Charles Lowenstein
| Title | Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Medicine |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 679-A
Rochester NY 14642
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| Title | Director |
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| Institution | University of Rochester Medical Center |
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| Department | Aab Cardiovascular Research Institute |
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| Title | Chief |
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| Institution | School of Medicine and Dentistry |
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| Department | Medicine |
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| Division | Medicine - Cardiology |
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| 2000 |
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| Young Investigators Conference on Atherosclerosis Award | Merck, Inc. | | 2002 |
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| Member | American Society for Clinical Investigation | | 2003 |
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| Sir William Osler Young Investigator Award | Interurban Clinical Club | | 2005 |
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| Peter Dolphin Award | Pfizer | | 2007 |
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| Member | InterUrban Clinical Club |
Dr. Lowenstein's research is focused on vascular biology. One team or researchers explores mechanisms of exocytosis, through which endothelial cells release pro-inflammatory and pro-thrombotic mediators. A second group of scientists study how platelets communicate with endothelial cells. A third area of research involves an exploration of the role of microRNA in endothelial cells. A fourth team investigates how nitric oxide affects vascular inflammation.
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Lowenstein CJ. Vav-Vav-Vav-voom! Blood. 2011 May 26; 117(21):5557-9.
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Yamakuchi M, Yagi S, Ito T, Lowenstein CJ. MicroRNA-22 regulates hypoxia signaling in colon cancer cells. PLoS One. 2011; 6(5):e20291.
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Ito T, Yamakuchi M, Lowenstein CJ. Thioredoxin increases exocytosis by denitrosylating N-ethylmaleimide-sensitive factor. J Biol Chem. 2011 Apr 1; 286(13):11179-84.
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Ferlito M, Fulton WB, Zauher MA, Marbán E, Steenbergen C, Lowenstein CJ. VAMP-1, VAMP-2, and syntaxin-4 regulate ANP release from cardiac myocytes. J Mol Cell Cardiol. 2010 Nov; 49(5):791-800.
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Kopin L, Lowenstein C. In the clinic. Dyslipidemia. Ann Intern Med. 2010 Aug 3; 153(3):ITC21.
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Harris TA, Yamakuchi M, Kondo M, Oettgen P, Lowenstein CJ. Ets-1 and Ets-2 regulate the expression of microRNA-126 in endothelial cells. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1990-7.
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Goel A, Su B, Flavahan S, Lowenstein CJ, Berkowitz DE, Flavahan NA. Increased endothelial exocytosis and generation of endothelin-1 contributes to constriction of aged arteries. Circ Res. 2010 Jul 23; 107(2):242-51.
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Bie B, Zhang Z, Cai YQ, Zhu W, Zhang Y, Dai J, Lowenstein CJ, Weinman EJ, Pan ZZ. Nerve growth factor-regulated emergence of functional delta-opioid receptors. J Neurosci. 2010 Apr 21; 30(16):5617-28.
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Lowenstein CJ, Cameron SJ. High-density lipoprotein metabolism and endothelial function. Curr Opin Endocrinol Diabetes Obes. 2010 Apr; 17(2):166-70.
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Yamakuchi M, Lotterman CD, Bao C, Hruban RH, Karim B, Mendell JT, Huso D, Lowenstein CJ. P53-induced microRNA-107 inhibits HIF-1 and tumor angiogenesis. Proc Natl Acad Sci U S A. 2010 Apr 6; 107(14):6334-9.
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Tseng EE, Brock MV, Lange MS, Troncoso JC, Blue ME, Lowenstein CJ, Johnston MV, Baumgartner WA. Glutamate excitotoxicity mediates neuronal apoptosis after hypothermic circulatory arrest. Ann Thorac Surg. 2010 Feb; 89(2):440-5.
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Yamakuchi M, Lowenstein CJ. MiR-34, SIRT1 and p53: the feedback loop. Cell Cycle. 2009 Mar 1; 8(5):712-5.
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Jeong Y, Chaupin DF, Matsushita K, Yamakuchi M, Cameron SJ, Morrell CN, Lowenstein CJ. Aldosterone activates endothelial exocytosis. Proc Natl Acad Sci U S A. 2009 Mar 10; 106(10):3782-7.
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Yamakuchi M, Ferlito M, Lowenstein CJ. miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A. 2008 Sep 9; 105(36):13421-6.
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Yamakuchi M, Bao C, Ferlito M, Lowenstein CJ. Epigallocatechin gallate inhibits endothelial exocytosis. Biol Chem. 2008 Jul; 389(7):935-41.
