Xiaochun Long
| Title | Research Assistant Professor |
|---|
| Institution | School of Medicine and Dentistry |
|---|
| Department | Medicine in the Aab Cardiovascular Research Institute |
|---|
| Address | Aab Cardiovascular Research Institute
211 Bailey Road
West Henrietta NY 14586
|
|---|
|
|
|
My research interest is focused on the regulation of SMC differentiation, particularly the regulation of Myocardin and miR-143/145, which are the key components of molecular switch of SMC differentiation. My approach is to utilize comparative genomics integrated with wet lab experiments to define the important cis-elements in the gene locus and screen for potential transcriptional factors. I am also interested in the study of functional role of novel microRNAs on SMC phenotypic modulation. By using different model systems, I screened a subset of microRNAs whose expression is closely linked to SMC phenotypic modulation. My long term goal is to uncover the functionality of those novel microRNA targets to SMC differentiation in vitro and in vivo.
-
Imamura M, Sugino Y, Long X, Slivano OJ, Nishikawa N, Yoshimura N, Miano JM. Myocardin and microRNA-1 modulate bladder activity through connexin 43 expression during post-natal development. J Cell Physiol. 2013 Sep; 228(9):1819-26.
-
Shi G, Field DJ, Long X, Mickelsen D, Ko KA, Ture S, Korshunov VA, Miano JM, Morrell CN. Platelet factor 4 mediates vascular smooth muscle cell injury responses. Blood. 2013 May 23; 121(21):4417-27.
-
Long X, Cowan SL, Miano JM. Mitogen-activated protein kinase 14 is a novel negative regulatory switch for the vascular smooth muscle cell contractile gene program. Arterioscler Thromb Vasc Biol. 2013 Feb; 33(2):378-86.
-
Kitchen CM, Cowan SL, Long X, Miano JM. Expression and promoter analysis of a highly restricted integrin alpha gene in vascular smooth muscle. Gene. 2013 Jan 15; 513(1):82-9.
-
Long X, Slivano OJ, Cowan SL, Georger MA, Lee TH, Miano JM. Smooth muscle calponin: an unconventional CArG-dependent gene that antagonizes neointimal formation. Arterioscler Thromb Vasc Biol. 2011 Oct; 31(10):2172-80.
-
Benson CC, Zhou Q, Long X, Miano JM. Identifying functional single nucleotide polymorphisms in the human CArGome. Physiol Genomics. 2011 Sep 22; 43(18):1038-48.
-
Long X, Miano JM. Transforming growth factor-beta1 (TGF-beta1) utilizes distinct pathways for the transcriptional activation of microRNA 143/145 in human coronary artery smooth muscle cells. J Biol Chem. 2011 Aug 26; 286(34):30119-29.
-
Streb JW, Long X, Lee TH, Sun Q, Kitchen CM, Georger MA, Slivano OJ, Blaner WS, Carr DW, Gelman IH, Miano JM. Retinoid-induced expression and activity of an immediate early tumor suppressor gene in vascular smooth muscle cells. PLoS One. 2011; 6(4):e18538.
-
Imamura M, Long X, Nanda V, Miano JM. Expression and functional activity of four myocardin isoforms. Gene. 2010 Sep 15; 464(1-2):1-10.
-
Long X, Tharp DL, Georger MA, Slivano OJ, Lee MY, Wamhoff BR, Bowles DK, Miano JM. The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin. J Biol Chem. 2009 Nov 27; 284(48):33671-82.
-
Sun Q, Taurin S, Sethakorn N, Long X, Imamura M, Wang DZ, Zimmer WE, Dulin NO, Miano JM. Myocardin-dependent activation of the CArG box-rich smooth muscle gamma-actin gene: preferential utilization of a single CArG element through functional association with the NKX3.1 homeodomain protein. J Biol Chem. 2009 Nov 20; 284(47):32582-90.
-
Bell RD, Deane R, Chow N, Long X, Sagare A, Singh I, Streb JW, Guo H, Rubio A, Van Nostrand W, Miano JM, Zlokovic BV. SRF and myocardin regulate LRP-mediated amyloid-beta clearance in brain vascular cells. Nat Cell Biol. 2009 Feb; 11(2):143-53.
-
Long X, Bell RD, Gerthoffer WT, Zlokovic BV, Miano JM. Myocardin is sufficient for a smooth muscle-like contractile phenotype. Arterioscler Thromb Vasc Biol. 2008 Aug; 28(8):1505-10.
-
Long X, Creemers EE, Wang DZ, Olson EN, Miano JM. Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation. Proc Natl Acad Sci U S A. 2007 Oct 16; 104(42):16570-5.
-
Long X, Miano JM. Remote control of gene expression. J Biol Chem. 2007 Jun 1; 282(22):15941-5.
-
Miano JM, Long X, Fujiwara K. Serum response factor: master regulator of the actin cytoskeleton and contractile apparatus. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C70-81.
-
Sun Q, Chen G, Streb JW, Long X, Yang Y, Stoeckert CJ, Miano JM. Defining the mammalian CArGome. Genome Res. 2006 Feb; 16(2):197-207.
|
Long's Networks
Concepts  Derived automatically from this person's publications. _
Co-Authors People in Profiles who have published with this person. _
Similar People People who share similar concepts with this person. _
Same Department
People who are also in this person's primary department.
|
