URMC Research Network - Wakenda Tyler

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Wakenda Tyler

Title	Assistant Professor
Institution	School of Medicine and Dentistry
Department	Orthopaedics
Address	University of Rochester Medical Center School of Medicine and Dentistry 601 Elmwood Ave, Box 665 Rochester NY 14642

Awards And Honors

1993	-	1994	Scholar Athlete Award receipient in cross country, track and field \| Millersville University
1996	-	1997	Phi Kappa Phi Honors Society inductee \| Millersville University
1997			The Class of 1895 Award \| Millersville University
1997			The Fontes Health Professions Award in Pre-Med
1997			The Cecil Upton Organic Chemistry Award
1997			Summa Cum Laude, Department Honors and University Honors \| Millersville University
2000	-	2001	Johns Hopkins School of Hygiene and Public Health Watt-Hansel Scholarship recipient \| Johns Hopkins School of Hygiene and Public Health
2001	-	2002	Monumental City Medical Society Scholarship Recipient
2002			Phi Beta Kappa Honors Society Inductee \| Johns Hopkins School of Hygiene and Public Health
2002			Alpha Omega Alpha National Medical Honors Society Inductee
2006			American Orthopaedic Association Future Leaders in Orthopaedics recipient \| American Orthopaedic Association
2006			Joseph M. Lane, MD Resident Research Grant recipient

Overview

Dr. Tyler's research interests overlap with her clinical practice and center around the treatment of patients with bone and soft tissue tumors and conditions that lead to osteolysis (bone destruction as a result of implant wear and loosening or presence of tumor). Her areas of on-going research at this time include:

1) Treatment of aggressive benign conditions, such as pigmented villonodular synovitis and giant cell tumor of bone. More specifically, the molecular and cellular signaling pathways of cells in these conditions and the genetic alterations that lead to such conditions.

2) Medical and surgical treatment of soft tissue sarcomas.

3) Inhibiting osteolysis in both benign and malignant bone conditions.

4) Allograft implantation for large bone defects.

5) Treatment of metastatic disease to bone from other organs systems.

Selected Publications

Xie C, Schwarz EM, Sampson ER, Dhillon RS, Li D, O'Keefe RJ, Tyler W. Unique angiogenic and vasculogenic properties of renal cell carcinoma in a xenograft model of bone metastasis are associated with high levels of vegf-a and decreased ang-1 expression. J Orthop Res. 2012 Feb; 30(2):325-33.

View in: PubMed
Tyler WK, Healey JH, Morris CD, Boland PJ, O'Donnell RJ. Compress periprosthetic fractures: interface stability and ease of revision. Clin Orthop Relat Res. 2009 Nov; 467(11):2800-6.

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DiResta GR, Manoso MW, Naqvi A, Zanzonico P, Smith-Jones P, Tyler W, Morris C, Healey JH. Bisphosphonate delivery to tubular bone allografts. Clin Orthop Relat Res. 2008 Aug; 466(8):1871-9.

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Shindle MK, Tyler W, Edobor-Osula F, Gardner MJ, Shindle L, Toro J, Lane JM. Unsuspected lymphoma diagnosed with use of biopsy during kyphoplasty. J Bone Joint Surg Am. 2006 Dec; 88(12):2721-4.

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Tyler WK, Vidal AF, Williams RJ, Healey JH. Pigmented villonodular synovitis. J Am Acad Orthop Surg. 2006 Jun; 14(6):376-85.

View in: PubMed
Domb BG, Tyler W, Ellis S, McCarthy E. Radiographic evaluation of pathological bone lesions: current spectrum of disease and approach to diagnosis. J Bone Joint Surg Am. 2004; 86-A Suppl 2:84-90.

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Tyler W, Frassica FJ, McCarthy EF. Recurrence of a unicameral bone cyst after nineteen years. Orthopedics. 2002 Apr; 25(4):435-6.

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Tyler W, McCarthy EF. Osteochondrosis of the superior pole of the patella: two cases with histologic correlation. Iowa Orthop J. 2002; 22:86-9.

View in: PubMed