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Cao W, Bao C, Padalko E, Lowenstein CJ. Acetylation of mitogen-activated protein kinase phosphatase-1 inhibits Toll-like receptor signaling. J Exp Med. 2008 Jun 9; 205(6):1491-503.
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Morrell CN, Sun H, Ikeda M, Beique JC, Swaim AM, Mason E, Martin TV, Thompson LE, Gozen O, Ampagoomian D, Sprengel R, Rothstein J, Faraday N, Huganir R, Lowenstein CJ. Glutamate mediates platelet activation through the AMPA receptor. J Exp Med. 2008 Mar 17; 205(3):575-84.
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Harris TA, Yamakuchi M, Ferlito M, Mendell JT, Lowenstein CJ. MicroRNA-126 regulates endothelial expression of vascular cell adhesion molecule 1. Proc Natl Acad Sci U S A. 2008 Feb 5; 105(5):1516-21.
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Yamakuchi M, Ferlito M, Morrell CN, Matsushita K, Fletcher CA, Cao W, Lowenstein CJ. Exocytosis of endothelial cells is regulated by N-ethylmaleimide-sensitive factor. Methods Mol Biol. 2008; 440:203-15.
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Lowenstein CJ. Myocardial reperfusion injury. N Engl J Med. 2007 Dec 6; 357(23):2409; author reply 2409-10.
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Kanno Y, Into T, Lowenstein CJ, Matsushita K. Nitric oxide regulates vascular calcification by interfering with TGF- signalling. Cardiovasc Res. 2008 Jan; 77(1):221-30.
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Calvert JW, Gundewar S, Yamakuchi M, Park PC, Baldwin WM, Lefer DJ, Lowenstein CJ. Inhibition of N-ethylmaleimide-sensitive factor protects against myocardial ischemia/reperfusion injury. Circ Res. 2007 Dec 7; 101(12):1247-54.
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Johnston CP, Qiu H, Ticehurst JR, Dickson C, Rosenbaum P, Lawson P, Stokes AB, Lowenstein CJ, Kaminsky M, Cosgrove SE, Green KY, Perl TM. Outbreak management and implications of a nosocomial norovirus outbreak. Clin Infect Dis. 2007 Sep 1; 45(5):534-40.
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Lamas S, Lowenstein CJ, Michel T. Nitric oxide signaling comes of age: 20 years and thriving. Cardiovasc Res. 2007 Jul 15; 75(2):207-9.
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Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH, Feldmann G, Yamakuchi M, Ferlito M, Lowenstein CJ, Arking DE, Beer MA, Maitra A, Mendell JT. Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell. 2007 Jun 8; 26(5):745-52.
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Lowenstein CJ. Nitric oxide regulation of protein trafficking in the cardiovascular system. Cardiovasc Res. 2007 Jul 15; 75(2):240-6.
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Saura M, Lizarbe TR, Rama-Pacheco C, Lowenstein CJ, Zaragoza C. Inhibitor of NF kappa B alpha is a host sensor of coxsackievirus infection. Cell Cycle. 2007 Mar 1; 6(5):503-6.
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Yamakuchi M, Kirkiles-Smith NC, Ferlito M, Cameron SJ, Bao C, Fox-Talbot K, Wasowska BA, Baldwin WM, Pober JS, Lowenstein CJ. Antibody to human leukocyte antigen triggers endothelial exocytosis. Proc Natl Acad Sci U S A. 2007 Jan 23; 104(4):1301-6.
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Into T, Kanno Y, Dohkan J, Nakashima M, Inomata M, Shibata K, Lowenstein CJ, Matsushita K. Pathogen recognition by Toll-like receptor 2 activates Weibel-Palade body exocytosis in human aortic endothelial cells. J Biol Chem. 2007 Mar 16; 282(11):8134-41.
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Zaragoza C, Saura M, Padalko EY, Lopez-Rivera E, Lizarbe TR, Lamas S, Lowenstein CJ. Viral protease cleavage of inhibitor of kappaBalpha triggers host cell apoptosis. Proc Natl Acad Sci U S A. 2006 Dec 12; 103(50):19051-6.
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Lowenstein CJ, Tsuda H. N-ethylmaleimide-sensitive factor: a redox sensor in exocytosis. Biol Chem. 2006 Oct-Nov; 387(10-11):1377-83.
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Lowenstein CJ. Integrin-linked kinase plays a key role in coxsackievirus replication. Circ Res. 2006 Aug 18; 99(4):346-7.
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Saura M, Zaragoza C, Bao C, Herranz B, Rodriguez-Puyol M, Lowenstein CJ. Stat3 mediates interleukin-6 [correction of interelukin-6] inhibition of human endothelial nitric-oxide synthase expression. J Biol Chem. 2006 Oct 6; 281(40):30057-62.
