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Kapitulnik J, Maines MD. The role of bile pigments in health and disease: effects on cell signaling, cytotoxicity, and cytoprotection. Front Pharmacol. 2012; 3:136.
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Miralem T, Lerner-Marmarosh N, Gibbs PE, Tudor C, Hagen FK, Maines MD. The Human Biliverdin Reductase-based Peptide Fragments and Biliverdin Regulate Protein Kinase Cd Activity: THE PEPTIDES ARE INHIBITORS OR SUBSTRATE FOR THE PROTEIN KINASE C. J Biol Chem. 2012 Jul 13; 287(29):24698-712.
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Gibbs PE, Tudor C, Maines MD. Biliverdin reductase: more than a namesake - the reductase, its Peptide fragments, and biliverdin regulate activity of the three classes of protein kinase C. Front Pharmacol. 2012; 3:31.
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Gibbs PE, Miralem T, Lerner-Marmarosh N, Tudor C, Maines MD. Formation of Ternary Complex of Human Biliverdin Reductase-Protein Kinase Cd-ERK2 Protein Is Essential for ERK2-mediated Activation of Elk1 Protein, Nuclear Factor-?B, and Inducible Nitric-oxidase Synthase (iNOS). J Biol Chem. 2012 Jan 6; 287(2):1066-79.
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Maines MD. Potential application of biliverdin reductase and its fragments to modulate insulin/IGF-1/MAPK/PI3-K signaling pathways in therapeutic settings. Curr Drug Targets. 2010 Dec; 11(12):1586-94.
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Ding B, Gibbs PE, Brookes PS, Maines MD. The coordinated increased expression of biliverdin reductase and heme oxygenase-2 promotes cardiomyocyte survival: a reductase-based peptide counters ß-adrenergic receptor ligand-mediated cardiac dysfunction. FASEB J. 2011 Jan; 25(1):301-13.
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Gibbs PE, Miralem T, Maines MD. Characterization of the human biliverdin reductase gene structure and regulatory elements: promoter activity is enhanced by hypoxia and suppressed by TNF-alpha-activated NF-kappaB. FASEB J. 2010 Sep; 24(9):3239-54.
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Miralem T, Gibbs PE, Revert F, Saus J, Maines MD. Human biliverdin reductase suppresses Goodpasture antigen-binding protein (GPBP) kinase activity: the reductase regulates tumor necrosis factor-alpha-NF-kappaB-dependent GPBP expression. J Biol Chem. 2010 Apr 23; 285(17):12551-8.
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Kapitulnik J, Maines MD. Pleiotropic functions of biliverdin reductase: cellular signaling and generation of cytoprotective and cytotoxic bilirubin. Trends Pharmacol Sci. 2009 Mar; 30(3):129-37.
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Tudor C, Lerner-Marmarosh N, Engelborghs Y, Gibbs PE, Maines MD. Biliverdin reductase is a transporter of haem into the nucleus and is essential for regulation of HO-1 gene expression by haematin. Biochem J. 2008 Aug 1; 413(3):405-16.
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Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. Human biliverdin reductase is an ERK activator; hBVR is an ERK nuclear transporter and is required for MAPK signaling. Proc Natl Acad Sci U S A. 2008 May 13; 105(19):6870-5.
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Gibbs PE, Maines MD. Biliverdin inhibits activation of NF-kappaB: reversal of inhibition by human biliverdin reductase. Int J Cancer. 2007 Dec 1; 121(11):2567-74.
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Maines MD. Biliverdin reductase: PKC interaction at the cross-talk of MAPK and PI3K signaling pathways. Antioxid Redox Signal. 2007 Dec; 9(12):2187-95.
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Lerner-Marmarosh N, Miralem T, Gibbs PE, Maines MD. Regulation of TNF-alpha-activated PKC-zeta signaling by the human biliverdin reductase: identification of activating and inhibitory domains of the reductase. FASEB J. 2007 Dec; 21(14):3949-62.
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Maines MD, Miralem T, Lerner-Marmarosh N, Shen J, Gibbs PE. Human biliverdin reductase, a previously unknown activator of protein kinase C betaII. J Biol Chem. 2007 Mar 16; 282(11):8110-22.
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Calabrese V, Maines MD. Antiaging medicine: antioxidants and aging. Antioxid Redox Signal. 2006 Mar-Apr; 8(3-4):362-4.
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Calabrese V, Butterfield DA, Scapagnini G, Stella AM, Maines MD. Redox regulation of heat shock protein expression by signaling involving nitric oxide and carbon monoxide: relevance to brain aging, neurodegenerative disorders, and longevity. Antioxid Redox Signal. 2006 Mar-Apr; 8(3-4):444-77.
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Ewing JF, Maines MD. Regulation and expression of heme oxygenase enzymes in aged-rat brain: age related depression in HO-1 and HO-2 expression and altered stress-response. J Neural Transm. 2006 Apr; 113(4):439-54.
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Maines MD. New insights into biliverdin reductase functions: linking heme metabolism to cell signaling. Physiology (Bethesda). 2005 Dec; 20:382-9.
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Maines MD. The heme oxygenase system: update 2005. Antioxid Redox Signal. 2005 Nov-Dec; 7(11-12):1761-6.
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Maines MD, Gibbs PE. 30 some years of heme oxygenase: from a "molecular wrecking ball" to a "mesmerizing" trigger of cellular events. Biochem Biophys Res Commun. 2005 Dec 9; 338(1):568-77.
