Randy Rosier
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Orthopaedics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 665
Rochester NY 14642
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| 1970 |
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| 1972 | Dana Award Scholar | Dickinson College | | 1971 |
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| Sigma Pi Sigma (physics honorary) | | 1972 |
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| Phi Beta Kappa | | 1979 |
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| Sigma Xi (scientific research society) | | 1989 |
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| Outstanding Teacher Award | Dept. Orthopaedics, University of Rochester School of Medicine | | 1991 |
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| American Orthopaedic Association: American-British Traveling Fellowship | | 1991 |
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| Shannon Award | National Institutes of Health | | 1992 |
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| Honorary member, Holdsworth Orthopaedic Club | Scarborough, England | | 1995 |
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| Kappa Delta Award for outstanding orthopaedic research | | 1998 |
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| Dean's Professorship | The University of Rochester | | 2009 |
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| The Alfred R. Shands Jr, MD Award | American Ortho Association and the Orthopaedic Research Society | | 2009 |
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| Best Doctors in America for Tumor Surgery |
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Kim KO, Sampson ER, Maynard RD, O'Keefe RJ, Chen D, Drissi H, Rosier RN, Hilton MJ, Zuscik MJ. Ski inhibits TGF-ß/phospho-Smad3 signaling and accelerates hypertrophic differentiation in chondrocytes. J Cell Biochem. 2012 Jun; 113(6):2156-66.
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Holz JD, Beier E, Sheu TJ, Ubayawardena R, Wang M, Sampson ER, Rosier RN, Zuscik M, Puzas JE. Lead induces an osteoarthritis-like phenotype in articular chondrocytes through disruption of TGF-ß signaling. J Orthop Res. 2012 Nov; 30(11):1760-6.
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Zuch D, Giang AH, Shapovalov Y, Schwarz E, Rosier R, O'Keefe R, Eliseev RA. Targeting radioresistant osteosarcoma cells with parthenolide. J Cell Biochem. 2012 Apr; 113(4):1282-91.
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Mooney RA, Sampson ER, Lerea J, Rosier RN, Zuscik MJ. High-fat diet accelerates progression of osteoarthritis after meniscal/ligamentous injury. Arthritis Res Ther. 2011; 13(6):R198.
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Sampson ER, Hilton MJ, Tian Y, Chen D, Schwarz EM, Mooney RA, Bukata SV, O'Keefe RJ, Awad H, Puzas JE, Rosier RN, Zuscik MJ. Teriparatide as a chondroregenerative therapy for injury-induced osteoarthritis. Sci Transl Med. 2011 Sep 21; 3(101):101ra93.
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Sampson ER, Martin BA, Morris AE, Xie C, Schwarz EM, O'Keefe RJ, Rosier RN. The orally bioavailable met inhibitor PF-2341066 inhibits osteosarcoma growth and osteolysis/matrix production in a xenograft model. J Bone Miner Res. 2011 Jun; 26(6):1283-94.
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Peppone LJ, Huston AJ, Reid ME, Rosier RN, Zakharia Y, Trump DL, Mustian KM, Janelsins MC, Purnell JQ, Morrow GR. The effect of various vitamin D supplementation regimens in breast cancer patients. Breast Cancer Res Treat. 2011 May; 127(1):171-7.
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Sampson ER, Beck CA, Ketz J, Canary KL, Hilton MJ, Awad H, Schwarz EM, Chen D, O'Keefe RJ, Rosier RN, Zuscik MJ. Establishment of an index with increased sensitivity for assessing murine arthritis. J Orthop Res. 2011 Aug; 29(8):1145-51.
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Jacobson JA, Yanoso-Scholl L, Reynolds DG, Dadali T, Bradica G, Bukata S, Puzas EJ, Zuscik MJ, Rosier R, O'Keefe RJ, Schwarz EM, Awad HA. Teriparatide therapy and beta-tricalcium phosphate enhance scaffold reconstruction of mouse femoral defects. Tissue Eng Part A. 2011 Feb; 17(3-4):389-98.
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Sampson ER, Amin V, Schwarz EM, O'Keefe RJ, Rosier RN. The histone deacetylase inhibitor vorinostat selectively sensitizes fibrosarcoma cells to chemotherapy. J Orthop Res. 2011 Apr; 29(4):623-32.
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Dhakal S, Chen J, McCance S, Rosier R, O'Keefe R, Constine LS. Bone density changes after radiation for extremity sarcomas: exploring the etiology of pathologic fractures. Int J Radiat Oncol Biol Phys. 2011 Jul 15; 80(4):1158-63.
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Peppone LJ, Mustian KM, Janelsins MC, Palesh OG, Rosier RN, Piazza KM, Purnell JQ, Darling TV, Morrow GR. Effects of a structured weight-bearing exercise program on bone metabolism among breast cancer survivors: a feasibility trial. Clin Breast Cancer. 2010 Jun; 10(3):224-9.
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Wu Q, Zhu M, Rosier RN, Zuscik MJ, O'Keefe RJ, Chen D. Beta-catenin, cartilage, and osteoarthritis. Ann N Y Acad Sci. 2010 Mar; 1192:344-50.
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Peppone LJ, Hebl S, Purnell JQ, Reid ME, Rosier RN, Mustian KM, Palesh OG, Huston AJ, Ling MN, Morrow GR. The efficacy of calcitriol therapy in the management of bone loss and fractures: a qualitative review. Osteoporos Int. 2010 Jul; 21(7):1133-49.
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Wu Q, Huang JH, Sampson ER, Kim KO, Zuscik MJ, O'Keefe RJ, Chen D, Rosier RN. Smurf2 induces degradation of GSK-3beta and upregulates beta-catenin in chondrocytes: a potential mechanism for Smurf2-induced degeneration of articular cartilage. Exp Cell Res. 2009 Aug 15; 315(14):2386-98.
