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Patricia Simpson-Haidaris

TitleAssociate Professor
InstitutionSchool of Medicine and Dentistry
DepartmentMedicine
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 610
Rochester NY 14642
 
 Awards And Honors
1970 - 1973Indiana University Merit Scholarship
1979 - 1981Miles Inc., Pre-doctoral Fellowship (Stipend and Tuition)
1980     American Society for Microbiology Garner Award for Oral Presentation
1981     Miles Inc., Post-doctoral Fellowship (Salary and Supplies)
 
 Overview
The role of fibrinogen in the pathogenesis of disease progression and resolution in the lung, the vasculature, and in prostate and breast carcinoma.

 
 Selected Publications
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  1. Avilés-Reyes A, Miller JH, Simpson-Haidaris PJ, Lemos JA, Abranches J. Cnm is a major virulence factor of invasive Streptococcus mutans and part of a conserved three-gene locus. Mol Oral Microbiol. 2014 Feb; 29(1):11-23.
    View in: PubMed
  2. Abranches J, Miller JH, Martinez AR, Simpson-Haidaris PJ, Burne RA, Lemos JA. The collagen-binding protein Cnm is required for Streptococcus mutans adherence to and intracellular invasion of human coronary artery endothelial cells. Infect Immun. 2011 Jun; 79(6):2277-84.
    View in: PubMed
  3. Simpson-Haidaris PJ, Seweryniak KE, Spinelli SL, Garcia-Bates TM, Murant TI, Pollock SJ, Sime PJ, Phipps RP. A putative role for platelet-derived PPAR? in vascular homeostasis demonstrated by anti-PPAR? induction of bleeding, thrombocytopenia and compensatory megakaryocytopoiesis. J Biotechnol. 2010 Nov; 150(3):417-27.
    View in: PubMed
  4. Simpson-Haidaris PJ, Pollock SJ, Ramon S, Guo N, Woeller CF, Feldon SE, Phipps RP. Anticancer Role of PPARgamma Agonists in Hematological Malignancies Found in the Vasculature, Marrow, and Eyes. PPAR Res. 2010; 2010:814609.
    View in: PubMed
  5. Garcia-Bates TM, Baglole CJ, Bernard MP, Murant TI, Simpson-Haidaris PJ, Phipps RP. Peroxisome proliferator-activated receptor gamma ligands enhance human B cell antibody production and differentiation. J Immunol. 2009 Dec 1; 183(11):6903-12.
    View in: PubMed
  6. Sahni A, Arévalo MT, Sahni SK, Simpson-Haidaris PJ. The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances transendothelial migration of malignant breast epithelial cells. Int J Cancer. 2009 Aug 1; 125(3):577-84.
    View in: PubMed
  7. Abranches J, Zeng L, Bélanger M, Rodrigues PH, Simpson-Haidaris PJ, Akin D, Dunn WA, Progulske-Fox A, Burne RA. Invasion of human coronary artery endothelial cells by Streptococcus mutans OMZ175. Oral Microbiol Immunol. 2009 Apr; 24(2):141-5.
    View in: PubMed
  8. Arévalo MT, Simpson-Haidaris PJ, Kou Z, Schlesinger JJ, Jin X. Primary human endothelial cells support direct but not antibody-dependent enhancement of dengue viral infection. J Med Virol. 2009 Mar; 81(3):519-28.
    View in: PubMed
  9. Garcia-Bates TM, Lehmann GM, Simpson-Haidaris PJ, Bernstein SH, Sime PJ, Phipps RP. Role of peroxisome proliferator-activated receptor gamma and its ligands in the treatment of hematological malignancies. PPAR Res. 2008; 2008:834612.
    View in: PubMed
  10. Sahni A, Simpson-Haidaris PJ, Sahni SK, Vaday GG, Francis CW. Fibrinogen synthesized by cancer cells augments the proliferative effect of fibroblast growth factor-2 (FGF-2). J Thromb Haemost. 2008 Jan; 6(1):176-83.
    View in: PubMed
  11. Mosesson MW, Hernandez I, Raife TJ, Medved L, Yakovlev S, Simpson-Haidaris PJ, Uitte DE Willige S, Bertina RM. Plasma fibrinogen gamma' chain content in the thrombotic microangiopathy syndrome. J Thromb Haemost. 2007 Jan; 5(1):62-9.