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Lerner-Marmarosh N, Shen J, Torno MD, Kravets A, Hu Z, Maines MD. Human biliverdin reductase: a member of the insulin receptor substrate family with serine/threonine/tyrosine kinase activity. Proc Natl Acad Sci U S A. 2005 May 17; 102(20):7109-14.
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Miralem T, Hu Z, Torno MD, Lelli KM, Maines MD. Small interference RNA-mediated gene silencing of human biliverdin reductase, but not that of heme oxygenase-1, attenuates arsenite-mediated induction of the oxygenase and increases apoptosis in 293A kidney cells. J Biol Chem. 2005 Apr 29; 280(17):17084-92.
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Maines MD. The heme oxygenase system: past, present, and future. Antioxid Redox Signal. 2004 Oct; 6(5):797-801.
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Kravets A, Hu Z, Miralem T, Torno MD, Maines MD. Biliverdin reductase, a novel regulator for induction of activating transcription factor-2 and heme oxygenase-1. J Biol Chem. 2004 May 7; 279(19):19916-23.
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Mayer RD, Wang X, Maines MD. Nitric oxide inhibitor N omega -nitro-l-arginine methyl ester potentiates induction of heme oxygenase-1 in kidney ischemia/reperfusion model: a novel mechanism for regulation of the oxygenase. J Pharmacol Exp Ther. 2003 Jul; 306(1):43-50.
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Wang X, Hauptmann N, Taylor E, Foreman M, Khawli LA, Maines MD. Neotrofin increases heme oxygenase-1 selectively in neurons. Brain Res. 2003 Feb 7; 962(1-2):1-14.
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Maines MD. Bile pigments: newcomers to the cell signaling arena. Toxicol Sci. 2003 Jan; 71(1):9-10.
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Whitby FG, Phillips JD, Hill CP, McCoubrey W, Maines MD. Crystal structure of a biliverdin IXalpha reductase enzyme-cofactor complex. J Mol Biol. 2002 Jun 21; 319(5):1199-210.
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Maines MD. Heme oxygenase 1 transgenic mice as a model to study neuroprotection. Methods Enzymol. 2002; 353:374-88.
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Ahmad Z, Salim M, Maines MD. Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in transcriptional activation of heme oxygenase-1 by oxidative stress. J Biol Chem. 2002 Mar 15; 277(11):9226-32.
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Huang TJ, McCoubrey WK, Maines MD. Heme oxygenase-2 interaction with metalloporphyrins: function of heme regulatory motifs. Antioxid Redox Signal. 2001 Aug; 3(4):685-96.
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Maines MD. Overview of heme degradation pathway. Curr Protoc Toxicol. 2001 May; Chapter 9:Unit9.1.
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Maines MD, Ewing JF, Huang TJ, Panahian N. Nuclear localization of biliverdin reductase in the rat kidney: response to nephrotoxins that induce heme oxygenase-1. J Pharmacol Exp Ther. 2001 Mar; 296(3):1091-7.
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Salim M, Brown-Kipphut BA, Maines MD. Human biliverdin reductase is autophosphorylated, and phosphorylation is required for bilirubin formation. J Biol Chem. 2001 Apr 6; 276(14):10929-34.
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Maines MD, Panahian N. The heme oxygenase system and cellular defense mechanisms. Do HO-1 and HO-2 have different functions? Adv Exp Med Biol. 2001; 502:249-72.
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Panahian N, Maines MD. Site of injury-directed induction of heme oxygenase-1 and -2 in experimental spinal cord injury: differential functions in neuronal defense mechanisms? J Neurochem. 2001 Jan; 76(2):539-54.
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Panahian N, Maines MD. Assessment of induction of biliverdin reductase in a mouse model of middle cerebral artery occlusion. Brain Res Brain Res Protoc. 2000 Nov; 6(1-2):53-70.
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Chen K, Gunter K, Maines MD. Neurons overexpressing heme oxygenase-1 resist oxidative stress-mediated cell death. J Neurochem. 2000 Jul; 75(1):304-13.
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Chen K, Maines MD. Nitric oxide induces heme oxygenase-1 via mitogen-activated protein kinases ERK and p38. Cell Mol Biol (Noisy-le-grand). 2000 May; 46(3):609-17.
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Maines MD. The heme oxygenase system and its functions in the brain. Cell Mol Biol (Noisy-le-grand). 2000 May; 46(3):573-85.
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Liu N, Wang X, McCoubrey WK, Maines MD. Developmentally regulated expression of two transcripts for heme oxygenase-2 with a first exon unique to rat testis: control by corticosterone of the oxygenase protein expression. Gene. 2000 Jan 4; 241(1):175-83.
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Panahian N, Huang T, Maines MD. Enhanced neuronal expression of the oxidoreductase--biliverdin reductase--after permanent focal cerebral ischemia. Brain Res. 1999 Dec 11; 850(1-2):1-13.
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Maines MD, Raju VS, Panahian N. Spin trap (N-t-butyl-alpha-phenylnitrone)-mediated suprainduction of heme oxygenase-1 in kidney ischemia/reperfusion model: role of the oxygenase in protection against oxidative injury. J Pharmacol Exp Ther. 1999 Nov; 291(2):911-9.
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Maines MD, Mayer RD, Erturk E, Huang TJ, Disantagnese A. The oxidoreductase, biliverdin reductase, is induced in human renal carcinoma--pH and cofactor-specific increase in activity. J Urol. 1999 Oct; 162(4):1467-72.
