URMC Research Network

Find People
Keyword
Last Name
 
More Search Options

George Porter

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 631
Rochester NY 14642
Other Positions
TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPharmacology and Physiology

 
 Awards And Honors
1992     Extended Neuroscience Research Award, The American Academy of Neurology
1994     The American Federation for Clinical Research Medical Student Award
1994     Dr. J. Edmund Bradley Award for Excellence in Pediatrics
1999     AHA Travel Award to the 1999 Weinstein Cardiovascular Development Conference
2004     The Mae Gailani Junior Faculty Award for Uncompromising Dedication to Research and Patient Care
2008     Second place, Basic Cardiovascular Science Poster Competion (Research Symposium)
 
 Overview
Dr. Porter's laboratory studies mechanisms that control the development of the heart, concentrating on the roles played by the intracellular organelles, mitochondria. Using in vivo and in vitro mouse models of cardiac development, the lab has shown that mitochondrial structure and function changes dramatically in muscle cells as the embryonic heart develops. In particular, we have found that closure of the mitochondrial permeability transition pore, or mPTP, between the early and mid embryonic period leads to a maturation of the structure of individual mitochondria and of the mitochondrial network throughout the cell. This also leads to an activation of oxidative phosphorylation, or ATP production, by mitochondria as the heart develops. These changes also cause a drop in cellular oxidative stress due to altered mitochondrial production of reactive oxygen species, and this signals to the myocytes to undergo further differentiation.
These findings have led to additional studies. 1. Determining the mechanisms that control the activity of the mPTP. 2. Determining how the assembly of the different components of the electron transport chain are controlled by and may control the creation of the pore of the mPTP. 3. Investigating the mechanisms by which mitochondria control oxidative stress in the embryonic heart. 4. Determining oxygen levels in vivo in the embryonic and fetal heart, lungs, and brain using a novel microelectrode to determine values under normal and abnormal conditions. 5. Investigating the role that mitochondria play in regulating intracellular calcium levels in the developing heart. 6. Determining how mitochondria regulate differentiation of cardiac myocytes in the neonatal period and how oxygen levels regulate these changes and cause maturation of the infant heart.
Finally, Dr. Porter is the site principal investigator at the University of Rochester for the Pediatric Cardiac Genomics Consortium. This international, multicenter arm of the NIH Bench to Bassinet program (http://www.benchtobassinet.net/) has collects material information patients with congenital heart defects to perform genotype-phenotype correlation using advanced genetic testing. This data derived from this study is being used to discover new genes that cause human congenital heart defects and to test the pathogenesis of these genes in animal models through collaboration with the Cardiovascular Development Consortium of the Bench to Bassinet program.
These studies have been funded by the Charles H. Hood Foundation, the Children's Cardiomyopathy Foundation, the NIH, Pfizer, and the University of Rochester CTSI and are currently funded by the Founder's Affiliate of American Heart Association, the NIH, and the Strong Children's Research Center.

