiac Purkinje fiber. Evidence for multiple state kinetics. Biophys J. 1985 Oct; 48(4):553-67.
    View in: PubMed
  • McKinney LC, Danko M, Smith CJ, Begenisich T. Permeability of the squid giant axon to organic cations and small nonelectrolytes. J Membr Biol. 1985; 83(1-2):177-86.
    View in: PubMed
  • Morello RS, Begenisich T, Yeh JZ. Determination of the active form of phenytoin. J Pharmacol Exp Ther. 1984 Jul; 230(1):156-61.
    View in: PubMed
  • Begenisich T, Danko M. Hydrogen ion block of the sodium pore in squid giant axons. J Gen Physiol. 1983 Nov; 82(5):599-618.
    View in: PubMed
  • Busath D, Begenisich T. Unidirectional sodium and potassium fluxes through the sodium channel of squid giant axons. Biophys J. 1982 Oct; 40(1):41-9.
    View in: PubMed
  • Begenisich T, Busath D. Sodium flux ratio in voltage-clamped squid giant axons. J Gen Physiol. 1981 May; 77(5):489-502.
    View in: PubMed
  • Begenisich TB, Cahalan MD. Sodium channel permeation in squid axons. II: Non-independence and current-voltage relations. J Physiol. 1980 Oct; 307:243-57.
    View in: PubMed
  • Begenisich TB, Cahalan MD. Sodium channel permeation in squid axons. I: Reversal potential experiments. J Physiol. 1980 Oct; 307:217-42.
    View in: PubMed
  • Morello R, Begenisich T, Trzos W, Reed JK. Interaction of nonylguanidine with the sodium channel. Biophys J. 1980 Sep; 31(3):435-40.
    View in: PubMed
  • Begenisich T, De Weer P. Potassium flux ratio in voltage-clamped squid giant axons. J Gen Physiol. 1980 Jul; 76(1):83-98.
    View in: PubMed
  • Begenisich T. Conditioning hyperpolarization-induced delays in the potassium channels of myelinated nerve. Biophys J. 1979 Aug; 27(2):257-65.
    View in: PubMed
  • Begenisich T, De Weer P. Ionic interactions in the potassium channel of squid giant axons. Nature. 1977 Oct 20; 269(5630):710-1.
    View in: PubMed
  • Cahalan M, Begenisich T. Sodium channel selectivity. Dependence on internal permeant ion concentration. J Gen Physiol. 1976 Aug; 68(2):111-25.
    View in: PubMed
  • Goldman L, Hahin R, Begenisich T. Letter: Sodium flux, action potential and temperature dependence. Nature. 1975 Oct 9; 257(5526):516-7.
    View in: PubMed
  • Begenisich T, Stevens CF. How many conductance states do potassium channels have? Biophys J. 1975 Aug; 15(8):843-6.
    View in: PubMed
  • Begenisich T. Magnitude and location of surface charges on Myxicola giant axons. J Gen Physiol. 1975 Jul; 66(1):47-65.
    View in: PubMed
  • Begenisich T, Lynch C. Effects of internal divalent cations on voltage-clamped squid axons. J Gen Physiol. 1974 Jun; 63(6):675-89.
    View in: PubMed

Visualizations


Begenisich's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department