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Lowenstein CJ, Michel T. What's in a name? eNOS and anaphylactic shock. J Clin Invest. 2006 Aug; 116(8):2075-8.
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Ferlito M, Irani K, Faraday N, Lowenstein CJ. Nitric oxide inhibits exocytosis of cytolytic granules from lymphokine-activated killer cells. Proc Natl Acad Sci U S A. 2006 Aug 1; 103(31):11689-94.
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Lowenstein CJ. Beneficial effects of neuronal nitric oxide synthase in atherosclerosis. Arterioscler Thromb Vasc Biol. 2006 Jul; 26(7):1417-8.
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Ohnishi T, Kakimoto K, Bandow K, Lowenstein CJ, Daikuhara Y, Matsuguchi T. Mature hepatocyte growth factor/scatter factor on the surface of human granulocytes is released by a mechanism involving activated factor Xa. J Immunol. 2006 Jun 1; 176(11):6945-53.
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Lowenstein CJ, Morrell CN, Yamakuchi M. Regulation of Weibel-Palade body exocytosis. Trends Cardiovasc Med. 2005 Nov; 15(8):302-8.
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Kittleson MM, Lowenstein CJ, Hare JM. Novel pathogenetic mechanisms in myocarditis: nitric oxide signaling. Heart Fail Clin. 2005 Oct; 1(3):345-61.
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Matsushita K, Morrell CN, Mason RJ, Yamakuchi M, Khanday FA, Irani K, Lowenstein CJ. Hydrogen peroxide regulation of endothelial exocytosis by inhibition of N-ethylmaleimide sensitive factor. J Cell Biol. 2005 Jul 4; 170(1):73-9.
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Yamakuchi M, Greer JJ, Cameron SJ, Matsushita K, Morrell CN, Talbot-Fox K, Baldwin WM, Lefer DJ, Lowenstein CJ. HMG-CoA reductase inhibitors inhibit endothelial exocytosis and decrease myocardial infarct size. Circ Res. 2005 Jun 10; 96(11):1185-92.
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Huang Y, Man HY, Sekine-Aizawa Y, Han Y, Juluri K, Luo H, Cheah J, Lowenstein C, Huganir RL, Snyder SH. S-nitrosylation of N-ethylmaleimide sensitive factor mediates surface expression of AMPA receptors. Neuron. 2005 May 19; 46(4):533-40.
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Morrell CN, Matsushita K, Lowenstein CJ. A novel inhibitor of N-ethylmaleimide-sensitive factor decreases leukocyte trafficking and peritonitis. J Pharmacol Exp Ther. 2005 Jul; 314(1):155-61.
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Morrell CN, Matsushita K, Chiles K, Scharpf RB, Yamakuchi M, Mason RJ, Bergmeier W, Mankowski JL, Baldwin WM, Faraday N, Lowenstein CJ. Regulation of platelet granule exocytosis by S-nitrosylation. Proc Natl Acad Sci U S A. 2005 Mar 8; 102(10):3782-7.
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Matsushita K, Morrell CN, Lowenstein CJ. A novel class of fusion polypeptides inhibits exocytosis. Mol Pharmacol. 2005 Apr; 67(4):1137-44.
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Lowenstein CJ. Exogenous thioredoxin reduces inflammation in autoimmune myocarditis. Circulation. 2004 Sep 7; 110(10):1178-9.
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Matsushita K, Yamakuchi M, Morrell CN, Ozaki M, O'Rourke B, Irani K, Lowenstein CJ. Vascular endothelial growth factor regulation of Weibel-Palade-body exocytosis. Blood. 2005 Jan 1; 105(1):207-14.
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Yang SX, Yan J, Deshpande SS, Irani K, Lowenstein CJ. Rac1 regulates the release of Weibel-Palade Bodies in human aortic endothelial cells. Chin Med J (Engl). 2004 Aug; 117(8):1143-50.
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Padalko E, Ohnishi T, Matsushita K, Sun H, Fox-Talbot K, Bao C, Baldwin WM, Lowenstein CJ. Peroxynitrite inhibition of Coxsackievirus infection by prevention of viral RNA entry. Proc Natl Acad Sci U S A. 2004 Aug 10; 101(32):11731-6.
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Matsushita K, Morrell CN, Lowenstein CJ. Sphingosine 1-phosphate activates Weibel-Palade body exocytosis. Proc Natl Acad Sci U S A. 2004 Aug 3; 101(31):11483-7.