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Ding Y, McCoubrey WK, Maines MD. Interaction of heme oxygenase-2 with nitric oxide donors. Is the oxygenase an intracellular 'sink' for NO? Eur J Biochem. 1999 Sep; 264(3):854-61.
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Panahian N, Yoshiura M, Maines MD. Overexpression of heme oxygenase-1 is neuroprotective in a model of permanent middle cerebral artery occlusion in transgenic mice. J Neurochem. 1999 Mar; 72(3):1187-203.
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Morgan D, Holcomb L, Saad I, Gordon M. Impaired spatial navigation learning in transgenic mice over-expressing heme oxygenase-1. Brain Res. 1998 Oct 12; 808(1):110-2.
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Woo J, Iyer S, Cornejo MC, Mori N, Gao L, Sipos I, Maines M, Buelow R. Stress protein-induced immunosuppression: inhibition of cellular immune effector functions following overexpression of haem oxygenase (HSP 32). Transpl Immunol. 1998 Jun; 6(2):84-93.
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Maines MD, Polevoda B, Coban T, Johnson K, Stoliar S, Huang TJ, Panahian N, Cory-Slechta DA, McCoubrey WK. Neuronal overexpression of heme oxygenase-1 correlates with an attenuated exploratory behavior and causes an increase in neuronal NADPH diaphorase staining. J Neurochem. 1998 May; 70(5):2057-69.
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Miller SM, Farrugia G, Schmalz PF, Ermilov LG, Maines MD, Szurszewski JH. Heme oxygenase 2 is present in interstitial cell networks of the mouse small intestine. Gastroenterology. 1998 Feb; 114(2):239-44.
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Farrugia G, Miller SM, Rich A, Liu X, Maines MD, Rae JL, Szurszewski JH. Distribution of heme oxygenase and effects of exogenous carbon monoxide in canine jejunum. Am J Physiol. 1998 Feb; 274(2 Pt 1):G350-8.
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Iyer S, Woo J, Cornejo MC, Gao L, McCoubrey W, Maines M, Buelow R. Characterization and biological significance of immunosuppressive peptide D2702.75-84(E --> V) binding protein. Isolation of heme oxygenase-1. J Biol Chem. 1998 Jan 30; 273(5):2692-7.
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McCoubrey WK, Huang TJ, Maines MD. Isolation and characterization of a cDNA from the rat brain that encodes hemoprotein heme oxygenase-3. Eur J Biochem. 1997 Jul 15; 247(2):725-32.
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Sturgill MG, Grasing KW, Rosen RC, Thomas TJ, Kulkarni GD, Trout JR, Maines M, Seibold JR. Yohimbine elimination in normal volunteers is characterized by both one- and two-compartment behavior. J Cardiovasc Pharmacol. 1997 Jun; 29(6):697-703.
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McCoubrey WK, Huang TJ, Maines MD. Heme oxygenase-2 is a hemoprotein and binds heme through heme regulatory motifs that are not involved in heme catalysis. J Biol Chem. 1997 May 9; 272(19):12568-74.
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Ewing JF, Maines MD. Histochemical localization of heme oxygenase-2 protein and mRNA expression in rat brain. Brain Res Brain Res Protoc. 1997 May; 1(2):165-74.
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Lagarias DM, Crepeau MW, Maines MD, Lagarias JC. Regulation of photomorphogenesis by expression of mammalian biliverdin reductase in transgenic Arabidopsis plants. Plant Cell. 1997 May; 9(5):675-88.
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Raju VS, McCoubrey WK, Maines MD. Regulation of heme oxygenase-2 by glucocorticoids in neonatal rat brain: characterization of a functional glucocorticoid response element. Biochim Biophys Acta. 1997 Mar 20; 1351(1-2):89-104.
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Maines MD. The heme oxygenase system: a regulator of second messenger gases. Annu Rev Pharmacol Toxicol. 1997; 37:517-54.
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Geddes JW, Pettigrew LC, Holtz ML, Craddock SD, Maines MD. Permanent focal and transient global cerebral ischemia increase glial and neuronal expression of heme oxygenase-1, but not heme oxygenase-2, protein in rat brain. Neurosci Lett. 1996 Jun 7; 210(3):205-8.
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Raju VS, Maines MD. Renal ischemia/reperfusion up-regulates heme oxygenase-1 (HSP32) expression and increases cGMP in rat heart. J Pharmacol Exp Ther. 1996 Jun; 277(3):1814-22.
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Maines MD, Eke BC, Zhao X. Corticosterone promotes increased heme oxygenase-2 protein and transcript expression in the newborn rat brain. Brain Res. 1996 May 25; 722(1-2):83-94.
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Maines MD, Abrahamsson PA. Expression of heme oxygenase-1 (HSP32) in human prostate: normal, hyperplastic, and tumor tissue distribution. Urology. 1996 May; 47(5):727-33.
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Maines MD, Ewing JF. Stress response of the rat testis: in situ hydridization and immunohistochemical analysis of heme oxygenase-1 (HSP32) induction by hyperthermia. Biol Reprod. 1996 May; 54(5):1070-9.
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Maines MD, Polevoda BV, Huang TJ, McCoubrey WK. Human biliverdin IXalpha reductase is a zinc-metalloprotein. Characterization of purified and Escherichia coli expressed enzymes. Eur J Biochem. 1996 Jan 15; 235(1-2):372-81.
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Maines M. Carbon monoxide and nitric oxide homology: differential modulation of heme oxygenases in brain and detection of protein and activity. Methods Enzymol. 1996; 268:473-88.
