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Jing Wang

TitleResearch Assistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentPediatrics
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box 850
Rochester NY 14642
 
 Awards And Honors
1990 - 1995Dean's Scholarship for Excellent Academic Achievement(five-time recipient)
1998     Travel Award  | The 22nd International Congress of Pediatrics
2008     Travel Award  | X International Workshops on Opportunistic Protists
2008     New York State Blavatnik Award for Young Scientists (Nominee)  | University of Rochester School of Medicine and Dentistry
2009     Travel Award  | 2009 American Thoracic Society International Conference
2010     Junior Faculty Travel Grant  | 2010 American Association of Immunologist, 97th AAI Annual Mtg
 
 Overview
1. Macrophage mediated fungal clearance and lung injury during
Pneumocystis pneumonia
2. Mechanism of immune mediated lung injury during infectious diseases
3. Seeking new strategies to treat inflammatory lung diseases

Pneumocystis is an opportunistic fungal respiratory pathogen that causes life-threatening pneumonia in patients suffering from defects in cell-mediated immunity, including those with acquired immunodeficiency syndrome (AIDS) and immunosuppression secondary to chemotherapy or organ transplantation. Despite dramatic advances in health care and the availability of antibiotics to treat this infection, mortality rates have improved little over the past 25 years. Pneumocystis carinii pneumonia remains a leading cause of death among HIV-infected patients and a significant cause of AIDS-related mortality and morbidity. This highlights the need for better understanding of the pathogenesis of the disease, and underscores the necessity of investigating new therapeutic strategies.

My research uses Pneumocystis pneumonia as one of the models to study the mechanisms of lung injury. I use a variety of immunology, imaging, and cell biolological techniques to study the role of alveolar macrophage phenotype during inflammatory lung diseases.

The specific goals of my research are to: 1) determine the functional changes in alveolar macrophages during inflammatory lung diseases, and 2) evaluate the feasibility of using specific macrophage phenotype subsets as adjunctive treatments to ameliorate inflammatory lung diseases.

 
 Selected Publications
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  1. Bello-Irizarry SN, Wang J, Olsen K, Gigliotti F, Wright TW. The Alveolar Epithelial Cell Chemokine Response to Pneumocystis Requires Adaptor Molecule MyD88 and Interleukin-1 Receptor but Not Toll-Like Receptor 2 or 4. Infect Immun. 2012 Nov; 80(11):3912-20.
    View in: PubMed
  2. Wang J, Wright TW, Gigliotti F. Immune Modulation as Adjunctive Therapy for Pneumocystis pneumonia. Interdiscip Perspect Infect Dis. 2011; 2011:918038.
    View in: PubMed

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