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Bhatia R, Matsushita K, Yamakuchi M, Morrell CN, Cao W, Lowenstein CJ. Ceramide triggers Weibel-Palade body exocytosis. Circ Res. 2004 Aug 6; 95(3):319-24.
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Lowenstein CJ, Padalko E. iNOS (NOS2) at a glance. J Cell Sci. 2004 Jun 15; 117(Pt 14):2865-7.
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Gellman J, Hare JM, Lowenstein CJ, Gerstenblith G, Coombs V, Langenberg P, Brinker JA, Resar JR. L-arginine ameliorates the abnormal sympathetic response of the dysfunctional human coronary microvasculature. Angiology. 2004 Jan-Feb; 55(1):1-8.
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Matsushita K, Morrell CN, Cambien B, Yang SX, Yamakuchi M, Bao C, Hara MR, Quick RA, Cao W, O'Rourke B, Lowenstein JM, Pevsner J, Wagner DD, Lowenstein CJ. Nitric oxide regulates exocytosis by S-nitrosylation of N-ethylmaleimide-sensitive factor. Cell. 2003 Oct 17; 115(2):139-50.
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Cao W, Baniecki ML, McGrath WJ, Bao C, Deming CB, Rade JJ, Lowenstein CJ, Mangel WF. Nitric oxide inhibits the adenovirus proteinase in vitro and viral infectivity in vivo. FASEB J. 2003 Dec; 17(15):2345-6.
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Cao W, Bao C, Lowenstein CJ. Inducible nitric oxide synthase expression inhibition by adenovirus E1A. Proc Natl Acad Sci U S A. 2003 Jun 24; 100(13):7773-8.
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Li Q, Guo Y, Xuan YT, Lowenstein CJ, Stevenson SC, Prabhu SD, Wu WJ, Zhu Y, Bolli R. Gene therapy with inducible nitric oxide synthase protects against myocardial infarction via a cyclooxygenase-2-dependent mechanism. Circ Res. 2003 Apr 18; 92(7):741-8.
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Saura M, Zaragoza C, Cao W, Bao C, Rodríguez-Puyol M, Rodríguez-Puyol D, Lowenstein CJ. Smad2 mediates transforming growth factor-beta induction of endothelial nitric oxide synthase expression. Circ Res. 2002 Nov 1; 91(9):806-13.
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Cao W, Mattagajasingh SN, Xu H, Kim K, Fierlbeck W, Deng J, Lowenstein CJ, Ballermann BJ. TIMAP, a novel CAAX box protein regulated by TGF-beta1 and expressed in endothelial cells. Am J Physiol Cell Physiol. 2002 Jul; 283(1):C327-37.
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López-Ongil S, Saura M, Zaragoza C, Gónzalez-Santiago L, Rodríguez-Puyol M, Lowenstein CJ, Rodríguez-Puyol D. Hydrogen peroxide regulation of bovine endothelin-converting enzyme-1. Free Radic Biol Med. 2002 Mar 1; 32(5):406-13.
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Lowenstein CJ. Purification and assessment of proteins associated with nitric oxide synthase. Methods Enzymol. 2002; 353:233-40.
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Lowenstein CJ. Measuring reactive oxygen species inhibition of endothelin-converting enzyme. Methods Enzymol. 2002; 353:263-8.
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Qian Z, Gelzer-Bell R, Yang Sx SX, Cao W, Ohnishi T, Wasowska BA, Hruban RH, Rodriguez ER, Baldwin WM, Lowenstein CJ. Inducible nitric oxide synthase inhibition of weibel-palade body release in cardiac transplant rejection. Circulation. 2001 Nov 6; 104(19):2369-75.
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Tendler DS, Bao C, Wang T, Huang EL, Ratovitski EA, Pardoll DA, Lowenstein CJ. Intersection of interferon and hypoxia signal transduction pathways in nitric oxide-induced tumor apoptosis. Cancer Res. 2001 May 1; 61(9):3682-8.
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Ozaki M, Deshpande S, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont P, Suzuki S, Irani K. Targeted inhibition of the small GTPase protects against ischemia/reperfusion liver injury in mice. Transplant Proc. 2001 Feb-Mar; 33(1-2):863-4.
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Sun B, Fan H, Honda T, Fujimaki R, Lafond-Walker A, Masui Y, Lowenstein CJ, Becker LC. Activation of NF kappa B and expression of ICAM-1 in ischemic-reperfused canine myocardium. J Mol Cell Cardiol. 2001 Jan; 33(1):109-19.
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Rothstein NM, Quinn TC, Madico G, Gaydos CA, Lowenstein CJ. Effect of azithromycin on murine arteriosclerosis exacerbated by Chlamydia pneumoniae. J Infect Dis. 2001 Jan 15; 183(2):232-238.