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McCoubrey WK, Eke B, Maines MD. Multiple transcripts encoding heme oxygenase-2 in rat testis: developmental and cell-specific regulation of transcripts and protein. Biol Reprod. 1995 Dec; 53(6):1330-8.
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McCoubrey WK, Cooklis MA, Maines MD. The structure, organization and differential expression of the rat gene encoding biliverdin reductase. Gene. 1995 Jul 28; 160(2):235-40.
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Ewing JF, Maines MD. Distribution of constitutive (HO-2) and heat-inducible (HO-1) heme oxygenase isozymes in rat testes: HO-2 displays stage-specific expression in germ cells. Endocrinology. 1995 May; 136(5):2294-302.
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Maines MD, Eke BC, Weber CM, Ewing JF. Corticosterone has a permissive effect on expression of heme oxygenase-1 in CA1-CA3 neurons of hippocampus in thermal-stressed rats. J Neurochem. 1995 Apr; 64(4):1769-79.
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Ewing JF, Maines MD. Immunohistochemical localization of biliverdin reductase in rat brain: age related expression of protein and transcript. Brain Res. 1995 Feb 20; 672(1-2):29-41.
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Vincent SR, Das S, Maines MD. Brain heme oxygenase isoenzymes and nitric oxide synthase are co-localized in select neurons. Neuroscience. 1994 Nov; 63(1):223-31.
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Rublevskaya I, Maines MD. Interaction of Fe-protoporphyrin IX and heme analogues with purified recombinant heme oxygenase-2, the constitutive isozyme of the brain and testes. J Biol Chem. 1994 Oct 21; 269(42):26390-5.
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Ewing JF, Raju VS, Maines MD. Induction of heart heme oxygenase-1 (HSP32) by hyperthermia: possible role in stress-mediated elevation of cyclic 3':5'-guanosine monophosphate. J Pharmacol Exp Ther. 1994 Oct; 271(1):408-14.
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Weber CM, Eke BC, Maines MD. Corticosterone regulates heme oxygenase-2 and NO synthase transcription and protein expression in rat brain. J Neurochem. 1994 Sep; 63(3):953-62.
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McCoubrey WK, Maines MD. Site-directed mutagenesis of cysteine residues in biliverdin reductase. Roles in substrate and cofactor binding. Eur J Biochem. 1994 Jun 1; 222(2):597-603.
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Raju VS, Maines MD. Coordinated expression and mechanism of induction of HSP32 (heme oxygenase-1) mRNA by hyperthermia in rat organs. Biochim Biophys Acta. 1994 Apr 6; 1217(3):273-80.
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McCoubrey WK, Maines MD. The structure, organization and differential expression of the gene encoding rat heme oxygenase-2. Gene. 1994 Feb 25; 139(2):155-61.
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Terry MJ, Maines MD, Lagarias JC. Inactivation of phytochrome- and phycobiliprotein-chromophore precursors by rat liver biliverdin reductase. J Biol Chem. 1993 Dec 15; 268(35):26099-106.
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Maines MD. Carbon Monoxide: An Emerging Regulator of cGMP in the Brain. Mol Cell Neurosci. 1993 Oct; 4(5):389-97.
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Maines MD, Mark JA, Ewing JF. Heme Oxygenase, a Likely Regulator of cGMP Production in the Brain: Induction in Vivo of HO-1 Compensates for Depression in NO Synthase Activity. Mol Cell Neurosci. 1993 Oct; 4(5):396-405.
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Ewing JF, Weber CM, Maines MD. Biliverdin reductase is heat resistant and coexpressed with constitutive and heat shock forms of heme oxygenase in brain. J Neurochem. 1993 Sep; 61(3):1015-23.
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McCoubrey WK, Maines MD. Domains of rat heme oxygenase-2: the amino terminus and histidine 151 are required for heme oxidation. Arch Biochem Biophys. 1993 May; 302(2):402-8.
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Ewing JF, Maines MD. Glutathione depletion induces heme oxygenase-1 (HSP32) mRNA and protein in rat brain. J Neurochem. 1993 Apr; 60(4):1512-9.
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Maines MD, Mayer RD, Ewing JF, McCoubrey WK. Induction of kidney heme oxygenase-1 (HSP32) mRNA and protein by ischemia/reperfusion: possible role of heme as both promotor of tissue damage and regulator of HSP32. J Pharmacol Exp Ther. 1993 Jan; 264(1):457-62.
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Maines MD, Trakshel GM. Purification and characterization of human biliverdin reductase. Arch Biochem Biophys. 1993 Jan; 300(1):320-6.
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Ewing JF, Maines MD. In situ hybridization and immunohistochemical localization of heme oxygenase-2 mRNA and protein in normal rat brain: Differential distribution of isozyme 1 and 2. Mol Cell Neurosci. 1992 Dec; 3(6):559-70.
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Mark JA, Maines MD. Tin-protoporphyrin-mediated disruption in vivo of heme oxygenase-2 protein integrity and activity in rat brain. Pediatr Res. 1992 Sep; 32(3):324-9.
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Maines MD, Trakshel GM. Differential regulation of heme oxygenase isozymes by Sn- and Zn-protoporphyrins: possible relevance to suppression of hyperbilirubinemia. Biochim Biophys Acta. 1992 Jun 15; 1131(2):166-74.