    View in: PubMed
  12. Duan HO, Simpson-Haidaris PJ. Cell type-specific differential induction of the human gamma-fibrinogen promoter by interleukin-6. J Biol Chem. 2006 May 5; 281(18):12451-7.
    View in: PubMed
  13. Sahni A, Sahni SK, Simpson-Haidaris PJ, Francis CW. Fibrinogen binding potentiates FGF-2 but not VEGF induced expression of u-PA, u-PAR, and PAI-1 in endothelial cells. J Thromb Haemost. 2004 Sep; 2(9):1629-36.
    View in: PubMed
  14. Lawrence SO, Simpson-Haidaris PJ. Regulated de novo biosynthesis of fibrinogen in extrahepatic epithelial cells in response to inflammation. Thromb Haemost. 2004 Aug; 92(2):234-43.
    View in: PubMed
  15. Wells J, Gigliotti F, Simpson-Haidaris PJ, Haidaris CG. Epitope mapping of a protective monoclonal antibody against Pneumocystis carinii with shared reactivity to Streptococcus pneumoniae surface antigen PspA. Infect Immun. 2004 Mar; 72(3):1548-56.
    View in: PubMed
  16. Rybarczyk BJ, Lawrence SO, Simpson-Haidaris PJ. Matrix-fibrinogen enhances wound closure by increasing both cell proliferation and migration. Blood. 2003 Dec 1; 102(12):4035-43.
    View in: PubMed
  17. Duan HO, Simpson-Haidaris PJ. Functional analysis of interleukin 6 response elements (IL-6REs) on the human gamma-fibrinogen promoter: binding of hepatic Stat3 correlates negatively with transactivation potential of type II IL-6REs. J Biol Chem. 2003 Oct 17; 278(42):41270-81.
    View in: PubMed
  18. Pereira M, Rybarczyk BJ, Odrljin TM, Hocking DC, Sottile J, Simpson-Haidaris PJ. The incorporation of fibrinogen into extracellular matrix is dependent on active assembly of a fibronectin matrix. J Cell Sci. 2002 Feb 1; 115(Pt 3):609-17.
    View in: PubMed
  19. Meh DA, Mosesson MW, Siebenlist KR, Simpson-Haidaris PJ, Brennan SO, DiOrio JP, Thompson K, Di Minno G. Fibrinogen naples I (B beta A68T) nonsubstrate thrombin-binding capacities. Thromb Res. 2001 Jul 1; 103(1):63-73.
    View in: PubMed
  20. Simpson-Haidaris PJ, Rybarczyk B. Tumors and fibrinogen. The role of fibrinogen as an extracellular matrix protein. Ann N Y Acad Sci. 2001; 936:406-25.
    View in: PubMed
  21. Pereira M, Simpson-Haidaris PJ. Fibrinogen modulates gene expression in wounded fibroblasts. Ann N Y Acad Sci. 2001; 936:438-43.
    View in: PubMed
  22. Odrljin TM, Haidaris CG, Lerner NB, Simpson-Haidaris PJ. Integrin alphavbeta3-mediated endocytosis of immobilized fibrinogen by A549 lung alveolar epithelial cells. Am J Respir Cell Mol Biol. 2001 Jan; 24(1):12-21.
    View in: PubMed
  23. Michelsen AE, Santi C, Holme R, Lord ST, Simpson-Haidaris PJ, Solum NO, Pedersen TM, Brosstad F. The charge-heterogeneity of human fibrinogen as investigated by 2D electrophoresis. Thromb Res. 2000 Dec 15; 100(6):529-35.
    View in: PubMed
  24. Rybarczyk BJ, Pereira M, Simpson-Haidaris PJ. Characterization of a monoclonal antibody, D73H, that maps to a highly conserved region on fibrinogen Bbeta chain. Thromb Haemost. 2000 Jul; 84(1):43-8.
    View in: PubMed
  25. Rybarczyk BJ, Simpson-Haidaris PJ. Fibrinogen assembly, secretion, and deposition into extracellular matrix by MCF-7 human breast carcinoma cells. Cancer Res. 2000 Apr 1; 60(7):2033-9.