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Horton MR, Olman MA, Bao C, White KE, Choi AM, Chin BY, Noble PW, Lowenstein CJ. Regulation of plasminogen activator inhibitor-1 and urokinase by hyaluronan fragments in mouse macrophages. Am J Physiol Lung Cell Mol Physiol. 2000 Oct; 279(4):L707-15.
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López-Ongil S, Senchak V, Saura M, Zaragoza C, Ames M, Ballermann B, Rodríguez-Puyol M, Rodríguez-Puyol D, Lowenstein CJ. Superoxide regulation of endothelin-converting enzyme. J Biol Chem. 2000 Aug 25; 275(34):26423-7.
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German Z, Chambliss KL, Pace MC, Arnet UA, Lowenstein CJ, Shaul PW. Molecular basis of cell-specific endothelial nitric-oxide synthase expression in airway epithelium. J Biol Chem. 2000 Mar 17; 275(11):8183-9.
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Marbán E, Bolli R, Breitwieser G, Busse R, Dietz H, Endoh M, Finkel T, Kass D, Lowenstein C, Rabinovitch M, Tomaselli G. Under new management: A six-month progress report on Circulation Research. Circ Res. 2000 Feb 4; 86(2):111-3.
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Ozaki M, Deshpande SS, Angkeow P, Bellan J, Lowenstein CJ, Dinauer MC, Goldschmidt-Clermont PJ, Irani K. Inhibition of the Rac1 GTPase protects against nonlethal ischemia/reperfusion-induced necrosis and apoptosis in vivo. FASEB J. 2000 Feb; 14(2):418-29.
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Zaragoza C, Ocampo CJ, Saura M, Bao C, Leppo M, Lafond-Walker A, Thiemann DR, Hruban R, Lowenstein CJ. Inducible nitric oxide synthase protection against coxsackievirus pancreatitis. J Immunol. 1999 Nov 15; 163(10):5497-504.
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Ratovitski EA, Bao C, Quick RA, McMillan A, Kozlovsky C, Lowenstein CJ. An inducible nitric-oxide synthase (NOS)-associated protein inhibits NOS dimerization and activity. J Biol Chem. 1999 Oct 15; 274(42):30250-7.
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Qian Z, Wasowska BA, Behrens E, Cangello DL, Brody JR, Kadkol SS, Horwitz L, Liu J, Lowenstein C, Hess AD, Sanfilippo F, Baldwin WM. C6 produced by macrophages contributes to cardiac allograft rejection. Am J Pathol. 1999 Oct; 155(4):1293-302.
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Lowenstein CJ. NO news is good news. Proc Natl Acad Sci U S A. 1999 Sep 28; 96(20):10953-4.
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Saura M, Zaragoza C, Bao C, McMillan A, Lowenstein CJ. Interaction of interferon regulatory factor-1 and nuclear factor kappaB during activation of inducible nitric oxide synthase transcription. J Mol Biol. 1999 Jun 11; 289(3):459-71.
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Horton MR, Shapiro S, Bao C, Lowenstein CJ, Noble PW. Induction and regulation of macrophage metalloelastase by hyaluronan fragments in mouse macrophages. J Immunol. 1999 Apr 1; 162(7):4171-6.
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Ratovitski EA, Alam MR, Quick RA, McMillan A, Bao C, Kozlovsky C, Hand TA, Johnson RC, Mains RE, Eipper BA, Lowenstein CJ. Kalirin inhibition of inducible nitric-oxide synthase. J Biol Chem. 1999 Jan 8; 274(2):993-9.
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Saura M, Zaragoza C, McMillan A, Quick RA, Hohenadl C, Lowenstein JM, Lowenstein CJ. An antiviral mechanism of nitric oxide: inhibition of a viral protease. Immunity. 1999 Jan; 10(1):21-8.
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Tseng EE, Brock MV, Lange MS, Troncoso JC, Lowenstein CJ, Blue ME, Johnston MV, Baumgartner WA. Nitric oxide mediates neurologic injury after hypothermic circulatory arrest. Ann Thorac Surg. 1999 Jan; 67(1):65-71.
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Hung K, Hayashi R, Lafond-Walker A, Lowenstein C, Pardoll D, Levitsky H. The central role of CD4(+) T cells in the antitumor immune response. J Exp Med. 1998 Dec 21; 188(12):2357-68.
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Rai RM, Lee FY, Rosen A, Yang SQ, Lin HZ, Koteish A, Liew FY, Zaragoza C, Lowenstein C, Diehl AM. Impaired liver regeneration in inducible nitric oxide synthasedeficient mice. Proc Natl Acad Sci U S A. 1998 Nov 10; 95(23):13829-34.