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Zhu M, Tang D, Wu Q, Hao S, Chen M, Xie C, Rosier RN, O'Keefe RJ, Zuscik M, Chen D. Activation of beta-catenin signaling in articular chondrocytes leads to osteoarthritis-like phenotype in adult beta-catenin conditional activation mice. J Bone Miner Res. 2009 Jan; 24(1):12-21.
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Wu Q, Kim KO, Sampson ER, Chen D, Awad H, O'Brien T, Puzas JE, Drissi H, Schwarz EM, O'Keefe RJ, Zuscik MJ, Rosier RN. Induction of an osteoarthritis-like phenotype and degradation of phosphorylated Smad3 by Smurf2 in transgenic mice. Arthritis Rheum. 2008 Oct; 58(10):3132-44.
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Kaback LA, Soung do Y, Naik A, Geneau G, Schwarz EM, Rosier RN, O'Keefe RJ, Drissi H. Teriparatide (1-34 human PTH) regulation of osterix during fracture repair. J Cell Biochem. 2008 Sep 1; 105(1):219-26.
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Elfar JC, Jacobson JA, Puzas JE, Rosier RN, Zuscik MJ. Erythropoietin accelerates functional recovery after peripheral nerve injury. J Bone Joint Surg Am. 2008 Aug; 90(8):1644-53.
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Zhu M, Chen M, Zuscik M, Wu Q, Wang YJ, Rosier RN, O'Keefe RJ, Chen D. Inhibition of beta-catenin signaling in articular chondrocytes results in articular cartilage destruction. Arthritis Rheum. 2008 Jul; 58(7):2053-64.
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Ehrhart N, Kraft S, Conover D, Rosier RN, Schwarz EM. Quantification of massive allograft healing with dynamic contrast enhanced-MRI and cone beam-CT: a pilot study. Clin Orthop Relat Res. 2008 Aug; 466(8):1897-904.
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Wu Q, Wang M, Zuscik MJ, Chen D, O'Keefe RJ, Rosier RN. Regulation of embryonic endochondral ossification by Smurf2. J Orthop Res. 2008 May; 26(5):704-12.
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Wu Q, Chen D, Zuscik MJ, O'Keefe RJ, Rosier RN. Overexpression of Smurf2 stimulates endochondral ossification through upregulation of beta-catenin. J Bone Miner Res. 2008 Apr; 23(4):552-63.
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Eliseev RA, Dong YF, Sampson E, Zuscik MJ, Schwarz EM, O'Keefe RJ, Rosier RN, Drissi MH. Runx2-mediated activation of the Bax gene increases osteosarcoma cell sensitivity to apoptosis. Oncogene. 2008 Jun 5; 27(25):3605-14.
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Rosier RN. Continuing competency in orthopaedics: the future of recertification. Clin Orthop Relat Res. 2006 Aug; 449:72-5.
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Rosier RN. Institutional barriers to the orthopaedic clinician-scientist. Clin Orthop Relat Res. 2006 Aug; 449:159-64.
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Eliseev RA, Filippov G, Velos J, VanWinkle B, Goldman A, Rosier RN, Gunter TE. Role of cyclophilin D in the resistance of brain mitochondria to the permeability transition. Neurobiol Aging. 2007 Oct; 28(10):1532-42.
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Garrett WE, Swiontkowski MF, Weinstein JN, Callaghan J, Rosier RN, Berry DJ, Harrast J, Derosa GP. American Board of Orthopaedic Surgery Practice of the Orthopaedic Surgeon: Part-II, certification examination case mix. J Bone Joint Surg Am. 2006 Mar; 88(3):660-7.
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Eliseev RA, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H, Rosier RN. Increased radiation-induced apoptosis of Saos2 cells via inhibition of NFkappaB: a role for c-Jun N-terminal kinase. J Cell Biochem. 2005 Dec 15; 96(6):1262-73.
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Andela VB, Schwarz EM, O'Keefe RJ, Puzas EJ, Rosenblatt JD, Rosier RN. A genome-wide expression profile and system-level integration of nuclear factor kappa B regulated genes reveals fundamental metabolic adaptations during cell growth and survival. FEBS Lett. 2005 Dec 19; 579(30):6814-20.
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Eliseev RA, Schwarz EM, Zuscik MJ, O'Keefe RJ, Drissi H, Rosier RN. Smad7 mediates inhibition of Saos2 osteosarcoma cell differentiation by NFkappaB. Exp Cell Res. 2006 Jan 1; 312(1):40-50.
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Evans CH, Rosier RN. Molecular biology in orthopaedics: the advent of molecular orthopaedics. J Bone Joint Surg Am. 2005 Nov; 87(11):2550-64.
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Li TF, Darowish M, Zuscik MJ, Chen D, Schwarz EM, Rosier RN, Drissi H, O'Keefe RJ. Smad3-deficient chondrocytes have enhanced BMP signaling and accelerated differentiation. J Bone Miner Res. 2006 Jan; 21(1):4-16.
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Carmouche JJ, Puzas JE, Zhang X, Tiyapatanaputi P, Cory-Slechta DA, Gelein R, Zuscik M, Rosier RN, Boyce BF, O'Keefe RJ, Schwarz EM. Lead exposure inhibits fracture healing and is associated with increased chondrogenesis, delay in cartilage mineralization, and a decrease in osteoprogenitor frequency. Environ Health Perspect. 2005 Jun; 113(6):749-55.