 
 Selected Publications
List All   |   Timeline
  1. Zaidi S, Choi M, Wakimoto H, Ma L, Jiang J, Overton JD, Romano-Adesman A, Bjornson RD, Breitbart RE, Brown KK, Carriero NJ, Cheung YH, Deanfield J, DePalma S, Fakhro KA, Glessner J, Hakonarson H, Italia MJ, Kaltman JR, Kaski J, Kim R, Kline JK, Lee T, Leipzig J, Lopez A, Mane SM, Mitchell LE, Newburger JW, Parfenov M, Pe'er I, Porter G, Roberts AE, Sachidanandam R, Sanders SJ, Seiden HS, State MW, Subramanian S, Tikhonova IR, Wang W, Warburton D, White PS, Williams IA, Zhao H, Seidman JG, Brueckner M, Chung WK, Gelb BD, Goldmuntz E, Seidman CE, Lifton RP. De novo mutations in histone-modifying genes in congenital heart disease. Nature. 2013 Jun 13; 498(7453):220-3.
    View in: PubMed
  2. The Congenital Heart Disease Genetic Network Study: rationale, design, and early results. Circ Res. 2013 Feb 15; 112(4):698-706.
    View in: PubMed
  3. Walters AM, Porter GA, Brookes PS. Mitochondria as a drug target in ischemic heart disease and cardiomyopathy. Circ Res. 2012 Oct 12; 111(9):1222-36.
    View in: PubMed
  4. Hom JR, Quintanilla RA, Hoffman DL, de Mesy Bentley KL, Molkentin JD, Sheu SS, Porter GA. The permeability transition pore controls cardiac mitochondrial maturation and myocyte differentiation. Dev Cell. 2011 Sep 13; 21(3):469-78.
    View in: PubMed
  5. Hom J, Yu T, Yoon Y, Porter G, Sheu SS. Regulation of mitochondrial fission by intracellular Ca2+ in rat ventricular myocytes. Biochim Biophys Acta. 2010 Jun-Jul; 1797(6-7):913-21.
    View in: PubMed
  6. Cummings C, McCarthy P, van Hoff J, Porter G. Kawasaki disease associated with reactive hemophagocytic lymphohistiocytosis. Pediatr Infect Dis J. 2008 Dec; 27(12):1116-8.
    View in: PubMed
  7. Henrich WL, Clark RL, Kelly JP, Buckalew VM, Fenves A, Finn WF, Shapiro JI, Kimmel PL, Eggers P, Agodoa LE, Porter GA, Shapiro S, Toto R, Anderson T, Cupples LA, Kaufman DW. Non-contrast-enhanced computerized tomography and analgesic-related kidney disease: report of the national analgesic nephropathy study. J Am Soc Nephrol. 2006 May; 17(5):1472-80.
    View in: PubMed
  8. Lakhani SA, Masud A, Kuida K, Porter GA, Booth CJ, Mehal WZ, Inayat I, Flavell RA. Caspases 3 and 7: key mediators of mitochondrial events of apoptosis. Science. 2006 Feb 10; 311(5762):847-51.
    View in: PubMed
  9. Moltedo JM, Kopf G, Mello DM, Porter GA. Right coronary artery arising from the left ventricular outflow tract: a rare congenital anomaly of the coronary arteries. Pediatr Cardiol. 2003 Nov-Dec; 24(6):598-600.
    View in: PubMed
  10. Porter GA, Makuck RF, Rivkees SA. Intracellular calcium plays an essential role in cardiac development. Dev Dyn. 2003 Jun; 227(2):280-90.
    View in: PubMed
  11. Rentschler S, Zander J, Meyers K, France D, Levine R, Porter G, Rivkees SA, Morley GE, Fishman GI. Neuregulin-1 promotes formation of the murine cardiac conduction system. Proc Natl Acad Sci U S A. 2002 Aug 6; 99(16):10464-9.
    View in: PubMed
  12. Porter GA, Makuck RF, Rivkees SA. Reduction in intracellular calcium levels inhibits myoblast differentiation. J Biol Chem. 2002 Aug 9; 277(32):28942-7.
    View in: PubMed
  13. Moltedo JM, Porter GA, State MW, Snyder CS. Sinus node dysfunction associated with lithium therapy in a child. Tex Heart Inst J. 2002; 29(3):200-2.
    View in: PubMed
  14. Porter GA, Rivkees SA. Ontogeny of humoral heart rate regulation in the embryonic mouse. Am J Physiol Regul Integr Comp Physiol. 2001 Aug; 281(2):R401-7.
    View in: PubMed
  15. Porter GA, Vincent MH, Penix LA. A 4-year-old girl with right elbow erythema, warmth, and induration. Curr Opin Pediatr. 1997 Feb; 9(1):31-4.
    View in: PubMed
  16. Porter GA, Scher MG, Resneck WG, Porter NC, Fowler VM, Bloch RJ. Two populations of beta-spectrin in rat skeletal muscle. Cell Motil Cytoskeleton. 1997; 37(1):7-19.
    View in: PubMed
  17. Porter GA, Dmytrenko GM, Winkelmann JC, Bloch RJ. Dystrophin colocalizes with beta-spectrin in distinct subsarcolemmal domains in mammalian skeletal muscle. J Cell Biol. 1992 Jun; 117(5):997-1005.
    View in: PubMed
  18. Milici AJ, Porter GA. Lectin and immunolabeling of microvascular endothelia. J Electron Microsc Tech. 1991 Nov; 19(3):305-15.
    View in: PubMed
  19. Porter GA, Palade GE, Milici AJ. Differential binding of the lectins Griffonia simplicifolia I and Lycopersicon esculentum to microvascular endothelium: organ-specific localization and partial glycoprotein characterization. Eur J Cell Biol. 1990 Feb; 51(1):85-95.
    View in: PubMed

Visualizations


Porter's Networks

Concepts
_
Co-Authors
_
Similar People
_
Same Department