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Tanaka K, Pracyk JB, Takeda K, Yu ZX, Ferrans VJ, Deshpande SS, Ozaki M, Hwang PM, Lowenstein CJ, Irani K, Finkel T. Expression of Id1 results in apoptosis of cardiac myocytes through a redox-dependent mechanism. J Biol Chem. 1998 Oct 2; 273(40):25922-8.
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Tseng EE, Brock MV, Lange MS, Troncoso JC, Blue ME, Lowenstein CJ, Johnston MV, Baumgartner WA. Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest. Surgery. 1998 Aug; 124(2):298-306.
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Zaragoza C, Ocampo C, Saura M, Leppo M, Wei XQ, Quick R, Moncada S, Liew FY, Lowenstein CJ. The role of inducible nitric oxide synthase in the host response to Coxsackievirus myocarditis. Proc Natl Acad Sci U S A. 1998 Mar 3; 95(5):2469-74.
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Ratovitski EA, Kotzbauer PT, Milbrandt J, Lowenstein CJ, Burrow CR. Midkine induces tumor cell proliferation and binds to a high affinity signaling receptor associated with JAK tyrosine kinases. J Biol Chem. 1998 Feb 6; 273(6):3654-60.
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Saura M, Zaragoza C, Díaz-Cazorla M, Hernández-Perera O, Eng E, Lowenstein CJ, Pérez-Sala D, Lamas S. Involvement of transcriptional mechanisms in the inhibition of NOS2 expression by dexamethasone in rat mesangial cells. Kidney Int. 1998 Jan; 53(1):38-49.
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Tseng EE, Brock MV, Lange MS, Blue ME, Troncoso JC, Kwon CC, Lowenstein CJ, Johnston MV, Baumgartner WA. Neuronal nitric oxide synthase inhibition reduces neuronal apoptosis after hypothermic circulatory arrest. Ann Thorac Surg. 1997 Dec; 64(6):1639-47.
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Zaragoza C, Ocampo CJ, Saura M, McMillan A, Lowenstein CJ. Nitric oxide inhibition of coxsackievirus replication in vitro. J Clin Invest. 1997 Oct 1; 100(7):1760-7.
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Lafond-Walker A, Chen CL, Augustine S, Wu TC, Hruban RH, Lowenstein CJ. Inducible nitric oxide synthase expression in coronary arteries of transplanted human hearts with accelerated graft arteriosclerosis. Am J Pathol. 1997 Oct; 151(4):919-25.
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Amin AR, Patel RN, Thakker GD, Lowenstein CJ, Attur MG, Abramson SB. Post-transcriptional regulation of inducible nitric oxide synthase mRNA in murine macrophages by doxycycline and chemically modified tetracyclines. FEBS Lett. 1997 Jun 30; 410(2-3):259-64.
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Merrill JE, Murphy SP, Mitrovic B, Mackenzie-Graham A, Dopp JC, Ding M, Griscavage J, Ignarro LJ, Lowenstein CJ. Inducible nitric oxide synthase and nitric oxide production by oligodendrocytes. J Neurosci Res. 1997 May 15; 48(4):372-84.
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McKee CM, Lowenstein CJ, Horton MR, Wu J, Bao C, Chin BY, Choi AM, Noble PW. Hyaluronan fragments induce nitric-oxide synthase in murine macrophages through a nuclear factor kappaB-dependent mechanism. J Biol Chem. 1997 Mar 21; 272(12):8013-8.
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Brock MV, Blue ME, Lowenstein CJ, Northington FA, Lange MS, Johnston MV, Baumgartner WA. Induction of neuronal nitric oxide after hypothermic circulatory arrest. Ann Thorac Surg. 1996 Nov; 62(5):1313-20.
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Wong HR, Finder JD, Wasserloos K, Lowenstein CJ, Geller DA, Billiar TR, Pitt BR, Davies P. Transcriptional regulation of iNOS by IL-1 beta in cultured rat pulmonary artery smooth muscle cells. Am J Physiol. 1996 Jul; 271(1 Pt 1):L166-71.
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Arnet UA, McMillan A, Dinerman JL, Ballermann B, Lowenstein CJ. Regulation of endothelial nitric-oxide synthase during hypoxia. J Biol Chem. 1996 Jun 21; 271(25):15069-73.
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Lowenstein CJ, Hill SL, Lafond-Walker A, Wu J, Allen G, Landavere M, Rose NR, Herskowitz A. Nitric oxide inhibits viral replication in murine myocarditis. J Clin Invest. 1996 Apr 15; 97(8):1837-43.