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Drissi H, Zuscik M, Rosier R, O'Keefe R. Transcriptional regulation of chondrocyte maturation: potential involvement of transcription factors in OA pathogenesis. Mol Aspects Med. 2005 Jun; 26(3):169-79.
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Courville XF, Cortés Z, Katzman PJ, Rosier RN. Case report: Bone metastases from fallopian tube carcinoma. Clin Orthop Relat Res. 2005 May; (434):278-81.
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Gordon AH, O'Keefe RJ, Schwarz EM, Rosier RN, Puzas JE. Nuclear factor-kappaB-dependent mechanisms in breast cancer cells regulate tumor burden and osteolysis in bone. Cancer Res. 2005 Apr 15; 65(8):3209-17.
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Andela VB, Altuwaijri S, Wood J, Rosier RN. Inhibition of beta-oxidative respiration is a therapeutic window associated with the cancer chemo-preventive activity of PPARgamma agonists. FEBS Lett. 2005 Mar 14; 579(7):1765-9.
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Andela VB, Siddiqui F, Groman A, Rosier RN. An immunohistochemical analysis to evaluate an inverse correlation between Runx2/Cbfa1 and NF kappa B in human osteosarcoma. J Clin Pathol. 2005 Mar; 58(3):328-30.
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Li TF, Zuscik MJ, Ionescu AM, Zhang X, Rosier RN, Schwarz EM, Drissi H, O'Keefe RJ. PGE2 inhibits chondrocyte differentiation through PKA and PKC signaling. Exp Cell Res. 2004 Oct 15; 300(1):159-69.
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Li TF, Dong Y, Ionescu AM, Rosier RN, Zuscik MJ, Schwarz EM, O'Keefe RJ, Drissi H. Parathyroid hormone-related peptide (PTHrP) inhibits Runx2 expression through the PKA signaling pathway. Exp Cell Res. 2004 Sep 10; 299(1):128-36.
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Eliseev RA, Vanwinkle B, Rosier RN, Gunter TE. Diazoxide-mediated preconditioning against apoptosis involves activation of cAMP-response element-binding protein (CREB) and NFkappaB. J Biol Chem. 2004 Nov 5; 279(45):46748-54.
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Campbell JR, Rosier RN, Novotny L, Puzas JE. The association between environmental lead exposure and bone density in children. Environ Health Perspect. 2004 Aug; 112(11):1200-3.
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Zuscik MJ, Baden JF, Wu Q, Sheu TJ, Schwarz EM, Drissi H, O'Keefe RJ, Puzas JE, Rosier RN. 5-azacytidine alters TGF-beta and BMP signaling and induces maturation in articular chondrocytes. J Cell Biochem. 2004 May 15; 92(2):316-31.
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Zhang X, Ziran N, Goater JJ, Schwarz EM, Puzas JE, Rosier RN, Zuscik M, Drissi H, O'Keefe RJ. Primary murine limb bud mesenchymal cells in long-term culture complete chondrocyte differentiation: TGF-beta delays hypertrophy and PGE2 inhibits terminal differentiation. Bone. 2004 May; 34(5):809-17.
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Andela VB, Rosier RN. The proteosome inhibitor MG132 attenuates retinoic acid receptor trans-activation and enhances trans-repression of nuclear factor kappaB. Potential relevance to chemo-preventive interventions with retinoids. Mol Cancer. 2004 Mar 22; 3:8.
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Ionescu AM, Drissi H, Schwarz EM, Kato M, Puzas JE, McCance DJ, Rosier RN, Zuscik MJ, O'Keefe RJ. CREB Cooperates with BMP-stimulated Smad signaling to enhance transcription of the Smad6 promoter. J Cell Physiol. 2004 Mar; 198(3):428-40.
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Bukata SV, Gelinas J, Wei X, Rosier RN, Puzas JE, Zhang X, Schwarz EM, Song XY, Griswold DE, O'Keefe RJ. PGE2 and IL-6 production by fibroblasts in response to titanium wear debris particles is mediated through a Cox-2 dependent pathway. J Orthop Res. 2004 Jan; 22(1):6-12.
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Drissi MH, Li X, Sheu TJ, Zuscik MJ, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Runx2/Cbfa1 stimulation by retinoic acid is potentiated by BMP2 signaling through interaction with Smad1 on the collagen X promoter in chondrocytes. J Cell Biochem. 2003 Dec 15; 90(6):1287-98.
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Ulrich-Vinther M, Maloney MD, Schwarz EM, Rosier R, O'Keefe RJ. Articular cartilage biology. J Am Acad Orthop Surg. 2003 Nov-Dec; 11(6):421-30.
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Andela VB, Pirri M, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosenblatt JD, Rosier RN. The mevalonate synthesis pathway as a therapeutic target in cancer. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S59-66.
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Andela VB, Gordon AH, Zotalis G, Rosier RN, Goater JJ, Lewis GD, Schwarz EM, Puzas JE, O'Keefe RJ. NFkappaB: a pivotal transcription factor in prostate cancer metastasis to bone. Clin Orthop Relat Res. 2003 Oct; (415 Suppl):S75-85.
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Li X, Ionescu AM, Schwarz EM, Zhang X, Drissi H, Puzas JE, Rosier RN, Zuscik MJ, O'Keefe RJ. Smad6 is induced by BMP-2 and modulates chondrocyte differentiation. J Orthop Res. 2003 Sep; 21(5):908-13.
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Zhang D, Schwarz EM, Rosier RN, Zuscik MJ, Puzas JE, O'Keefe RJ. ALK2 functions as a BMP type I receptor and induces Indian hedgehog in chondrocytes during skeletal development. J Bone Miner Res. 2003 Sep; 18(9):1593-604.