    View in: PubMed
  26. Shi RJ, Simpson-Haidaris PJ, Marder VJ, Silverman DJ, Sporn LA. Post-transcriptional regulation of endothelial cell plasminogen activator inhibitor-1 expression during R. rickettsii infection. Microb Pathog. 2000 Mar; 28(3):127-33.
    View in: PubMed
  27. Nguyen MD, Simpson-Haidaris PJ. Cell type-specific regulation of fibrinogen expression in lung epithelial cells by dexamethasone and interleukin-1beta. Am J Respir Cell Mol Biol. 2000 Feb; 22(2):209-17.
    View in: PubMed
  28. Lee LH, Gigliotti F, Wright TW, Simpson-Haidaris PJ, Weinberg GA, Haidaris CG. Molecular characterization of KEX1, a kexin-like protease in mouse Pneumocystis carinii. Gene. 2000 Jan 25; 242(1-2):141-50.
    View in: PubMed
  29. Guadiz G, Haidaris CG, Maine GN, Simpson-Haidaris PJ. The carboxyl terminus of Pneumocystis carinii glycoprotein A encodes a functional glycosylphosphatidylinositol signal sequence. J Biol Chem. 1998 Oct 2; 273(40):26202-9.
    View in: PubMed
  30. Simpson-Haidaris PJ, Courtney MA, Wright TW, Goss R, Harmsen A, Gigliotti F. Induction of fibrinogen expression in the lung epithelium during Pneumocystis carinii pneumonia. Infect Immun. 1998 Sep; 66(9):4431-9.
    View in: PubMed
  31. Haidaris CG, Medzihradsky OF, Gigliotti F, Simpson-Haidaris PJ. Molecular characterization of mouse Pneumocystis carinii surface glycoprotein A. DNA Res. 1998 Apr 30; 5(2):77-85.
    View in: PubMed
  32. Haidaris CG, Fisher DJ, Gigliotti F, Simpson-Haidaris PJ. Antigenic properties of recombinant glycosylated and nonglycosylated Pneumocystis carinii glycoprotein A polypeptides expressed in baculovirus-infected insect cells. Mol Biotechnol. 1998 Apr; 9(2):91-7.
    View in: PubMed
  33. Shi RJ, Simpson-Haidaris PJ, Lerner NB, Marder VJ, Silverman DJ, Sporn LA. Transcriptional regulation of endothelial cell tissue factor expression during Rickettsia rickettsii infection: involvement of the transcription factor NF-kappaB. Infect Immun. 1998 Mar; 66(3):1070-5.
    View in: PubMed
  34. Simpson-Haidaris PJ, Guadiz G. Host response to inflammation elicited during Pneumocystis carinii pneumonia. J Eukaryot Microbiol. 1997 Nov-Dec; 44(6):33S.
    View in: PubMed
  35. Guadiz G, Sporn LA, Simpson-Haidaris PJ. Thrombin cleavage-independent deposition of fibrinogen in extracellular matrices. Blood. 1997 Oct 1; 90(7):2644-53.
    View in: PubMed
  36. Guadiz G, Sporn LA, Goss RA, Lawrence SO, Marder VJ, Simpson-Haidaris PJ. Polarized secretion of fibrinogen by lung epithelial cells. Am J Respir Cell Mol Biol. 1997 Jul; 17(1):60-9.
    View in: PubMed
  37. Haidaris PJ. Induction of fibrinogen biosynthesis and secretion from cultured pulmonary epithelial cells. Blood. 1997 Feb 1; 89(3):873-82.
    View in: PubMed
  38. Odrljin TM, Francis CW, Sporn LA, Bunce LA, Marder VJ, Simpson-Haidaris PJ. Heparin-binding domain of fibrin mediates its binding to endothelial cells. Arterioscler Thromb Vasc Biol. 1996 Dec; 16(12):1544-51.
    View in: PubMed
  39. Odrljin TM, Rybarczyk BJ, Francis CW, Lawrence SO, Hamaguchi M, Simpson-Haidaris PJ. Calcium modulates plasmin cleavage of the fibrinogen D fragment gamma chain N-terminus: mapping of monoclonal antibody J88B to a plasmin sensitive domain of the gamma chain. Biochim Biophys Acta. 1996 Nov 14; 1298(1):69-77.
