Jing Wang
| Title | Research Assistant Professor |
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| Institution | School of Medicine and Dentistry |
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| Department | Pediatrics |
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| Address | University of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester NY 14642
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| 1990 |
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| 1995 | Dean's Scholarship for Excellent Academic Achievement(five-time recipient) | | 1998 |
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| Travel Award | The 22nd International Congress of Pediatrics | | 2008 |
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| Travel Award | X International Workshops on Opportunistic Protists | | 2008 |
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| New York State Blavatnik Award for Young Scientists (Nominee) | University of Rochester School of Medicine and Dentistry | | 2009 |
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| Travel Award | 2009 American Thoracic Society International Conference | | 2010 |
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| Junior Faculty Travel Grant | 2010 American Association of Immunologist, 97th AAI Annual Meeti |
1. Macrophage mediated fungal clearance and lung injury during
Pneumocystis pneumonia
2. Mechanism of immune mediated lung injury during infectious diseases
3. Seeking new strategies to treat inflammatory lung diseases
Pneumocystis is an opportunistic fungal respiratory pathogen that causes life-threatening pneumonia in patients suffering from defects in cell-mediated immunity, including those with acquired immunodeficiency syndrome (AIDS) and immunosuppression secondary to chemotherapy or organ transplantation. Despite dramatic advances in health care and the availability of antibiotics to treat this infection, mortality rates have improved little over the past 25 years. Pneumocystis carinii pneumonia remains a leading cause of death among HIV-infected patients and a significant cause of AIDS-related mortality and morbidity. This highlights the need for better understanding of the pathogenesis of the disease, and underscores the necessity of investigating new therapeutic strategies.
My research uses Pneumocystis pneumonia as one of the models to study the mechanisms of lung injury. I use a variety of immunology, imaging, and cell biolological techniques to study the role of alveolar macrophage phenotype during inflammatory lung diseases.
The specific goals of my research are to: 1) determine the functional changes in alveolar macrophages during inflammatory lung diseases, and 2) evaluate the feasibility of using specific macrophage phenotype subsets as adjunctive treatments to ameliorate inflammatory lung diseases.
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Bello-Irizarry SN, Wang J, Olsen K, Gigliotti F, Wright TW. The Alveolar Epithelial Cell Chemokine Response to Pneumocystis Requires Adaptor Molecule MyD88 and Interleukin-1 Receptor but Not Toll-Like Receptor 2 or 4. Infect Immun. 2012 Nov; 80(11):3912-20.
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Massie R, Wang J, Chen LC, Zhang VW, Collins MP, Wong LJ, Milone M. Mitochondrial myopathy due to novel missense mutation in the cytochrome c oxidase 1 gene. J Neurol Sci. 2012 Aug 15; 319(1-2):158-63.
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Wang J, Wright TW, Gigliotti F. Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia. Interdiscip Perspect Infect Dis. 2011; 2011:918038.
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Milone M, Wang J, Liewluck T, Chen LC, Leavitt JA, Wong LJ. Novel POLG splice site mutation and optic atrophy. Arch Neurol. 2011 Jun; 68(6):806-11.
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Wang J, Gigliotti F, Bhagwat SP, George TC, Wright TW. Immune modulation with sulfasalazine attenuates immunopathogenesis but enhances macrophage-mediated fungal clearance during Pneumocystis pneumonia. PLoS Pathog. 2010; 6(8):e1001058.
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Wang J, Yin G, Menon P, Pang J, Smolock EM, Yan C, Berk BC. Phosphorylation of G protein-coupled receptor kinase 2-interacting protein 1 tyrosine 392 is required for phospholipase C-gamma activation and podosome formation in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2010 Oct; 30(10):1976-82.
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Milone M, Younge BR, Wang J, Zhang S, Wong LJ. Mitochondrial disorder with OPA1 mutation lacking optic atrophy. Mitochondrion. 2009 Jul; 9(4):279-81.
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Pang J, Hoefen R, Pryhuber GS, Wang J, Yin G, White RJ, Xu X, O'Dell MR, Mohan A, Michaloski H, Massett MP, Yan C, Berk BC. G-protein-coupled receptor kinase interacting protein-1 is required for pulmonary vascular development. Circulation. 2009 Mar 24; 119(11):1524-32.
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Wang J, Taba Y, Pang J, Yin G, Yan C, Berk BC. GIT1 mediates VEGF-induced podosome formation in endothelial cells: critical role for PLCgamma. Arterioscler Thromb Vasc Biol. 2009 Feb; 29(2):202-8.
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Wang J, Pan S, Berk BC. Glutaredoxin mediates Akt and eNOS activation by flow in a glutathione reductase-dependent manner. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1283-8.
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Wang J, Gigliotti F, Bhagwat SP, Maggirwar SB, Wright TW. Pneumocystis stimulates MCP-1 production by alveolar epithelial cells through a JNK-dependent mechanism. Am J Physiol Lung Cell Mol Physiol. 2007 Jun; 292(6):L1495-505.
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Wang J, Gigliotti F, Maggirwar S, Johnston C, Finkelstein JN, Wright TW. Pneumocystis carinii activates the NF-kappaB signaling pathway in alveolar epithelial cells. Infect Immun. 2005 May; 73(5):2766-77.
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