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Ionescu AM, Schwarz EM, Zuscik MJ, Drissi H, Puzas JE, Rosier RN, O'Keefe RJ. ATF-2 cooperates with Smad3 to mediate TGF-beta effects on chondrocyte maturation. Exp Cell Res. 2003 Aug 1; 288(1):198-207.
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Zuscik MJ, Rosier RN, Schwarz EM. Altered negative regulation of transforming growth factor beta signaling in scleroderma: potential involvement of SMURF2 in disease. Arthritis Rheum. 2003 Jul; 48(7):1779-80.
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Li X, Schwarz EM, Zuscik MJ, Rosier RN, Ionescu AM, Puzas JE, Drissi H, Sheu TJ, O'Keefe RJ. Retinoic acid stimulates chondrocyte differentiation and enhances bone morphogenetic protein effects through induction of Smad1 and Smad5. Endocrinology. 2003 Jun; 144(6):2514-23.
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Andela VB, Gingold BI, Souza MD, O'Keefe RJ, Puzas EJ, Schwarz EM, Rosier RN. Clinical relevance of increased retinoid and cAMP transcriptional programs in tumor cells rendered non-malignant by dominant negative inhibition of NFkappaB. Cancer Lett. 2003 May 8; 194(1):37-43.
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Sheu TJ, Schwarz EM, Martinez DA, O'Keefe RJ, Rosier RN, Zuscik MJ, Puzas JE. A phage display technique identifies a novel regulator of cell differentiation. J Biol Chem. 2003 Jan 3; 278(1):438-43.
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Pateder DB, Gish MW, O'Keefe RJ, Hicks DG, Teot LA, Rosier RN. Parathyroid hormone-related Peptide expression in cartilaginous tumors. Clin Orthop Relat Res. 2002 Oct; (403):198-204.
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Andela VB, Sheu TJ, Puzas EJ, Schwarz EM, O'Keefe RJ, Rosier RN. Malignant reversion of a human osteosarcoma cell line, Saos-2, by inhibition of NFkappaB. Biochem Biophys Res Commun. 2002 Sep 20; 297(2):237-41.
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Zuscik MJ, O'Keefe RJ, Gunter TE, Puzas JE, Schwarz EM, Rosier RN. Parathyroid hormone-related peptide regulation of chick tibial growth plate chondrocyte maturation requires protein kinase A. J Orthop Res. 2002 Sep; 20(5):1079-90.
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Soloviev A, Schwarz EM, Kuprash DV, Nedospasov SA, Puzas JE, Rosier RN, O'Keefe RJ. The role of p105 protein in NFkappaB activation in ANA-1 murine macrophages following stimulation with titanium particles. J Orthop Res. 2002 Jul; 20(4):714-22.
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Guo X, Lee KM, Law LP, Chow HK, Rosier R, Cheng CY. Recombinant human bone morphogenetic protein-4 (rhBMP-4) enhanced posterior spinal fusion without decortication. J Orthop Res. 2002 Jul; 20(4):740-6.
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Zuscik MJ, Pateder DB, Puzas JE, Schwarz EM, Rosier RN, O'Keefe RJ. Lead alters parathyroid hormone-related peptide and transforming growth factor-beta1 effects and AP-1 and NF-kappaB signaling in chondrocytes. J Orthop Res. 2002 Jul; 20(4):811-8.
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Zuscik MJ, D'Souza M, Ionescu AM, Gunter KK, Gunter TE, O'Keefe RJ, Schwarz EM, Puzas JE, Rosier RN. Growth plate chondrocyte maturation is regulated by basal intracellular calcium. Exp Cell Res. 2002 Jun 10; 276(2):310-9.
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Zhang X, Schwarz EM, Young DA, Puzas JE, Rosier RN, O'Keefe RJ. Cyclooxygenase-2 regulates mesenchymal cell differentiation into the osteoblast lineage and is critically involved in bone repair. J Clin Invest. 2002 Jun; 109(11):1405-15.
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Sheu TJ, Schwarz EM, O'Keefe RJ, Rosier RN, Puzas JE. Use of a phage display technique to identify potential osteoblast binding sites within osteoclast lacunae. J Bone Miner Res. 2002 May; 17(5):915-22.
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Carmody EE, Schwarz EM, Puzas JE, Rosier RN, O'Keefe RJ. Viral interleukin-10 gene inhibition of inflammation, osteoclastogenesis, and bone resorption in response to titanium particles. Arthritis Rheum. 2002 May; 46(5):1298-308.
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Andela VB, Rosenblatt JD, Schwarz EM, Puzas EJ, O'Keefe RJ, Rosier RN. Synergism of aminobisphosphonates and farnesyl transferase inhibitors on tumor metastasis. Clin Orthop Relat Res. 2002 Apr; (397):228-39.
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Cheng JC, Guo X, Law LP, Lee KM, Chow DH, Rosier R. How does recombinant human bone morphogenetic protein-4 enhance posterior spinal fusion? Spine (Phila Pa 1976). 2002 Mar 1; 27(5):467-74.
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Good CR, O'Keefe RJ, Puzas JE, Schwarz EM, Rosier RN. Immunohistochemical study of receptor activator of nuclear factor kappa-B ligand (RANK-L) in human osteolytic bone tumors. J Surg Oncol. 2002 Mar; 79(3):174-9.
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Goater JJ, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. Efficacy of ex vivo OPG gene therapy in preventing wear debris induced osteolysis. J Orthop Res. 2002 Mar; 20(2):169-73.