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McCoubrey WK, Ewing JF, Maines MD. Human heme oxygenase-2: characterization and expression of a full-length cDNA and evidence suggesting that the two HO-2 transcripts may differ by choice of polyadenylation signal. Arch Biochem Biophys. 1992 May 15; 295(1):13-20.
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Ewing JF, Haber SN, Maines MD. Normal and heat-induced patterns of expression of heme oxygenase-1 (HSP32) in rat brain: hyperthermia causes rapid induction of mRNA and protein. J Neurochem. 1992 Mar; 58(3):1140-9.
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Fakhrai H, Maines MD. Expression and characterization of a cDNA for rat kidney biliverdin reductase. Evidence suggesting the liver and kidney enzymes are the same transcript product. J Biol Chem. 1992 Feb 25; 267(6):4023-9.
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Trakshel GM, Sluss PM, Maines MD. Comparative effects of tin- and zinc-protoporphyrin on steroidogenesis: tin-protoporphyrin is a potent inhibitor of cytochrome P-450-dependent activities in the rat adrenals. Pediatr Res. 1992 Feb; 31(2):196-201.
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Maines MD, Trakshel GM. Tin-protoporphyrin: a potent inhibitor of hemoprotein-dependent steroidogenesis in rat adrenals and testes. J Pharmacol Exp Ther. 1992 Feb; 260(2):909-16.
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Rotenberg MO, Maines MD. Characterization of a cDNA-encoding rabbit brain heme oxygenase-2 and identification of a conserved domain among mammalian heme oxygenase isozymes: possible heme-binding site? Arch Biochem Biophys. 1991 Nov 1; 290(2):336-44.
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Krueger BA, Trakshel GM, Sluss PM, Maines MD. Cyclosporin-mediated depression of luteinizing hormone receptors and heme biosynthesis in rat testes: a possible mechanism for decrease in serum testosterone. Endocrinology. 1991 Nov; 129(5):2647-54.
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Saunders EL, Maines MD, Meredith MJ, Freeman ML. Enhancement of heme oxygenase-1 synthesis by glutathione depletion in Chinese hamster ovary cells. Arch Biochem Biophys. 1991 Aug 1; 288(2):368-73.
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Ewing JF, Maines MD. Rapid induction of heme oxygenase 1 mRNA and protein by hyperthermia in rat brain: heme oxygenase 2 is not a heat shock protein. Proc Natl Acad Sci U S A. 1991 Jun 15; 88(12):5364-8.
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Trakshel GM, Ewing JF, Maines MD. Heterogeneity of haem oxygenase 1 and 2 isoenzymes. Rat and primate transcripts for isoenzyme 2 differ in number and size. Biochem J. 1991 Apr 1; 275 ( Pt 1):159-64.
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Sun Y, Maines MD. Heme oxygenase-2 mRNA: developmental expression in the rat liver and response to cobalt chloride. Arch Biochem Biophys. 1990 Nov 1; 282(2):340-5.
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Maines MD. Multiple forms of biliverdin reductase: age-related change in pattern of expression in rat liver and brain. Mol Pharmacol. 1990 Oct; 38(4):481-5.
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Iscan M, Reuhl K, Weiss B, Maines MD. Regional and subcellular distribution of cytochrome P-450-dependent drug metabolism in monkey brain: the olfactory bulb and the mitochondrial fraction have high levels of activity. Biochem Biophys Res Commun. 1990 Jun 29; 169(3):858-63.
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Sun Y, Rotenberg MO, Maines MD. Developmental expression of heme oxygenase isozymes in rat brain. Two HO-2 mRNAs are detected. J Biol Chem. 1990 May 15; 265(14):8212-7.
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Mayer RD, Maines MD. Promotion of trans-platinum in vivo effects on renal heme and hemoprotein metabolism by D,L-buthionine-S,R-sulfoximine. Possible role of glutathione. Biochem Pharmacol. 1990 May 15; 39(10):1565-71.
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Rotenberg MO, Maines MD. Isolation, characterization, and expression in Escherichia coli of a cDNA encoding rat heme oxygenase-2. J Biol Chem. 1990 May 5; 265(13):7501-6.
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Maines MD, Sluss PM, Iscan M. cis-platinum-mediated decrease in serum testosterone is associated with depression of luteinizing hormone receptors and cytochrome P-450scc in rat testis. Endocrinology. 1990 May; 126(5):2398-406.
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Iscan M, Maines MD. Differential regulation of heme and drug metabolism in rat testis and prostate: response to cis-platinum and human chorionic gonadotropin. J Pharmacol Exp Ther. 1990 Apr; 253(1):73-9.
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Maines MD. Effect of cis-platinum on heme, drug, and steroid metabolism pathways: possible involvement in nephrotoxicity and infertility. Crit Rev Toxicol. 1990; 21(1):1-20.
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Huang TJ, Maines MD. Bromobenzene-mediated alteration in activity and electrophoretic pattern of biliverdin reductase variants in rat kidney. Mol Pharmacol. 1990 Jan; 37(1):25-9.
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Huang TJ, Trakshel GM, Maines MD. Microheterogeneity of biliverdin reductase in rat liver and spleen: selective suppression of enzyme variants in liver by bromobenzene. Arch Biochem Biophys. 1989 Nov 1; 274(2):617-25.
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Huang TJ, Trakshel GM, Maines MD. Detection of 10 variants of biliverdin reductase in rat liver by two-dimensional gel electrophoresis. J Biol Chem. 1989 May 15; 264(14):7844-9.
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Huang TJ, Trakshel GM, Maines MD. Multiple forms of biliverdin reductase: modification of the pattern of expression in rat liver by bromobenzene. Arch Biochem Biophys. 1989 May 1; 270(2):513-20.