    View in: PubMed
  40. Odrljin TM, Shainoff JR, Lawrence SO, Simpson-Haidaris PJ. Thrombin cleavage enhances exposure of a heparin binding domain in the N-terminus of the fibrin beta chain. Blood. 1996 Sep 15; 88(6):2050-61.
    View in: PubMed
  41. Shi RJ, Simpson-Haidaris PJ, Marder VJ, Silverman DJ, Sporn LA. Increased expression of plasminogen activator inhibitor-1 in R. rickettsii-infected endothelial cells. Thromb Haemost. 1996 Apr; 75(4):600-6.
    View in: PubMed
  42. Courtney MA, Haidaris PJ, Marder VJ, Sporn LA. Tissue factor mRNA expression in the endothelium of an intact umbilical vein. Blood. 1996 Jan 1; 87(1):174-9.
    View in: PubMed
  43. Wright TW, Gigliotti F, Haidaris CG, Simpson-Haidaris PJ. Cloning and characterization of a conserved region of human and rhesus macaque Pneumocystis carinii gpA. Gene. 1995 Dec 29; 167(1-2):185-9.
    View in: PubMed
  44. Simpson-Haidaris PJ, Wright TW, Earnest BJ, Hui Z, Neroni LA, Courtney MA. Cloning and characterization of a lung-specific cDNA corresponding to the gamma chain of hepatic fibrinogen. Gene. 1995 Dec 29; 167(1-2):273-8.
    View in: PubMed
  45. Wright TW, Bissoondial TY, Haidaris CG, Gigliotti F, Haidaris PJ. Isoform diversity and tandem duplication of the glycoprotein A gene in ferret Pneumocystis carinii. DNA Res. 1995; 2(2):77-88.
    View in: PubMed
  46. Harbol AW, Liesveld JL, Simpson-Haidaris PJ, Abboud CN. Mechanisms of cytopenia in human immunodeficiency virus infection. Blood Rev. 1994 Dec; 8(4):241-51.
    View in: PubMed
  47. Courtney MA, Bunce LA, Neroni LA, Simpson-Haidaris PJ. Cloning of the complete coding sequence of rat fibrinogen B beta chain cDNA: interspecies conservation of fibrin beta 15-42 primary structure. Blood Coagul Fibrinolysis. 1994 Aug; 5(4):487-96.
    View in: PubMed
  48. Thertulien R, Simpson-Haidaris PJ, Haidaris CG. Intracellular localization of a Trypanosoma cruzi kDNA minicircle transcript using RNA: RNA in situ hybridization. J Eukaryot Microbiol. 1994 Jul-Aug; 41(4):402-7.
    View in: PubMed
  49. Wright TW, Simpson-Haidaris PJ, Gigliotti F, Harmsen AG, Haidaris CG. Conserved sequence homology of cysteine-rich regions in genes encoding glycoprotein A in Pneumocystis carinii derived from different host species. Infect Immun. 1994 May; 62(5):1513-9.
    View in: PubMed
  50. Sporn LA, Haidaris PJ, Shi RJ, Nemerson Y, Silverman DJ, Marder VJ. Rickettsia rickettsii infection of cultured human endothelial cells induces tissue factor expression. Blood. 1994 Mar 15; 83(6):1527-34.
    View in: PubMed
  51. Lawrence SO, Wright TW, Francis CW, Fay PJ, Haidaris PJ. Purification and functional characterization of homodimeric gamma B-gamma B fibrinogen from rat plasma. Blood. 1993 Oct 15; 82(8):2406-13.
    View in: PubMed
  52. Grøn B, Filion-Myklebust C, Bjørnsen S, Haidaris P, Brosstad F. Cross-linked alpha s gamma t-chain hybrids in plasma clots studied by 1D- and 2D electrophoresis and western blotting. Thromb Haemost. 1993 Sep 1; 70(3):438-42.
    View in: PubMed
  53. Fay PJ, Haidaris PJ, Huggins CF. Role of the COOH-terminal acidic region of A1 subunit in A2 subunit retention in human factor VIIIa. J Biol Chem. 1993 Aug 25; 268(24):17861-6.