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Childs LM, Paschalis EP, Xing L, Dougall WC, Anderson D, Boskey AL, Puzas JE, Rosier RN, O'Keefe RJ, Boyce BF, Schwarz EM. In vivo RANK signaling blockade using the receptor activator of NF-kappaB:Fc effectively prevents and ameliorates wear debris-induced osteolysis via osteoclast depletion without inhibiting osteogenesis. J Bone Miner Res. 2002 Feb; 17(2):192-9.
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Zhang D, Ferguson CM, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. A role for the BMP antagonist chordin in endochondral ossification. J Bone Miner Res. 2002 Feb; 17(2):293-300.
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Mungo DV, Zhang X, O'Keefe RJ, Rosier RN, Puzas JE, Schwarz EM. COX-1 and COX-2 expression in osteoid osteomas. J Orthop Res. 2002 Jan; 20(1):159-62.
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Pateder DB, Sheu TJ, O'Keefe RJ, Puzas JE, Schwarz EM, Constine LS, Okunieff P, Rosier RN. Role of pentoxifylline in preventing radiation damage to epiphyseal growth plate chondrocytes. Radiat Res. 2002 Jan; 157(1):62-8.
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Pateder DB, Ferguson CM, Ionescu AM, Schwarz EM, Rosier RN, Puzas JE, O'Keefe RJ. PTHrP expression in chick sternal chondrocytes is regulated by TGF-beta through Smad-mediated signaling. J Cell Physiol. 2001 Sep; 188(3):343-51.
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Buckwalter JA, Callaghan JJ, Rosier RN. From oranges and lemons to glucosamine and chondroitin sulfate: clinical observations stimulate basic research. J Bone Joint Surg Am. 2001 Aug; 83-A(8):1266-8.
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Pollice PF, Rosier RN, Looney RJ, Puzas JE, Schwarz EM, O'Keefe RJ. Oral pentoxifylline inhibits release of tumor necrosis factor-alpha from human peripheral blood monocytes : a potential treatment for aseptic loosening of total joint components. J Bone Joint Surg Am. 2001 Jul; 83-A(7):1057-61.
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Pateder DB, Eliseev RA, O'Keefe RJ, Schwarz EM, Okunieff P, Constine LS, Puzas JE, Rosier RN. The role of autocrine growth factors in radiation damage to the epiphyseal growth plate. Radiat Res. 2001 Jun; 155(6):847-57.
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Buckwalter JA, Stanish WD, Rosier RN, Schenck RC, Dennis DA, Coutts RD. The increasing need for nonoperative treatment of patients with osteoarthritis. Clin Orthop Relat Res. 2001 Apr; (385):36-45.
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Rosier RN. Expanding the role of the orthopaedic surgeon in the treatment of osteoporosis. Clin Orthop Relat Res. 2001 Apr; (385):57-67.
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Zhang X, Morham SG, Langenbach R, Young DA, Xing L, Boyce BF, Puzas EJ, Rosier RN, O'Keefe RJ, Schwarz EM. Evidence for a direct role of cyclo-oxygenase 2 in implant wear debris-induced osteolysis. J Bone Miner Res. 2001 Apr; 16(4):660-70.
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Ionescu AM, Schwarz EM, Vinson C, Puzas JE, Rosier R, Reynolds PR, O'Keefe RJ. PTHrP modulates chondrocyte differentiation through AP-1 and CREB signaling. J Biol Chem. 2001 Apr 13; 276(15):11639-47.
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Greenwald AS, Boden SD, Goldberg VM, Khan Y, Laurencin CT, Rosier RN. Bone-graft substitutes: facts, fictions, and applications. J Bone Joint Surg Am. 2001; 83-A Suppl 2 Pt 2:98-103.
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Andela VB, Schwarz EM, Puzas JE, O'Keefe RJ, Rosier RN. Tumor metastasis and the reciprocal regulation of prometastatic and antimetastatic factors by nuclear factor kappaB. Cancer Res. 2000 Dec 1; 60(23):6557-62.
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Ferguson CM, Schwarz EM, Reynolds PR, Puzas JE, Rosier RN, O'Keefe RJ. Smad2 and 3 mediate transforming growth factor-beta1-induced inhibition of chondrocyte maturation. Endocrinology. 2000 Dec; 141(12):4728-35.
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Schwarz EM, Benz EB, Lu AP, Goater JJ, Mollano AV, Rosier RN, Puzas JE, Okeefe RJ. Quantitative small-animal surrogate to evaluate drug efficacy in preventing wear debris-induced osteolysis. J Orthop Res. 2000 Nov; 18(6):849-55.
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Chi H, Yang X, Kingsley PD, O'Keefe RJ, Puzas JE, Rosier RN, Shears SB, Reynolds PR. Targeted deletion of Minpp1 provides new insight into the activity of multiple inositol polyphosphate phosphatase in vivo. Mol Cell Biol. 2000 Sep; 20(17):6496-507.
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Reynolds SD, Zhang D, Puzas JE, O'Keefe RJ, Rosier RN, Reynolds PR. Cloning of the chick BMP1/Tolloid cDNA and expression in skeletal tissues. Gene. 2000 May 2; 248(1-2):233-43.
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Schwarz EM, Lu AP, Goater JJ, Benz EB, Kollias G, Rosier RN, Puzas JE, O'Keefe RJ. Tumor necrosis factor-alpha/nuclear transcription factor-kappaB signaling in periprosthetic osteolysis. J Orthop Res. 2000 May; 18(3):472-80.
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Pateder DB, Rosier RN, Schwarz EM, Reynolds PR, Puzas JE, D'Souza M, O'Keefe RJ. PTHrP expression in chondrocytes, regulation by TGF-beta, and interactions between epiphyseal and growth plate chondrocytes. Exp Cell Res. 2000 May 1; 256(2):555-62.
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Rosier RN, O'Keefe RJ. Hyaluronic acid therapy. Instr Course Lect. 2000; 49:495-502.