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Mayer RD, Berman S, Cockett AT, Maines MD. Differential effects of cyclosporin on hepatic and renal heme, cytochrome P-450 and drug metabolism. Possible role in nephrotoxicity of the drug. Biochem Pharmacol. 1989 Mar 15; 38(6):1001-7.
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Trakshel GM, Maines MD. Multiplicity of heme oxygenase isozymes. HO-1 and HO-2 are different molecular species in rat and rabbit. J Biol Chem. 1989 Jan 15; 264(2):1323-8.
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Liccione JJ, Maines MD. Manganese-mediated increase in the rat brain mitochondrial cytochrome P-450 and drug metabolism activity: susceptibility of the striatum. J Pharmacol Exp Ther. 1989 Jan; 248(1):222-8.
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Kutty RK, Maines MD. Selective induction of heme oxygenase-1 isozyme in rat testis by human chorionic gonadotropin. Arch Biochem Biophys. 1989 Jan; 268(1):100-7.
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Liccione JJ, Maines MD. Selective vulnerability of glutathione metabolism and cellular defense mechanisms in rat striatum to manganese. J Pharmacol Exp Ther. 1988 Oct; 247(1):156-61.
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Trakshel GM, Maines MD. Detection of two heme oxygenase isoforms in the human testis. Biochem Biophys Res Commun. 1988 Jul 15; 154(1):285-91.
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Maines MD. Heme oxygenase: function, multiplicity, regulatory mechanisms, and clinical applications. FASEB J. 1988 Jul; 2(10):2557-68.
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Trakshel GM, Maines MD. Characterization of glutathione S-transferases in rat kidney. Alteration of composition by cis-platinum. Biochem J. 1988 May 15; 252(1):127-36.
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Bell JE, Maines MD. Kinetic properties and regulation of biliverdin reductase. Arch Biochem Biophys. 1988 May 15; 263(1):1-9.
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Cruse I, Maines MD. Evidence suggesting that the two forms of heme oxygenase are products of different genes. J Biol Chem. 1988 Mar 5; 263(7):3348-53.
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Kutty RK, Daniel RF, Ryan DE, Levin W, Maines MD. Rat liver cytochrome P-450b, P-420b, and P-420c are degraded to biliverdin by heme oxygenase. Arch Biochem Biophys. 1988 Feb 1; 260(2):638-44.
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Trakshel GM, Kutty RK, Maines MD. Resolution of the rat brain heme oxygenase activity: absence of a detectable amount of the inducible form (HO-1). Arch Biochem Biophys. 1988 Feb 1; 260(2):732-9.
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Trakshel GM, Rowley PT, Maines MD. Regulation of the activity of heme degradative enzymes in K562 erythroleukemic cells: induction by thymidine. Exp Hematol. 1987 Sep; 15(8):859-63.
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Kutty RK, Maines MD. Characterization of an NADH-dependent haem-degrading system in ox heart mitochondria. Biochem J. 1987 Sep 1; 246(2):467-74.
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Chung AS, Maines MD. Differential effect of cadmium on GSH-peroxidase activity in the Leydig and the Sertoli cells of rat testis. Suppression by selenium and the possible relationship to heme concentration. Biochem Pharmacol. 1987 Apr 15; 36(8):1367-72.
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Braggins PE, Trakshel GM, Kutty RK, Maines MD. Characterization of two heme oxygenase isoforms in rat spleen: comparison with the hematin-induced and constitutive isoforms of the liver. Biochem Biophys Res Commun. 1986 Dec 15; 141(2):528-33.
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Trakshel GM, Kutty RK, Maines MD. Cadmium-mediated inhibition of testicular heme oxygenase activity: the role of NADPH-cytochrome c (P-450) reductase. Arch Biochem Biophys. 1986 Nov 15; 251(1):175-87.
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Veltman JC, Maines MD. Regulatory effect of copper on rat adrenal cytochrome P-450 and steroid metabolism. Biochem Pharmacol. 1986 Sep 1; 35(17):2903-9.
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Trakshel GM, Kutty RK, Maines MD. Purification and characterization of the major constitutive form of testicular heme oxygenase. The noninducible isoform. J Biol Chem. 1986 Aug 25; 261(24):11131-7.
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Veltman JC, Maines MD. Alterations of heme, cytochrome P-450, and steroid metabolism by mercury in rat adrenal. Arch Biochem Biophys. 1986 Aug 1; 248(2):467-78.
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Maines MD. Differential effect of cis-platinum (cis-diamminedichloroplatinum) on regulation of liver and kidney haem and haemoprotein metabolism. Possible involvement of gamma-glutamyl-cycle enzymes. Biochem J. 1986 Aug 1; 237(3):713-21.
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Maines MD, Trakshel GM, Kutty RK. Characterization of two constitutive forms of rat liver microsomal heme oxygenase. Only one molecular species of the enzyme is inducible. J Biol Chem. 1986 Jan 5; 261(1):411-9.
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Veltman JC, Maines MD. Sex difference in adrenal heme and cytochrome P-450 metabolism: evidence for the repressive regulatory role of testosterone. J Pharmacol Exp Ther. 1985 Oct; 235(1):71-5.
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Jollie DR, Maines MD. Effect of cis-platinum on kidney cytochrome P-450 and heme metabolism: evidence for the regulatory role of the pituitary hormones. Arch Biochem Biophys. 1985 Jul; 240(1):51-9.
