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David Morrow

TitleAssistant Professor
InstitutionSchool of Medicine and Dentistry
DepartmentSurgery
AddressUniversity of Rochester Medical Center
School of Medicine and Dentistry
601 Elmwood Ave, Box SURG
Rochester NY 14642
 
 Awards And Honors
2006 - 2008AHA Postdoctoral Fellowship Award  | American Heart Association
2008     ATVB Merit Award  | American Heart Association
2009 - 2011K99/R00 Pathway to Independence Award  | NIH
 
 Overview
Dr. Morrow received a PhD in cardiovascular biology from the Vascular Health Research Center, Dublin City University, Ireland in 2005. Following postdoctoral training at the Department of Surgery, University of Rochester in the lab of Dr Eileen Redmond (2006-2009), he was promoted to Instructor of Surgery in April 2009. Dr Morrow was awarded a postdoctoral fellowship from the American Heart Association in June 2006 to work on the effects of hemodynamic forces on Notch Signaling and Angiogenesis. As a result of this work he received an American Heart Association Merit award in April 2008. In April 2009 he was awarded a K99/R00 "Pathway to Independence Award" from the National Heart, Blood and Lung institute at the National Institute of Health. Dr Morrow currently has 15 peer reviewed articles with 11 as primary author focusing on the role of Notch and Hedgehog signaling in controlling vascular cell fate.