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Vena VE, Hsu J, Rosier RN, O'Keefe RJ. Pelvic reconstruction for severe periacetabular metastatic disease. Clin Orthop Relat Res. 1999 May; (362):171-80.
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Grimsrud CD, Romano PR, D'Souza M, Puzas JE, Reynolds PR, Rosier RN, O'Keefe RJ. BMP-6 is an autocrine stimulator of chondrocyte differentiation. J Bone Miner Res. 1999 Apr; 14(4):475-82.
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Chi H, Tiller GE, Dasouki MJ, Romano PR, Wang J, O'keefe RJ, Puzas JE, Rosier RN, Reynolds PR. Multiple inositol polyphosphate phosphatase: evolution as a distinct group within the histidine phosphatase family and chromosomal localization of the human and mouse genes to chromosomes 10q23 and 19. Genomics. 1999 Mar 15; 56(3):324-36.
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Pollice PF, Hsu J, Hicks DG, Bukata S, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. Interleukin-10 inhibits cytokine synthesis in monocytes stimulated by titanium particles: evidence of an anti-inflammatory regulatory pathway. J Orthop Res. 1998 Nov; 16(6):697-704.
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Rosier RN. Breakout session. 6: Regional gene therapy. Clin Orthop Relat Res. 1998 Oct; (355 Suppl):S361-3.
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Rosier RN, O'Keefe RJ, Hicks DG. The potential role of transforming growth factor beta in fracture healing. Clin Orthop Relat Res. 1998 Oct; (355 Suppl):S294-300.
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Serletti JM, Carras AJ, O'Keefe RJ, Rosier RN. Functional outcome after soft-tissue reconstruction for limb salvage after sarcoma surgery. Plast Reconstr Surg. 1998 Oct; 102(5):1576-83; discussion 1584-5.
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Ishibe M, Ishibashi T, Kaneda K, Koda T, Rosier RN, Puzas JE. Stimulation of bone formation in vivo by insulin-like growth factor-II in rats. Calcif Tissue Int. 1998 Jul; 63(1):36-8.
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Rapoport AP, Constine LS, Packman CH, Rosier RN, O'Keefe R, Hicks DG, Rubin SJ, Rowe JM. Treatment of multifocal lymphoma of bone with intensified ProMACE-CytaBOM chemotherapy and involved field radiotherapy. Am J Hematol. 1998 May; 58(1):1-7.
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Romano PR, Wang J, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. HiPER1, a phosphatase of the endoplasmic reticulum with a role in chondrocyte maturation. J Cell Sci. 1998 Mar; 111 ( Pt 6):803-13.
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Grimsrud CD, Rosier RN, Puzas JE, Reynolds PR, Reynolds SD, Hicks DG, O'Keefe RJ. Bone morphogenetic protein-7 in growth-plate chondrocytes: regulation by retinoic acid is dependent on the stage of chondrocyte maturation. J Orthop Res. 1998 Mar; 16(2):247-55.
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O'Keefe RJ, Rosier RN, Teot LA, Stewart JM, Hicks DG. Cytokine and matrix metalloproteinase expression in pigmented villonodular synovitis may mediate bone and cartilage destruction. Iowa Orthop J. 1998; 18:26-34.
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Rosier RN, O'Keefe RJ. Autocrine regulation of articular cartilage. Instr Course Lect. 1998; 47:469-75.
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Blaine TA, Pollice PF, Rosier RN, Reynolds PR, Puzas JE, O'Keefe RJ. Modulation of the production of cytokines in titanium-stimulated human peripheral blood monocytes by pharmacological agents. The role of cAMP-mediated signaling mechanisms. J Bone Joint Surg Am. 1997 Oct; 79(10):1519-28.
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Rosier RN, O'Keefe RJ, Teot LA, Fox EJ, Nester TA, Puzas JE, Reynolds PR, Hicks DG. P-glycoprotein expression in cartilaginous tumors. J Surg Oncol. 1997 Jun; 65(2):95-105.
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Zuscik MJ, Gunter TE, Puzas JE, Rosier RN. Characterization of voltage-sensitive calcium channels in growth plate chondrocytes. Biochem Biophys Res Commun. 1997 May 19; 234(2):432-8.
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O'Keefe RJ, Teot LA, Singh D, Puzas JE, Rosier RN, Hicks DG. Osteoclasts constitutively express regulators of bone resorption: an immunohistochemical and in situ hybridization study. Lab Invest. 1997 Apr; 76(4):457-65.
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O'Keefe RJ, Loveys LS, Hicks DG, Reynolds PR, Crabb ID, Puzas JE, Rosier RN. Differential regulation of type-II and type-X collagen synthesis by parathyroid hormone-related protein in chick growth-plate chondrocytes. J Orthop Res. 1997 Mar; 15(2):162-74.
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Hicks DG, O'Keefe RJ, Reynolds KJ, Cory-Slechta DA, Puzas JE, Judkins A, Rosier RN. Effects of lead on growth plate chondrocyte phenotype. Toxicol Appl Pharmacol. 1996 Sep; 140(1):164-72.
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Blaine TA, Rosier RN, Puzas JE, Looney RJ, Reynolds PR, Reynolds SD, O'Keefe RJ. Increased levels of tumor necrosis factor-alpha and interleukin-6 protein and messenger RNA in human peripheral blood monocytes due to titanium particles. J Bone Joint Surg Am. 1996 Aug; 78(8):1181-92.
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Reynolds SD, Johnston C, Leboy PS, O'Keefe RJ, Puzas JE, Rosier RN, Reynolds PR. Identification and characterization of a unique chondrocyte gene involved in transition to hypertrophy. Exp Cell Res. 1996 Jul 10; 226(1):197-207.