    View in: PubMed
  54. Gigliotti F, Harmsen AG, Haidaris CG, Haidaris PJ. Pneumocystis carinii is not universally transmissible between mammalian species. Infect Immun. 1993 Jul; 61(7):2886-90.
    View in: PubMed
  55. Gigliotti F, Haidaris PJ, Haidaris CG, Wright TW, Van der Meid KR. Further evidence of host species-specific variation in antigens of Pneumocystis carinii using the polymerase chain reaction. J Infect Dis. 1993 Jul; 168(1):191-4.
    View in: PubMed
  56. Haidaris PJ, Wright TW, Gigliotti F, Fallon MA, Whitbeck AA, Haidaris CG. In situ hybridization analysis of developmental stages of Pneumocystis carinii that are transcriptionally active for a major surface glycoprotein gene. Mol Microbiol. 1993 Mar; 7(5):647-56.
    View in: PubMed
  57. Haidaris PJ, Wright TW, Gigliotti F, Haidaris CG. Expression and characterization of a cDNA clone encoding an immunodominant surface glycoprotein of Pneumocystis carinii. J Infect Dis. 1992 Nov; 166(5):1113-23.
    View in: PubMed
  58. Haidaris PJ, Courtney MA. Liver-specific RNA processing of the ubiquitously transcribed rat fibrinogen gamma-chain gene. Blood. 1992 Mar 1; 79(5):1218-24.
    View in: PubMed
  59. Haidaris CG, Wright TW, Gigliotti F, Haidaris PJ. Molecular cloning and characterization of ferret Pneumocystis carinii gp120. J Protozool. 1991 Nov-Dec; 38(6):5S-6S.
    View in: PubMed
  60. Fay PJ, Haidaris PJ, Smudzin TM. Human factor VIIIa subunit structure. Reconstruction of factor VIIIa from the isolated A1/A3-C1-C2 dimer and A2 subunit. J Biol Chem. 1991 May 15; 266(14):8957-62.
    View in: PubMed
  61. Courtney MA, Stoler MH, Marder VJ, Haidaris PJ. Developmental expression of mRNAs encoding platelet proteins in rat megakaryocytes. Blood. 1991 Feb 1; 77(3):560-8.
    View in: PubMed
  62. Haidaris PJ, Courtney MA. Tissue-specific and ubiquitous expression of fibrinogen gamma-chain mRNA. Blood Coagul Fibrinolysis. 1990 Oct; 1(4-5):433-7.
    View in: PubMed
  63. Haidaris PJ, Peerschke EI, Marder VJ, Francis CW. The C-terminal sequences of the gamma 57.5 chain of human fibrinogen constitute a plasmin sensitive epitope that is exposed in crosslinked fibrin. Blood. 1989 Nov 15; 74(7):2437-44.
    View in: PubMed
  64. Haidaris PJ, Francis CW, Sporn LA, Arvan DS, Collichio FA, Marder VJ. Megakaryocyte and hepatocyte origins of human fibrinogen biosynthesis exhibit hepatocyte-specific expression of gamma chain-variant polypeptides. Blood. 1989 Aug 1; 74(2):743-50.
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  65. Mayadas T, Wagner DD, Simpson PJ. von Willebrand factor biosynthesis and partitioning between constitutive and regulated pathways of secretion after thrombin stimulation. Blood. 1989 Feb 15; 73(3):706-11.
    View in: PubMed
  66. Francis CW, Müller E, Henschen A, Simpson PJ, Marder VJ. Carboxyl-terminal amino acid sequences of two variant forms of the gamma chain of human plasma fibrinogen. Proc Natl Acad Sci U S A. 1988 May; 85(10):3358-62.
    View in: PubMed
  67. Simpson PJ. An improved method for mRNA isolation and characterization of in vitro translation products by Western blotting. Gene. 1987; 56(2-3):161-71.
    View in: PubMed
  68. Simpson PJ, Chou WG, Whitbeck AA, Young FE, Zain S. Evidence for prokaryotic transcription and translation control regions in the human factor IX gene. Gene. 1987; 61(3):373-83.
    View in: PubMed

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