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Perrella MA, Hsieh CM, Lee WS, Shieh S, Tsai JC, Patterson C, Lowenstein CJ, Long NC, Haber E, Shore S, Lee ME. Arrest of endotoxin-induced hypotension by transforming growth factor beta1. Proc Natl Acad Sci U S A. 1996 Mar 5; 93(5):2054-9.
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Day JD, Rayburn BK, Gaudin PB, Baldwin WM, Lowenstein CJ, Kasper EK, Baughman KL, Baumgartner WA, Hutchins GM, Hruban RH. Cardiac allograft vasculopathy: the central pathogenetic role of ischemia-induced endothelial cell injury. J Heart Lung Transplant. 1995 Nov-Dec; 14(6 Pt 2):S142-9.
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Ungureanu-Longrois D, Balligand JL, Okada I, Simmons WW, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. Contractile responsiveness of ventricular myocytes to isoproterenol is regulated by induction of nitric oxide synthase activity in cardiac microvascular endothelial cells in heterotypic primary culture. Circ Res. 1995 Sep; 77(3):486-93.
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Ungureanu-Longrois D, Balligand JL, Simmons WW, Okada I, Kobzik L, Lowenstein CJ, Kunkel SL, Michel T, Kelly RA, Smith TW. Induction of nitric oxide synthase activity by cytokines in ventricular myocytes is necessary but not sufficient to decrease contractile responsiveness to beta-adrenergic agonists. Circ Res. 1995 Sep; 77(3):494-502.
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Shaul PW, North AJ, Brannon TS, Ujiie K, Wells LB, Nisen PA, Lowenstein CJ, Snyder SH, Star RA. Prolonged in vivo hypoxia enhances nitric oxide synthase type I and type III gene expression in adult rat lung. Am J Respir Cell Mol Biol. 1995 Aug; 13(2):167-74.
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Flynn JL, Goldstein MM, Chan J, Triebold KJ, Pfeffer K, Lowenstein CJ, Schreiber R, Mak TW, Bloom BR. Tumor necrosis factor-alpha is required in the protective immune response against Mycobacterium tuberculosis in mice. Immunity. 1995 Jun; 2(6):561-72.
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Gutierrez HH, Pitt BR, Schwarz M, Watkins SC, Lowenstein C, Caniggia I, Chumley P, Freeman BA. Pulmonary alveolar epithelial inducible NO synthase gene expression: regulation by inflammatory mediators. Am J Physiol. 1995 Mar; 268(3 Pt 1):L501-8.
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Balligand JL, Ungureanu-Longrois D, Simmons WW, Kobzik L, Lowenstein CJ, Lamas S, Kelly RA, Smith TW, Michel T. Induction of NO synthase in rat cardiac microvascular endothelial cells by IL-1 beta and IFN-gamma. Am J Physiol. 1995 Mar; 268(3 Pt 2):H1293-303.
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Lomis TJ, Siffring CW, Chalasani S, Ziegler DW, Lentz KE, Stauffer KE, McMillan A, Agarwal N, Lowenstein CJ, Rhoads JE. First place winner of the Conrad Jobst Award in the gold medal paper competition. Nitric oxide synthase inhibitors N-monomethylarginine and aminoguanidine prevent the progressive and severe hypotension associated with a rat model of pancreatitis. Am Surg. 1995 Jan; 61(1):7-10.
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Wynn TA, Oswald IP, Eltoum IA, Caspar P, Lowenstein CJ, Lewis FA, James SL, Sher A. Elevated expression of Th1 cytokines and nitric oxide synthase in the lungs of vaccinated mice after challenge infection with Schistosoma mansoni. J Immunol. 1994 Dec 1; 153(11):5200-9.
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Balligand JL, Ungureanu-Longrois D, Simmons WW, Pimental D, Malinski TA, Kapturczak M, Taha Z, Lowenstein CJ, Davidoff AJ, Kelly RA, et al. Cytokine-inducible nitric oxide synthase (iNOS) expression in cardiac myocytes. Characterization and regulation of iNOS expression and detection of iNOS activity in single cardiac myocytes in vitro. J Biol Chem. 1994 Nov 4; 269(44):27580-8.
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Felley-Bosco E, Ambs S, Lowenstein CJ, Keefer LK, Harris CC. Constitutive expression of inducible nitric oxide synthase in human bronchial epithelial cells induces c-fos and stimulates the cGMP pathway. Am J Respir Cell Mol Biol. 1994 Aug; 11(2):159-64.