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Teot LA, O'Keefe RJ, Rosier RN, O'Connell JX, Fox EJ, Hicks DG. Extraosseous primary and recurrent giant cell tumors: transforming growth factor-beta1 and -beta2 expression may explain metaplastic bone formation. Hum Pathol. 1996 Jul; 27(7):625-32.
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Reynolds PR, Reynolds SD, O'Keefe RJ, Puzas JE, Rosier RN. Alternative splicing of a chondrocyte-specific gene. Ann N Y Acad Sci. 1996 Jun 8; 785:321-4.
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Hicks DG, Judkins AR, Sickel JZ, Rosier RN, Puzas JE, O'Keefe RJ. Granular histiocytosis of pelvic lymph nodes following total hip arthroplasty. The presence of wear debris, cytokine production, and immunologically activated macrophages. J Bone Joint Surg Am. 1996 Apr; 78(4):482-96.
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Delsignore JL, Dvoretsky PM, Hicks DG, O'Keefe RJ, Rosier RN. Mastocytosis presenting as a skeletal disorder. Iowa Orthop J. 1996; 16:126-34.
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Ishibe M, Nojima T, Ishibashi T, Koda T, Kaneda K, Rosier RN, Puzas JE. 17 beta-estradiol increases the receptor number and modulates the action of 1,25-dihydroxyvitamin D3 in human osteosarcoma-derived osteoblast-like cells. Calcif Tissue Int. 1995 Dec; 57(6):430-5.
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Martinez DA, Zuscik MJ, Ishibe M, Rosier RN, Romano PR, Cushing JE, Puzas JE. Identification of functional insulin-like growth factor-II/mannose-6-phosphate receptors in isolated bone cells. J Cell Biochem. 1995 Oct; 59(2):246-57.
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Ishibe M, Nojima T, Ishibashi T, Koda T, Rosier RN, Puzas JE, Kaneda K. Comparison of the type-2 insulin-like growth factor receptor in normal osteoblasts and osteosarcoma-derived osteoblast-like cells. J Orthop Res. 1995 Sep; 13(5):643-8.
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Hughes SS, Hicks DG, O'Keefe RJ, Hurwitz SR, Crabb ID, Krasinskas AM, Loveys L, Puzas JE, Rosier RN. Shared phenotypic expression of osteoblasts and chondrocytes in fracture callus. J Bone Miner Res. 1995 Apr; 10(4):533-44.
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Hicks DG, Gokan T, O'Keefe RJ, Totterman SM, Fultz PJ, Judkins AR, Meyers SP, Rubens DJ, Sickel JZ, Rosier RN. Primary lymphoma of bone. Correlation of magnetic resonance imaging features with cytokine production by tumor cells. Cancer. 1995 Feb 15; 75(4):973-80.
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Landesberg R, Proctor RL, Rosier RN, Puzas JE. The mandibular condylar growth center: separation and characterization of the cellular elements. Calcif Tissue Int. 1995 Jan; 56(1):71-7.
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Rosier RN, Teot LA, Hicks DG, Schwartz C, O'Keefe RJ, Puzas JE. Multiple drug resistance in osteosarcoma. Iowa Orthop J. 1995; 15:66-73.
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Zuscik MJ, Puzas JE, Rosier RN, Gunter KK, Gunter TE. Cyclic-AMP-dependent protein kinase activity is not required by parathyroid hormone to stimulate phosphoinositide signaling in chondrocytes but is required to transduce the hormone's proliferative effect. Arch Biochem Biophys. 1994 Dec; 315(2):352-61.
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O'Keefe RJ, Puzas JE, Loveys L, Hicks DG, Rosier RN. Analysis of type II and type X collagen synthesis in cultured growth plate chondrocytes by in situ hybridization: rapid induction of type X collagen in culture. J Bone Miner Res. 1994 Nov; 9(11):1713-22.
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Zuscik MJ, Gunter TE, Rosier RN, Gunter KK, Puzas JE. Activation of phosphoinositide metabolism by parathyroid hormone in growth plate chondrocytes. Cell Calcium. 1994 Aug; 16(2):112-22.
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O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. Effects of transforming growth factor-beta 1 and fibroblast growth factor on DNA synthesis in growth plate chondrocytes are enhanced by insulin-like growth factor-I. J Orthop Res. 1994 May; 12(3):299-310.
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Alioto RJ, Rosier RN, Burton RI, Puzas JE. Comparative effects of growth factors on fibroblasts of Dupuytren's tissue and normal palmar fascia. J Hand Surg Am. 1994 May; 19(3):442-52.
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Ishibe M, Ishibe Y, Ishibashi T, Nojima T, Rosier RN, Puzas JE, Kaneda K. Low content of estrogen receptors in human giant cell tumors of bone. Arch Orthop Trauma Surg. 1994; 113(2):106-9.
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Loveys LS, Gelb D, Hurwitz SR, Puzas JE, Rosier RN. Effects of parathyroid hormone-related peptide on chick growth plate chondrocytes. J Orthop Res. 1993 Nov; 11(6):884-91.
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Kreipe RE, Hicks DG, Rosier RN, Puzas JE. Preliminary findings on the effects of sex hormones on bone metabolism in anorexia nervosa. J Adolesc Health. 1993 Jun; 14(4):319-24.
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Kramer K, Hicks DG, Palis J, Rosier RN, Oppenheimer J, Fallon MD, Cohen HJ. Epithelioid osteosarcoma of bone. Immunocytochemical evidence suggesting divergent epithelial and mesenchymal differentiation in a primary osseous neoplasm. Cancer. 1993 May 15; 71(10):2977-82.