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Maines MD, Mayer RD. Inhibition of testicular cytochrome P-450-dependent steroid biosynthesis by cis-platinum. Reversal by human chorionic gonadotropin. J Biol Chem. 1985 May 25; 260(10):6063-8.
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Qato MK, Maines MD. Regulation of heme and drug metabolism activities in the brain by manganese. Biochem Biophys Res Commun. 1985 Apr 16; 128(1):18-24.
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Qato MK, Maines MD. Prevention of neonatal hyperbilirubinaemia in non-human primates by Zn-protoporphyrin. Biochem J. 1985 Feb 15; 226(1):51-7.
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Kutty RK, Maines MD. Effects of induction of heme oxygenase by cobalt and tin on the in vivo degradation of myoglobin. Biochem Pharmacol. 1984 Sep 15; 33(18):2924-6.
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Maines MD, Jollie DR. Dissociation of heme metabolic activities from the microsomal cytochrome P-450 turnover in testis of hypophysectomized rats. J Biol Chem. 1984 Aug 10; 259(15):9557-62.
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Kutty RK, Maines MD. Hepatic heme metabolism: possible role of biliverdin in the regulation of heme oxygenase activity. Biochem Biophys Res Commun. 1984 Jul 18; 122(1):40-6.
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Maines MD. Characterization of heme oxygenase activity in Leydig and Sertoli cells of the rat testes. Differential distribution of activity and response to cadmium. Biochem Pharmacol. 1984 May 1; 33(9):1493-502.
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Maines MD, Veltman JC. Phenylhydrazine-mediated induction of haem oxygenase activity in rat liver and kidney and development of hyperbilirubinaemia. Inhibition by zinc-protoporphyrin. Biochem J. 1984 Jan 15; 217(2):409-17.
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Maines MD. New developments in the regulation of heme metabolism and their implications. Crit Rev Toxicol. 1984; 12(3):241-314.
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Maines MD, Kutty RK. Differential response of testicular and ovarian heme oxygenase activity to metal ions. Arch Biochem Biophys. 1983 Oct 1; 226(1):134-44.
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Kutty RK, Maines MD. Biliverdin reductase: characterization in the rat kidney and the inhibition of activity by mercuric chloride. Biochem Pharmacol. 1983 Jul 1; 32(13):2095-102.
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Maines MD, Chung AS, Kutty RK. The inhibition of testicular heme oxygenase activity by cadmium. A novel cellular response. J Biol Chem. 1982 Dec 10; 257(23):14116-21.
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Chung AS, Maines MD, Reynolds WA. Inhibition of the enzymes of glutathione metabolism by mercuric chloride in the rat kidney: reversal by selenium. Biochem Pharmacol. 1982 Oct 1; 31(19):3093-100.
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Kutty RK, Maines MD. Oxidation of heme c derivatives by purified heme oxygenase. Evidence for the presence of one molecular species of heme oxygenase in the rat liver. J Biol Chem. 1982 Sep 10; 257(17):9944-52.
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Maines MD. Enhancement and inhibition of enzymes of heme metabolism by diethyl maleate in the rat kidney. Arch Biochem Biophys. 1982 Jun; 216(1):17-26.
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Chung AS, Maines MD. Effect of selenium on glutathione metabolism. Induction of gamma-glutamylcysteine synthetase and glutathione reductase in the rat liver. Biochem Pharmacol. 1981 Dec 1; 30(23):3217-23.
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Maines MD, Senft AW. Host heme biosynthesis and degradation in schistosomiasis. Am J Trop Med Hyg. 1981 Sep; 30(5):1010-9.
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Maines MD. Enzymatic basis of metal ion alterations of cellular heme and glutathione metabolism. Fundam Appl Toxicol. 1981 Sep-Oct; 1(5):358-67.
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Kutty RK, Maines MD. Purification and characterization of biliverdin reductase from rat liver. J Biol Chem. 1981 Apr 25; 256(8):3956-62.
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Maines MD. Effect of allylisopropylacetamide on glutathione metabolism in the rat liver. The possible role of glutathione in the induction of 5-aminolaevulinate synthase. Biochem J. 1981 Apr 15; 196(1):285-92.
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Maines MD. Zinc . protoporphyrin is a selective inhibitor of heme oxygenase activity in the neonatal rat. Biochim Biophys Acta. 1981 Mar 18; 673(3):339-50.
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Maines MD. Regional distribution of the enzymes of haem biosynthesis and the inhibition of 5-aminolaevulinate synthase by manganese in the rat brain. Biochem J. 1980 Aug 15; 190(2):315-21.
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Maines MD. Evidence for the catalytic activity of endogenous iron in the lipid peroxidative destruction of heme by allylisopropylacetamide in the rat liver. Int J Biochem. 1980; 12(5-6):781-5.
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Maines MD. Role of trace metals in regulation of cellular heme and hemoprotein metabolism: sensitizing effects of chronic iron treatment on acute gold toxicity. Drug Metab Rev. 1979; 9(2):237-55.
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Maines MD, Kappas A. Prematurely evoked synthesis and induction of delta-aminolevulinate synthetase in neonatal liver. Evidence for metal ion repression of enzyme formation. J Biol Chem. 1978 Apr 10; 253(7):2321-6.
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Maines MD, Kappas A. Metals as regulators of heme metabolism. Science. 1977 Dec 23; 198(4323):1215-21.