 
 Selected Publications
List All   |   Timeline
  1. Redmond EM, Hamm K, Cullen JP, Hatch E, Cahill PA, Morrow D. Inhibition of patched-1 prevents injury-induced neointimal hyperplasia. Arterioscler Thromb Vasc Biol. 2013 Aug; 33(8):1960-4.
    View in: PubMed
  2. Walshe TE, Connell P, Cryan L, Ferguson G, Gardiner T, Morrow D, Redmond EM, O'Brien C, Cahill PA. Microvascular retinal endothelial and pericyte cell apoptosis in vitro: role of hedgehog and Notch signaling. Invest Ophthalmol Vis Sci. 2011 Jun; 52(7):4472-83.
    View in: PubMed
  3. Guha S, Cullen JP, Morrow D, Colombo A, Lally C, Walls D, Redmond EM, Cahill PA. Glycogen synthase kinase 3 beta positively regulates Notch signaling in vascular smooth muscle cells: role in cell proliferation and survival. Basic Res Cardiol. 2011 Sep; 106(5):773-85.
    View in: PubMed
  4. Banerjee S, Lin CF, Skinner KA, Schiffhauer LM, Peacock J, Hicks DG, Redmond EM, Morrow D, Huston A, Shayne M, Langstein HN, Miller-Graziano CL, Strickland J, O'Donoghue L, De AK. Heat shock protein 27 differentiates tolerogenic macrophages that may support human breast cancer progression. Cancer Res. 2011 Jan 15; 71(2):318-27.
    View in: PubMed
  5. Morrow D, Cullen JP, Liu W, Cahill PA, Redmond EM. Alcohol inhibits smooth muscle cell proliferation via regulation of the Notch signaling pathway. Arterioscler Thromb Vasc Biol. 2010 Dec; 30(12):2597-603.
    View in: PubMed
  6. Morrow DJ, Avissar NE, Toia L, Redmond EM, Watson TJ, Jones C, Raymond DP, Litle V, Peters JH. Pathogenesis of Barrett's esophagus: bile acids inhibit the Notch signaling pathway with induction of CDX2 gene expression in human esophageal cells. Surgery. 2009 Oct; 146(4):714-21; discussion 721-2.
    View in: PubMed
  7. Morrow D, Cullen JP, Liu W, Guha S, Sweeney C, Birney YA, Collins N, Walls D, Redmond EM, Cahill PA. Sonic Hedgehog induces Notch target gene expression in vascular smooth muscle cells via VEGF-A. Arterioscler Thromb Vasc Biol. 2009 Jul; 29(7):1112-8.
    View in: PubMed
  8. Morrow D, Guha S, Sweeney C, Birney Y, Walshe T, O'Brien C, Walls D, Redmond EM, Cahill PA. Notch and vascular smooth muscle cell phenotype. Circ Res. 2008 Dec 5; 103(12):1370-82.
    View in: PubMed
  9. Redmond EM, Morrow D, Kundimi S, Miller-Graziano CL, Cullen JP. Acetaldehyde stimulates monocyte adhesion in a P-selectin- and TNFalpha-dependent manner. Atherosclerosis. 2009 Jun; 204(2):372-80.
    View in: PubMed
  10. Morrow D, Cullen JP, Cahill PA, Redmond EM. Ethanol stimulates endothelial cell angiogenic activity via a Notch- and angiopoietin-1-dependent pathway. Cardiovasc Res. 2008 Jul 15; 79(2):313-21.
    View in: PubMed
  11. Cullen JP, Morrow D, Jin Y, von Offenberg Sweeney N, Sitzmann JV, Cahill PA, Redmond EM. Resveratrol inhibits expression and binding activity of the monocyte chemotactic protein-1 receptor, CCR2, on THP-1 monocytes. Atherosclerosis. 2007 Nov; 195(1):e125-33.
    View in: PubMed
  12. Morrow D, Cullen JP, Cahill PA, Redmond EM. Cyclic strain regulates the Notch/CBF-1 signaling pathway in endothelial cells: role in angiogenic activity. Arterioscler Thromb Vasc Biol. 2007 Jun; 27(6):1289-96.
    View in: PubMed
  13. Morrow D, Sweeney C, Guha S, Walshe T, O'Brien C, Walls D, Redmond EM, Cahill PA. Notch signaling and vascular cell fate--how vascular cells respond to stress. Wien Klin Wochenschr. 2007; 119(11-12 Suppl 1):7-10.
    View in: PubMed
  14. Cullen JP, Morrow D, Jin Y, Curley B, Robinson A, Sitzmann JV, Cahill PA, Redmond EM. Resveratrol, a polyphenolic phytostilbene, inhibits endothelial monocyte chemotactic protein-1 synthesis and secretion. J Vasc Res. 2007; 44(1):75-84.
    View in: PubMed
  15. Morrow D, Sweeney C, Birney YA, Guha S, Collins N, Cummins PM, Murphy R, Walls D, Redmond EM, Cahill PA. Biomechanical regulation of hedgehog signaling in vascular smooth muscle cells in vitro and in vivo. Am J Physiol Cell Physiol. 2007 Jan; 292(1):C488-96.
    View in: PubMed
  16. Morrow D, Scheller A, Birney YA, Sweeney C, Guha S, Cummins PM, Murphy R, Walls D, Redmond EM, Cahill PA. Notch-mediated CBF-1/RBP-J{kappa}-dependent regulation of human vascular smooth muscle cell phenotype in vitro. Am J Physiol Cell Physiol. 2005 Nov; 289(5):C1188-96.
    View in: PubMed
  17. Morrow D, Sweeney C, Birney YA, Cummins PM, Walls D, Redmond EM, Cahill PA. Cyclic strain inhibits Notch receptor signaling in vascular smooth muscle cells in vitro. Circ Res. 2005 Mar 18; 96(5):567-75.
    View in: PubMed
  18. Sweeney C, Morrow D, Birney YA, Coyle S, Hennessy C, Scheller A, Cummins PM, Walls D, Redmond EM, Cahill PA. Notch 1 and 3 receptor signaling modulates vascular smooth muscle cell growth, apoptosis, and migration via a CBF-1/RBP-Jk dependent pathway. FASEB J. 2004 Sep; 18(12):1421-3.
    View in: PubMed
  19. Morrow DJ. Swallowing bitter pills for pay: trials of human guinea pigs. NY Times (Print). 1996 Sep 29; F1, F10.
    View in: PubMed

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