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Quatela VC, Sherris DA, Rosier RN. The human auricular chondrocyte. Responses to growth factors. Arch Otolaryngol Head Neck Surg. 1993 Jan; 119(1):32-7.
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Crabb ID, Hughes SS, Hicks DG, Puzas JE, Tsao GJ, Rosier RN. Nonradioactive in situ hybridization using digoxigenin-labeled oligonucleotides. Applications to musculoskeletal tissues. Am J Pathol. 1992 Sep; 141(3):579-89.
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O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. Influence of prostaglandins on DNA and matrix synthesis in growth plate chondrocytes. J Bone Miner Res. 1992 Apr; 7(4):397-404.
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Karasek K, Constine LS, Rosier R. Sarcoma therapy: functional outcome and relationship to treatment parameters. Int J Radiat Oncol Biol Phys. 1992; 24(4):651-6.
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Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. Differential effects of parathyroid hormone on chick growth plate and articular chondrocytes. Calcif Tissue Int. 1992 Jan; 50(1):61-6.
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Ishibe M, Rosier RN, Puzas JE. Human prostatic acid phosphatase directly stimulates collagen synthesis and alkaline phosphatase content of isolated bone cells. J Clin Endocrinol Metab. 1991 Oct; 73(4):785-92.
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Sawyer JR, Myers MA, Rosier RN, Puzas JE. Heterotopic ossification: clinical and cellular aspects. Calcif Tissue Int. 1991 Sep; 49(3):208-15.
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Ishibe M, Rosier RN, Puzas JE. Activation of osteoblast insulin-like growth factor-II/cation-independent mannose-6-phosphate receptors by specific phosphorylated sugars and antibodies induce insulin-like growth factor-II effects. Endocr Res. 1991; 17(3-4):357-66.
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Crabb ID, O'Keefe RJ, Puzas JE, Rosier RN. Synergistic effect of transforming growth factor beta and fibroblast growth factor on DNA synthesis in chick growth plate chondrocytes. J Bone Miner Res. 1990 Nov; 5(11):1105-12.
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Gelb DE, Rosier RN, Puzas JE. The production of transforming growth factor-beta by chick growth plate chondrocytes in short term monolayer culture. Endocrinology. 1990 Oct; 127(4):1941-7.
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Gunter TE, Zuscik MJ, Puzas JE, Gunter KK, Rosier RN. Cytosolic free calcium concentrations in avian growth plate chondrocytes. Cell Calcium. 1990 Aug; 11(7):445-57.
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Konski A, Pellegrini V, Poulter C, DeVanny J, Rosier R, Evarts CM, Henzler M, Rubin P. Randomized trial comparing single dose versus fractionated irradiation for prevention of heterotopic bone: a preliminary report. Int J Radiat Oncol Biol Phys. 1990 May; 18(5):1139-42.
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Konski A, Weiss C, Rosier R, Poulter C, Pelligrini V, Anthony P, Evarts CM, Richardson M, Henzler M, Rubin P. The use of postoperative irradiation for the prevention of heterotopic bone after total hip replacement with biologic fixation (porous coated) prosthesis: an animal model. Int J Radiat Oncol Biol Phys. 1990 Apr; 18(4):861-5.
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O'Keefe RJ, Rosier RN, Puzas JE. Differential expression of biological effects in maturationally distinct subpopulations of growth plate chondrocytes. Connect Tissue Res. 1990; 24(1):53-66.
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Puzas JE, Miller MD, Rosier RN. Pathologic bone formation. Clin Orthop Relat Res. 1989 Aug; (245):269-81.
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O'Keefe RJ, Crabb ID, Puzas JE, Rosier RN. Countercurrent centrifugal elutriation. High-resolution method for the separation of growth-plate chondrocytes. J Bone Joint Surg Am. 1989 Apr; 71(4):607-20.
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Rosier RN, O'Keefe RJ, Crabb ID, Puzas JE. Transforming growth factor beta: an autocrine regulator of chondrocytes. Connect Tissue Res. 1989; 20(1-4):295-301.
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O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. Effect of transforming growth factor-beta on DNA synthesis by growth plate chondrocytes: modulation by factors present in serum. Calcif Tissue Int. 1988 Dec; 43(6):352-8.
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O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes. Endocrinology. 1988 Jun; 122(6):2953-61.
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Rosier RN. Orthopedic basic science: update. Orthopedics. 1987 Dec; 10(12):1793-805.
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Rosier RN, Blair WF. Preliminary clinical evaluation of the digital electroneurometer. Biomed Sci Instrum. 1984; 20:55-62.
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Gunter KK, Gunter TE, Jarkowski A, Rosier RN. A method of resuspending small vesicles separated from suspension by protamine aggregation and centrifugation. Anal Biochem. 1982 Feb; 120(1):113-24.
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Rosier RN, Tucker DA, Meerdink S, Jain I, Gunter TE. Ca2+ transport against its electrochemical gradient in cytochrome oxidase vesicles reconstituted with mitochondrial hydrophobic proteins. Arch Biochem Biophys. 1981 Sep; 210(2):549-64.
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Rosier RN, Gunter TE. Calcium uptake by cytochrome oxidase vesicles. FEBS Lett. 1980 Jan 1; 109(1):99-103.
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Rosier RN, Gunter TE, Tucker DA, Gunter KK. A rapid method for separating small vesicles from suspension. Anal Biochem. 1979 Jul 15; 96(2):384-90.
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Gunter TE, Rosier RN, Tucker DA, Gunter KK. Uptake of calcium and manganese by rat liver submitochondrial particles. Ann N Y Acad Sci. 1978 Apr 28; 307:246-7.
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