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Maines MD, Kappas A. Regulation of cytochrome P-450-dependent microsomal drug-metabolizing enzymes by nickel, cobalt, and iron. Clin Pharmacol Ther. 1977 Nov; 22(5 Pt 2):780-90.
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Maines MD, Kappas A. Enzymes of heme metabolism in the kidney: regulation by trace metals which do not form heme complexes. J Exp Med. 1977 Nov 1; 146(5):1286-93.
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Maines MD, Ibrahim NG, Kappas A. Solubilization and partial purification of heme oxygenase from rat liver. J Biol Chem. 1977 Aug 25; 252(16):5900-3.
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Maines MD, Kappas A. Regulation of heme pathway enzymes and cellular glutathione content by metals that do not chelate with tetrapyrroles: blockade of metal effects by thiols. Proc Natl Acad Sci U S A. 1977 May; 74(5):1875-8.
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Maines MD, Cohn J. Bile pigment formation by skin heme oxygenase: studies on the response of the enzyme to heme compounds and tissue injury. J Exp Med. 1977 Apr 1; 145(4):1054-9.
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Maines MD, Kappas A. Enzymatic oxidation of cobalt protoporphyrin IX: observations on the mechanism of heme oxygenase action. Biochemistry. 1977 Feb 8; 16(3):419-23.
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Maines MD, Sinclair P. Cobalt regulation of heme synthesis and degradation in avian embryo liver cell culture. J Biol Chem. 1977 Jan 10; 252(1):219-23.
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Maines MD, Kappas A. Selenium regulation of hepatic heme metabolism: induction of delta-aminolevulinate synthase and heme oxygenase. Proc Natl Acad Sci U S A. 1976 Dec; 73(12):4428-31.
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Maines MD. Evidence for the catabolism of polychlorinated biphenyl-induced cytochrome P-448 by microsomal heme oxygenase, and the inhibition of delta-aminolevulinate dehydratase by polychlorinated biphenyls. J Exp Med. 1976 Dec 1; 144(6):1509-19.
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Maines MD, Janousek V, Tomio JM, Kappas A. Cobalt inhibition of synthesis and induction of delta-aminolevulinate synthase in liver. Proc Natl Acad Sci U S A. 1976 May; 73(5):1499-503.
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Kappas A, Maines MD. Tin: a potent inducer of heme oxygenase in kidney. Science. 1976 Apr 2; 192(4234):60-2.
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Maines MD, Kappas A. Studies on the mechanism of induction of haem oxygenase by cobalt and other metal ions. Biochem J. 1976 Jan 15; 154(1):125-31.
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Maines MD, Kappas A. The induction of heme oxidation in various tissues by trace metals: evidence for the catabolism of endogenous heme by hepatic heme oxygenase. Ann Clin Res. 1976; 8 Suppl 17:39-46.
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Maines MD, Kappas A. Cobalt stimulation of heme degradation in the liver. Dissociation of microsomal oxidation of heme from cytochrome P-450. J Biol Chem. 1975 Jun 10; 250(11):4171-7.
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Maines MD, Kappas A. Study of the developmental pattern of heme catabolism in liver and the effects of cobalt on cytochrome P-450 and the rate of heme oxidation during the neonatal period. J Exp Med. 1975 Jun 1; 141(6):1400-10.
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Maines MD, Kappas A. The degradative effects of porphyrins and heme compounds on components of the microsomal mixed function oxidase system. J Biol Chem. 1975 Mar 25; 250(6):2363-9.
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Maines MD, Kappas A. Cobalt induction of hepatic heme oxygenase; with evidence that cytochrome P-450 is not essential for this enzyme activity. Proc Natl Acad Sci U S A. 1974 Nov; 71(11):4293-7.
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Maines MD, Anders MW, Muller-Eberhard U. Studies on heme transfer from microsomal hemoproteins to heme-binding plasma proteins. Mol Pharmacol. 1974 Mar; 10(2):204-13.
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Maines MD, Anders MW. Characterization of the heme of cytochrome P-450 using gas chromatography-mass spectrometry. Arch Biochem Biophys. 1973 Nov; 159(1):201-5.
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Maines MD, Anders MW. Reconstitution of carbon monoxide-binding particles after removal of heme by serum albumin. Mol Pharmacol. 1973 Mar; 9(2):219-28.
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Maines MD, Anders MW. The possible implication of heme transfer from cytochrome P-420 to albumin in the metabolism of cytochrome P-450. Drug Metab Dispos. 1973 Jan-Feb; 1(1):293-8.
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Short CR, Maines MD, Davis LE. Preparation of hepatic microsomal fraction for drug metabolism studies by rapid decompression homogenization. Proc Soc Exp Biol Med. 1972 May; 140(1):58-65.
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Short CR, Maines MD, Westfall BA. Postnatal development of drug-metabolizing enzyme activity in liver and extrahepatic tissues of swine. Biol Neonate. 1972; 21(1):54-68.
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Maines MD, Westfall BA. Sex difference in the metabolism of hexobarbital in the mongolian gerbil (Meriones unguiculatus). Proc Soc Exp Biol Med. 1971 Dec; 138(3):820-2.
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Maines MD, Westfall BA. Effect of water deprivation on the metabolism of hexobarbital in the Mongolian gerbil (Meriones unguiculatus). Comp Gen Pharmacol. 1971 Sep; 2(7):311-6.
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Maines MD, Wosilait WD. An autoradiographic study of the distribution and excretion of 14C-dicoumarol in the rat. Comp Gen Pharmacol. 1971 Jun; 2(6):184-8.