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North AJ, Star RA, Brannon TS, Ujiie K, Wells LB, Lowenstein CJ, Snyder SH, Shaul PW. Nitric oxide synthase type I and type III gene expression are developmentally regulated in rat lung. Am J Physiol. 1994 Jun; 266(6 Pt 1):L635-41.
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Johnson BA, Lowenstein CJ, Schwarz MA, Nakayama DK, Pitt BR, Davies P. Culture of pulmonary microvascular smooth muscle cells from intraacinar arteries of the rat: characterization and inducible production of nitric oxide. Am J Respir Cell Mol Biol. 1994 Jun; 10(6):604-12.
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Lowenstein CJ, Dinerman JL, Snyder SH. Nitric oxide: a physiologic messenger. Ann Intern Med. 1994 Feb 1; 120(3):227-37.
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Lowenstein CJ, Snyder SH. Purification, cloning, and expression of nitric-oxide synthase. Methods Enzymol. 1994; 233:264-9.
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Lowenstein CJ, Alley EW, Raval P, Snowman AM, Snyder SH, Russell SW, Murphy WJ. Macrophage nitric oxide synthase gene: two upstream regions mediate induction by interferon gamma and lipopolysaccharide. Proc Natl Acad Sci U S A. 1993 Oct 15; 90(20):9730-4.
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Kobzik L, Bredt DS, Lowenstein CJ, Drazen J, Gaston B, Sugarbaker D, Stamler JS. Nitric oxide synthase in human and rat lung: immunocytochemical and histochemical localization. Am J Respir Cell Mol Biol. 1993 Oct; 9(4):371-7.
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Vanderwinden JM, De Laet MH, Schiffmann SN, Mailleux P, Lowenstein CJ, Snyder SH, Vanderhaeghen JJ. Nitric oxide synthase distribution in the enteric nervous system of Hirschsprung's disease. Gastroenterology. 1993 Oct; 105(4):969-73.
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Dinerman JL, Lowenstein CJ, Snyder SH. Molecular mechanisms of nitric oxide regulation. Potential relevance to cardiovascular disease. Circ Res. 1993 Aug; 73(2):217-22.
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Burnett AL, Tillman SL, Chang TS, Epstein JI, Lowenstein CJ, Bredt DS, Snyder SH, Walsh PC. Immunohistochemical localization of nitric oxide synthase in the autonomic innervation of the human penis. J Urol. 1993 Jul; 150(1):73-6.
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Geller DA, Lowenstein CJ, Shapiro RA, Nussler AK, Di Silvio M, Wang SC, Nakayama DK, Simmons RL, Snyder SH, Billiar TR. Molecular cloning and expression of inducible nitric oxide synthase from human hepatocytes. Proc Natl Acad Sci U S A. 1993 Apr 15; 90(8):3491-5.
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Lorsbach RB, Murphy WJ, Lowenstein CJ, Snyder SH, Russell SW. Expression of the nitric oxide synthase gene in mouse macrophages activated for tumor cell killing. Molecular basis for the synergy between interferon-gamma and lipopolysaccharide. J Biol Chem. 1993 Jan 25; 268(3):1908-13.
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Geller DA, Nussler AK, Di Silvio M, Lowenstein CJ, Shapiro RA, Wang SC, Simmons RL, Billiar TR. Cytokines, endotoxin, and glucocorticoids regulate the expression of inducible nitric oxide synthase in hepatocytes. Proc Natl Acad Sci U S A. 1993 Jan 15; 90(2):522-6.
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Nakayama DK, Geller DA, Lowenstein CJ, Chern HD, Davies P, Pitt BR, Simmons RL, Billiar TR. Cytokines and lipopolysaccharide induce nitric oxide synthase in cultured rat pulmonary artery smooth muscle. Am J Respir Cell Mol Biol. 1992 Nov; 7(5):471-6.
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Lowenstein CJ, Snyder SH. Nitric oxide, a novel biologic messenger. Cell. 1992 Sep 4; 70(5):705-7.
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Lowenstein CJ, Glatt CS, Bredt DS, Snyder SH. Cloned and expressed macrophage nitric oxide synthase contrasts with the brain enzyme. Proc Natl Acad Sci U S A. 1992 Aug 1; 89(15):6711-5.
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Burnett AL, Lowenstein CJ, Bredt DS, Chang TS, Snyder SH. Nitric oxide: a physiologic mediator of penile erection. Science. 1992 Jul 17; 257(5068):401-3.
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Bredt DS, Hwang PM, Glatt CE, Lowenstein C, Reed RR, Snyder SH. Cloned and expressed nitric oxide synthase structurally resembles cytochrome P-450 reductase. Nature. 1991 Jun 27; 351(6329):714-8.
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